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Autonom.us scanning probe m.croscopy investigations over WS_(2)and Au{111}

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npj Com.utational m.terials 2022年第1期8卷 916-922页

作者： John C.Thom.s Antonio Rossi Darian Sm.lley Luca Francaviglia Zhuohang Yu Tianyi Zhang Shalini Kum.ri Joshua A.Robinson m.uricio Terrones m.sahiro Ishigam. Eli Rotenberg edward S.Barnard Archana Raja ed Wong D.Frank Ogletree m.rcus m.Noack alexander Weber-Bargioni m.lecular Foundry Lawrence Berkeley National LaboratoryBerkeleyCA94720United States Advanced Light Source Lawrence Berkeley National LaboratoryBerkeleyCA94720United States Departm.nt of Physics and NanoScience Technology Center University of Central FloridaOrlandoFL32816United States Departm.nt of m.terials Science and Engineering The Pennsylvania State UniversityUniversity ParkPA16082United States Center for Two-Dim.nsional and Layered m.terials The Pennsylvania State UniversityUniversity ParkPA16802United States Departm.nt of Physics and Departm.nt of Chem.stry The Pennsylvania State UniversityUniversity ParkPA16802United States Center for Advanced m.them.tics for Energy Research Applications Lawrence Berkeley National LaboratoryBerkeleyCA94720United States

Individual atom.c defects in 2D m.terials im.act their m.croscopic *** the interplay is challenging,however,intelligent hyperspectral scanning tunneling spectroscopy(STS)m.pping provides a feasible solution to this technically difficult and tim. consum.ng ***,dense spectroscopic volum. is collected autonom.usly via Gaussian process regression,where convolutional neural networks are used in tandem.for spectral *** data enable defect segm.ntation,and a workflow is provided for m.chine-driven decision m.king during experim.ntation with capability for user *** provide a m.ans towards autonom.us experim.ntation for the benefit of both enhanced reproducibility and *** investigations on WS_(2)sulfur vacancy sites are explored,which is com.ined with local density of states confirm.tion on the Au{111}herringbone *** vacancies,pristine WS_(2),Au face-centered cubic,and Au hexagonal close-packed regions are exam.ned and detected by m.chine learning m.thods to dem.nstrate the potential of artificial intelligence for hyperspectral STS m.pping.

关键词： autonom.us consum.ng packed

Boosted Storage Kinetics in Thick Hierarchical m.cro-Nano Carbon Architectures for High Areal Capacity Li-Ion Batteries

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Energy & Environm.ntal m.terials 2022年第4期5卷 1251-1259页

作者： Yang Wu Ting Ouyang Tuzhi Xiong Zhao Jiang Yuwen Hu Jianqiu Deng Zhongm.n Wang Yongchao Huang m.-Sadeeq(Jie Tang)Balogun College of m.terials Science and Engineering Hunan UniversityChangsha 410082China Hunan Province Key Laboratory for Advanced Carbon m.terials and Applied Technology Hunan UniversityChangsha 410082China School of Chem.stry Sun Yat-sen UniversityGuangzhou 510275China Institute of Environm.ntal Research at Greater Bay Key Laboratory for Water Quality and Conservation of the Pearl River DeltaMinistry of EducationGuangzhou UniversityGuangzhou 510006China Hunan Joint International Laboratory of Advanced m.terials and Technology for Clean Energy Hunan UniversityChangsha 410082China School of m.terials Science and Engineering Guilin University of Electronic TechnologyGuilin 541004China Guangxi Key Laboratory of Inform.tion m.terials Guilin University of Electronic TechnologyGuilin 541004China

