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Assessment of alpine summit flora in Kashmir Himalaya and its implications for long-term monitoring of climate change impacts

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Journal of Mountain Science 2020年第8期17卷 1974-1988页

作者： Maroof HAMID Anzar Ahmad KHUROO akhtar hussain malik Rameez AHMAD Chandra Prakash SINGH Centre for Biodiversity&Taxonomy Department of BotanyUniversity of KashmirSrinagar-190006J&KIndia Space Applications Centre Indian Space Research OrganizationAhmedabad-380015India

In an era of climate change,the availability of empirical data on alpine summit vegetation in the Himalaya is still *** we report the assessment of alpine summit flora in Gulmarg Wildlife Sanctuary,Kashmir *** employed a globally standardized Multi-Summit Approach and four spatially isolated summits spanning an elevation gradient of 210 m(between 3530-3740 m a.s.l.)from natural treeline to nival zone were *** of the summits was carried out in the year 2018 to collect floristic data together with records of soil temperature.A total of 142 vascular plant species were recorded in the sampled *** of the species were of herbaceous growth form and with perennial life *** on Raunkiaer’s life form,hemicryptophytes were the most dominant followed by therophytes and *** summit flora showed the predominance of narrow-endemic species,with broad-and non-endemics declining with elevation.A significant relationship between growth form,Raunkiaer’s life form,and the degree of endemism with elevation was *** species diversity and soil temperature showed a monotonic decrease with increasing ***,soil temperature clearly determined the magnitude of species diversity on the ***,based on floristic composition,the lowest summit had the highest dissimilarity with the rest of the *** present study employed globally standardized protocol to scientifically assess the patterns of plant diversity on the alpine mountain summits of Kashmir Himalaya,which in turn has wide implications towards long-term monitoring of climate change impact on alpine biodiversity in the rapidly warming Himalaya.

关键词： Alpine ecosystem Elevation gradient Endemism Himalaya Mountain summits

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Benefitting from Geoinformatics: Estimating Floristic Diversity of Warwan Valley in Northwestern Himalaya,India

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Journal of Mountain Science 2015年第4期12卷 854-863页

作者： akhtar hussain malik Irfan RASHID Aijaz Hassan GANIE Anzar Ahmad KHUROO Ghulam Hassan DAR Centre for Biodiversity and Taxonomy Department of Botany University of Kashmir Department of Earth Sciences University of Kashmir Department of Botany University of Kashmir Mahatma Gandhi Chair on Ecology and Environment Centre for Biodiversity Studies Baba Ghulam Shah Badshah University

The Himalaya harbor rich floristic diversity which is of immense scientific interest and socio-economic *** this study, floristic diversity of a remote alpine valley has been studied based on information extracted from remotely sensed satellite data along with field surveys undertaken during *** of vegetation information from satellite data revealed that ~75% of the area is covered with natural vegetation which comprises lush green coniferous forests, alpine pastures and alpine scrub *** inputs from vegetation information extracted from satellite data, comprehensive field surveys were planned to document the floristic diversity of the *** of species composition showed a total of 285 plant species,belonging to 191 genera in 60 *** these, 250 species are herbs, 14 shrubs, 2 sub-shrubs and 19 *** dicotyledons are represented by 240 species, monocotyledons 30, gymnosperms 04, andpteriodophytes 11 *** is the largest family with 35 *** the present study, 5species（Corydalis cashmeriana, Hippophae rhamnoides, Primula minutissima, Saussurea sacra and Inula orientalis） have been recorded for the first time from this Himalayan *** study demonstrates the benefits of geo-informatics in floristic studies, particularly the robustness of remotely sensed data in identifying areas with potentially high species richness, which would be otherwise difficult in a complex mountainous terrain using traditional floristic surveys *** present study is expected to provide baseline scientific data for cutting edge studies relating to long term ecological research, bioprospecting, possible impacts of changing climate on vegetation and sustainable use of plant resources in this Himalayan region.

关键词： Floristic diversity Northwestern Himalaya Remote sensing GIS Vegetation sampling

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MicroRNAs modulation in lung cancer: exploring dual mechanisms and clinical prospects

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BIOCELL 2024年第3期48卷 403-413页

作者： SHAHID hussain HABIB BOKHARI XINGXING FAN SHAUKAT IQBAL malik SUNDAS IJAZ MUHAMMAD ADNAN SHEREEN AIMAN FATIMA Department of Biotechnology Kohsar University MurreeMurreePakistan Macao University of Science and Technology State Key Laboratory of Quality Research in Chinese Medicines TaipaMacao Department of Bioinformatics and Biosciences Capital University of Science and TechnologyIslamabadPakistan Department of Microbiology Kohsar University MurreeMurreePakistan

