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Assessment and prediction of tablet properties using transmission and backscattering Raman spectroscopy and transmission NIR spectroscopy

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Asian Journal of Pharmaceutical Sciences 2016年第4期11卷 547-558页

作者： Elisabeth Peeters Ana Filipa Tavares da silva Maunu Toiviainen Jeroen Van Renterghem Jurgen Vercruysse Mikko Juuti Joao Almeida lopes Thomas De Beer Chris Vervaet Jean-Paul Remon Laboratory of Pharmaceutical Technology Ghent UniversityOttergemsesteenweg 4609000GhentBelgium Laboratory of Pharmaceutical Process Analytical Technology Ghent UniversityOttergemsesteenweg 4609000GhentBelgium REQUIMTE Department of Chemical SciencesUniversity of PortoRua de Jorge Viterbo Ferreira2284050-313PortoPortugal VTT Technical Research Centre of Finland Optical Measurement TechnologiesKaitoväylä190570 OuluFinland

This study investigated whether Raman and Near Infrared(NIR) spectroscopy could predict tablet properties. Granules were produced on a continuous line by varying granulation parameters. Tableting process parameters were adjusted to obtain uniform tablet weight and thickness. Spectra were collected offline and tablet properties determined with traditional analyzing methods. Partial Least Squares(PLS) regression was used to correlate spectral information to tablet properties, but predictive models couldn’t be established. Principal component analysis(PCA) was effectively used to distinguish theophylline concentrations and hydration levels and multiple linear regression(MLR) analysis allowed insight on how granulation parameters affect granule and tablet properties.

关键词： Continuous production PAT Granulation Tableting NIR Raman

The Effect of the Atmospheric and Cloud Properties on the Retrieval of Fog Microphysics at Night for MSG/SEVIRI: A Sensitivity Test Using LibRadtran

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Atmospheric and Climate Sciences 2021年第3期11卷 441-457页

作者： Aliton Oliveira da silva Augusto Jose Pereira filho Hugo Abi Karam Departamento de Ciências Atmosféricas Instituto de Astronomia Geofísica e Ciências Atmosféricas Universidade de S&#227 o Paulo S&#227 o Paulo Rua do Mat&#227 o 1226 S&#227 o Paulo Brazil Centro de Ciências Matemáticas e da Natureza Instituto de Geociências Federal Universidade Federal do Rio de Janeiro Rio de Janeiro Rua Athos da Silveira Ramos 274 Rio de Janeiro Brazil

The simplest way of building a look-up table (LUT) for the retrieval of cloud microphysical properties is to use a standard atmospheric profile and vertically uniform cloud microphysics. Such an assumption has been demonstrated to be incoherent with in-cloud observations. This paper aims to show the effect of some atmospheric conditions associated with fog as well as its macro-and microstructure on brightness temperature (BT) for the MSG/ SEVIRI satellite using libRadtran. The sensitivity tests were performed by gradually changing some features from the initial data, such as cloud cover, total water vapor column, thermal inversion intensity, fog depth, fog microstructure, and others. The results revealed that some variables can cause significant variations on BT and, consequently, discrepancies in the retrieval of fog microphysical properties. Also, a variation as high as 0.5°C was found on BT just by switching uniform to the non-uniform profile of fog microphysics depending on the channel, the droplet size, and optical thickness.

关键词： Fog Microphysics MSG/SEVIRI Sensitivity Test LibRadtran

Cystic fibrosis and the relevance of the whole-body vibration exercises in oscillating platforms: a short review

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Health 2011年第10期3卷 656-662页

作者： Adalgisa Ieda Maiworm Milena B.Monteiro Sebastiao D.Santos-filho agnaldo J.lopes Leandro Azeredo Sotiris Missailidis Pedro J.Marin Mario Bernardo-filho Hospital Universitario Pedro Ernesto Setor de FisioterapiaUniversidade do Estado do Rio de JaneiroRio de JaneiroBrazil Clinica de Fisioterapia e Biomedicina Rio de JaneiroBrazil Universidade do Estado do Rio de Janeiro Instituto de Biologia Roberto Alcantara GomesDepartamento de Biofisica e BiometriaRio de JaneiroBrazil Departamento de Pneumologia e Coordenacao do Centro de Referencia de Fibrose Cistica em Adultos do Estado do Rio de Janeiro Universidade do Estado do Rio de JaneiroRio de JaneiroBrazil Hospital da Policia Militar NiteroiBrazil The Open University Milton KeynesUK Laboratory of Physiology European University Miguel de CervantesValladolidSpain Research Center on Physical Disability ASPAYMCastilla y LeonSpain Coordenadoria de Pesquisa Instituto Nacional do CancerINCaRio de Janeiro Brazil.

