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PREPARATION AND CHARACTERIZATION OF BIMETALliC Pd-Fe/Al2O3 CATALYSTS—CHARACTERIZATION BY TEM,EDX,XPS and ESR

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Journal of Energy Chemistry 1994年第1期 13-23页

作者： XIAO Tian-Cun AN li-Dun TANG ai-Huali Shehg-li xu Xian-LunLanzhou Institute of Chemical Physics, Academia Sinica Lanzhou, Gansu 730000

Suppurted bimetallic catalysts Pd-Fe/AlOwere prepared by im-pregnating method in different dipping *** electron mi-croscopy（TEM-EDX）,X-ray diffraction（XRD）,X-ray photoelectron spec-troscopy（XPS）and electron spin resonance（ESR）were employed to charac-terize the *** is shown that the impregnating sequence has influence onthe diffusiun and distribution of the metals in the pores of *** group diffusion is controlled by its *** the surface of the cata-lysts,the iron is in oxidative state while the palladium is zerovalent whenFeClis first ***,on the surface of the other two,the palladiumis in both oxidated and metallic *** amount of Fein the catalyst dif-fers with the dipping *** results shows that in different catalystsprepared in various sequences Feexists in different environments.

关键词： Pd PREPARATION AND CHARACTERIZATION OF BIMETALliC Pd-Fe/Al2O3 CATALYSTS CHARACTERIZATION BY TEM,EDX,XPS and ESR Fe TEM EDX XPS Al

Resveratrol improves learning and memory in normally aged mice through microRNA-CREB pathway

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Resveratrol improves learning and memory in normally aged mi...

中国神经科学学会第十届全国学术会议

作者： ai-li xu Bei-Bei Lai Cui QI Jun GAO Department of Physiology Binzhou Medical University Model Animal Research Center of Nanjing University and MOE Key Laboratory of Model Animals for Disease Study

Objective Resveratrol（RSV） is a natural compound found in grapes and red *** has been well known for its beneficial effects as a dietary supplement in prevention of cardiovascular diseases and ***,in vitro studies have reported the neuroprotective role of RSV in neurodegenerative process in Alzheimer’s disease（AD）.However,in vivo effects of RSV on the decline of brain function accompanying the aging process,especially those on cognitive loss,have not been not *** we report that,after intraventricular injection of RSV for one week in 8-9 month-old mice,the long-term memory formation and the LTP induction from hippocampus CA1were *** RSV enhancement effects were blocked in SIRT1 mutant *** experiments suggest that RSV effects are likely to be mediated through reduced expressions of miR-134 and miR-124,which may in turn up-regulate CREB levels to subsequently promote BDNF *** findings demonstrate a role for RSV in cognition and a microRNA-CREB-BDNF mechanism by which RSV regulates these processes,demonstrating its value as a potential therapeutic target against CNS disorders in *** Memory formation and synaptic plasticity is identified by fear conditioning tests and electrophysiological *** and real time qPCR respectively measures the expression of protein and ***（l）RSV improves memory formation through increasing SIRT1 activity.（2）RSV facilitates LTP induction in hippocampus slices.（3）RSV enhances the level of miR-124 and miR-134 and increases the expression of CREB and *** RSV improves memory formation and synaptic plasticity through microRNA-CREB-BDNF pathway.

关键词： resveratrol learning and memory aging sirtuin micro-RNA CREB BDNF

Perirenal adipose tissue-derived exosome-like vesicles from Wistar-Kyoto rats attenuates hypertension in spontaneous hypertensive rats

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Perirenal adipose tissue-derived exosome-like vesicles from ...

2019中国生理学会学术年会暨张锡钧基金第十五届全国青年优秀生理学学术论文交流会及第十三届全国青年生理学工作者学术会议

作者： li-wen liang Shu-jun Jiang ai-li xu Hong Pan La-mei Yu 施真 Department of Physiology Binzhou Medical University Sino-US Translational Medicine Institute and College of Pharmacy Binzhou Medical University

