检索结果-南通市图书馆

Extreme Weather Disruptions and Emergency Preparedness Among Older Adults in Ohio: An Eight-County Assessment

在线全文

学校读者我要写书评

暂无评论

International Journal of Disaster Risk Science 2024年第2期15卷 213-225页

作者： Smitha Rao Fiona C.doherty Anthony Traver Marisa Sheldon Emma Sakulich Holly Dabelko-Schoeny College of Social Work The Ohio State University Age Friendly Innovation Center College of Social Work The Ohio State University College of Public Health The Ohio State University

The disproportionate risks and impacts of climate change and extreme weather on older adults are increasingly evident. While especially true in disaster-prone areas, human-caused climate change introduces an element of uncertainty even in previously identified “safe” regions such as the Midwestern United States. Using a cumulative disadvantage and vulnerability-informed framework and descriptive statistics from multiple data sources, this article provides an overview of climate impacts, vulnerabilities, and county-level characteristics, focusing on older adults living in Central Ohio. A comparative multiple-case study methodology was used to triangulate regionally representative primary and secondary data sources to examine state and county-level measures of vulnerability, emergency preparedness, and disruptions caused by extreme weather among older adults across eight counties in Central Ohio. Seventy-eight percent of older adults in the sample reported being prepared for emergencies per Federal Emergency Management Agency guidelines. Older adults in Union County reported the highest rates of preparedness, while those in Fayette County reported the lowest. County-level rates of disruption of life activities by extreme weather ranged widely. Among the most rural in the region, Fayette County emerged as uniquely disadvantaged, with the lowest median income, the most vulnerable across multiple social vulnerability dimensions, and the most reported disruptions to life activities from extreme weather. County profiles offer a snapshot of existing vulnerabilities, socioeconomic conditions, special needs, preparedness, and current disruptions among older adults in the region and can inform resource mobilization across community and policy contexts.

关键词： Disaster preparedness Extreme weather Midwestern United States Older adults Regional assessment Social vulnerability

Aerosol jet printing of surface acoustic wave microfluidic devices

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Microsystems & Nanoengineering 2024年第1期10卷 231-242页

作者： Joseph Rich Brian Cole Teng Li Brandon Lu Hanyu Fu Brittany N.Smith Jianping Xia Shujie Yang Ruoyu Zhong James L.doherty Kanji Kaneko Hiroaki Suzuki Zhenhua Tian Aaron D.Franklin Tony Jun Huang Department of Biomedical Engineering Duke UniversityDurhamNC 27708USA Department of Electrical and Computer Engineering Duke UniversityDurhamNC 27708USA Department of Mechanical Engineering Virginia Polytechnic Institute and State UniversityBlacksburgVA 24061USA Thomas Lord Department of Mechanical Engineering and Materials Science Duke UniversityDurhamNC 27708USA Deptartment of Precision Mechanics Faculty of Science and EngineeringChuo UniversityTokyo 112-8551Japan Department of Chemistry Duke UniversityDurhamNC 27708USA

The addition of surface acoustic wave(SAW)technologies to microfluidics has greatly advanced lab-on-a-chip applications due to their unique and powerful attributes,including high-precision manipulation,versatility,integrability,biocompatibility,contactless nature,and rapid actuation.However,the development of SAW microfluidic devices is limited by complex and time-consuming micro/nanofabrication techniques and access to cleanroom facilities for multistep photolithography and vacuum-based processing.To simplify the fabrication of SAW microfluidic devices with customizable dimensions and functions,we utilized the additive manufacturing technique of aerosol jet printing.We successfully fabricated customized SAW microfluidic devices of varying materials,including silver nanowires,graphene,and poly(3,4-ethylenedioxythiophene)polystyrene sulfonate(PEDOT:PSS).To characterize and compare the acoustic actuation performance of these aerosol jet printed SAW microfluidic devices with their cleanroom-fabricated counterparts,the wave displacements and resonant frequencies of the different fabricated devices were directly measured through scanning laser Doppler vibrometry.Finally,to exhibit the capability of the aerosol jet printed devices for lab-on-a-chip applications,we successfully conducted acoustic streaming and particle concentration experiments.Overall,we demonstrated a novel solution-based,direct-write,single-step,cleanroom-free additive manufacturing technique to rapidly develop SAW microfluidic devices that shows viability for applications in the fields of biology,chemistry,engineering,and medicine.

