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Acta Pharmaceutica Sinica B 2024年第1期14卷 421-432页

作者： Dexiu Yan Jemma Arakelyan Teng Wan Ritvik Raina Tsz Ki Chan Dohyun Ahn Vladimir Kushnarev Tsz Kiu Cheung ho Ching Chan Inseo choi Pui Yi ho Feijun Hu Yujeong Kim Hill Lam Lau Ying Lo Law Chi Seng Leung Chun Yin Tong Kai Kap Wong Wing Lam Yim Nikolay S.Karnaukhov Richard Y.C.Kong Maria V.Babak Yudai Matsuda Department of Chemistry City University of Hong KongHong Kong SARChina iGEM Team“VarieCure” City University of Hong KongHong Kong SARChina Department of Biomedical Engineering City University of Hong KongHong Kong SARChina Moscow Clinical Research Center Named After A.S.Loginov Moscow 111123Russian Federation

A biosynthetic gene cluster for the bioactive fungal sesterterpenoids variecolin(1)and variecolactone(2)was identified in Aspergillus aculeatus ATCC *** production of 1 and 2 was achieved in Aspergillus oryzae by expressing the sesterterpene synthase VrcA and the cytochrome P450 ***,the replacement of VrcB with homologous P450s from other fungal terpenoid pathways yielded three new variecolin analogues(5-7).Analysis of the compounds’anticancer activity in vitro and in vivo revealed that although 5 and 1 had comparable activities,5 was associated with significantly reduced toxic side effects in cancer-bearing mice,indicating its potentially broader therapeutic *** study describes the first tests of variecolin and its analogues in animals and demonstrates the utility of synthetic biology for creating molecules with improved biological activities.

关键词： Animal studies Anticancer properties Biosynthesis Natural products Sesterterpenoids Synthetic biology Terpene synthases Variecolin

Unveiling the role of Ni in Ru-Ni oxide for oxygen evolution: Lattice oxygen participation enhanced by structural distortion

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Journal of Energy Chemistry 2023年第2期77卷 54-61,I0003页

作者： Young-Jin Ko man ho Han Chulwan Lim Seung-ho Yu Chang Hyuck choi Byoung Koun Min Jae-Young choi Woong Hee Lee Hyung-Suk Oh Clean Energy Research Center Korea Institute of Science and Technology(KIST)Hwarang-ro 14-gil 5Seongbuk-guSeoul 02792Republic of Korea Department of Chemical and Biological Engineering Korea University145Anam-roSeongbuk-guSeoul 02841Republic of Korea Department of Chemistry Pohang University of Science and Technology(POSTECH)Pohang 37673Republic of Korea National Agenda Research Division Korea Institute of Science and Technology(KIST)Hwarang-ro 14-gil 5Seonbuk-guSeoul 02792Republic of Korea Graduate School of Energy and Environment(KU-KIST Green School) Korea University145 Anam-roSeongbuk-guSeoul 02841Republic of Korea School of Advanced Materials Science&Engineering Sungkyunkwan University(SKKU)Suwon 16419Republic of Korea KIST-SKKU Carbon-Neutral Research Center Sungkyunkwan University(SKKU)Suwon 16419Republic of Korea

Introducing Ni in Ru oxide is a promising approach to enhance the catalytic activity for the oxygen evolution reaction(OER).however,the role of Ni(which has a poor intrinsic activity)is not fully ***,a Ru NiO_(x)electrode fabricated via a modified dip coating method exhibited excellent OER performance in acidic media,and neutral media for CO_(2)reduction *** combined in-situ/operando X-ray absorption near-edge structure and on-line inductively coupled plasma mass spectrometry studies to unveil the role of the Ni introduced in the Ru *** propose that the Ni not only transforms the electronic structure of the Ru oxide,but also produces a large number of oxygen vacancies by distorting the oxygen lattice structure at low overpotentials,increasing the participation of lattice oxygen for *** work demonstrates the real behavior of bimetallic oxide materials under applied potentials and provides new insights into the development of efficient electrocatalysts.

