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Treatment of liver metastases from uveal melanoma: a retrospective single-center analysis

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Hepatobiliary & Pancreatic Diseases International 2013年第6期12卷 602-606页

作者： Xiao-Yu Yang Feng Xie Ran Tao ai-jun li Meng-Chao Wu Division of Special Treatment II Eastern Hepatobiliary Surgery Hospital Second Military Medical University Division of Special Treatment I Eastern Hepatobiliary Surgery Hospital Second Military Medical University Center for Organ Transplantation and Department of General Surgery Ruijin Hospital

BACKGROUND:Metastatic liver melanoma is a rare event in the Chinese population with extremely poor *** treatment that controls a metastatic hepatic lesion potentially prolongs *** study aimed to evaluate the survival of patients with isolated liver metastases from uveal melanoma treated with partial hepatectomy or non-surgical management and to find the best therapeutic modality for these ***:From January 1996 to September 2008,eight patients with liver metastases secondary to uveal melanoma were admitted to our *** patients underwent partial hepatectomy and 3 received other treatments(TACE,RFA,PEI).Their medical records were reviewed and overall survival was ***:The patients comprised 3 men and 5 women,with a median age of 44 *** patients presented with liver metastases at the time the primary tumor was *** interval from the diagnosis of uveal melanoma to liver metastasis in the remaining 2 patients was 9.5 and 32.5 months,*** median survival after the treatment of liver metastasis was 11.5 and 7.5 months in the surgical and nonsurgical groups,*** was no procedure-related mortality in the whole study ***:Partial hepatectomy or other therapies were safe and feasible for isolated liver metastases from uveal *** treatment with multidisciplinary modalities may result in prolonged survival.

关键词： liver metastasis uveal melanoma therapy

Inhibition of autophagy significantly enhances combination therapy with sorafenib and HDAC inhibitors for human hepatoma cells

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World Journal of Gastroenterology 2014年第17期20卷 4953-4962页

作者： Hang Yuan ai-jun li Sen-lin Ma Long-Jiu Cui Bin Wu Lei Yin Meng-Chao Wu Department of the 2~(nd) Special Treatment Eastern Hepatobiliary Surgery HospitalSecond Military Medical University

aiM: To clarify whether histone deacetylase inhibitors histone deacetylase inhibitors (HDACIs) can sensitize hepatocellular carcinoma (HCC) cells to sorafenib treatment. METHODS: Bax, Bcl-2, ATG5-ATG12, p21, and p27 protein levels in Hep3B, HepG2, and PLC/PRF/5 cells were examined by Western blot. CCK8 and a fluoro-metric caspase-3 assay were used to examine cellular viability and apoptosis levels. The effect of Beclin-1 on sensitization of HCC cells to sorafenib was examined by transfecting Beclin-1 siRNA into Hep3B, HepG2, and PLC/PRF/5 cells. RESULTS: Autophagy inhibition enhances the inhibitory effects of vorinostat and sorafenib alone or in combination on HCC cell growth. Vorinostat and sorafenib synergistically induced apoptosis and cell cycle alterations. Western blot data indicated that HDACIs and Beclin- 1 knockdown increased the p53 acetylation level. The knockdown of Beclin-1 enhanced the synergistic effect of the combination of vorinostat with sorafenib. CONCLUSION: HDACIs can sensitize HCC cells to sorafenib treatment by regulating the acetylation level of Beclin-1. (C) 2014 Baishideng Publishing Group Co., limited. All rights reserved.

关键词： Hepatocellular carcinoma Histone deacetylase inhibitors Autophagy Sorafenib Chemoresistance

Autologous bone marrow infusion via portal vein combined with splenectomy for decompensated liver cirrhosis: A retrospective study

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World Journal of Gastrointestinal Surgery 2023年第9期15卷 1919-1931页