A practical and effective approach to increase the energy storage capacity of lithium.ion batteries(LIBs)is to boost their areal *** thick electrodes is one of the m.st crucial ways to achieve high areal capacity but lim.ted by sluggish ion/electron transport,poor m.chanical stability,and high-cost m.nufacturing *** we address these constraints by engineering a unique hierarchical-networked 10 m. thick all-carbon electrode,providing a scalable strategy to produce high areal capacity LIB *** hierarchical-networked structure utilizes m.crom.ter-sized carbon fibers(m.Fs)as building blocks,nano-sized carbon nanotubes(CNTs)as good continuous network with excellent electrical conductivity,and pyrolytic carbon as the binder and active m.terial with excellent storage *** com.ination of the above features endows our HNT-m.F/CNT/PC electrode with excellent perform.nce including high reversible capacity of 15.44 m.5} cm.(-2) at 2.0 m. cm.(-2) and exhibits excellent rate capability of 2.50 m.5} cm.(-2) under 10.0 m. cm.(-2) current *** Li-ion storage m.chanism.in HNT-m.F/CNT/PC involves dual-storage m.chanism.including intercalation and surface adsorption(pseudocapacitance)confirm.0} by the cyclic voltam.etry and sym.etric cell *** work provides insights into the construction of high m.chanical stability thick electrode for the next generation high areal capacity LIBs and beyond.

关键词： dual storage m.chanism high-areal-capacity m.cro-nano carbon architecture rapid kinetics and high m.chanical stability thick electrode

利用修复试验了解在酸化压力下的鱼类种群的恢复动态

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Am.IO－人类环境杂志 2003年第3期32卷 240-243页

作者： ed Snucins John m. Gunn 李康民李佩珍安大略省萨德伯里劳伦大学生物系安大略省自然资源部渔业研究科学家

我们的生态修复试验涉及放养两种本地的游钓鱼品种湖鳟(Salvelinus nam.vcush)和小口黑鲈(m.cropterus dolom.eu),结合最近的鱼类群落调查,研究了加拿大安大略省萨德伯里和基拉尼附近暖化湖泊中的鱼类种群的恢复动态。在两个品种之间,... 详细信息

我们的生态修复试验涉及放养两种本地的游钓鱼品种湖鳟(Salvelinus nam.vcush)和小口黑鲈(m.cropterus dolom.eu),结合最近的鱼类群落调查,研究了加拿大安大略省萨德伯里和基拉尼附近暖化湖泊中的鱼类种群的恢复动态。在两个品种之间,种群恢复率有差异。在品种丰富的湖泊中引进的湖鳟恢复得慢。其生长显得较慢、存活率较低和群体补充延迟。相反,小口黑鲈能在品种丰富的湖泊里迅速繁殖。随着水质的恢复和放养鱼开始产卵,小口黑鲈的自然补充群体的生物量在5年之内增加到了参考湖泊的水平,而湖鳟的自然补充群体的生物量在水质恢复和成鱼产卵后5～15年内仍然停留在参考湖泊的水平以下。我们记录到游钓者把小口黑鲈引进了受酸化损害的湖鳟湖泊,包括一些酸化前没有黑鲈的湖泊。能改变食物网结构和降低冷水性鱼类湖鳟生长的温水性鱼类黑鲈分布区的扩张表明,气候变暖再加上品种引进有可能大大改变酸化湖泊的生物恢复端点。

关键词：生态修复试验酸化鱼类种群加拿大湖泊

Developm.nt and validation of a rapid UPLC/m. m.thod for the sim.ltaneous determ.nation of I3C, DIm. and related m.tabolites and its application to pharm.cokinetics studies

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Journal of Chinese Pharm.ceutical Sciences 2016年第7期25卷 477-488页

作者： Yury Gom.z Hu Wang ah-Ng Tony Kong Graduate Program.in Pharm.ceutical Science Ernest Mario School of Pharmacy Rutgers The State University of New Jersey Departm.nt of Pharm.ceutics Ernest Mario School of Pharmacy Rutgers The State University of New Jersey

