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Understanding the impact of HIV on mpox transmission in the MSM population: A mathematical modeling study

Infectious Disease Modelling 2024年第4期9卷 1117-1137页

作者： Andrew Omame Qing Han Sarafa A.Iyaniwura adeniyi Ebenezer Nicola L.Bragazzi Xiaoying Wang Jude D.Kong Woldegebriel A.Woldegerima Abdus Salam School of Mathematical Sciences Government College UniversityLahorePakistan Laboratory for Industrial and Applied Mathematics(LIAM) Department of Mathematics and StatisticsYork UniversityTorontoOntarioCanada Africa-Canada Artificial Intelligence and Data Innovation Consortium(ACADIC) Canada Theoretical Biology and Biophysics Theoretical DivisionLos Alamos National LaboratoryLos AlamosNM87545USA Postgraduate School of Public Health Department of Health Sciences(DISSAL)University of Genoa16126GenoaItaly United Nations Educational Scientific and Cultural Organization(UNESCO)Health Anthropology Biosphere and Healing SystemsUniversity of Genoa16126GenoaItaly Department of Food and Drugs University of Parma43125ParmaItaly Department of Mathematics Trent University PeterboroughOntarioCanada Artificial Intelligence&Mathematical Modeling Lab(AIMM Lab) Dalla Lana School of Public HealthUniversity of Toronto155 College St Room 500TorontoONM5T 3M7Canada Department of Mathematics University of TorontoOntarioCanada Global South Artificial Intelligence for Pandemic and Epidemic Preparedness and Response Network(AI4PEP) Canada Department of Mathematics Federal University of TechnologyOwerriNigeria

The recent mpox outbreak(in 2022e2023)has different clinical and epidemiological features compared with previous outbreaks of the *** this outbreak,sexual contact was believed to be the primary transmission route of the *** addition,the community of men having sex with men(MSM)was disproportionately affected by the *** population is also disproportionately affected by HIV *** that both diseases can be transmitted sexually,the endemicity of HIV,and the high sexual behavior associated with the MSM community,it is essential to understand the effect of the two diseases spreading simultaneously in an MSM ***,we aim to understand the potential effects of HIV on an mpox outbreak in the MSM *** develop a mechanistic mathematical model of HIV and mpox *** model incorporates the dynamics of both diseases and considers HIV treatment with antiretroviral therapy(ART).In addition,we consider a potential scenario where HIV infection increases susceptibility to mpox,and investigate the potential impact of this mechanism on mpox *** analysis shows that HIV can facilitate the spread of mpox in an MSM population,and that HIV treatment with ART may not be sufficient to control the spread of mpox in the ***,we showed that a moderate use of condoms or reduction in sexual contact in the population combined with ART is beneficial in controlling mpox *** on our analysis,it is evident that effective control of HIV,specifically through substantial ART use,moderate condom compliance,and reduction in sexual contact,is imperative for curtailing the transmission of mpox in an MSM population and mitigating the compounding impact of these intertwined epidemics.

关键词： HIV-mpox co-infection Infectious disease modeling Invasion reproduction number Control reproduction number sensitivity analysis MSM

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In-vitro antioxidant and anti-inflammatory activities of ethanol stem-bark extract of Blighia sapida ***

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Journal of Pharmaceutical Analysis 2022年第2期12卷 350-354页

作者： Mukaila B.Adekola Jacob O.Areola Oladapo F.Fagbohun Funke T.Asaolu Gbenga E.Ogundepo adeniyi O.Fajobi Olubunmi O.Babalola Department of Environmental Management and Toxicology Federal University of AgricultureAbeokuta110001Nigeria Department of Medical Biochemistry Obafemi Awolowo UniversityIle-Ife230001Nigeria Department of Biomedical Engineering First Technical University IbadanOyo StateIbadan200001Nigeria Department of Biochemistry and Molecular Biology Obafemi Awolowo UniversityIle-Ife230001Nigeria