作者： Bao-Chi liu Ming-Rong Cheng lin Lang Lei li Yan-Hui Si ai-jun li Qing Xu Hui Zhang Department of Surgery Shanghai Public Health Clinical CenterFudan UniversityShanghai 201508China He Nuo Medical Clinic Shanghai New Hongqiao International Medical CenterShanghai 201100China Department of Anorectal Surgery The Third Affiliated Hospital of Guizhou Medical UniversityDuyun 558000Guizhou ProvinceChina Department of Hepatobiliary Surgery Oriental Hepatobiliary Surgery HospitalShanghai 200433China Department of Hepatobiliary Surgery Renji HospitalShanghai Jiao Tong University School of MedicineShanghai 200127China Department of Hepatobiliary Surgery Shanghai Oriental Hospital Affiliated to Tongji UniversityShanghai 200120China

BACKGROUND In a previous study,autologous bone marrow infusion(ABMI)was performed in patients with decompensated liver cirrhosis(DLC)and acquired immunodefi-ciency syndrome and achieved good results,but whether splenectomy affected outcome was *** To investigate the efficacy of ABMI combined with splenectomy for treatment of *** Eighty-three patients with DLC were divided into an intervention group(43 cases)and control group(40 cases)according to whether splenectomy was *** control group was treated with ABMI through the right omental RESULTS After ABMI,the prothrombin time,serum total bilirubin levels,ascites volume and model for end-stage liver disease score in both groups were significantly lower,while the albumin levels were significantly higher than before ABMI(P0.05).After ABMI,the white blood cell and platelets counts in both groups were significantly higher than before ABMI(Pliver synthetic and secretory functions,and splenectomy promotes improvement of bone marrow hematopoietic and cellular immune functions.

关键词： Autologous bone marrow Splenectomy Cell therapy Cirrhosis Cellular immunity

Spontaneous complete necrosis of hepatocellular carcinoma: a case report

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Hepatobiliary & Pancreatic Diseases International 2003年第1期2卷 152-154页

作者： ai-jun li Meng-Chao Wu Wen-Ming Cong Feng Shen Bing Yi Eastern Hospital of Hepatobiliary Surgery Second Military Medical University Shanghai 200438 China. liaijun172@***

Spontaneous regression of hepatocellular carci- noma (HCC) is rare. We found spontaneousregression of HCC in a 53-year-old Chinese withliver cirrhosis. A liver mass 3cm in diameter wasrevealed by B-ultrasonography. The resected massshowed histologically complete necrosis. The nec-rotic tissue was filled with large debris from a neo-plastic tissue, regardless of no viable tumor cellswere seen among them. The postoperative coursewas uneventful, and the patient is alive and wellfor 4 years after surgery.

关键词： HCC in on et is as of a case report Spontaneous complete necrosis of hepatocellular carcinoma case

Effect of dexmedetomidine on the stress reaction caused by sevoflurance anesthesia in school-age children with different personality characteristics

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Journal of Hainan Medical University 2017年第2期23卷 17-20页

作者： Juan Fan ai-jun li Fu-Long li The First Hospital Affiliated to Hebei North University ZhangjiakouHebei075000

Objective:To observe the effect of dexmedetomidine on the stress reaction caused by sevoflurance anesthesia during the perianesthesia period in school-age children with different personality ***:A total of 160 children who were admitted in our hospital for transumbilical single-port laparoscopic hernia inner ring ligation were included in the study and randomized into dexmedetomidine (D) group and midazolam (M) group. The children were performed with Eysenck Personality Questionnaire before operation (children edition). Children were divided into the emotion group (group I) and stable group (group II). The operation was performed under sevoflurance inhalation anesthesia. Patients in DI and DII groups were given 1 μg/kg DEX, MI and MII groups were given 0.05 mg/kg midazolam, for 15 min. MAP and HR one day before operation (T0), before anesthesia induction (T1), 1 min after pneumoperitoneum establishment (T2), the time after pulling out the laryngeal mask (T3), and the time after shifting from the recovery room (T4) were recorded. A volume of 6 mL venous blood 1 d before operation and 4 h after operation was collected. Blood sugar concentration, cortisol and IL-6 levels were ***:MAP at T1, T2, T3, and T4 in DI and MI groups were significantly elevated when compared with at T0. MAP at T2 and T3 in DII group was significantly elevated when compared with at T0. MAP at T2, T3, and T4 in MII group was significantly elevated when compared with at T0. When compared with DI group, MAP at T1, T2, and T3 in DII group was significantly reduced;MAP at T2, T3, and T4 in MI group was significantly elevated;MAP at T1 in MII group was significantly reduced. When compared with DII group, MAP at T2, T3, and T4 in MI and MII groups was significantly elevated. HR at T1, T2, T3, and T4 was significantly elevated when compared with at T0. When compared with DI group, HR at T1, T2, and T3 in DII group was significantly reduced;HR at each timing point in MI g