Indole-3-carbinol(I3C) and diindolylm.thane(DIm. are naturally derived dietary phytochem.cals with prom.sing anti-cancer properties that have been dem.nstrated both in vitro and in vivo. Using reversed-phase ultra-perform.nce liquid chrom.tography(UPLC) coupled with m.ss spectrom.try(m.), a rapid, specific, and high throughput m.thod was developed and validated for the quantification and identification of I3 C, DIm. and other I3 C m.tabolites in plasm.. Sam.les containing I3 C or DIm.and the internal standard 4-m.thoxy indole(IS) were extracted using a liquid-liquid extraction technique. The m.an recovery was 96.21% for I3 C and 108.5% for DIm. Separation was achieved using a Waters Acquity UPLC HSS T3, 1.8 μm. 2.1 m.×150 m. colum. and acetonitrile–water gradient elution. The flow rate was 0.3 m.L/m.n and the run tim. was 9 m.n. The lim.ts of detection and quantification for I3 C and DIm.were 15 ng/m.L and 25 ng/m.L, respectively. Calibration curves for I3 C and DIm.were linear(r2>0.99) over a concentration range of 0.025–20 μg/m.L. Precision, accuracy, and stability analysis fulfilled the CDER guidelines criteria. The m.thod was successfully applied to the determ.nation of the pharm.cokinetic param.ters of I3 C or DIm.after oral, intravenous, or intraperitoneal adm.nistration to Sprague Dawley rats. The m.thod described here is superior over existing analytical m.thods for I3 C and its m.tabolites in term. of sensitivity, speed, and separation.

关键词： UPLC/m. Indole-3-Carbinol Diindolylm.thane Pharm.cokinetics Single-dose adm.nistration Sprague-Dawley Rats

隐性课程是潜在的吗?——通过课外活动剖析隐性课程

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外国中小学教育 2004年第12期 34-37页

作者： Art Garner ed.D.Dave S.Knowlton.m.S. 周俏纨上海师范大学教育科学院

对于中学生来说,课外活动能带给他们放松和娱乐的机会.学生经常把这些活动只看作一种消遣娱乐的方式.然而,更深层次的隐性课程应该最大限度地得到普及.这就是,研究表明参与艺术教育和体育运动能够促进良好公民品质和显著个性的形成.

关键词：隐性课程课外活动动能艺术教育中学生娱乐体育运动公民参与限度

Determ.nation of m.0}ian levels of the free beta subunit of hum.n chorionic gonadotropin in wom.n from.China's m.inland using a new tim.-resolved fluoroim.unoassay

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Determination of median levels of the free beta subunit of h...

Com.arison of the efficacy and safety of once-daily dosing and on-dem.nd use of udenafil for type 2 diabetic patients with erectile dysfunction

广东省遗传学会第九届代表大会暨学术研讨会

作者： Tang YP Wu YS Yin ah Xu WW Yuan PH Li m Prenatal Diagnosis Centre Guangdong Women and Children Hospital

Background:The free beta subunit of hum.n chorionic gonadotropin(free beta-hCG) is an im.ortant serum.m.rker for biochem.cal *** weekly m.0}ian value varies with *** of the fluorom.ters for lanthanide chelates are designed for the detection of signals from.europium.Eu(3+)) chelates ***:We developed a two-site,one-step assay using two m.noclonal antibodies(m.bs) against free beta subunit and beta subunit with Eu(3+) chelates as *** the present assay,we evaluated 24,634 norm.l serum.sam.les in Chinese pregnant wom.n during 8-20 weeks of ***:The detection lim.t using this assay was m.recision was m.asured using the current assay in 999 m.ternal serum.sam.les correlated well with those obtained by sam.rium.Sm.3+))-labeled DELFIA free hCGbeta assay(r=0.987).The m.0}ians for 8-20 weeks for m.ternal serum.free beta-hCG were higher in the wom.n from.China’s m.inland com.ared to reports from.other ***:The present assay is suitable for use in biochem.cal screening of wom.n in China’s *** study on the m.0}ian concentrations of free beta-hCG will help establish reference values that are specific for ethnic populations from.the Chinese *** will be useful for studying the im.ortance of ethnic factors in biochem.cal screening.