关键词： Oxygen evolution reaction Ru electrode Ni electrode Oxygen vacancies In-situ/Operando studies

Effects of prostaglandin F_(2α) on small intestinal interstitial cells of Cajal

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World Journal of Gastroenterology 2011年第9期17卷 1143-1151页

作者： Chan Guk Park Young Dae Kim man Yoo Kim Jae Woong Koh Jae Yeoul Jun Cheol ho Yeum Insuk So Seok choi Department of Internal Medicine College of MedicineChosun University Department of Ophthalmology College of MedicineChosun University Department of Physiology College of MedicineChosun University Department of Physiology and Biophysics College of MedicineSeoul National University

AIM：To explore the role of prostaglandin F2α（PGF2α） on pacemaker activity in interstitial cells of Cajal（ICC）from mouse small intestine. METhoDS：In this study,effects of PGF2αin the cultured ICC cells were investigated with patch clamp technology combined with Ca 2＋ image analysis. RESULTS：Externally applied PGF2α（10μmol/L）produced membrane depolarization in current-clamp mode and increased tonic inward pacemaker currents in voltage-clamp *** application of flufenamic acid（a non-selective cation channel inhibitor）or niflumic acid（aCl channel inhibitor）abolished the generation of pacemaker currents but only flufenamic acid inhibited the PGF2α-induced tonic inward *** addition,the tonic inward currents induced by PGF2αwere not inhibited by intracellular application of 5’-[-thio]diphosphate trilithium *** with Ca 2＋ free solution, U-73122,an active phospholipase C inhibitor,and thapsigargin,a Ca 2＋ -ATPase inhibitor in endoplasmic reticulum,abolished the generation of pacemaker currents and suppressed the PGF2α-induced tonic inward ***,chelerythrine or calphostin C,protein kinase C inhibitors,did not block the PGF2α-induced effects on pacemaker *** recording intracellular Ca 2＋（[Ca 2＋ ]i）concentration using fluo-3/AM,PGF2α broadly increased the spontaneous[Ca 2＋ ]i oscillations. CONCLUSION：These results suggest that PGF2αcan modulate pacemaker activity of ICC by acting non-selective action channels through phospholipase C-dependent pathway via[Ca2＋]i regulation

关键词： Prostaglandin F2α Interstitial cells of Cajal Tonic inward currents Intestinal motility

Revisiting oral fluoropyrimidine with cetuximab in metastatic colorectal cancer: Real-world data in Chinese population

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World Journal of Gastrointestinal Oncology 2019年第11期11卷 1031-1042页

作者： Ka-On Lam man-Chi Fu Kin-Sang Lau Kam-Mo Lam Cheuk-Wai choi Wan-Hang Chiu Cheng-man Yuen Lai-Han Kwok Fong-Kit Tam Wing-Lok Chan Sum-Yin Chan Pui-Ying ho To-Wai Leung ho-Fun Lee Department of Clinical Oncology LKS Faculty of MedicineThe University of Hong KongHong KongChina Department of Clinical Oncology Queen Mary HospitalHong KongChina Clinical Oncology Centre The University of Hong Kong-Shenzhen HospitalShenzhen 518053Guangdong ProvinceChina Department of Pharmacy Queen Mary HospitalHong KongChina Department of Diagnostic Radiology LKS Faculty of MedicineThe University of Hong KongHong KongChina

BACKGROUND Cetuximab in combination with oral fluoropyrimidine(FP)remains controversial in metastatic colorectal cancer(mCRC).In view of the regional variation in the tolerability of FP,we conducted a retrospective analysis to compare oral FP with infusional FP in combination with cetuximab in Chinese *** To compare the efficacy and safety profile of cetuximab in combination with oral FP and infusional FP in Chinese population in the real-world *** A retrospective cohort study was done to analyse consecutive patients with Kras wild-type mCRC who received first-line treatment with cetuximab and FP-based chemotherapy in our unit from January 2010 to December ***-five eligible patients were *** median follow-up of our cohort was 65.0 *** The median progression-free survival(mPFS)and median overall survival(mOS)of the entire cohort were 9.66 mo(95%CI:7.72–12.5)and 25.8 mo(95%CI:18.7–35.6),*** oral FP and infusional FP,there was no statistical significant difference in the mPFS[9.79 mo(95%CI:7.49–12.7)vs 9.63 mo(95%CI:6.34–13.4);P=0.72]and mOS[25.8 mo(95%CI:15.2–35.6)vs 26.3 mo(95%CI:18.7–41.2);P=0.63].Grade 3 or above adverse events were reported in 28.4%of patients,being similar with oral and infusional FP,and included 10.5%of neutropenia and 2.1%of diarrhoea *** The current analysis demonstrates comparable efficacy and safety profiles of cetuximab in combination with oral and infusional FP in Chinese *** results expand treatment options for Chinese patients and invite revision of existing treatment guidelines to incorporate oral FP-based chemotherapy plus cetuximab.