关键词： Dexmedetomidine Personality characteristics School-age children Stress reaction

Surgical treatment of hepatocellular carcinoma with inferior vena cava tumor thrombus: a new classification for surgical guidance

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Hepatobiliary & Pancreatic Diseases International 2013年第3期12卷 263-269页

作者： ai-jun li Wei-Ping Zhou Chuan lin Xi-Long Lang Zhen-Guang Wang Xiao-Yu Yang Qing-He Tang Ran Tao Meng-Chao Wu Division of Special Treatment Ⅱ Eastern Hepatobiliary Surgery Hospital Second Military Medical University Division of Hepatic Surgery Third Eastern Hepatobiliary Surgery Hospital Second Military Medical University Department of Cardiothoracic Surgery Changhai Hospital Second Military Medical University Center for Organ Transplantation and Department of General Surgery Ruijin Hospital

BACKGROUND: Hepatic resection is the main treatment modality for hepatic tumors. Advances in diagnostic technique, preoperative preparation, surgical technique, and postoperative management increased the success rate. The present study aimed to evaluate hepatectomy and resection of inferior vena cava tumor thrombus (IVCTT) in patients with hepatocellular carcinoma, and the relationship between IVCTT classification and selection of surgical technique. METHODS: We retrospectively reviewed 13 patients with hepatocellular carcinoma who had undergone hepatectomy with IVCTT resection between May 1997 and August 2009. Age, gender, diagnosis, findings of physical examination, results of preoperative laboratory investigations, radiological examination, criteria for resection, postoperative pathological results, incisions, operative technique, intraoperative transfusion, drains, and intraoperative and postoperative complications were evaluated for all patients. RESULTS: Type Ⅰ IVCTT (10 patients) was posterior to the liver and below the diaphragm; type Ⅱ IVCTT (2 patients) was above the diaphragm but still outside the atrium; and type Ⅲ IVCTT (1 patient) was above the diaphragm and in the right atrium. Type Ⅰ was treated by radical hepatectomy and removal of IVCTT with total hepatic vascular exclusion. Type Ⅱ was treated by radical hepatectomy and removal of IVCTT by incision of the diaphragm. Type Ⅲ was treated by hepatectomy and resection of the thrombus from the right atrium under cardiopulmonary bypass. There were no surgical complications and one patient has been survived for 4 years with cancer-free status. The median survival time was 18.2 months, and the 1-and 2-year survival rates were 53.8% and 15.4%, respectively. CONCLUSION: Surgical treatment is safe and feasible for treatment of IVCTT in patients with hepatocellular carcinoma, and surgical resectability can be judged according to the classification of tumor thrombus.

关键词： liver tumor inferior vena cava hepatectomy tumor thrombus total hepatic vascular exclusion

An Approach to Star Map Simulation for Star Sensor Considering the Effect of Image Motion

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Optics and Photonics Journal 2013年第2期3卷 108-111页

作者： ai-jun li Chao-Shan liu Xiao-fang Shen Department of Physics College of Science High Technology Research Institute Xi’ an China

To test high resolution and dynamic performance of star sensor, a method of consideration image motion on Modeling the motion blur of star sensor is proposed. Firstly, image motion geometric model based on the rotation of Starlight vector is studied. Secondly, with the help of the normal distribution of static star image energy model, introducing the star image motion speed, obtaining the energy distribution function of moving stars, implementing high dynamic simulation of star map. Finally, establishing the simulation environment, through adjusting input parameters such as integral time, rate of change of three attitude angle, the launch time, location, then, important simulation data of stars observed by star sensor in orbit can quickly be obtained, such as navigation stars information, value and direction of image motion, intensity distribution, signal to noise ratio. This work is very important to research and evaluate the star image motion compensation algorithm.