Blighia sapida(***)***(Family Sapindaceae)is a branchless straight bole approximately 15 m in *** study evaluated the antioxidant and anti-inflammatory activities of ethanol extract and fractions of *** stem-bark using in vitro *** extract and its fractions were investigated for 1,1-diphenyl-2-picrylhydrazyl(DPPH)radical scavenging activity,ferric reducing antioxidant power(FRAP),total antioxidant capacity(TAC),and quantitative phenolic and flavonoid ***-inflammatory activity was evaluated using albumin denaturation and membrane stabilization *** extract and its fractions exhibited radical scavenging and anti-inflammatory *** ethyl acetate fraction possessed maximum phenolic and flavonoid contents(136.67±1.55 gallic acid equivalent mg/g and 75.76±4.03 quercetin equivalent mg/g,respectively).Antioxidant studies revealed that the ethyl acetate fraction displayed superior activity with an IC_(50)=0.09±0.03 mg/mL DPPH,and values of 146.96±3.81 ascorbic acid equivalent(AAE)mg/g and 359.20±4.98 AAE mg/g for FRAP and TAC,***,the anti-inflammatory activity was revealed by inhibition of heatinduced albumin denaturation and red blood cell membrane stabilization at concentrations of 200 -1000 mg/mL and 50-250 mg/mL,*** ethanol extract and fractions exhibited antioxidant and anti-inflammatory activities,with ethyl acetate fraction showing superior activity,which could be attributed to secondary metabolites,mainly phenolic ***,the antioxidant and antiinflammatory activities of *** can be exploited by ethnomedicinal users.

关键词： Blighia sapida Extract Anti-inflammatory Antioxidant Radical scavenging

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Assessment of Child Labour Practices among Market Women and Food Sellers in Ife Central Local Government Area of Osun State,Nigeria

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Psychology Research 2021年第4期11卷 185-190页

作者： Babatunde adeniyi Adeyemi Adeyemi Ayobami Ebo Ibukun Diadem Adeyemi Obafemi Awolowo University Ile-IfeNigeria Lead City University IbadanNigeria

The study examined the forms of child labour practices common among market women and food sellers in Ife Central local government area of Osun *** also determined the awareness level of market women and food sellers on the existing child labour law in Nigeria and finally examined factors contributing to child labour practices among market women and food *** study employed the descriptive research of the survey *** study population consisted of market women and food sellers in Ife Central local government in Osun *** sample consisted of 170 market women and 80 food sellers in conveniently selected five markets in the study *** researchers developed three research instruments for this study,namely:Knowledge of Child Labour Questionnaire(KCLQ),Forms of Child Labour Practices Questionnaire(FCLPQ),and Factors Contributing to Child Labour Questionnaire(FCCLQ).The three instruments were validated by the investigators,using Cronbach alpha which yielded 0.79,0.77,and 0.78 values for KCLQ,FCLPQ,and FCCLQ *** collected were analyzed by using simple percentage and Relative Importance *** results among others showed that domesticlabour ranked the first significantly influential forms of child labour practiced among market women and food sellers in Ife Central local government,Osun State with RII analysis of 0.810 and 0.850 *** study therefore concluded that majority of the respondents have low awareness level on the existing child labour law hence government should intensify the creation of awareness of the child labour law among market women and food sellers in Ife Central local government,Osun State.

关键词： assessment child labour practices market women food sellers

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Quantitation of Pesticide Residue in Water and Food in Louisiana, USA

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Journal of Water Resource and Protection 2016年第12期8卷 1145-1157页

作者： Olubode adeniyi Amy Hernandez Mark LeBlanc Joan King Marlene Janes School of Nutrition and Food Science AgCenter Louisiana State University Baton Rouge USA Agricultural Chemistry Department AgCenter Louisiana State University Baton Rouge USA Agricultural Chemistry Division Louisiana State Department of Agriculture and Forestry Baton Rouge USA

Pesticides can remain in the environment for decades and contaminate surface water that is used for irrigation of produce. This study examined pesticide residues in some surface waters and foods in Louisiana. Samples of 8 foods (tomato, corn, rice, blueberry, cucumber, cabbage, wheat and melon) and 35 surface waters were studied using a QuEChERS extraction method for food samples and liquid-liquid extraction method for the water samples. Gas chromatography-mass spectrometry was used to analyze water and food samples. Nine pesticides were detected in the surface water samples and 5 in the food samples. Pesticides detected in foods were below FDA tolerance limit but 0.18 ppm cypermethrin found in tomato was within 90% of the FDA limit (0.2 ppm). Four water samples had atrazine levels that were above the FDA limit for potable water. This study suggests the need to intermittently monitor pesticide contamination in our food and water.

关键词： Gas Chromatography Mass Spectrometry QuEChERS Cypermethrin Atrazine Pesticide FDA

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Morphological characterization of indigenous and crossbred pigs in rural and peri-urban areas of southwestern Nigeria

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Open Journal of Animal Sciences 2013年第3期3卷 230-235页

作者： adeniyi Charles Adeola Saidu O. Oseni Ofelia Galma Omitogun Department of Animal Sciences Obafemi Awolowo University Ile-Ife Nigeria