The global incidence of lung cancer is marked by a considerably elevated mortality ***(miRNAs)exert pivotal inﬂuence in the intricate orchestration of gene regulation,and their dysregulation can precipitate dire consequences,notably *** this context,miRNAs encapsulated in exosomes manifest a diversiﬁed impact on the landscape of lung cancer,wherein their actions may either foster angiogenesis,cell proliferation,and metastasis,or counteract these *** comprehensive review article discerns potential targets for the prospective development of therapeutic agents tailored for lung ***-suppressive miRNAs,such as miR-204,miR-192,miR-30a,miR-34a,miR-34b,miR-203,and miR-212,exhibit heightened expression and demonstrate the capacity to inhibit cellular proliferation and ***,the deleterious effects of tumor-promoting miRNAs like miR-21,miR-106a,miR-155,miR-205,and miR-210 can be attenuated through the application of their respective *** miRNAs selectively target various oncogenes,including NUAK Family Kinase 1(NUAK1),Snail Family Transcriptional Repressor 1(Snai1),Astrocyte elevated gene-1(AEG-1),Vimentin,Proliferation and apoptosis adaptor protein 15(PEA-15/PED),Hypoxia-inducible factor 1-alpha(HIF1),as well as tumor suppressor genes such as phosphatase and tensin homolog(PTEN),Suppressor of cytokine signaling 1(SOCS1),Tumor protein P53 binding protein 1(TP53BP1),and PH Domain and Leucine Rich Repeat Protein Phosphatase 2(PHLP22).This investigative approach proves invaluable in elucidating the speciﬁc miRNAs implicated in the deregulation of crucial genes pivotal to the pathogenesis of cancer.

关键词： miRNAs Oncogenes Tumor suppressive genes Lung cancer therapy

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Recent advances on vaccines against malaria: A review

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Asian Pacific Journal of Tropical Medicine 2024年第4期17卷 143-159页

作者： Shiza malik Yasir Waheed Bridging Health Foundation Rawalpindi 46000Pakistan Gilbert and Rose-Marie Chagoury School of Medicine Lebanese American UniversityByblos 1401Lebanon MEU Research Unit Middle East UniversityAmman11831Jordan

This review aims to summarize the currently viable vaccine strategies including the approved vaccines and the those in trials for next-generation malaria *** on malaria vaccine development was collected through a comprehensive *** literature search was performed using databases including Google Scholar,PubMed,NIH,and Web of *** novel approaches of vaccination are being developed,including those based on radiation-attenuated strategies,monoclonal antibodies,targeted immunogenic peptides,RNA and DNA vaccines,nanoparticle-based vaccines,protein-based vaccination protocols,and whole organism-based vaccination *** on RTS,S have entered phase Ⅲtesting,and those based on blood-stage vaccines and vaccines to interrupt malarial transmission have advanced to higher stages of *** modeling,combined drug and vaccine strategies,mass drug administration,polyvalent vaccine formulations,and targeted vaccination campaigns is playing an important role in malarial ***,assessing coverage,accessibility,acceptability,deployment,compilation,and adherence to specific vaccination strategies in endemic regions is essential for vaccination drives against malaria.

关键词： Vaccines against malaria Drugs and adjuvant Malarial treatment Plasmodium RTS,S vaccine

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Unveiling a new regulator: Vacuolar V-ATPase mediates brassinosteroid signaling in Arabidopsis

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Molecular Plant 2024年第2期17卷 227-229页

作者： Shikha malik Justin W.Walley Department of Plant Pathology Entomologyand Microbiologylowa State UniversityAmesIA 50011USA

Plant growth and development are intricately regulated by hormones such as auxins,gibberellins,jamonates,cytokinins,and brassinosteroids(BRs).BRs are a group of plant steroid hormones that play a vital role in plant growth and response to the *** regulate many biological processes including cell elongation,cell division,and male fertility,as well as abiotic and biotic stress responses.

关键词： media fertility brassinosteroid

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Detailed analysis of the relativistic configuration of Bardeen anisotropic spheres in modified f(G)gravity

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Communications in Theoretical Physics 2024年第6期76卷 45-56页

作者： Adnan malik Ayesha Almas Tayyaba Naz Rubab Manzoor M Z Bhatti School of Mathematical Sciences Zhejiang Normal UniversityJinhuaZhejiangChina Department of Mathematics University of Management and TechnologySialkot CampusLahorePakistan National University of Computer and Emerging Sciences Lahore CampusPakistan Department of Mathematics University of Management and TechnologyJohar Town CampusLahore 54782Pakistan Department of Mathematics University of the PunjabQuaid-i-Azam CampusLahore-54590Pakistan

The aim of this work is to investigate anisotropic compact objects within the framework of f(G)modified theory of *** our present work,we utilize Krori-Barua metrics,i.e.,λ(r)=Xr^(2)+Y andβ(r)=Zr^(2).We use some matching conditions of spherically symmetric spacetime with Bardeen's model as an exterior ***,we establish some expressions of energy density and pressure components to analyze the stellar configuration of Bardeen compact stars by assuming viable f(G)*** examine the energy conditions for different stellar structures to verify the viability of our considered ***,we also investigate some other physical features,such as equilibrium condition,equation of state parameters,adiabatic index,stability analysis,mass function,surface redshift,and compactness factor,*** is worthwhile to mention here for the current study that our stellar structure in the background of Bardeen's model is more viable and stable.

