In-vitro antioxidant and anti-inflammatory activities of ethanol stem-bark extract of Blighia sapida ***

作     者：Mukaila B.Adekola Jacob O.Areola Oladapo F.Fagbohun Funke T.Asaolu Gbenga E.Ogundepo Adeniyi O.Fajobi Olubunmi O.Babalola Mukaila B.Adekola;Jacob O.Areola;Oladapo F.Fagbohun;Funke T.Asaolu;Gbenga E.Ogundepo;Adeniyi O.Fajobi;Olubunmi O.Babalola

作者机构：Department of Environmental Management and ToxicologyFederal University of AgricultureAbeokuta110001Nigeria Department of Medical BiochemistryObafemi Awolowo UniversityIle-Ife230001Nigeria Department of Biomedical EngineeringFirst Technical University IbadanOyo StateIbadan200001Nigeria Department of Biochemistry and Molecular BiologyObafemi Awolowo UniversityIle-Ife230001Nigeria 

出 版 物：《Journal of Pharmaceutical Analysis》 (药物分析学报（英文版）)

年 卷 期：2022年第12卷第2期

页      面：350-354页

核心收录：

学科分类：1007[医学-药学(可授医学、理学学位)] 10[医学] 

基　　金：Obafemi Awolowo University 

主　　题：Blighia sapida Extract Anti-inflammatory Antioxidant Radical scavenging 

摘      要：Blighia sapida(***)***(Family Sapindaceae)is a branchless straight bole approximately 15 m in *** study evaluated the antioxidant and anti-inflammatory activities of ethanol extract and fractions of *** stem-bark using in vitro *** extract and its fractions were investigated for 1,1-diphenyl-2-picrylhydrazyl(DPPH)radical scavenging activity,ferric reducing antioxidant power(FRAP),total antioxidant capacity(TAC),and quantitative phenolic and flavonoid ***-inflammatory activity was evaluated using albumin denaturation and membrane stabilization *** extract and its fractions exhibited radical scavenging and anti-inflammatory *** ethyl acetate fraction possessed maximum phenolic and flavonoid contents(136.67±1.55 gallic acid equivalent mg/g and 75.76±4.03 quercetin equivalent mg/g,respectively).Antioxidant studies revealed that the ethyl acetate fraction displayed superior activity with an IC_(50)=0.09±0.03 mg/mL DPPH,and values of 146.96±3.81 ascorbic acid equivalent(AAE)mg/g and 359.20±4.98 AAE mg/g for FRAP and TAC,***,the anti-inflammatory activity was revealed by inhibition of heatinduced albumin denaturation and red blood cell membrane stabilization at concentrations of 200 -1000 mg/mL and 50-250 mg/mL,*** ethanol extract and fractions exhibited antioxidant and anti-inflammatory activities,with ethyl acetate fraction showing superior activity,which could be attributed to secondary metabolites,mainly phenolic ***,the antioxidant and antiinflammatory activities of *** can be exploited by ethnomedicinal users.