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城市道路修复水泥混凝土路面的施工技术

山西建筑 2018年第5期44卷 135-137页

作者：贾爱丽山西临汾市政工程集团股份有限公司山西临汾041000

早期修建的水泥混凝土路面大部分已接近使用年限,因为交通压力、保养等多方面的原因,路面产生了破损。为了对其进行修复,可采用水泥混凝土修复技术来进行施工,从而修复病害,保证交通道路的质量。介绍了水泥混凝土路面破损的一般形式,以... 详细信息

早期修建的水泥混凝土路面大部分已接近使用年限,因为交通压力、保养等多方面的原因,路面产生了破损。为了对其进行修复,可采用水泥混凝土修复技术来进行施工,从而修复病害,保证交通道路的质量。介绍了水泥混凝土路面破损的一般形式,以及产生破损的主要原因,并提出了病害处理和维修的措施,从而为相关技术提供了一些依据,同时也为城市交通的维护奠定了坚实的基础。

关键词：城市道路水泥混凝土路面施工技术

冲突监控中兴奋与抑制过程的事件相关电位N450的研究

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生物医学工程研究 2024年第2期43卷 144-150页

作者：王爱莉贾美雪随力上海理工大学健康科学与工程学院上海200093

为探讨健康人执行Stroop变式(字义-时长)任务时,冲突监控过程中兴奋与抑制对事件相关电位N450的影响。本研究选取了46名本科生随机分配至时长估计任务组(n=22)和一致性判断任务组(n=24),分别诱发字义的抑制及字义的兴奋与抑制,对两组在... 详细信息

为探讨健康人执行Stroop变式(字义-时长)任务时,冲突监控过程中兴奋与抑制对事件相关电位N450的影响。本研究选取了46名本科生随机分配至时长估计任务组(n=22)和一致性判断任务组(n=24),分别诱发字义的抑制及字义的兴奋与抑制,对两组在两种条件下(字义-时长判断冲突与不冲突)的行为数据和事件相关电位N450进行研究。结果发现:(1)两组冲突条件下,反应时显著增加;在时长估计任务组中,冲突条件下正确率显著下降(P<0.05);(2)仅诱导字义的抑制,冲突与不冲突条件下N450波幅无显著差异;同时诱导字义的抑制与兴奋,冲突与不冲突条件下N450波幅有显著差异(P<0.05);(3)sLORETA溯源结果表明,冲突处理与扣带回和额顶叶网络被激活有关。研究表明,刺激冲突时被试的反应会受到显著影响,事件相关电位N450与刺激的兴奋与抑制过程有关。

关键词： Stroop 认知控制事件相关电位冲突监控 N450

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时距记忆提取阶段的脑电信号研究

国际生物医学工程杂志 2024年第3期47卷 234-241页

作者：王爱莉贾美雪随力上海理工大学健康科学与工程学院上海200093

目的对时距记忆提取阶段的行为学指标以及脑电信号在不同提取次数下的变化规律进行探讨。方法随机抽取2022年11月招募的上海理工大学健康被试30名, 采用时间估计任务的再现法, 记录被试1 500 ms时距记忆提取阶段的反应时间和脑电信号, ... 详细信息

目的对时距记忆提取阶段的行为学指标以及脑电信号在不同提取次数下的变化规律进行探讨。方法随机抽取2022年11月招募的上海理工大学健康被试30名, 采用时间估计任务的再现法, 记录被试1 500 ms时距记忆提取阶段的反应时间和脑电信号, 计算记忆错误率、精度和准确度以及脑电信号低频段功率, 进行时频分析和溯源分析, 并对记忆错误率、精度与θ、β节律的相关性进行pearson相关性分析。结果时间差和记忆精度在提取次数间存在主效应[F(3, 1 196)=2.932, P=0.033;F(3, 1 196)=3.191, P=0.026], 且随着提取次数的增加而变大。记忆准确度不存在主效应, 但随着提取次数增加, 准确度均值变大。随着记忆提取次数增加, 左侧额叶的θ节律功率逐渐变大[F(3, 116)=2.668, P=0.035], 额中叶β节律平均功率逐渐减小[F(3, 116)=2.810, P=0.029]。上顶叶体感联合皮层(BA7)、背外侧前额叶(BA9)和前运动皮层(BA6)脑区在第1次与第2次、第2次与第3次、第3次与第4次记忆提取中的电流密度分布差异均出现了增加(P<0.01)。θ节律与记忆精度呈正相关(r=0.258, P<0.05), β节律与记忆精度呈负相关(r=?0.404, P<0.01)。结论时距记忆提取阶段, 增加时距记忆的提取次数会提高记忆错误率和精度, 记忆精度与左侧额叶θ节律功率增加以及额中央区域β节律减小有关。

关键词：脑电信号记忆提取效应记忆精度时频分析 θ节律 β节律

Phenotype and metabolism alterations in PCB-degrading Rhodococcus biphenylivorans TG9^(T) under acid stress

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Journal of Environmental Sciences 2023年第5期127卷 441-452页