Objective: The aim is to present a review about the whole-body vibration (WBV) exercises in the management of cystic fibrosis (CF). Methods: Computerized literature searches were performed using the PubMed databases. Results: A strong interest in studies, considering the number of publications, involving CF and lung was found. Although, the exercises and physical activities seem to have a high relevance in the management of the patients with CF, the number of publications involving these procedures is limited. Moreover, a modality of exercise involving WBV seems to be poorly utilized by the patients with CF and only two papers were found with positive actions. Conclusion: Oscillating platform is a promising technique to manage patients with CF. Moreover, as (i) the use of the oscillating platforms is inexpensive, (ii) the vibration exercise requires less technical abilities as compared to the performance of conventional resistance training and (iii) positive clinical findings have been noticed with the use of WBV in CF, it is suggested to implement the studies involving the application of the exercises with WBV in oscillating platforms to manage the patients with CF.

关键词： Cystic fibrosis whole body vibration PubMed

Clinical outcomes of hospitalized patients with chikungunya fever: A retrospective analysis

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Asian Pacific Journal of Tropical Medicine 2021年第4期14卷 183-186页

作者： Lucas Lobo Mesquita Enio Simas Macedo Sergio Luiz Arruda Parente filho Francisca Lillyan Christyan Nunes Beserra Evelyne Santana Girao Juliana Mandato Ferragut Roberto da Justa Pires Neto Geraldo Bezerra da silva Junior Elizabeth De Francesco daher School of Medicine Federal University of CearaFortalezaCearaBrazil Hospital Regional da Unimed FortalezaCearaBrazil Intensive Care Unit Hospital Sao CarlosFortalezaCearaBrazil Department of Public Health School of MedicineFederal University of CearaFortalezaCearaBrazil Public Health and Medical Sciences Post-Graduation Programs School of MedicineHealth Sciences CenterUniversity of Fortaleza.FortalezaCearaBrazil Medical Sciences Post Graduate Program Department of Internal MedicineSchool of MedicineFederal University of Ceara.FortalezaCearáBrazil

Objective:To describe the prognostic and clinical profile of hospitalized patients with chikungunya virus(CHIKV)infection focusing on renal ***:This is a cross-sectional study including all patients with confirmed chikungunya fever(CHIKF)admitted to 3 different highcomplexity hospitals in Fortaleza,Brazil between January 2016 and June *** analysis was carried out to evaluate correlation between clinical profile and ***:Fifty-five patients were included,with a median age of 77(IQR=21)years,and 23(41.82%)were ***-five patients(45.45%,25/55)developed acute kidney injury(AKI),and 15(60.00%,15/25)were classified as KDIGO 1,1(4.00%)as KDIGO 2,and 9(36.00%)as KDIGO *** overall mortality was 34.54%whilst AKI-related mortality was 64.00%(16/25).Both AKI and encephalitis were associated with higher *** who died were significantly older[82(IQR=12)years vs.70(IQR=28.75)years,P<0.001].In the multivariate analysis,abdominal pain was associated with an increased risk of severe AKI(OR=5.33,95%CI=1.11–25.64,P=0.037)and AKI was an independent risk factor of death(OR=12.06,95%CI=2.55–57.15,P=0.002).Recovery of renal function was similar among the different age ***:AKI is present in half of the study population and is an independent risk factor of ***,renal function should be carefully monitored in hospitalized patients with CHIKV infection.

关键词： Arbovirus infections Chikungunya fever Acute kidney injury Elderly Mortality

Serological evidence of Toxoplasma gondii infection as potential risk for the development of lepromatous leprosy in an endemic area for both neglected tropical diseases in Brazil

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Infectious Diseases of Poverty 2020年第1期9卷 36-45页

作者： Luciana Regina Pereira Oliveira Lívia Mattos Martins Rebeka da Conceição Souza Yuri Scheidegger de Castro Letícia silva Nascimento Juliana Azevedo da silva Edilbert Pellegrini Nahn Junior Wilmar Dias da silva Alba Lucínia Peixoto-Rangel Laboratory of Recognition Biology Center of Biosciences and BiotechnologyState University of Northern Rio de JaneiroCampos dos GoytacazesRJBrazil Campos Medical School Campos dos GoytacazesRJBrazil Laboratory of Immunochemistry Butantan InstituteSão PauloSPBrazil