Adipose tissue, especially visceral fat, has long been considered to be involved in the development and pathological process of ***, the mechanism of blood pressure regulation from adipose tissue sources is *** study was designed to investigate the effect of perirenal adipose tissue-derived exosome-like vesicles on arterial blood *** perirenal fats of normotensive Wistar-Kyoto(WKY) and spontaneous hypertensive rats(SHRs) were cultured in serum-free(exosome-free) medium, and the secretory vesicles were isolated using exoEasy Maxi *** particle size determination and transmission electron microscope identification, PKH67 green fluorescent dye-labeled exosome-like vesicles were injected through the tail vein or were incubated with primary cultured neurons or neuronal differentiated PC12 *** 24 hours, the frozen sections of brain, liver, kidney, lung, heart, aorta as well as cultured neurons and PC12 cells were observed under the confocal laser *** addition, exosome-like vesicles from SHRs(Exo-SHR) or from WKY rats(Exo-WKY) were injected into the SHRs or WKY rats through their tail veins once a week for six consecutive *** arterial blood pressure was measured under conscious condition using a non-invasive caudal cuff *** experiments were conducted at the end of the 6 th week after the injection of exosome-like *** pathological remodeling was observed by HE staining and Masson’s *** level of Interleukin(IL)-1βmRNA in paraventricular nucleus of the hypothalamus(PVH) and PC12 cells was measured using reverse transcriptase polymerase chain reaction(RT-PCR).The peripheral sympathetic tone(PST)was expressed as the relative ratio of depression response induced by intravenous injection of hexamethonium hydrochloride to that in WKY rats treated with *** addition, total RNA was isolated from the Exo-WKY and Exo-SHR for high-throughput sequencing of differentially expressed

关键词： adipose exosome high-throughput sequencing long noncoding RNA hypertension

Expression of ghrelin and insulin-like growth factor-1 in immature piglet model of chronic cyanotic congenital heart defects with decreased pulmonary blood flow

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Chinese Medical Journal 2011年第15期124卷 2354-2360页

作者： WANG Dong liU Ying-long LU Xiao-dong ZHU Yao-bin liNG Feng liU ai-jun li Gang xu Yu-lin Department of Pediatric Cardiac Surgery Center Fuwai Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100037 China

Background Cyanotic patients have potential growth retardation and malnutrition due to hypoxemia and other reasons. Ghrelin is a novel endogenous growth hormone secretagogue that has effects on growth and cardiovascular activities. The aim of this study was to evaluate the plasma level and myocardial expression of ghrelin and insulin-like growth factor-1 （IGF-1） using an immature piglet model of chronic cyanotic congenital heart defects with decreased pulmonary blood flow. Methods Twelve weanling Chinese piglets underwent procedures of main pulmonary artery-left atrium shunt with pulmonary artery banding or sham operation as control. Four weeks later, hemodynamic parameters were measured. Enzyme-linked immunosorbent assay for plasma ghrelin and IGF-1 level measurement were performed. Ventricular ghrelin and IGF-1 mRNA expressions were measured by quantitative real-time polymerase chain reaction. Results Four weeks after surgical procedure, the cyanotic model produced lower arterial oxygen tension （（68.73±15.09） mmHg）, arterial oxygen saturation （（82.35±8.63）%）, and higher arterial carbon dioxide tension （（51.83±6.12） mmHg）, hematocrit （（42.67±3.83）%） and hemoglobin concentration （（138.17±16.73） g/L） than the control piglets （（194.08±98.79） mmHg, （96.43±7.91）%, （36.9±4.73） mmHg, （31.17±3.71）%, （109.83±13.75） g/L）（all P 〈0.05）. Plasma ghrelin level was significantly higher in the cyanotic model group in comparison to the control （P=0.004）, and the plasma IGF-1 level was significantly lower than control （P=0.030）. Compared with control animals, the expression of ghrelin mRNAs in the ventricular myocardium was significantly decreased in the cyanotic model group （P=0.000）, and the expression of IGF-1 mRNAs was elevated （P=0.001）. Conclusions Chronic cyanotic congenital heart defects model was successfully established. Plasma ghrelin level and myocardial IGF-1 mRNA expression were significantly up-regulated, while plasma iGF-1 level and myocardial ghrelin mRNA expression

关键词： congenital heart defects cyanosis piglet ghrelin insulin-like growth factor-1

