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Infiltration by monocytes of the central nervous system and its role in multiple sclerosis: reflections on therapeutic strategies

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Neural Regeneration Research 2025年第3期20卷 779-793页

作者： Guangyong Zhang Qing Yao Chubing Long Pengcheng Yi Jiali song Luojia Wu Wei Wan Xiuqin Rao Yue Lin Gen Wei Jun Ying Fuzhou Hua Department of Anesthesiology the Second Affiliated Hospital of Nanchang UniversityNanchangJiangxi ProvinceChina Key Laboratory of Anesthesiology of Jiangxi Province NanchangJiangxi ProvinceChina

Mononuclear macrophage infiltration in the central nervous system is a prominent feature of neuroinflammation. Recent studies on the pathogenesis and progression of multiple sclerosis have highlighted the multiple roles of mononuclear macrophages in the neuroinflammatory process. Monocytes play a significant role in neuroinflammation, and managing neuroinflammation by manipulating peripheral monocytes stands out as an effective strategy for the treatment of multiple sclerosis, leading to improved patient outcomes. This review outlines the steps involved in the entry of myeloid monocytes into the central nervous system that are targets for effective intervention: the activation of bone marrow hematopoiesis, migration of monocytes in the blood, and penetration of the blood–brain barrier by monocytes. Finally, we summarize the different monocyte subpopulations and their effects on the central nervous system based on phenotypic differences. As activated microglia resemble monocyte-derived macrophages, it is important to accurately identify the role of monocyte-derived macrophages in disease. Depending on the roles played by monocyte-derived macrophages at different stages of the disease, several of these processes can be interrupted to limit neuroinflammation and improve patient prognosis. Here, we discuss possible strategies to target monocytes in neurological diseases, focusing on three key aspects of monocyte infiltration into the central nervous system, to provide new ideas for the treatment of neurodegenerative diseases.

关键词： blood–brain barrier macrophages monocytes multiple sclerosis neuroinflammation review therapy

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电解水制氢技术:进展、挑战与未来展望

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工程科学学报 2025年第2期47卷 282-295页

作者：张正宋凌珺北京航空航天大学交通科学与工程学院北京102200

实现全球碳中和是各国在2050年制定的重要目标之一,旨在减缓气候变化的不良影响.氢能作为一种极具潜力的清洁能源,凭借其高能量密度、零碳排放、可再生性强等特性,被视为实现能源转型与应对气候变化的重要载体.为了实现这些目标,利用电... 详细信息

实现全球碳中和是各国在2050年制定的重要目标之一,旨在减缓气候变化的不良影响.氢能作为一种极具潜力的清洁能源,凭借其高能量密度、零碳排放、可再生性强等特性,被视为实现能源转型与应对气候变化的重要载体.为了实现这些目标,利用电解水制取氢气已经成为解决全球碳中和问题的重要关键方案之一.本文综述了碱性电解水、质子交换膜电解水、阴离子交换膜电解水和固体氧化物电解水制氢技术的最新进展,并对这四种电解水技术的工作原理、结构特点以及优缺点进行了详尽比较.此外,总结了电解水制氢催化剂材料的研究进展,尤其是新型材料的开发与结构优化,旨在提升材料的催化活性与稳定性.讨论了海水电解制氢和耦合制氢等新兴技术,强调通过电解质组成优化、高效双功能催化剂开发及利用小分子氧化反应热力学优势,可有效提升电解水制氢效率和系统稳定性.最后,提出了电解水制氢技术的发展趋势与未来研究方向,包括提升催化剂性能、降低电解过程能耗、开发新型电解设备等,旨在促进电解水制氢技术的进步,助力全球碳中和目标的实现,并为未来的研究提供参考与指导.

关键词：碳中和氢能电解水制氢催化剂电极材料

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Anlotinib-induced sick sinus syndrome:Two case reports

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World Journal of Clinical Cases 2025年第6期13卷 30-34页

作者： Cheng-Feng Fu Li-Fen Yang Lei Tian song Deng Qi Zhang Biao Yao Department of Oncology Tongren People’s HospitalTongren 554300Guizhou ProvinceChina Department of Oncology Guizhou Provincial People’s HospitalGuiyang 550000Guizhou ProvinceChina

BACKGROUND This manuscript describes the first known cases of sick sinus syndrome(SSS)associated with the use of anlotinib in non-small cell lung cancer patients,highlighting the need for increased vigilance and cardiac *** SUMMARY Two patients with non-small cell lung cancer developed SSS after 15 months and 5 months of anlotinib treatment,respectively,presenting with syncope and *** confirmed SSS,and different treatment approaches were taken for each *** patient received a dual-chamber permanent pacemaker,while the other discontinued the medication and experienced symptom *** Anlotinib can induce SSS,suggesting that cardiac monitoring is crucial during anlotinib *** management strategies are necessary for affected individuals.