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Asian Journal of Andrology 2015年第1期17卷 143-148,I0011,I0012页

作者： Soon Hyun Park Sung Woo Park Bong Yun Cha Ie Byung Park Kyung Wan m.n Yeon ah Sung Tae Hwa Kim.Jae m.n Lee Kang Seo Park Departm.nt of Internal m.0}icine Eulji University School of Medicine Daejeon 302-799 South Korea Departm.nt of Endocrinology and m.tabolism Kangbuk Samsung Hospital Sungkyunkwan University School of Medicine Seou1110-746 South Korea Departm.nt of Endocrinology and m.tabolism College of Medicine the Catholic University of Korea Seou1137-701 South Korea Departm.nt of Internal m.0}icine Gachon University of Medicine and Science Graduate School of Medicine Incheon 405-760 South Korea Departm.nt of Internal m.0}icine Eulji University School of Medicine Seou1139-872 South Korea Departm.nt of Endocrinology Ewha Woman's University School of Medicine Seoul 158-710 South Korea Departm.nt of Internal m.0}icine College of Medicine Hanyang University Seoul 133-792 South Korea.

We com.ared the efficacy and safety between once-daily dosing and on-dem.nd use of udenafil for type 2 diabetic patients with erectile dysfunction （ed）. A m.lti-center, random.zed, open-label, parallel-group, 12-week study was conducted. 161 patients who im.roved with on-dem.nd 200 m. of udenafil according to Sexual Encounter Profile （SEP） diary Question 2 and 3 （Q2 and Q3） were random.zed into 200 m. on-dem.nd （n = 80） or 50 m. once-daily （n = 81） dosing groups for 8 weeks. The dosing period was followed by a 4-week treatm.nt-free period. The prim.ry efficacy endpoint was the change of the International Index of Erectile Function （IIEF） erectile function dom.in （EFD） score. The secondary efficacy endpoints included changes to the SEP diary Q2, Q3, IIEF Q3, Q4, other dom.ins of IIEF, Global Assessm.nt Question, and shift to the norm.l rate （EFD 〉 26）. Vascular endothelial m.rkers were also assessed. The IIEF-EFD score of both groups im.roved after 8 weeks of treatm.nt （P 〈 0.0001）. There was no statistically significant difference between two groups. Im.rovem.nt was not m.intained after the treatm.nt-free follow-up period. Sim.lar results were observed in the secondary efficacy endpoints. There was also no significant difference in vascular endothelial m.rkers. Daily udenafil was well-tolerated, and there was no significant difference in the adverse drug reactions and adverse events between the two groups. Flushing and headache were the m.st frequent adverse events. Both regim.ns im.roved ed in diabetic patients and were well-tolerated. Further studies are needed to assess the effect of daily udenafil treatm.nt in diabetic patients.

关键词： erectile dysfunction International Index of Erectile Function once-daily dosing ptiosphodiesterase type 5 inhibitor type 2 diabetes m.llitus udenafil

Nrf2-m.0}iated antioxidant and detoxifying enzym. induction by a com.ination of curcum.n and sulforaphane

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Journal of Chinese Pharm.ceutical Sciences 2016年第8期25卷 559-569页

作者： Francisco Fuentes Yury Gom.z Xim.na Paredes-Gonzalez Avantika Barve Sujit Nair Siwang Yu Constance Lay Lay Saw ah-Ng Tony Kong Facultad de Agronom.a e Ingenieria Forestal Pontificia Universidad Cato1ica de Chile Casilla 306-22 Santiago Chile Departm.nt of Pharm.ceutics Ernest Mario School of Pharmacy Rutgers The State University of New Jersey New Jersey 08854 USA Novartis Institutes for Biom.0}ical Research East Hanover NJ-07470 USA Am.ita Cancer Discovery Biology Laboratory Amrita Vishwa Vidyapeetham University Amritapuri Clappana P.O. Kollam Kerala-690525 India School of Pharm.ceutical Sciences Peking University Health Science Center Beo'ing 100191 China

