Protein Phosphatases 2A in Hippocampal CA1 Area Is Involved in Memory Updating
作者单位：Department of Neurobiology Nanjing Medical University Department of Physiology Binzhou Medical College Model Animal Research Center and MOE Key Laboratory of Model Animals for Disease Study Nanjing University
会议名称：《中国神经科学学会第十二届全国学术会议》
会议日期：2017年
学科分类：0710[理学-生物学] 07[理学] 071006[理学-神经生物学]
关 键 词：PP2A memory updating hippocampus synaptic plasticity HDAC4
摘 要：Objective Memory updating is one of the essential brain functions in animal and human survival and development. A large number of studies have demonstrated that protein phosphorylation played an important role in learning and memory. Protein Phosphatases 2 A（PP2A） is a serine/threonine phosphatase involved in regulation of cell growth, development, and neural synaptic plasticity. However, whether PP2A participates in memory updating and how it works is unclear. Methods Here, we assessed the effect of PP2 A deficiency on memory updating by analyzing behavior, electrophysiological and biochemical data. Results No abnormal changes of morphology of hippocampus and basic behaviors in the hippocampal area of PP2A conditional knockout（KO） mice. Loss of PP2A in hippocampal CA1 area also did not affect the formation of short-term and long-term memory, but impaired spatial memory and contextual fear memory updating. Studying hippocampal synaptic plasticity, we found that the paired-pulse facilitation of KO mice was decreased. Also, long-term potentiation was impaired and long-term depression was facilitated in PP2A KO mice. This change might be influenced by the histone deacetylase 4（HDAC4）, which affected the acetylation of histones, then regulated some learning and memory related genes. Conclusion These findings indicate that PP2A via HDAC4 plays an important role in memory updating progress.