关键词： printing wave fluid

A surface sampling and liquid chromatography mass spectrometry method for the analysis of quaternary ammonium compounds collected from public transportation buses in New Jersey

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Emerging Contaminants 2022年第1期8卷 318-328页

作者： Abigail Lazofsky Cathleen doherty Patrick Szary Brian Buckley Environmental and Occupational Health Sciences Institute Rutgers University170 Frelinghuysen RoadPiscatawayNJ08854USA Center for Advanced Infrastructure and Transportation Rutgers University100 Brett RoadPiscatawayNJ08854USA

Quaternary ammonium compounds(QACs)are a class of antimicrobial disinfectants whose use in cleaning products increased during the COVID-19 pandemic.Chemically,their low vapor pressure indicates a proclivity to persist on surfaces,and their presence suggests a level of protection against microorganisms.The widespread application of QACs in response to the SARS CoV-2 virus created a need to evaluate their longevity on surfaces,for both efficacy and possible health risks.There are however,no standardized analytical methods for QAC surface sampling and analysis,and no published studies quantifying their concentrations on mass transportation vehicles-a high occupancy,close-contact microenvironment documented to facilitate the spread the SARS CoV-2 virus.Here,we describe a robust liquid chromatography mass spectrometry(LC-MS)method for the analysis of QACs and simultaneous development of a direct surface sampling and extraction protocol.We demonstrate the applicability of the method through the analysis of surface samples collected from in-service public transportation buses.The rapid,sensitive LC-MS method included 8 target QACs quantified on a Q-Exactive HF Hybrid Quadrupole-Orbitrap mass spectrometer using an electrospray ionization source and Dionex UltiMate 3000 UHPLC system for analyte separation.QAC standard mixtures at concentrations between 0.1 ng mL^(-1)and 2000 ng mL^(-1)were analyzed,and chromatographic separation of all analytes was achieved in less than 10 min.All correlation coefficients were reported at r>0.986,and LODs ranged from 0.007 to 2.103 ng mL^(-1)for all compounds,confirming the method's sensitivity.A previously reported surface sampling and extraction protocol was modified to further simplify the procedure and expand the number of target compounds.The new sampling protocol was optimized from 10 commercially available wipes and 4 solvent types by quantifying recovery from the surface.Band-Aid brand small gauze pads saturated with isopropanol had the highest recovery efficiencies,ranging from 6

关键词： Alkyl dimethyl benzyl ammonium chloride Alkyl(ethyl benzyl)dimethyl ammonium chloride Surface sampling Orbitrap mass spectrometry Public transportation COVID-19

The effects of dietary supplementation with mushroom or selenium enriched mushroom powders on the growth performance and intestinal health of post-weaned pigs

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Animal Science and Biotechnology 2023年第3期14卷 1167-1181页

作者： Alison Dowley Torres Sweeney Eadaoin Conway Stafford Vigors Marion T.Ryan Supriya Yadav Jude Wilson John V.O’doherty School of Agriculture and Food Science University College DublinBelfieldDublin 4Ireland School of Veterinary Medicine University College DublinBelfieldDublin 4Ireland Mbio Monaghan Mushroom GroupTyhollandCo.MonaghanIreland