关键词： Lung cancer Anlotinib Sick sinus syndrome Cardiac pacemaker Adverse drug reaction Case report

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Pulp health and calcific healing of a complicated crown–root fracture with additional root fracture in a maxillary incisor: A case report

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World Journal of Clinical Cases 2025年第3期13卷 42-49页

作者： Na Li Yue-Yue Ren Ying Tang Qi Yang Tian-Tian Meng song Li Jing Zhang Stomatological Hospital and College Anhui Medical UniversityHefei 230032Anhui ProvinceChina Department of Endodontics The Affiliated Stomatological Hospital of Xuzhou Medical UniversityXuzhou 221000Jiangsu ProvinceChina

BACKGROUND Complicated crown–root fracture (CRF) involves severe injury to the crown, root,and pulp, and may be accompanied by multiple root fractures. The loss of a toothhas lifelong consequences for children and teenagers, but the maintenance of pulphealth and the calcific healing of multiple root fractures are rarely reported in *** SUMMARY This case reports healing of a permanent tooth with complicated crown–root andadditional root fractures, in which pulp health was maintained. A 10-year-old girlfell and fractured the root of her maxillary left central incisor at the cervical *** the coronal fragment was repositioned, the tooth was splinted until thetooth was no longer mobile, 2 years later. Eight years after treatment, the toothhas remained asymptomatic with vital pulp and localized gingival ***-beam computed tomography revealed not only calcified healing of the CRFbut also spontaneous healing in an additional undiagnosed root fracture. Thefracture line on the enamel could not be healed by hard tissue and formed agroove in the cervical crown. It was speculated that the groove was related to thelocalized gingival *** This case provides a clinical perspective of the treatment of a tooth with acomplicated CRF and an additional root fracture.

关键词： Complicated crown-root fracture Multiple root fracture Spontaneous healing Cone-beam computed tomography Long-term follow-up Case report

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发展银发经济的战略设计、焦点难点及路径优化

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新疆师范大学学报（哲学社会科学版） 2025年第2期46卷 59-69,F0002页

作者：黄石松胡清中国人民大学国家发展与战略研究院北京100872 中国人民大学老年学研究所北京100872

我国正处于由中度老龄化社会步入重度老龄化社会的进程,银发经济将逐步从“以政府为主导的事业发展”阶段转向“事业和产业协同发展”的新阶段。准确把握这一转型发展特征,适时调整工作重心和节奏,注重运用市场机制推进产业发展迫在眉... 详细信息

我国正处于由中度老龄化社会步入重度老龄化社会的进程,银发经济将逐步从“以政府为主导的事业发展”阶段转向“事业和产业协同发展”的新阶段。准确把握这一转型发展特征,适时调整工作重心和节奏,注重运用市场机制推进产业发展迫在眉睫。对银发产业进行业态划分是制定产业组织政策、产业管理政策、产业发展政策的前提和基础,文本尝试将我国银发产业划分为基础性产业、延伸性产业和战略性产业,并据此分析三类产业在发展中存在的焦点难点问题,按照分类精准施策原则,提出优化我国银发经济发展路径的政策建议。

关键词：银发经济老龄产业老龄事业战略设计业态划分

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A novel flexible nerve guidance conduit promotes nerve regeneration while providing excellent mechanical properties

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Neural Regeneration Research 2025年第7期20卷 2084-2094页