关键词： Bardeen compact stars f(G)modified gravity Krori-Barua potential

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Improved Dwarf Mongoose Optimization Algorithm for Feature Selection:Application in Software Fault Prediction Datasets

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Journal of Bionic Engineering 2024年第4期21卷 2000-2033页

作者： Abdelaziz I.Hammouri Mohammed A.Awadallah malik ShBraik Mohammed Azmi Al-Betar Majdi Beseiso Department of Computer Science Al-Balqa Applied UniversityAl-Salt19117Jordan Department of Scientific Research and Graduate Studies University of Prince Mugrin42241MedinaSaudi Arabia Department of Computer Science Al-Aqsa UniversityGaza4051Palestine Artificial Intelligence Research Center(AIRC) Ajman UniversityAjmanUnited Arab Emirates Department of Information Technology Al-Huson University CollegeAl-Balqa Applied UniversityAl-HusonIrbid21110Jordan

Feature selection(FS)plays a crucial role in pre-processing machine learning datasets,as it eliminates redundant features to improve classification accuracy and reduce computational *** paper presents an enhanced approach to FS for software fault prediction,specifically by enhancing the binary dwarf mongoose optimization(BDMO)algorithm with a crossover mechanism and a modified positioning updating *** proposed approach,termed iBDMOcr,aims to fortify exploration capability,promote population diversity,and lastly improve the wrapper-based FS process for software fault prediction *** gained superb performance compared to other well-esteemed optimization methods across 17 benchmark *** ranked first in 11 out of 17 datasets in terms of average classification ***,iBDMOcr outperformed other methods in terms of average fitness values and number of selected features across all *** findings demonstrate the effectiveness of iBDMOcr in addressing FS problems in software fault prediction,leading to more accurate and efficient models.

关键词： Dwarf mongoose optimization algorithm Optimization Feature selection Classification

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Advances in Zika virus vaccines and therapeutics:A systematic review

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Asian Pacific Journal of Tropical Medicine 2024年第3期17卷 97-109页

作者： Shiza malik Khalid Muhammad Omar Ahsan Muhammad Tahir Khan Ranjit Sah Yasir Waheed Bridging Health Foundation Rawalpindi 46000Pakistan Department of Biology College of SciencesUAE University15551Al AinUnited Arab Emirates Department of Medicine Foundation University Medical CollegeFoundation University IslamabadIslamabad 44000Pakistan INTI International University Persiaran Perdana BBN Putra Nilai71800 NilaiNegeri SembilanMalaysia Institute of Molecular Biology and Biotechnology the University of LahoreKM Defence RoadLahore 58810Pakistan Zhongjing Research and Industrialization Institute of Chinese Medicine Zhongguancun Scientific ParkNanyang 473006China Department of Microbiology Tribhuvan University Teaching HospitalInstitute of MedicineKathmandu 44600Nepal Department of Microbiology Dr.D.Y.Patil Medical CollegeHospital and Research CentreDr.D.Y.Patil VidyapeethPune 411018MaharashtraIndia Department of Public Health Dentistry Dr.D.Y.Patil Dental College and HospitalDr.D.Y.Patil VidyapeethPune 411018MaharashtraIndia Gilbert and Rose-Marie Chagoury School of Medicine Lebanese American UniversityByblos 1401Lebanon

Zika virus(ZIKV)is the causative agent of a viral infection that causes neurological complications in newborns and adults *** wide transmission route and alarming spread rates are of great concern to the scientific *** trials have been conducted to develop treatment options for ZIKV *** review highlights the latest developments in the fields of vaccinology and pharmaceuticals developments for ZIKV infection.A systematic and comprehensive approach was used to gather relevant and up-to-date data so that inferences could be made about the gaps in therapeutic *** results indicate that several therapeutic interventions are being tested against ZIKV infection,such as DNA vaccines,subunit vaccines,live-attenuated vaccines,virus-vector-based vaccines,inactivated vaccines,virus-like particles,and mRNA-based *** addition,approved anti-ZIKV drugs that can reduce the global burden are *** many vaccine candidates for ZIKV are at different stages of development,none of them have received Food and Drug Authority approval for use up to *** issue of side effects associated with these drugs in vulnerable newborns and pregnant women is a major obstacle in the therapeutic pathway.