Background There is an urgent need to identify natural bioactive compounds that can enhance gastrointestinal health and promote pig growth performance in the absence of pharmacological levels of zinc oxide(ZnO).The objectives of this study were to:1)compare the effects of mushroom powder supplemented with inorganic selenium(inSeMP)to mushroom powder enriched with organic selenium(orgSeMP)to pharmacological levels of ZnO on growth performance and faecal scores(FS)for the first 21 d post-weaning(Period 1);and 2)compare the molecular and microbial effects of inSeMP and orgSeMP in these pigs on d 39 post-weaning(Period 2).Methods In Period 1,pigs(3 pigs/pen;8 pens/treatment)were assigned to:(1)basal diet(control);(2)basal diet+zinc oxide(ZnO)(3100 mg/kg d 1–14,1550 mg/kg d 15–21);(3)basal diet+mushroom powder supplemented with inorganic selenium(inSeMP)containing selenium(selenite)content of 0.3 mg/kg feed;(4)basal diet+mushroom powder enriched with organic selenium(orgSeMP)containing selenium(selenocysteine)content of 0.3 mg/kg feed.Mushroom powders were included at 6.5 g/kg of feed.Results In Period 1,there was no effect of diets on average daily gain(ADG)and gain:feed(G:F)ratio(P>0.05).The orgSeMP supplemented pigs had a lower average daily feed intake(ADFI)compared to all other groups(P0.05).The orgSeMP supplementation increased the caecal abundance of bacterial members of the Firmicutes and Bacteroidetes phylum,including Lactobacillus,Agathobacter,Roseburia,and Prevotella and decreased the abundance of Sporobacter compared to the basal group,while inSeMP increased the caecal abundance of Prevotella and decreased the caecal abundance of Sporobacter compared to the basal group(P<0.05).Dietary supplementation with inSeMP increased expression

关键词： Agaricus bisporus Gastrointestinal microbiota Mushroom powder Organic selenium Pig Zinc oxide

Achmatowicz approach to the asymmetric synthesis of(+)-and(−)-monanchorin

在线全文

学校读者我要写书评

暂无评论

Green Synthesis and Catalysis

Green Synthesis and Catalysis 2022年第2期3卷 156-161页

作者： Yuzhi Ma Rajender Vemula Qi Zhang Bulan Wu George A.O'doherty Department of Chemistry and Chemical Biology Northeastern UniversityBoston MA 02115United States Department of Pharmacology and Experimental Therapeutics Boston University School of MedicineBoston MA 02118United States Division of Natural Sciences College of Natural&Applied SciencesUniversity of GuamMangilao GU 96923United States

The full account of our development of a de novo asymmetric total synthesis of(+)-monanchorin has been reported.The optimized synthesis provided access to either enantiomer of the guanidine alkaloid natural product in nine steps from the commodity chemicals furan and caproic acid.The route relied upon the asymmetric Noyori hydrogen transfer reduction of an achiral acylfuran to introduce the absolute stereochemistry.In addition,an Achmatowicz rearrangement,a diastereoselective palladium-catalyzed glycosylation,a reductive amination and an acid-catalyzed bicyclic guanidine mixed acetal formation were used to complete the synthesis.

关键词： Monanchorin Asymmetric synthesis Achmatowicz Pd-glycosylation Reductive amination Guanidine natural product Alkaloid natural product

Potential of a fucoidan-rich Ascophyllum nodosum extract to reduce Salmonella shedding and improve gastrointestinal health in weaned pigs naturally infected with Salmonella

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Animal Science and Biotechnology 2022年第4期13卷 1193-1208页

作者： Brigkita Venardou John VO’doherty Shane Maher Marion TRyan Vivian Gath Rajeev Ravindran Claire Kiely Gaurav Rajauria Marco Garcia-Vaquero Torres Sweeney School of Veterinary Medicine University College DublinBelfield Dublin 4Ireland School of Agriculture and Food Science University College DublinBelfield Dublin 4Ireland.

Background:Dietary supplementation with a fucoidan-rich Ascophyllum nodosum extract(ANE),possessing an in vitro anti-Salmonella Typhimurium activity could be a promising on-farm strategy to control Salmonella infection in pigs.The objectives of this study were to:1)evaluate the anti-S.Typhimurium activity of ANE(containing 46.6%fucoidan,18.6%laminarin,10.7%mannitol,4.6%alginate)in vitro,and;2)compare the effects of dietary supplementation with ANE and Zinc oxide(ZnO)on growth performance,Salmonella shedding and selected gut parameters in naturally infected pigs.This was established post-weaning(newly weaned pig experiment)and following regrouping of post-weaned pigs and experimental re-infection with S.Typhimurium(challenge experiment).Results:In the in vitro assay,increasing ANE concentrations led to a linear reduction in S.Typhimurium counts(P0.05).ANE supplementation decreased the Enterobacteriaceae counts compared to the control.Enterobacteriaceae counts were also reduced in the ZnO-residual group compared to the control(P<0.05).ANE supplementation decreased the expression of interleukin 22 and transforming growth factor beta 1 in the ileum compared to the control(P<0.05).Conclusions:ANE supplementation was associated with some beneficial changes in the composition of the colonic microbiota,Salmonella shedding,and the expression of inflammatory genes