关键词： Capecitabine 5-Fluorouracil Cetuximab Metastatic colorectal cancer Chinese

A Secure Routing Method for Detecting False Reports and Wormhole Attacks in Wireless Sensor Networks

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Wireless Sensor Network 2013年第3期5卷 33-40页

作者： Hyeon Myeong choi Su man Nam Tae ho Cho College of Information and Communication Engineering Sungkyunkwan University Suwon South Korea

Wireless sensor networks (WSNs) consist of a large number of sensor nodes that monitor the environment and a few base stations that collect the sensor readings. Individual sensor nodes are subject to compromised security because they may be deployed in hostile environments and each sensor node communicates wirelessly. An adversary can inject false reports into the networks via compromised nodes. Furthermore, an adversary can create a wormhole by directly linking two compromised nodes or using out-of-band channels. If these two kinds of attacks occur simultaneously in a network, existing methods cannot defend against them adequately. We thus propose a secure routing method for detecting false report injections and wormhole attacks in wireless sensor networks. The proposed method uses ACK messages for detecting wormholes and is based on a statistical en-route filtering (SEF) scheme for detecting false reports. Simulation results show that the proposed method reduces energy consumption by up to 20% and provide greater network security.

关键词： Wireless Sensor Network Security Statistical En-Route Wormhole Secure Routing

Malignant melanotic nerve sheath tumors in the spinal canal of psammomatous and non-psammomatous type: Two case reports

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World Journal of Clinical Cases 2022年第24期10卷 8735-8741页

作者： Jeong A Yeom You Seon Song In Sook Lee In ho Han Kyung Un choi Department of Radiology Pusan National University Yangsan HospitalYangsan 50612South Korea Department of Radiology Pusan National University HospitalBusan 49241South Korea Department of Neurosurgery Pusan National University HospitalBusan 49241South Korea Department of Pathology Pusan National University HospitalBusan 49241South Korea

BACKGROUND A malignant melanotic nerve sheath tumor(MMNST),previously known as a melanotic schwannoma,is a rare variant of a peripheral nerve sheath tumor composed of Schwann cells with melanotic *** a few reports of spinal MMNST have been *** SUMMARY In the first case,a 58-year-old woman presented with a history of low back pain and *** resonance imaging(MRI)and computed tomography(CT)of the lumbar spine revealed an intradural extramedullary mass lesion with amorphous linear *** tumor resection was performed and histological examination revealed a psammomatous melanotic *** the second case,a 72-year-old man presented with low back pain and *** of the thoracolumbar spine revealed an intramedullary mass lesion at the T11 vertebral body *** mass lesion was hypointense on T2WI and hyperintense on *** resection was performed and the histologic result was melanotic *** MMNST should be considered in the differential diagnosis when calcification or melanin is seen in an intradural spinal tumor.

关键词： Nerve sheath neoplasm Extramedullary Malignant Melanotic Magnetic resonance imaging Case reports

Finger compartment syndrome due to a high-pressure washer injury:A case report

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World Journal of Clinical Cases 2023年第13期11卷 3017-3021页

作者： Jun ho choi Seung Yeon choi Jae Ha Hwang Kwang Seog Kim Sam Yong Lee Department of Plastic and Reconstructive Surgery Chonnam National University Hospital Chonnam National University Medical SchoolGwangju 61469South Korea

BACKGROUND Although the finger compartment syndrome is not common,it compresses the neurovascular bundles in a limited space and blocks blood flow to the fingers,causing necrosis of the *** fasciotomy through unilateral or bilateral midline release of the finger can achieve decompression of the finger ***,we report a case of the compartment syndrome in a finger injury caused by a high-pressure water flow which is commonly used in car washing *** SUMMARY A 60-year-old man injured his right middle finger while using a high-pressure washer at a car washing *** patient complained of severe pain in his middle finger and a 0.2 cm punctured open wound on the volar side of the distal phalangeal joint of the middle *** fingertip was pale,numb,and characterized by severe swelling and a limited range of *** radiography showed that there was no fracture in the *** decompression was performed through finger fasciotomy by bilateral midline *** the second day after surgery,the color of the fingertip returned to pink,swelling was resolved,and the range of motion returned to *** sensation of the fingertip was completely restored,and the capillary refill test and pinprick test were *** The fingertip compartment syndrome can be caused by a high-pressure water flow damage to the fingers when using high-pressure washers at a car washing *** avoid finger necrosis,rapid diagnosis of the finger compartment syndrome and appropriate digital decompression are essential to better outcome.