关键词： Zika virus Infection Therapeutics Antiviral agents Vaccines Therapies Treatment Novel therapeutic Clinical management

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The Combination of Achnatherum inebrians Extracts and Soil Microorganisms Inhibited Seed Germination and Seedling Growth in Elymus nutans

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Phyton-International Journal of Experimental Botany 2024年第3期93卷 567-580页

作者： Rui Zhang Taixiang Chen Zhenjiang Chen Hao Chen Xuekai Wei malik Kamran Chunjie Li State Key Laboratory of Herbage Improvement and Grassland Agro-Ecosystems Key Laboratory of Animal Husbandry InnovationMinistry of Agriculture and Rural AffairsEngineering Research Center of Grassland AgricultureMinistry of EducationWest Gansu Province Prataculture Technology Innovation CenterCollege of Pastoral Agriculture Science and TechnologyLanzhou UniversityLanzhou730020China Center for Grassland Research National Forestry and Grassland AdministrationCaFBeijing100091China

In a greenhouse experiment,the effects of soil microorganisms and extracts of Achnatherum inebrians on the seed germination and seedling growth of Elymus nutans were *** results showed that both the extracts from aboveground and belowground parts of *** signiﬁcantly inhibited the germination rate,germination potential,germination index,vigor index,seedling height,root length,and fresh weight of ***,but increased malondialdehyde content,catalase,peroxidase and superoxide dismutase activity of *** seedlings(p<0.05).The allelopathy of aqueous extracts of the aboveground parts of *** was stronger than that of the *** extracts of the aboveground parts of *** decreased seed germination rate,germination potential,germination index,vigor index,seedling length,root length,and seedling fresh weight by 10.45%-74.63%,24.18%-32.50%,19.03%-73.36%,37.83%-88.41%,21.42%-53.14%,2.65%-40.21%,and 20.45%-61.36%,respectively,and malondialdehyde content,peroxidase,catalase,and superoxide dismutase activity increased by 8.09%-62.24%,27.83%-86.47%,22.90%-93.17%,and 11.15%-75.91%,*** above indexes were higher in live soil than in sterilized *** microorganisms increased the allelopathy of *** seed germination rate,germination potential,germination index,vigor index,seedling length,and seedling fresh weight of *** planted in live soil decreased by 8.22%-48.48%,10.00%-51.85%,8.19%-53.26%,16.43%-60.03%,12.91%-28.81%,and 9.09%-22.86%compared with sterilized soil,*** content,peroxidase,catalase,and superoxide dismutase activity of *** planted in live soil increased by 53.91%-81.06%,15.71%-57.34%,33.33%-86.31%,and 9.78%-52.51%compared with sterilized soil,*** existence of soil microorganisms enhanced the allelopathy of the secondary metabolites of ***.A combination of microorganisms and aqueous extracts from the aboveground parts of *** had the s

关键词： Achnatherum inebrians water immersion liquid aqueous leachate precipitate allelopathy Elymus nutans soil microorganisms

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An Explanation of the Temperature-Dependent Upper Critical Field Data of H3S on the Basis of the Thermodynamics of a Superconductor in a Magnetic Field

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World Journal of Condensed Matter Physics 2024年第3期14卷 45-50页

作者： Gulshan Prakash malik Gurugram India Theory Group School of Environmental Sciences Jawaharlal Nehru University New Delhi India

Excellent fits to a couple of the data-sets on the temperature (T)-dependent upper critical field (Hc2) of H3S (critical temperature, Tc ≈ 200 K at pressure ≈ 150 GPa) reported by Mozaffari, et al. (2019) were obtained by Talantsev (2019) in an approach based on an ingenious mix of the Ginzberg-Landau (GL), the Werthamer, Helfand and Hohenberg (WHH), and the Gor’kov, etc., theories which have individually been employed for the same purpose for a long time. Up to the lowest temperature (TL) in each of these data-sets, similarly accurate fits have also been obtained by malik and Varma (2023) in a radically different approach based on the Bethe-Salpeter equation (BSE) supplemented by the Matsubara and the Landau quantization prescriptions. For T TL, however, while the (GL, WHH, etc.)-based approach leads to Hc2(0) ≈ 100 T, the BSE-based approach leads to about twice this value even at 1 K. In this paper, a fit to one of the said data-sets is obtained for the first time via a thermodynamic approach which, up to TL, is as good as those obtained via the earlier approaches. While this is interesting per se, another significant result of this paper is that for T TL it corroborates the result of the BSE-based approach.

关键词： H3S Upper Critical Field (Hc2) Variation of Hc2 with Temperature Clausius-Clapeyron equation in a magnetic field Behavior of Hc2 for Temperatures Close to 0 K

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