We sought to determine morphological descriptors of Nigerian indigenous pigs (NIP) and crossbred pigs (CBP) based on relationships among live weight (LW) and a suite of 18 morphometric measurements plus the number of teats. We sampled four locations in southwestern Nigeria and obtained data for a total of 120 NIP and CBP. More female pigs (61.7%) than males (38.3%) were sampled, and they had a mean live weight of 19.9 ± 6.10 kg (range 9 - 32 kg) and 20.1 ± 6.08 kg (range 8 - 37 kg), respectively. The NIP had a longer snout, wider head and longer erect ears than CBP (P 2) of 0.97, 0.92, 0.96, 0.97, 0.91, 0.97, 0.97, 0.90, and 0.93, respectively (all P 2 = 0.93;P 2 = 0.96;P 2 = 0.84;P 2 = 0.94;

关键词： Nigerian Indigenous Pigs Live Weight Morphological Descriptors Relationship

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Expanded Scope of Bacillus Calmette-Guerin(BCG)Vaccine Applicability in Disease Prophylaxis,Diagnostics,and Immunotherapeutics

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Infectious Microbes & Diseases 2020年第4期2卷 144-150页

作者： Oluwafolajimi A.Adesanya Christabel I.Uche-Orji Yeshua A.Adedeji John I.Joshua adeniyi A.Adesola Chibuike J.Chukwudike Institute for Advanced Medical Research and Training(IAMRAT) College of MedicineUniversity of IbadanIbadanNigeria Department of Medicine College of MedicineUniversity of IbadanIbadanNigeria.

Following the discovery of the Bacillus Calmette-Guerin(BCG)vaccine,its efficacy against Mycobacterium tuberculosis was soon established,with several countries adopting universal BCG vaccination schemes for their ***,however,studies aimed to further establish the efficacy of the vaccine in different populations discovered that the vaccine has a larger effect in reducing mortality rate than could be explained by its effect on tuberculosis alone,which sparked suggestions that the BCG vaccine could have effects on other unrelated or non-mycobacterial pathogens causing diseases in *** effects were termed heterologous,non-specific or off-target effects and have been shown to be due to both innate and adaptive immune system *** carried out in a bid to further understand these effects led to many more discoveries about the applicability of the BCG vaccine for the prevention,diagnosis,and treatment of certain disease *** we approach the second century since the discovery of the vaccine,we believe it is timely to review these interesting applications of the BCG vaccine,such as in the prevention of diabetes,atherosclerosis,and leukemia;the diagnosis of Kawasaki disease;and the treatment of multiple sclerosis,non-muscle invading bladder cancer,and stage III ***,complications associated with the administration of the BCG vaccine to certain groups of patients,including those with severe combined immunodeficiency and HIV,have been well described in literature,and we conclude by describing the mechanisms behind these complications and discuss their implications on vaccination strategies,especially in low-resource settings.

关键词： BCG autoimmunity immunotherapeutics complications non-specific effects

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Caesarean section at a tertiary institution in Southwestern Nigeria—A 6-year audit

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Open Journal of Obstetrics and Gynecology 2013年第3期3卷 357-361页

作者： Daniel Adebode Adekanle Adewale Samson Adeyemi adeniyi Olanipekun Fasanu Department of Obstetrics & Gynaecology Faculty of Clinical Sciences College of Health Sciences Ladoke Akintola University of Technology Osogbo Nigeria

Introduction: Caesarean section is one of the commonest surgical procedures worldwide. Its upward trend and associated morbidity/mortality especially in low-resource setting makes regular appraisal of the practice necessary. Methodology: A retrospective study. Labour ward logbook and case records were looked into, and all information extracted. Results: Caesarean section rate was 35.5%, with an upward trend. Perinatal death was still high. Main indication was previous caesarean section followed by obstructed labour while major maternal morbidity was wound sepsis. Identifiable factors to perinatal death were multiparity, emergency caesarean section and women that were referred to our health facility. Conclusion: Risk appraisal and all efforts must be geared towards reducing caesarean section rate especially in our environment where subsequent deliveries might not be attended to by skilled health personnel.

关键词： Caesarean Section Trends Morbidity Mortality and Perinatal Outcome

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High Fat Diet Alteration of Gut Microbiota Impacts Learning, Memory and Anxiety Response in Mice: Cannabidiol and Omega 3 Possible Remedies

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Advances in Alzheimer's Disease 2022年第1期11卷 1-9页

作者： Innocent Abi Moses Ashiekaa Eugenia Abi Olasupo Stephen adeniyi Linus Chia Saalu Department of Physiology College of Health Sciences Benue State University Makurdi Nigeria Department of Biochemistry Faculty of Science University of Agriculture Makurdi Nigeria Department of Human Anatomy College of Health Sciences Benue State University Makurdi Nigeria