作者： Tong Li Quhan Cheng Jingai Zhang Boxin Liu Yu Shi Haoxue Wang Lijie Huang Su Zhang Ruixin Zhang song Wang Guangxu Lu Peifu Tang Zhongyang Liu Kai Wang Department of Orthopedics the Fourth Medical Center of Chinese PLA General HospitalBeijingChina Department of Training and Sports Medicine Characteristic Medical Center of Chinese People’s Armed Police ForceTianjinChina Medical School of Chinese PLA BeijingChina Key Laboratory of Bioactive Materials for the Ministry of Education College of Life SciencesNankai UniversityTianjinChina Department of Orthopedics Tianjin HospitalTianjinChina Department of Rehabilitation Medicine Er Quan Hospital of PAPWuxiJiangsu ProvinceChina

Autografting is the gold standard for surgical repair of nerve defects>5 mm in length;however,autografting is associated with potential complications at the nerve donor *** an alternative,nerve guidance conduits may be *** ideal conduit should be flexible,resistant to kinks and lumen collapse,and provide physical cues to guide nerve *** designed a novel flexible conduit using electrospinning technology to create fibers on the innermost surface of the nerve guidance conduit and employed melt spinning to align ***,we prepared disordered electrospun fibers outside the aligned fibers and helical melt-spun fibers on the outer wall of the electrospun fiber *** presence of aligned fibers on the inner surface can promote the extension of nerve cells along the *** helical melt-spun fibers on the outer surface can enhance resistance to kinking and compression and provide *** novel conduit promoted nerve regeneration and functional recovery in a rat sciatic nerve defect model,suggesting that it has potential for clinical use in human nerve injuries.

关键词： aligned fibers anti-kinking helical fibers nerve guidance conduit nerve regeneration peripheral nerve injury topological guidance

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Profile of Weibo song

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Science China(Life Sciences) 2016年第9期59卷 906-908页

作者： song Weibo

*** song received his *** in the Zoological Institute,Bonn University,Germany,in January *** then joined the College of Fisheries,Ocean University of China（OUC）,and was qualified as a lecturer,associate professor an... 详细信息

关键词：新浪中国海洋大学动物研究所波恩大学博士生实验室

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AAV-mediated expression of p65shRNA and bone morphogenetic protein 4 synergistically enhances chondrocyte regeneration

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中国组织工程研究 2025年第17期29卷 3537-3547页

作者： Yu Yangyi song Zhuoyue Lian Qiang Ding Kang Li Guangheng Shenzhen Key Laboratory of Musculoskeletal Tissue Reconstruction and Function Restoration Division of Adult Joint Reconstruction and Sports MedicineDepartment of Orthopedic SurgeryShenzhen People’s Hospital(The Second Clinical Medical College Jinan UniversityThe First Affiliated HospitalSouthern University of Science and Technology)Shenzhen 518020Guangdong ProvinceChina Department of Orthopedics Zhengzhou Orthopedics HospitalZhengzhou 450000Henan ProvinceChina Department of Orthopedics Shenzhen Pingle Orthopedics HospitalShenzhen 518000Guangdong ProvinceChina

BACKGROUND:Adeno-associated virus(AAV)gene therapy has been proven to be reliable and safe for the treatment of osteoarthritis in recent ***,given the complexity of osteoarthritis pathogenesis,single gene manipulation for the treatment of osteoarthritis may not produce satisfactory *** studies have shown that nuclear factorκB could promote the inflammatory pathway in osteoarthritic chondrocytes,and bone morphogenetic protein 4(BMP4)could promote cartilage ***:To test whether combined application of AAV-p65shRNA and AAV-BMP4 will yield the synergistic effect on chondrocytes regeneration and osteoarthritis ***:Viral particles containing AAV-p65-shRNA and AAV-BMP4 were *** efficacy in inhibiting inflammation in chondrocytes and promoting chondrogenesis was assessed in vitro and in vivo by transfecting AAV-p65-shRNA or AAV-BMP4 into *** experiments were divided into five groups:PBS group;osteoarthritis group;AAV-BMP4 group;AAV-p65shRNA group;and BMP4-p65shRNA 1:1 *** were collected at 4,12,and 24 weeks *** staining,including safranin O and Alcian blue,was applied after collecting articular ***,the optimal ratio between the two types of transfected viral particles was further investigated to improve the chondrogenic potential of mixed cells in *** AND CONCLUSION:The combined application of AAV-p65shRNA and AAV-BMP4 together showed a synergistic effect on cartilage regeneration and osteoarthritis *** cells transfected with AAV-p65shRNA and AAV-BMP4 at a 1:1 ratio produced the most extracellular matrix synthesis(P<0.05).In vivo results also revealed that the combination of the two viruses had the highest regenerative potential for osteoarthritic cartilage(P<0.05).In the present study,we also discovered that the combined therapy had the maximum effect when the two viruses were administered in equal *** either p65shRNA or BMP4

关键词： osteoarthritis adeno-associated virus bone morphogenetic protein 4 p65-short hairpin RNA gene therapy short hairpin RNA transforming growth factor-β1 extracellular matrix articular cartilage chondrocytes.