关键词： Ascophyllum nodosum Gastrointestinal microbiota Inflammation Pig Salmonella Seaweed extract Zinc oxide

Underlying solvent-based factors that influence permanent porosity in porous liquids

在线全文

学校读者我要写书评

暂无评论

Nano Research 2022年第4期15卷 3533-3538页

作者： Hamidreza Mahdavi Huacheng Zhang Lauren K.Macreadie Cara M.doherty Durga Acharya Stefan J.DSmith Xavier Mulet Matthew R.Hill Department of Chemical Engineering Monash UniversityClaytonVIC 3800Australia CSIRO Manufacturing Private Bag 10Clayton SouthVIC 3169Australia School of Chemistry University of SydneySydney 2006Australia

Porous liquids(PLs)offer the potential to combine the ready handling and mature industry status of liquid absorbents,with the high permanent porosity of metal organic frameworks.To be functional,these nanocomposites need to satisfy a number of performance parameters,such as stability and viscosity of the porogen-solvent combination,avoiding solvent penetration into metal organic framework(MOF)pores,suitable capacities,and kinetics for gas sorption.In this work,we systematically investigate the component materials to elucidate the parametric space where stable photoluminescence(PL)can be generated.In this situation,deeper conclusions were able to be drawn with regard to the influence of hydrophobicity/philicity on the properties of the resulting nanocomposites.Zeolitic imidazolate frameworks(ZIFs)were combined with a range of solvents varying in steric bulk,to deliver CO_(2)sorption capacities as high as 4.2 mmol·g^(-1)at 10 bar.These findings may have broader implications for future investigations of this tantalising field of nanocomposites.

关键词： zeolitic imidazolate frameworks porous liquids permanent porosity gas sorption

Combining single-cell RNA sequencing and population-based studies reveals hand osteoarthritis-associated chondrocyte subpopulations and pathways

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Bone Research 2023年第4期11卷 834-846页

作者： Hui Li Xiaofeng Jiang Yongbing Xiao Yuqing Zhang Weiya Zhang Michael doherty Jacquelyn Nestor Changjun Li Jing Ye Tingting Sha Houchen Lyu Jie Wei Chao Zeng Guanghua Lei Department of Orthopaedics Xiangya HospitalCentral South UniversityChangsha 410008 HunanChina Hunan Key Laboratory of Joint Degeneration and Injury Changsha 410008 HunanChina Key Laboratory of Aging-related Bone and Joint Diseases Prevention and Treatment Ministry of EducationXiangya HospitalCentral South UniversityChangshaChina Division of Rheumatology Allergyand ImmunologyDepartment of MedicineMassachusetts General HospitalHarvard Medical SchoolBostonMA 02115USA The Mongan Institute Massachusetts General HospitalHarvard Medical SchoolBostonMA 02115USA Academic Rheumatology School of MedicineUniversity of NottinghamNottingham NG51PBUK Pain Centre Versus Arthritis UK Nottingham NG51PBUK Department of Endocrinology Endocrinology Research CenterXiangya HospitalCentral South UniversityChangsha 410008 HunanChina National Clinical Research Center for Geriatric Disorders Xiangya HospitalCentral South UniversityChangsha 410008 HunanChina Health Management Center Xiangya HospitalCentral South UniversityChangsha 410008 HunanChina Department of Epidemiology and Health Statistics Xiangya School of Public HealthCentral South UniversityChangsha 410008 HunanChina

