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Wound healing effect of methanolic leaf extract of Napoleona vogelii(Family:Lecythidaceae) in rats

Asian Pacific Journal of Tropical Medicine 2014年第8期7卷 620-624页

作者： adiele LC adiele rc Enye JC Department of Pharmacology and Toxicology Faculty of PharmacyMadonna UniversityEleleRiver StateNigeria Department of Pharmacy Federal Medical CenterOwerriImo StateNigeria Department of Anatomy and Cell Biology Division of Biomedical SciencesCollege of MedicineUniversity of SaskatchewanSaskatoonSKS7N 5E5Canada Cameco MS Neuroscience Research Center Saskatoon City HospitalSaskatoonSKS7K 0M7Canada

Objective:To investigate the wound healing properly of Napoleona vogelii leaf extract in folkloric ***:Roth sexes of adult albino rats(n=25) were used in this study and another group(n=30) were subjected to acute toxicity test(LD_(50)) of the plant *** the LD_(50),three randomized groups of 5 rats were first treated with 10,100,1 000 mg/kg body weight(bw),*** w as followed by a second treatment of 1500,3000,and 5 000 mg/kg bw of the leaf extract with continual monitoring of the animals for mortality or *** wounds(1.3cm) were created on the skin of five groups of 5 rals using surgical blade under *** first group was topically treated with petroleum jelly alone,group 2 was topically applied 400 mg/mL w/v of the reference drug,Neobaein,while group 3-5 were topically treated with 5-50 mg/mL w/v of the plant extract,***:The percentage yield of the extract was 49.80%w/w dry *** phytochemical analysis revealed several bioactive constituents including glycosides,tannins,alkaloids,***,steroids,proteins,and *** LD_(50) was beyond our experimental limit and was not *** concentrations(5,20,and 50mg/mL w/v) of the extract had significant(ANOVA,P<0.05) healing effect on the incision wounds giving rise to 125%-140% while treatmentawith Neobacin resulted in 150% healing effect on the third treatment regimen compared to the control(100%).Conclusions:These data indicate that Napoleona vogelii leaf extract contains potent bioactive compounds containing wound healing activity,substantiating its use as a wound healer in folkloric medicine.

关键词： Wound healing Napoleona vogelii Petroleum jelly Neobacin Folkloric medicine

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Anthelmintic activity of Securidaca longepedunculata(Family:Polygalaceae)root extract in mice,in vitro and in vivo

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Asian Pacific Journal of Tropical Medicine 2013年第11期6卷 841-846页

作者： adiele rc Fakae BB Isuzu IU Department of Anatomy and Cell Biology.Division of Biomedical Sciences College of MedicineUniversity of SaskatchewanSaskatoon.SK.S7N5E Cameco MS Neuroscience Research Center Saskatoon City HospitalSaskatoonSKS7K OM7 Department of Veterinary Parasitology and Entomology Faculty of Veterinary MedicineUniversity of NigeriaNsukka Vice Chancellor's Office River State university of Science and TechnologyPort Harcourt Department of Veterinary Physiology and Pharmacology Faculty of Veterinary MedicineUniversity of NigeriaNsukka Deputy Vice Chancellor's Office.University of Nigeria Nsukka

Objective:To elucidate the pharmacological bases of oral administration of Securidaca longepedunculata(***) root extract as an anthelmintic in folkloric medicine. Methods:Albino mice were infected with infective third(L3) larval stage of Heligmosomoides polygyrus(***) by esophageal *** establishment of the adult worms in the intestine,the mice were treated with 0-2 000 mg/kg body weight(bw) of methanolic root extract of *** and 100 mg/kg bw of pyrantel embonate,the reference drug in vivo. Bioactivity and larvicidal effects of the extract were tested by exposing brine shrimps(Artemia salina) to 0.00-1.00 mg/mL and the L3 stage of Heligmosomoides contortus(***) and *** to 0.00-2.50 mg/mL of the extract in ***:The percentage yield of the extract was 7.13%w/w dry *** brine shrimps toxicity bioassay resulted in an LC_(50) of 74.18 μ g/*** extract had a significant,dose-dependent larvicidal effect on the L3 stage of *** and *** with the terminal effect of 75%and 70%at the highest exposure concentrations,*** extract however,did not affect the number of worm eggs per gram(epg) of fecal materials(P<0.05) and total worm burden(twb) of adult *** in infected *** with pyrantel embonate significant reduced both the fecal egg count and twb to 0 compared to the untreated control(P<0.05).Conclusions:These results indicate that *** root extract contains potent bioactive compounds and has larvicidal effect on L3 stage of *** and ***,substantiating its use as anthelmintic in alternative medicine.

关键词： Anthelmintic Securidaca longepedunculata Haemonchus contortus Heligmosomoides polygyrus Brine shrimps Larvicidal Fecal egg count

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