Background:Mycobacterium leprae and Toxoplasma gondii infections are both neglected tropical diseases highly prevalent in *** with certain parasite species can significantly alter susceptibility to other important pathogens,and/or influence the development of *** we investigated the possible influence of ***/*** co-parasitism on the manifestation of leprosy and its clinical ***:Participants(n=291)were recruited in Campos dos Goytacazes city,Rio de Janeiro state,southeast Brazil,from August 2015 to December 2019 and clinically diagnosed for *** were selected based on the presence(patients)or absence(healthy controls)of the leprosy *** of patients were also recruited for this *** samples from patients(n=199)with leprosy,contacts(n=40)and healthy controls(n=52)were investigated for levels of IgM and IgG anti-phenolic glycolipid-1(PGL-1)by ***,IgG antibody against soluble Toxoplasma antigen(STAg)was measured in sera samples from leprosy patients,contacts and healthy controls for Toxoplasma gondii serology by ***-PGL-1 IgG and IgM levels were compared using one-way ANOVA Kruskal-Wallis or Mann-Whitney,while Spearman test was used to correlate levels of IgG anti-STAg and IgM/IgG anti-PGL-1 from seropositive and seronegative individuals for *** *** risk of *** infection for leprosy disease was assessed using Fisher’s ***:Levels of IgM anti-PGL-1 antibodies were significantly higher in multibacillary(MB)patients compared to paucibacillary(PB)patients(P=0.0068).Higher IgM and IgG levels anti-PGL-1 were detected in patients with the lepromatous *** serologic prevalence for *** infection was 74.9%.We detected increased anti-STAg antibody levels in leprosy patients(79.4%),reaching 88.8%within those with lepromatous form of this *** leprosy risk increase in *** seropositive individuals was two-fold(odds ratio[OR]=2.055;95% c

关键词： Leprosy Toxoplasmosis Coinfection Co-immunomodulation Immunoglobulins Immune response

Valorization of semi-solid by-product from distillation of cellulosic ethanol into blends for heating and power

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Waste Disposal and Sustainable Energy 2021年第1期3卷 49-61页

作者： Bruno Rafael de Almeida Moreira Victor Hugo Cruz Matheus Luís Oliveira Cunha Nathaly Proença lopes Anderson Chagas Magalhães Celso Tadao Miasaki JoséClaudio Caraschi Ronaldo da silva Viana Department of Phytosanitary Rural Engineering and SoilsSchool of EngineeringSão Paulo State University(Unesp)Ilha SolteiraSão PauloBrazil Department of Plant Production College of Agricultural and Technological SciencesSão Paulo State University(Unesp)DracenaSão PauloBrazil São Paulo State University(Unesp) ItapevaSão PauloBrazil

Burning down on semi-solid by-product from distillation of cellulosic ethanol to power upstream steps of its manufacturing is ***,this feedstock is homogenous in size and shape,hygroscopic and poorly *** disadvantages make its re-use in the industrial plant very *** of this agro-residue into high-performance blends for heating and power is,accordingly,the scientific point of this *** pilot-scale manufacturing of composite pellets consisted of systematically pressing the residue with sugarcane bagasse at the mass ratios of 1:4,2:4,and 3:4 on an automatic pelletizer machine at 200 MPa and 125℃.The process of compaction lasted for 90 *** and energy density,both increased significantly,from 95.85%to 99.55%and from 27.95 GJ m^(−3) to 32.20 GJ m^(−3) with blending at 3:***,the semi-solid by-product considerably improved the feeding,thus,enabling the layers of particles to go smoothly through the channel-forming die of the ***,blends became stiffer and denser than pellets purely consisting of sugarcane *** evidence of the process of pelleting capable of highly valorizing the semi-solid by-product from distillation of cellulosic bioethanol into mechanically stable and energetically effective hybrid fuel grade biosolids *** major findings of this paper should be of great relevance to ensure safe and effective transportation and storage of biomass in indoor facili-ties where the risk for the generation of dust and fines and the subsequent off-gassing and self-firing is ***,pelletization may optimize the co-generation of heat and steam at the large-scale bioethanol station.