Hand osteoarthritis is a common heterogeneous joint disorder with unclear molecular mechanisms and no disease-modifying drugs.In this study,we performed single-cell RNA sequencing analysis to compare the cellular composition and subpopulationspecific gene expression between cartilage with macroscopically confirmed osteoarthritis(n=5)and cartilage without osteoarthritis(n=5)from the interphalangeal joints of five donors.Of 105142 cells,we identified 13 subpopulations,including a novel subpopulation with inflammation-modulating potential annotated as inflammatory chondrocytes.Fibrocartilage chondrocytes exhibited extensive alteration of gene expression patterns in osteoarthritic cartilage compared with nonosteoarthritic cartilage.Both inflammatory chondrocytes and fibrocartilage chondrocytes showed a trend toward increased numbers in osteoarthritic cartilage.In these two subpopulations from osteoarthritic cartilage,the ferroptosis pathway was enriched,and expression of iron overload-related genes,e.g.,FTH1,was elevated.To verify these findings,we conducted a Mendelian randomization study using UK Biobank and a population-based cross-sectional study using data collected from Xiangya Osteoarthritis Study.Genetic predisposition toward higher expression of FTH1 mRNA significantly increased the risk of hand osteoarthritis(odds ratio=1.07,95%confidence interval:1.02–1.11)among participants(n=332668)in UK Biobank.High levels of serum ferritin(encoded by FTH1),a biomarker of body iron overload,were significantly associated with a high prevalence of hand osteoarthritis among participants(n=1241)of Xiangya Osteoarthritis Study(P-for-trend=0.037).In conclusion,our findings indicate that inflammatory and fibrocartilage chondrocytes are key subpopulations and that ferroptosis may be a key pathway in hand osteoarthritis,providing new insights into the pathophysiology and potential therapeutic targets of hand osteoarthritis.

关键词： osteoarthritis subpopulations elevated

Router and gateway node placement in wireless mesh networks for emergency rescue scenarios

在线全文

学校读者我要写书评

暂无评论

Autonomous Intelligent Systems 2021年第1期1卷 202-231页

作者： Mariusz Wzorek Cyrille Berger Patrick doherty Department of Computer and Information Science Linköping UniversityLinköpingSweden School of Intelligent Systems and Engineering Jinan University(Zhuhai Campus)Zhuhai 519070China

The focus of this paper is on base functionalities required for UAV-based rapid deployment of an ad hoc communication infrastructure in the initial phases of rescue operations.The main idea is to use heterogeneous teams of UAVs to deploy communication kits that include routers,and are used in the generation of ad hoc Wireless Mesh Networks(WMN).Several fundamental problems are considered and algorithms are proposed to solve these problems.The Router Node Placement problem(RNP)and a generalization of it that takes into account additional constraints arising in actual field usage is considered first.The RNP problem tries to determine how to optimally place routers in a WMN.A new algorithm,the RRT-WMN algorithm,is proposed to solve this problem.It is based in part on a novel use of the Rapidly Exploring Random Trees(RRT)algorithm used in motion planning.A comparative empirical evaluation between the RRT-WMN algorithm and existing techniques such as the Covariance Matrix Adaptation Evolution Strategy(CMA-ES)and Particle Swarm Optimization(PSO),shows that the RRT-WMN algorithm has far better performance both in amount of time taken and regional coverage as the generalized RNP problem scales to realistic scenarios.The Gateway Node Placement Problem(GNP)tries to determine how to locate a minimal number of gateway nodes in a WMN backbone network while satisfying a number of Quality of Service(QoS)constraints.Two alternatives are proposed for solving the combined RNP-GNP problem.The first approach combines the RRT-WMN algorithm with a preexisting graph clustering algorithm.The second approach,WMNbyAreaDecomposition,proposes a novel divide-and-conquer algorithm that recursively partitions a target deployment area into a set of disjoint regions,thus creating a number of simpler RNP problems that are then solved concurrently.Both algorithms are evaluated on real-world GIS models of different size and complexity.WMNbyAreaDecomposition is shown to outperform existing algorithms using 73%to 92%fewer router nodes while at the sa

关键词： Robotics UAV deployed ad hoc networks Wireless mesh networks Router node placement Gateway node placement Emergency rescue