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马铃薯转录因子StFBH3对非生物逆境胁迫的响应分析

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作物学报 2025年第1期51卷 247-259页

作者：宋倩娜宋慧洋李京昊段永红梅超冯瑞云山西农业大学农学院山西太谷030801 山西省农业科学院作物科学研究所山西太原030031

bHLH (basic helix-loop-helix)作为植物界第二大类转录因子,在植物应对环境胁迫响应中起着重要的调控作用。探究马铃薯(Solanum tuberosum L.) bHLH家族基因功能将为马铃薯改良和育种提供一定的理论依据。本研究克隆了马铃薯StFBH3基因... 详细信息

bHLH (basic helix-loop-helix)作为植物界第二大类转录因子,在植物应对环境胁迫响应中起着重要的调控作用。探究马铃薯(Solanum tuberosum L.) bHLH家族基因功能将为马铃薯改良和育种提供一定的理论依据。本研究克隆了马铃薯StFBH3基因(Gene ID:102582309),利用qPCR技术分析了不同逆境胁迫下StFBH3基因表达模式,结果表明, StFBH3基因在马铃薯根和叶中的表达量较高,且该基因的表达受渗透、高盐和脱落酸(abscisic acid, ABA)诱导;以过表达StFBH3基因的马铃薯试管苗为材料,在分别含有不同浓度甘露醇(mannitol)、NaCl和ABA的MS培养基中,过表达StFBH3马铃薯株系的叶绿素含量显著高于野生型,根长显著长于野生型。在干旱和高盐处理下,土壤栽培的过表达马铃薯株系较野生型表现较强的耐受性,叶片相对含水量、叶绿素含量和过氧化物歧化酶(SOD)活性显著高于野生型。qPCR分析发现,干旱和盐胁迫处理下相关基因(KAT1)的表达量在过表达马铃薯株系中较野生型显著降低。以上结果表明, StFBH3基因可能在马铃薯对渗透、干旱和高盐等胁迫响应中起正向调控作用。本研究也为StFBH3基因在马铃薯中的生物学功能深入理解提供一定的参考依据。

关键词：马铃薯 StFBH3 转录因子逆境胁迫

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A cellulose-based lithium-ion battery separator with regulated ionic transport and high thermal stability for extreme environments

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Nano Research 2025年第1期18卷 315-322页

作者： Kun-Peng Yang song Xie Zi-Meng Han Hao-Cheng Liu Chong-Han Yin Wen-Bin Sun Zhang-Chi Ling Huai-Bin Yang De-Han Li Qing-Fang Guan Shu-Hong Yu Department of Chemistry New Cornerstone Science LaboratoryInstitute of Biomimetic Materials&ChemistryAnhui Engineering Laboratory of Biomimetic MaterialsDivision of Nanomaterials&ChemistryHefei National Research Center for Physical Sciences at the MicroscaleUniversity of Science and Technology of ChinaHefei 230026China Institute of Innovative Materials Department of Materials Science and EngineeringDepartment of ChemistrySouthern University of Science and TechnologyShenzhen 518055China

Separators play a critical role in lithium-ion ***,the restrictions of thermal stability and inferior electrical performance in commercial polyolefin separators significantly limit their applications under harsh ***,we report a cellulose-assisted self-assembly strategy to construct a cellulose-based separator massively and *** an ultrahigh ionic conductivity in electrolytes of 3.7 mS·cm^(-1) and the ability to regulate ion transport,the obtained separator is a promising alternative for high-performance lithium-ion *** addition,integrated with high thermal stability,the cellulose-based separator endows batteries with high safety at high temperatures,greatly expanding the application scenarios of energy storage devices in extreme environments.

关键词： lithium-ion batteries bio-inspired materials battery separators cellulose nanofiber ultrahigh ionic conductivity high safety

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