关键词： Fuel grade biosolids Non-woody biomass Pelletization Second-generation biofuel Sustainable waste-to-energy technique

Effect of Pseudomonas fluorescensand Burkholderia pyrrociniaon the Growth Improvement and Physiological Responses in Brachiaria brizantha

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American Journal of Plant Sciences 2018年第2期9卷 250-265页

作者： Monyck Jeane dos Santos lopes Moacyr Bernardino Dias filho Thomaz Henrique dos Reis Castro Marta Cristina Corsi de Filippi Gisele Barata da silva Plant Protection Laboratory Institute of Agricultural Sciences Federal Rural University of Amazonia (UFRA) Belém Brazil Brazilian Agricultural Research Corporation (Embrapa) Belém Brazil Brazilian Agricultural Research Corporation (Embrapa) Goiania Brazil

The use of beneficial microorganisms in forage grasses is a potentially advantageous technique for a more sustainable pasture management by decreasing the need for chemical fertilization. Our aims were to determine the best method of microorganism inoculation on Brachiaria (Syn. Urochloa) brizantha cv. BRS Piata, compare the responses of inoculated plants of this forage grass with fertilized and unfertilized controls and examine its effect on some morphological, physiological and biochemical responses. On the first experiment, three inoculation methods were tested: in the seed, seed and soil, and soil, with Pseudomonas fluorescens (BRM-32111) and Burkholderia pyrrocinia (BRM-32113). In the second experiment, fertilized and unfertilized plants were either inoculated with BRM-32111, BRM-32113 and co-inoculated (BRM-32111 + BRM-32113). In a final experiment, B. brizantha was inoculated by soil drenching with BRM-32111, BRM-32113 and co-inoculated (BRM-32111 + BRM-32113), and compared to fertilized- and unfertilized-controls. The inoculation by soil drenching, at seedling stage, was more effective than inoculation only in the seed or both in the seed and by soil drenching. The fertilizer may have suppressed the beneficial bacterial effects on the growth of B. brizantha. P. fluorescens and B. pyrrocinia co-inoculated increased nitrate, protein, nitrogen concentration, Spad index (chlorophyll content), leaf area, number of tillers, net photosynthesis and total biomass production of B. brizantha plants. Our results point out to a potentially valuable source of practical information in the search of an eco-friendlier approach to increase pasture productivity.

关键词： Forage Grass Rhizobacteria Photosynthesis Nitrate Nitrogen

Practices and Knowledge on the Prevention of Cervical Cancer in Elderly Women

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Open Journal of Epidemiology 2018年第1期8卷 29-42页

作者： Candyce Simoes Malta Marques silva Camila Maria Beder Ribeiro Evanio da silva Evanio da silva José Gildo da silva Euclides Maurício Trindade filho Kristiana Cerqueira Mousinho CESMAC University Center Maceió Alagoas State Brazil

Cancer is a public health problem, primarily in developing countries. Elderly women are more prone to contracting different diseases, including sexual related neoplasms. The aim of this study was to determine the strategies used and knowledge regarding the prevention of cervical cancer in elderly women. This is a cross-sectional observational study. The sample was comprised of elderly women residents from the Brazilian Northeastern city who attended a coexistence group for elder people. After sample, calculation was obtained N of 209 participants. Associations between the independent and dependent variables were analyzed using the chi-squared test, considering p ≤ 0.05 as significant. The following programs were used for statistical analyses: Excel (Microsoft Office?), to tabulate the data and prepare the tables and Bioestat? 5.3 to test the associations. The prevalent age range was 60 to 70 years;most of the subjects were retired and had secondary schooling. Although a large number of those interviewed knew about cervical cancer, their knowledge was insufficient to take preventive measures. It is important that the elderly undergo a Pap smear, since the number of increasing cervical cancer cases is known to increase in this age range. In the coming decades, Brazil will have a significant elderly population, reaffirming the growing need for educational campaigns related to the health of elderly women, encouraging self-care and prevention in old age.

关键词： Cancer Cervical Cancer Elderly Women

Vaccine against Dental Caries: An Update

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Advances in Microbiology 2014年第13期4卷 925-933页

作者： Diego Romário da silva Andréa Cristina Barbosa da silva Robeci Macedo filho Flaviana Dornela Verli Sandra Aparecida Marinho Graduate Program in Dentistry Technology and Health State University of Paraiba UEPB Araruna Paraíba Brazil Department of Biological Sciences Federal University of the Jequitinhonha and Mucuri Valleys UFVJM Diamantina Paraíba Brazil

Dental caries, the disease that causes tooth decay, is infectious, and the mutans streptococci bacteria have long been identified as the primary disease-causing agents. Caries vaccines showed promising results in experimental studies;however, it remains far the effective use in humans due to political-economic and ethical issues. Progress towards practical vaccine development requires evaluation of candidate vaccines in clinical trials. Promising strategies of passive immunization also require further clinical evaluation. The purpose of this chapter is to review the literature on the main research projects aimed at developing caries vaccines.

关键词： Caries Vaccine Immunology