关键词： Compartment syndrome Crush injuries Fasciotomy Finger injuries Case report

Down-regulation of tyrosinase,TRP-1,TRP-2 and MITF expressions by citrus press-cakes in murine B16 F10 melanoma

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Asian Pacific Journal of Tropical Biomedicine 2013年第8期3卷 617-622页

作者： Sang Suk Kim Min-Jin Kim Young Hun choi Byung Kuk Kim Kwang Sik Kim Kyung Jin Park Suk man Park Nam ho Lee Chang-Gu Hyun Cosmetic Science Center Department of ChemistryJeju National UniversityJeju 690-756Korea Citrus Research Station National Institute of Horticultural & Herbal ScienceRDAJeju 699-946Korea Jeju Technopark Ara-1-dongJeju-siJeju 690-121Korea Ohyun High School 1 Hwabook-dongJeju-siJeju 690-061Korea LINC Agency Jeju National UniversityAra-1-dongJeju 690-756Korea

Objective:To investigate the suitability of citrus-press cakes,by-products of the juice industry as a source for the whitening agents for cosmetic ***:Ethylacetate extracts of citrus-press cakes(CCE)were examined for their anti-melanogenic potentials in terms of the inhibition of melanin production and mechanisim of melanogenesis by using Western Blot analysis with tyrosinese,tyrosinase-related protein-1(TRP-1),TRP2,and microphthalmia-associated transcription factor(MITF)*** apply the topical agents,citrus-press cakes was investigated the safety in human skin cell *** flavonoid analysis of CCE was also determined by HPLC ***:Results indicated that CCE were shown to down-regulate melanin content in a dose-dependent *** CCE inhibited tyrosinase,TRP-2,and MITF expressions in a dose-dependent *** test the applicability of CCE to human skin,we used MTT assay to assess the cytotoxic effects of CCE on human keratinocyte HaCaT *** CCE exhibited low cytotoxicity at 50μg/*** of the citrus-press cakes for flavonoid contents using HPLC showed varied quantity of rutin,narirutin,and ***:Considering the anti-melanogenic activity and human safety,CCE is considered as a potential anti-melanogenic agent and may be effective for topical application for treating hyperpigmentation disorders.

关键词： Citrus-press cakes Melanin Melanogenesis Tyrosinase MITF TRP-1 TRP-2

Rare case of compartment syndrome provoked by inhalation of polyurethane agent:A case report

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World Journal of Clinical Cases 2022年第22期10卷 8003-8008页

作者： Jun ho choi Hyun Myung Oh Jae Ha Hwang Kwang Seog Kim Sam Yong Lee Department of Plastic and Reconstructive Surgery Chonnam National University HospitalGwangju 61469South Korea Department of Plastic and Reconstructive Surgery Chonnam National University Medical SchoolGwangju 61469South Korea

BACKGROUND The most common causes of compartment syndrome in the lower extremities include lower limb fractures,trauma-induced crushing injuries,severe burns,and non-traumatic ***,there have been no reports of compartment syndrome secondary to toxic *** SUMMARY A 59-year-old man,who lost consciousness after applying polyurethane-based paint on a water tank,was brought to the emergency *** initial blood test showed apparent *** day later,pain and swelling in both legs were observed,and the physical examination confirmed the presence of compartment ***-incision fasciotomy was performed on both *** dressings and negative pressure wound treatment were done on both legs,and skin grafting was performed after healthy granulation tissue had been *** other complications were observed after ***,symptoms of peroneal neuropathy,particularly limited ankle dorsiflexion and reduced sensation on the lower extremities,were *** Workers using polyurethane agents should wear gas masks and be evaluated for compartment syndrome and rhabdomyolysis secondary to toxic inhalation.

关键词： Compartment syndrome Polyurethanes Rhabdomyolysis Hypoxia Peroneal neuropathies Case report