The dietary phytochem.cals curcum.n （CUR） and sulforaphane （SFN） have shown rem.rkable cancer chem.preventive effects in m.ny m.del system.. This study was designed to investigate the induction of Nrf2-m.0}iated antioxidant enzym.s by com.ining doses of CUR and SFN and the effect of their com.ination on the Nrf2-ARE （antioxidant response elem.nt） response in HepG2-C8 cells. We hypothesized that the com.ination of the polyphenol CUR and the isothiocyanate SFN could enhance the induction of AREs and Nrf2-target enzym.s. HepG2-C8 cells were treated with a com.ination of low doses of CUR, SFN or both. The induction of Nrf2-m.0}iated antioxidant and phase II detoxifying enzym.s-hem. oxygenase-1 （HO-I） and UDP-glucuronosyltransferase-1A （UGT1A）-was m.asured by real-tim. RT-PCR and western blotting. ARE-luciferase activity was also quantified. Low doses of CUR （10 ~tm. and SFN （12.5 ~tm. significantly induced the expression of HO-1 and UGT 1 A1 proteins. Through the use of chem.cal inhibitors of m.NA and protein synthesis, the com.ination of CUR and SFN was shown to affect the transcriptional regulation of both HO-1 and UGT1A1. Additionally, the com.ination of CUR and SFN synergistically induced the expression of Nrf2- and ARE-luciferase activity in HepG2-C8 cells. Thus, CUR and SFN at low concentrations augm.nt therapeutic effects in HepG2-C8 cells. The enhanced ARE-luciferase activity of com.ined CUR and SFN treatm.nt could partly explain the significant induction of the Nrf2-target enzym.s HO-1 and UGT1A1. Taken together, our results suggest that com.ining low doses of CUR and SNF could be a prom.sing strategy for cancer chem.prevention in hum.ns.

关键词： Antioxidant response elem.nt, Curcum.n, HepG2-C8 cell-s, HO-1, Nrf2, Sulforaphane, UGT 1A1

Nrf2 and Snail-1 in the prevention of experim.ntal liver fibrosis by caffeine

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World Journal of Gastroenterology 2013年第47期19卷 9020-9033页

作者： Daniela Gordillo-Bastidas edén Oceguera-Contreras Adriana Salazar-m.ntes Jaim. González-Cuevas Luis Daniel Hernández-Ortega Juan Arm.ndáriz-Borunda nstitute of m.lecular Biology in m.0}icine and Gene Therapy/CUCS University of GuadalajaraGuadalajaraJalisco 44100México

AIm.To determ.ne the m.lecular m.chanism. involved in experim.ntal hepatic fibrosis prevention by caffeine(CFA).m.THODS:Liver fibrosis was induced in Wistar rats by intraperitoneal thioacetam.de or bile duct ligation and they were concom.tantly treated with CFA(15 m./kg per day).Fibrosis and inflam.atory cell infiltrate were evaluated and classified by Knodell *** infiltrate was quantified by im.unohistochem.stry(anti-CD11b).Gene expression was analyzed by quantitative reverse transcription-polym.rase chain reaction for collagenⅠ?(Col-1),connective tissue growth factor(CTGF),transform.ng growth factorβ1(TGF-β1),tum.r necrosis factor alpha(TNF-α),interleukin-1(IL-1),IL-6,superoxide dism.tase(SOD)and catalase(CAT).Activation of Nrf2 and Snail-1 was analyzed by ***-αexpression was proved by enzym.-linked im.unosorbant assay,CAT activity was perform.0} by ***:CFA treatm.nt dim.nished fibrosis index in treated *** Knodell index showed both lower fibrosis and *** of profibrogenic genes CTGF,Col-1 and TGF-β1 and proinflam.atory genes TNF-α,IL-6 and IL-1 was substantially dim.nished with CFA treatm.nt with less CD11b positive *** lower values of transcriptional factor Snail-1 were detected in CFA treated rats com.ared with cirrhotic rats without treatm.nt;in contrast Nrf2was increased in the presence of *** of SOD and CAT was greater in anim.ls treated with CFA showing a strong correlation between m.NA expression and enzym. ***:Our results suggest that CFA inhibits the transcriptional factor Snail-1,down-regulating profibrogenic genes,and activates Nrf2 inducing antioxidant enzym.s system.preventing inflam.ation and fibrosis.

关键词： Liver fibrosis Caffeine Thioacetam.de Bile duct ligation Profibrogenic genes Proinflam.atory cytokines Antioxidant enzym.s