作者： aili Li jiahui Fan Yangyang jia Xianjin Tang Jingwen Chen Chaofeng Shen Department of Environmental Engineering College of Environmental and Resource SciencesZhejiang UniversityHangzhou 310058China MOE Key Lab of Environmental Remediation and Ecosystem Health College of Environmental and Resource SciencesZhejiang UniversityHangzhou 310058China

Environmental acidification impairs microorganism diversity and their functions on substance *** is a ubiquitously distributed genus for contaminant detoxification in the environment,and it can also adapt a certain range of *** work interpreted the acid responses from both phenotype and metabolism in strain Rhodococcus biphenylivorans TG9^(T)(TG9)induced at pH *** phenotype alterations were described with the number of culturable and viable cells,intracellular ATP concentrations,cell shape and entocyte,degradation efficiency of polychlorinated biphenyl(PCB)31 and *** number of culturable cells maintained rather stable within the first 10 days,even though the other phenotypes had noticeable alterations,indicating that TG9 possesses certain capacities to survive under acid *** metabolism responses were interpreted based on transcription analyses with four treatments including log phase(LP),acid-induced(PER),early recovery after removing acid(RE)and later recovery(REL).With the overview on the expression regulations among the 4 treatments,the RE sample presented more upregulated and less downregulated genes,suggesting that its metabolism was somehow more active after recovering from acid *** addition,the response mechanism was interpreted on 10 individual metabolism pathways mainly covering protein modification,antioxidation,antipermeability,H+consumption,neutralization and ***,the transcription variations were verified with RT-qPCR on 8 genes with 24-hr,48-hr and 72-hr acid *** together,TG9 possesses comprehensive metabolism strategies defending against acid ***,a model was built to provide an integrate insight to understand the acid resistance/tolerance metabolisms in microorganisms.

关键词： Environmental acidification Rhodococcus biphenylivorans Contaminant degradation Phenotypic response Transcription analysis Metabolism pathway Mechanism model

应用品管圈对肠镜检查前口服聚乙二醇电解质散剂住院患者肠道清洁度合格率的影响

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中国医药 2017年第10期12卷 1552-1556页

作者：杨军李井娜段爱丽乔佳高峰张杰首都医科大学附属北京安贞医院消化内科 100029

目的探讨应用品管圈对肠镜检查前口服聚乙二醇电解质散剂（舒泰清）住院患者肠道清洁度合格率的影响，从而探索出肠镜检查肠道准备更科学的方法。方法选取首都医科大学附属北京安贞医院2016年3月至2017年2月需要做肠镜检查的住院患者77... 详细信息

目的探讨应用品管圈对肠镜检查前口服聚乙二醇电解质散剂（舒泰清）住院患者肠道清洁度合格率的影响，从而探索出肠镜检查肠道准备更科学的方法。方法选取首都医科大学附属北京安贞医院2016年3月至2017年2月需要做肠镜检查的住院患者776例作为研究对象，将2016年3—9月调查的480例患者设为活动前组，将2016年10月至2017年2月调查的296例患者设为活动后组。成立品管圈小组，以“提高住院患者肠镜检查前口服舒泰清药物肠道准备清洁度合格率”为活动主题，通过现状调查，设定目标值，解析出影响患者肠道准备清洁度的主要因素为：患者对清肠药物舒泰清饮水量大不耐受、护士宣教形式单一和护士无法评估患者肠镜检查前3 d饮食，故针对这3个真因来拟定对策并组织实施改进方案。比较活动前后肠道清洁度合格率，计算品管圈活动后的目标达成率和进步率，评估品管圈活动对圈员综合能力的影响。结果活动后组肠道清洁度合格率明显高于活动前组［95.6％（283/296）比87.1％（418/480）］，差异有统计学意义（P＜0.001）。品管圈活动后的目标达成率为93.4％，进步率为65.9％。品管圈活动后，圈员对品管圈手法的认知和沟通协调、脑力激荡、团队精神、发掘问题的能力均有成长。结论本次品管圈活动制定了肠道准备的宣传手册和宣传展板，规范了预约肠镜的流程，提高了患者肠道准备清洁度合格率，提升了护理人员的专业知识水平、团队协作精神及质量管理能力。

关键词：肠镜检查品管圈肠道清洁度聚乙二醇电解质散剂

Wheat functional genomics in the era of next generation sequencing: An update

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The Crop Journal 2018年第1期6卷 7-14页

作者： Meiling jia jiantao Guan Zhiwen Zhai Shuaifeng Geng Xueyong Zhang Long Mao aili Li National Key Facility for Crop Gene Resources and Genetic Improvement Institute of Crop ScienceChinese Academy of Agricultural Sciences

Bread wheat is not only an important cereal crop but also a model for study of an allopolyploid plant with a large, highly repetitive genome. Advances in next-generation sequencing(NGS) technology provide needed throughput to conquer the enormous size of the wheat genome. Multiple high quality reference genome sequences will soon be available. Full-scale wheat functional genomics studies are dawning. In this review we highlight the available tools and methodologies for wheat functional genomics research developed with the assistance of NGS technology and recent progress, particularly the concerted effort in generating multiple reference genomes, strategies to attain genome-wide genetic variation, genome-wide association studies, mutant population generation, and NGS-supported gene cloning and functional characterization. These resources and platforms lay a solid foundation for wheat research, leading to a new era of wheat functional genomics that will bridge the gap between genotype and *** of wheat genomes and gene functions should assist in genomics-assisted selection and facilitate breeding of elite varieties for sustainable agriculture in China and the world.