Protein Phosphatases 2A in Hippocampal CA1 Area Is Involved in Memory Updating

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中国神经科学学会第十二届全国学术会议

作者： Jie Wang Jing Wang Min xu Xiao lin Kou ai li xu Cui Qi Xiang Gao Jun Gao Department of Neurobiology Nanjing Medical University Department of Physiology Binzhou Medical College Model Animal Research Center and MOE Key Laboratory of Model Animals for Disease Study Nanjing University

Objective Memory updating is one of the essential brain functions in animal and human survival and development. A large number of studies have demonstrated that protein phosphorylation played an important role in learning and memory. Protein Phosphatases 2 A（PP2A） is a serine/threonine phosphatase involved in regulation of cell growth, development, and neural synaptic plasticity. However, whether PP2A participates in memory updating and how it works is unclear. Methods Here, we assessed the effect of PP2 A deficiency on memory updating by analyzing behavior, electrophysiological and biochemical data. Results No abnormal changes of morphology of hippocampus and basic behaviors in the hippocampal area of PP2A conditional knockout（KO） mice. Loss of PP2A in hippocampal CA1 area also did not affect the formation of short-term and long-term memory, but impaired spatial memory and contextual fear memory updating. Studying hippocampal synaptic plasticity, we found that the paired-pulse facilitation of KO mice was decreased. Also, long-term potentiation was impaired and long-term depression was facilitated in PP2A KO mice. This change might be influenced by the histone deacetylase 4（HDAC4）, which affected the acetylation of histones, then regulated some learning and memory related genes. Conclusion These findings indicate that PP2A via HDAC4 plays an important role in memory updating progress.

关键词： PP2A memory updating hippocampus synaptic plasticity HDAC4

Synergistic effect of bonding heterogeneity and phonon localization in introducing excellent thermoelectric properties in layered heteroanionic NdZnSbO material

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Journal of Energy Chemistry 2025年第1期100卷 259-272页

作者： Da Wan Shuwei Tang Shulin Bai Xiaodong li Peng ai Wanrong Guo Tuo Zheng College of Materials Science and Engineering Liaoning Technical University Faculty of Chemistry Northeast Normal University

Layered rare-earth metal oxides, harnessing the dual properties of oxides and two-dimensional layered materials, exhibit remarkable thermal stability and quantum confinement effects. Therefore, this work adopts the first-principles calculation combined with the Boltzmann transport theory to predict the thermoelectric properties of NdZnSbO compound. The coexistence of weak interlayer van der Waals interactions, robust intralayer ionic bonding, and partial covalent bonding leads to remarkable bonding heterogeneity, which engenders pronounced phonon scattering and imposes constraints on thermal transport along the out-of-plane direction. The weakened chemical bonds induced by the antibonding states, together with the rattling-like behavior of the Zn atom, culminate in the profound anharmonicity in the layered NdZnSbO compound. The weakening bond and heavy element contribute to the softness of phonon modes, which significantly diminishes the phonon group velocity. The redistribution-dominated four-phonon scattering process spans a large optical gap, which effectively reduces the lattice thermal conductivity. The NdZnSbO compound exhibits direct semiconductor characteristic with a bandgap of 0.73 e V by adopting the Heyd-Scuseria-Ernzerhof(HSE06) functional in combination with spin–orbit coupling(SOC) effect. The multi-valley feature of NdZnSbO compound augur favorably for band degeneracy, thus amplifying the power factor. Consequently, an optimal figure-of-merit(ZT) of 3.40 at 900 K is achieved for the n-type NdZnSbO compound. The present study delves deeply insights into the origins for the low thermal conductivity of NdZnSbO compound and proposes an optimization scheme to enhance overall thermoelectric performance.

关键词： Bond strength (chemical)

The neuroprotective effect of icariin in the cell model of Parkinson's disease

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中国神经科学学会第九届全国学术会议暨第五次会员代表大会

作者： lin WU,ai-li xu,Wen-Fang CHEN~* Department of Physiology,Medical College of Qingdao University,Qingdao 266071,China

