Assessment and prediction of tablet properties using transmission and backscattering Raman spectroscopy and transmission NIR spectroscopy

作     者：Elisabeth Peeters Ana Filipa Tavares da Silva Maunu Toiviainen Jeroen Van Renterghem Jurgen Vercruysse Mikko Juuti Joao Almeida Lopes Thomas De Beer Chris Vervaet Jean-Paul Remon 

作者机构：Laboratory of Pharmaceutical TechnologyGhent UniversityOttergemsesteenweg 4609000GhentBelgium Laboratory of Pharmaceutical Process Analytical TechnologyGhent UniversityOttergemsesteenweg 4609000GhentBelgium REQUIMTEDepartment of Chemical SciencesUniversity of PortoRua de Jorge Viterbo Ferreira2284050-313PortoPortugal VTT Technical Research Centre of FinlandOptical Measurement TechnologiesKaitoväylä190570 OuluFinland 

出 版 物：《Asian Journal of Pharmaceutical Sciences》 (亚洲药物制剂科学（英文）)

年 卷 期：2016年第11卷第4期

页      面：547-558页

核心收录：

学科分类：100702[医学-药剂学] 1007[医学-药学(可授医学、理学学位)] 1006[医学-中西医结合] 100602[医学-中西医结合临床] 10[医学] 

主　　题：Continuous production PAT Granulation Tableting NIR Raman 

摘      要：This study investigated whether Raman and Near Infrared(NIR) spectroscopy could predict tablet properties. Granules were produced on a continuous line by varying granulation parameters. Tableting process parameters were adjusted to obtain uniform tablet weight and thickness. Spectra were collected offline and tablet properties determined with traditional analyzing methods. Partial Least Squares(PLS) regression was used to correlate spectral information to tablet properties, but predictive models couldn’t be established. Principal component analysis(PCA) was effectively used to distinguish theophylline concentrations and hydration levels and multiple linear regression(MLR) analysis allowed insight on how granulation parameters affect granule and tablet properties.