Chronic intake of High Fat Diet (HFD) has the potential of causing a number of metabolic disorders. It is also theorized to be involved in perturbation of gut microbiota. Cannabididol (CBD) and omega 3 are known to possess a number of medicinal usefulness. Their combined use in experimental interventions is quite limited. A total of 15 mice were used for this research divided into three groups of five animals each. Group 1 was administered water and normal chow ad libidum. Group 2 had HFD and water ad libidum. Group 3 had HFD plus CBD (10 mg/kg) and omega 3 (200 mg/kg) all for a total of 12 weeks. They were tested on the elevated plus maze (EPM) and average entry time into the closed arm was recorded. They were also tested on the Y-maze and spontaneous alternations were measured. Thereafter animals were sacrificed and faecal content in the caecum was collected in sterile bottles and cultured for E. coli count. It was found that HFD group at p value E. coli count (2.4 × 106 ± 4.5) compared to group 1 (1.4 × 106 ± 5.6) and group 3 (1.42 × 106 ± 6.3). The findings revealed that HFD enhanced gut E. coli overgrowth which was reduced by CBD and Omega 3. The memory impairment and anxiety induction by HFD was also significantly ameliorated by CBD and omega 3. E. coli known to be implicated in dementia induction was suppressed by the interventions. Possible mechanisms proposed are actions of CBD and omega 3 on CB1, TRVP and 5HT receptors in reducing anxiety and their antioxidant/anti-inflammatory actions in mitigating the neuro-inflammatory effect of HFD and immune hyperstimulation of E. coli via the gutbrain-axis.

关键词： HFD Learning Memory CBD Omega 3 Anxiety EPM

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OrthReg:a tool to predict cis-regulatory elements based on cross-species orthologous sequence conservation

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Zoological Research 2020年第4期41卷 471-475页

作者： Yun-Fei Ma Cui-Ping Huang Fang-Ru Lu Jin-Xiu Li Xu-Man Han adeniyi CAdeola Yun Gao Jia-Kun Deng Hai-Bing Xie Ya-Ping Zhang State Key Laboratory of Genetic Resources and Evolution Kunming Institute of ZoologyChinese Academy of SciencesKunmingYunnan 650223China Kunming College of Life Science University of Chinese Academy of SciencesKunmingYunnan 650204China University of Chinese Academy of Sciences Beijing100049China Center for Excellence in Animal Evolution and Genetics Chinese Academy of SciencesKunmingYunnan 650223China State Key Laboratory for Conservation and Utilization of Bio-Resource in Yunnan Yunnan UniversityKunmingYunnan 650091China Key Laboratory for Animal Genetic Diversity and Evolution of High Education in Yunnan Province School of Life SciencesYunnan UniversityKunmingYunnan 650091China

DEAR EDITOR,Cis-regulatory elements play an important role in the development of traits and disease in organisms(Ma et al.,2020;Woolfe et al., 2005) and their annotation could facilitate genetic studies. The Encyclopedia of DNA Elements(ENCODE)(Davis et al., 2018) and Functional Annotation of Animal Genomes(FAANG)(FAANG Consortium et al., 2015)offer pioneering data on regulatory elements in several species. Currently, however, regulatory element annotation data remain limited for most organisms.

关键词： species. traits regulatory

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Yohimbine in the treatment of orgasmic dysfunction

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Asian Journal of Andrology 2007年第3期9卷 403-407页

作者： Ade A. adeniyi Giles S. Brindley John P. Pryor David J. Ralph Institute of Urology and Nephrology London W1P 7EY UK I02 Ferdene Road London SE24 OAA UK

Aim： To study the effect of yohimbine in the treatment of men with orgasmic dysfunction. Methods： A 20-mg dose of yohimbine was first given to 29 men with orgasmic dysfunction of different aetiology in the clinic. Patients were then allowed to increase the dose at home （titration） under more favourable circumstances. The outcome and side effects were subsequently assessed. Results： The patients were classified into three groups of orgasmic dysfunction： primary complete （13）, primary incomplete （8） and secondary （8）. Nocturnal emissions were present in 75%, 40% and 50% of patients in the above groups, respectively （overall average 62%）. The men presented because of fertility problems （52%） or because they wanted to experience the pleasure of orgasm （48%）. Of the 29 patients who completed the treatment, 16 managed to reach orgasm and were able to ejaculate either during masturbation or sexual intercourse. A further three achieved orgasm, but only with the additional stimulation of a vibrator. A history of preceding nocturnal emissions was present in 69% of the men in whom orgasm was induced but only 50% who failed treatment. Of the patients, two have subsequently fathered children （one set of twins） and another 3 men were also cured. Side effects were not sufficient to cause the men to cease treatment. Conclusion： Yohimbine is a useful treatment option in orgasmic dysfunction.

关键词： Yohimbine anorgasmia orgasm orgasmic dysfunction impotence ejaculation

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