关键词： Star Sensor Image Motion Model Simulation of Star Map

基于PG值的机场道面沥青抗老化性能预估模型

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建筑材料学报 2017年第1期20卷 73-77页

作者：刘芳夏洪山艾军刘丽南京航空航天大学民航学院江苏南京210016 南京航空航天大学航空宇航学院江苏南京210016 西安建筑科技大学土木工程学院陕西西安710055

从沥青老化机理出发,提出了预测机场道面沥青抗老化性能的预估模型.在标准大气压下针对1种基质沥青和2种改性沥青进行4种温度下不同时间段的老化处理,同时采用动态流变剪切仪(DSR)对沥青试样的PG上限温度值进行测试,研究其在老化作用下... 详细信息

从沥青老化机理出发,提出了预测机场道面沥青抗老化性能的预估模型.在标准大气压下针对1种基质沥青和2种改性沥青进行4种温度下不同时间段的老化处理,同时采用动态流变剪切仪(DSR)对沥青试样的PG上限温度值进行测试,研究其在老化作用下的变化规律.结果表明:3种沥青的PG上限温度值随老化条件的变化均存在一定的规律,但在相同老化条件下,沥青种类不同,其老化速率不同;无论是基质沥青还是改性沥青,其实测数据与预估模型吻合良好,PG上限温度值可作为评价机场沥青道面抗老化性能的指标.

关键词：老化机场沥青道面 PG 模型预测

Expression of ghrelin and insulin-like growth factor-1 in immature piglet model of chronic cyanotic congenital heart defects with decreased pulmonary blood flow

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Chinese Medical Journal 2011年第15期124卷 2354-2360页

作者： WANG Dong liU Ying-long LU Xiao-dong ZHU Yao-bin liNG Feng liU ai-jun li Gang XU Yu-lin Department of Pediatric Cardiac Surgery Center Fuwai Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100037 China

Background Cyanotic patients have potential growth retardation and malnutrition due to hypoxemia and other reasons. Ghrelin is a novel endogenous growth hormone secretagogue that has effects on growth and cardiovascular activities. The aim of this study was to evaluate the plasma level and myocardial expression of ghrelin and insulin-like growth factor-1 （IGF-1） using an immature piglet model of chronic cyanotic congenital heart defects with decreased pulmonary blood flow. Methods Twelve weanling Chinese piglets underwent procedures of main pulmonary artery-left atrium shunt with pulmonary artery banding or sham operation as control. Four weeks later, hemodynamic parameters were measured. Enzyme-linked immunosorbent assay for plasma ghrelin and IGF-1 level measurement were performed. Ventricular ghrelin and IGF-1 mRNA expressions were measured by quantitative real-time polymerase chain reaction. Results Four weeks after surgical procedure, the cyanotic model produced lower arterial oxygen tension （（68.73±15.09） mmHg）, arterial oxygen saturation （（82.35±8.63）%）, and higher arterial carbon dioxide tension （（51.83±6.12） mmHg）, hematocrit （（42.67±3.83）%） and hemoglobin concentration （（138.17±16.73） g/L） than the control piglets （（194.08±98.79） mmHg, （96.43±7.91）%, （36.9±4.73） mmHg, （31.17±3.71）%, （109.83±13.75） g/L）（all P 〈0.05）. Plasma ghrelin level was significantly higher in the cyanotic model group in comparison to the control （P=0.004）, and the plasma IGF-1 level was significantly lower than control （P=0.030）. Compared with control animals, the expression of ghrelin mRNAs in the ventricular myocardium was significantly decreased in the cyanotic model group （P=0.000）, and the expression of IGF-1 mRNAs was elevated （P=0.001）. Conclusions Chronic cyanotic congenital heart defects model was successfully established. Plasma ghrelin level and myocardial IGF-1 mRNA expression were significantly up-regulated, while plasma iGF-1 level and myocardial ghrelin mRNA expression

关键词： congenital heart defects cyanosis piglet ghrelin insulin-like growth factor-1