关键词： GWAS NGS TILLING Triticum aestivum

CRISPR/Cas9:A powerful tool for crop genome editing

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The Crop Journal 2016年第2期4卷 75-82页

作者： Gaoyuan Song Meiling jia Kai Chen Xingchen Kong Bushra Khattak Chuanxiao Xie aili Li Long Mao National Key Facility for Crop Gene Resources and Genetic Improvement Institute of Crop ScienceChinese Academy of Agricultural Sciences

The CRISPR/Cas9 technology is evolved from a type II bacterial immune system and represents a new generation of targeted genome editing technology that can be applied to nearly all organisms. Site-specific modification is achieved by a single guide RNA(usually about 20nucleotides) that is complementary to a target gene or locus and is anchored by a protospaceradjacent motif. Cas9 nuclease then cleaves the targeted DNA to generate double-strand breaks(DSBs), which are subsequently repaired by non-homologous end joining(NHEJ) or homology-directed repair(HDR) mechanisms. NHEJ may introduce indels that cause frame shift mutations and hence the disruption of gene functions. When combined with double or multiplex guide RNA design, NHEJ may also introduce targeted chromosome deletions,whereas HDR can be engineered for target gene correction, gene replacement, and gene knock-in. In this review, we briefly survey the history of the CRISPR/Cas9 system invention and its genome-editing mechanism. We also describe the most recent innovation of the CRISPR/Cas9 technology, particularly the broad applications of modified Cas9 variants, and discuss the potential of this system for targeted genome editing and modification for crop improvement.

关键词： CRISPR/Cas9 Double-strand break Genome editing TALENs ZFNs

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建筑工程施工中绿色施工技术的应用

中国厨卫 2023年第7期22卷 244-246页

作者：孙东霞贾爱丽龙达恒信工程咨询有限公司山东济南250000

建筑的工程规模的不断扩大不仅会造成建筑施工的材料浪费,还会污染和破坏施工的周围环境。为了保证工程高质量、高效率地完成,施工单位应用了绿色施工技术,在施工过程中能减少能源的消耗以及对环境的影响。基于此,文章阐述了绿色施工管... 详细信息

建筑的工程规模的不断扩大不仅会造成建筑施工的材料浪费,还会污染和破坏施工的周围环境。为了保证工程高质量、高效率地完成,施工单位应用了绿色施工技术,在施工过程中能减少能源的消耗以及对环境的影响。基于此,文章阐述了绿色施工管理的基本概念,分析了绿色施工技术的科学应用,探讨了完善建筑工程绿色施工管理的具体措施,以期为相关工作提供参考。

关键词：建筑工程施工技术可持续发展

Application of sodium alginate microspheres in ischemic stroke modeling in miniature pigs

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Neural Regeneration Research 2013年第16期8卷 1473-1480页

作者： Yongchun Cui Yi Tian Yue Tang Liujun jia aili Wu Peng Peng jianzhong Yang Hong Du Xiaojuan Wang Like Wu State Key Laboratory of Cardiovascular Disease Fuwai Hospital National Center for Cardiovascular Diseases Chinese Academy of Medical Sciences and Peking Union Medical College Wu Stem Cells Medical Center Beijing Union Health Co. Ltd.

The miniature pig is an optimal animal model for studying nervous system disease because of its physiologic and pathologic features. However, the rete mirabile composed of arteries and veins at the skull base limits their application as a model of ischemic stroke by middle cerebral artery occlusion. The present study investigated the possibility of establishing an ischemic stroke model in the miniature pig by blocking the skull base retia with sodium alginate microspheres. Three Bama miniature pigs were used. Using the monitor of C-arm X-ray machine, sodium aiginate microspheres （100-300 pm）, a novel embolic material, were injected through the femoral artery, aortic arch, common carotid artery, ascending pharyngeal artery and the retia. Results were evaluated using carotid arteriography, MRI, behavior observation and histology. The unilateral rete mirabile was completely blocked, resulting in disturbance in blood supply to the basal ganglia, astasia of the dght hind limb and salivation. MRI and hematoxylin-eosin staining showed an evident infarction focus in the basal ganglia. These findings indicate that sodium alginate microspheres are a suitable embolic material for blocking the skull base retia in miniature pigs to establish an ischemic stroke models.

关键词： neural regeneration brain injury stroke miniature pig sodium alginate microsphere basilar bloodvessels middle cerebral artery grants-supported paper neuroregeneration