Objective Herba Epimedii(HEP) is one of the most frequently prescribed herbs in traditional Chinese medicine formula for treatment of osteoporosis,cardiovascular diseases,and improvement of neurological functions in ***,a marker flavonoid glycoside in HEP,is believed to be the major active ingredient that account for its biological *** present study was designed to investigate the protective effect of icariin against 1-methyl- 4-phenylpyridinium(MPP)-induced neurotoxicity and the possible *** MES23.5 cells were routinely cultured and treated with icariin in the presence or absence of MPP+.MTT method was used to detect the cell *** mitochondrial membrane potential was determined by flow *** real time RT-PCR was used to detect the gene expression of Bcl-2 and *** activity of ERE promoter was detected by Dual Luciferase Assay. Results Pretreatment with icariin resulted in an enhancement of survival of MES23.5 cells against MPP-induced *** decreased the mitochondrial membrane *** pretreatment could partly reverse the toxic effect of ***,pretreatment with icariin could increase the Bcl-2 gene expression and decrease the Bax gene expression which affected by *** treatment alone could not induce the ERE promoter luciferase *** The present study clearly demonstrated that icariin has neuroprotective effects against MPP- induced neurotoxicity in MES23.5 cells,and its mechanism may be related to its anti-apoptosis eflfects.

关键词： icariin MPP+ apoptosis MES23.5 cell

Aquaporin-4-IgG-seropositive neuromyelitis optica spectrum disorders:progress of experimental models based on disease pathogenesis

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Neural Regeneration Research 2025年第2期20卷 354-365页

作者： li xu Huiming xu Changyong Tang Department of Neurology The Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhouGuangdong ProvinceChina

Neuromyelitis optica spectrum disorders are neuroinflammatory demyelinating disorders that lead to permanent visual loss and motor *** date,no effective treatment exists as the exact causative mechanism remains ***,experimental models of neuromyelitis optica spectrum disorders are essential for exploring its pathogenesis and in screening for therapeutic *** most patients with neuromyelitis optica spectrum disorders are seropositive for IgG autoantibodies against aquaporin-4,which is highly expressed on the membrane of astrocyte endfeet,most current experimental models are based on aquaporin-4-IgG that initially targets *** experimental models have successfully simulated many pathological features of neuromyelitis optica spectrum disorders,such as aquaporin-4 loss,astrocytopathy,granulocyte and macrophage infiltration,complement activation,demyelination,and neuronal loss;however,they do not fully capture the pathological process of human neuromyelitis optica spectrum *** this review,we summarize the currently known pathogenic mechanisms and the development of associated experimental models in vitro,ex vivo,and in vivo for neuromyelitis optica spectrum disorders,suggest potential pathogenic mechanisms for further investigation,and provide guidance on experimental model *** addition,this review summarizes the latest information on pathologies and therapies for neuromyelitis optica spectrum disorders based on experimental models of aquaporin-4-IgG-seropositive neuromyelitis optica spectrum disorders,offering further therapeutic targets and a theoretical basis for clinical trials.

关键词： aquaporin-4 experimental model neuromyelitis optica spectrum disorder pathogenesis

Cell polarization in ischemic stroke: molecular mechanisms and advances

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Neural Regeneration Research 2025年第3期20卷 632-645页

作者： Yuanwei li Xiaoxiao xu xuan Wu Jiarui li Shiling Chen Danyang Chen Gaigai li Zhouping Tang Department of Neurology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei ProvinceChina

Ischemic stroke is a cerebrovascular disease associated with high mortality and disability rates. Since the inflammation and immune response play a central role in driving ischemic damage, it becomes essential to modulate excessive inflammatory reactions to promote cell survival and facilitate tissue repair around the injury site. Various cell types are involved in the inflammatory response, including microglia, astrocytes, and neutrophils, each exhibiting distinct phenotypic profiles upon stimulation. They display either proinflammatory or anti-inflammatory states, a phenomenon known as ‘cell polarization.’ There are two cell polarization therapy strategies. The first involves inducing cells into a neuroprotective phenotype in vitro, then reintroducing them autologously. The second approach utilizes small molecular substances to directly affect cells in vivo. In this review, we elucidate the polarization dynamics of the three reactive cell populations(microglia, astrocytes, and neutrophils) in the context of ischemic stroke, and provide a comprehensive summary of the molecular mechanisms involved in their phenotypic switching. By unraveling the complexity of cell polarization, we hope to offer insights for future research on neuroinflammation and novel therapeutic strategies for ischemic stroke.

关键词： astrocyte polarization immune regulation inflammation ischemic injury microglia polarization neutrophil polarization signaling pathways stroke