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Apoptosis,antimicrobial and antioxidant activities of phytochemicals from Garcinia malaccensis Hk.f

Asian Pacific Journal of Tropical Medicine 2012年第2期5卷 136-141页

作者： Muhammad Taher Deny Susanti Mohamad Fazlin Rezali farah Syahidah Ahmad Zohri Solachuddin Jauhari Arief Ichwan Suhaib Ibrahim Alkhamaiseh Farediah Ahmad Department of Pharmaceutical Technology Kulliyyah of PharmacyInternational Islamic University MalaysiaJalan IstanaBandar Indera Mahkota25200 KuantanPahangMalaysia Department of Biomedical Science Kulliyyah of ScienceInternational Islamic University MalaysiaJalan IstanaBandar Indera Mahkota25200 KuantanPahangMalaysia SIRIM Rerhad(National Metrology Laboratory) Lot PT 4803Bandar Baru Salak Tinggi43900 SepangSelangorMalaysia Kulliyyah of Dentistry International Islamic University MalaysiaJalan IstanaBandar Indera Mahkota25200 KuantanPahangMalaysia Department of Chemistry Faculty of ScienceUniversity Teknologi Malaysia81310 UTMJohorMalaysia

Objective:To study the chemical constituents of stembark of Garcinia malaccenm（***） together with *** and antioxidant ***:Purification and structure elucidation were carried out by chromatographic and spectroscopic techniques, *** and trypan blue exclusion methods were performed to study the cytotoxic *** activity was conducted by dise diffusion and microdilulion methods, whereas antioxidant activities were done by ferric thiocyanate method and DPPH radical ***:The phylochemical study led lo the isolation ofα,β-mangostin and cycloarl-24-en-3β-ol.α-Mangostin exhibited cytotoxic activity against HSC-3 cells with an IC50 of 0.33μM.β- andα-mangostin showed activity against K562 cells with IC50 of 0.40μM and 0.48μM,respectively,α-Mangostin was active against Gram-positive bacteria, Staphylococcus aureus（***） and Bacilus anthracis（***） with inhibition zone and MIC value of（19 mm;0.02S mg/mL） and（20 mm;0.013 mg/mL）,*** antioxidant assay,α-mangostin exhibited activity as an inhibitor of lipid ***:*** presenceα- andβ-mangostin and cycloart-24-en-3β-ol.β-Mangostin was found very active against ***-3 cells and *** results suggest that mangoslins derivatives have the potential to inhibit the growth of cancer cells by inducing *** addition,α-andβ-mangostin was found inhibit the growth of Cram-positive pathogenic bacteria and also showed the activity as an inhibitor of lipid peroxidation.

关键词： Garcinia malaccensis Guttiferae Apoptosis Antibacterial Antioxidant

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How to overcome ATP-binding cassette drug efflux transporter-mediated drug resistance?

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Cancer Drug Resistance 2018年第1期1卷 6-29页

作者： Adrian C.Jaramillo farah Al Saig Jacqueline Cloos Gerrit Jansen Godefridus J.Peters Department of Hematology VU University Medical CenterCancer Center AmsterdamAmsterdam 1007 MBThe Netherlands Department of Medical Oncology VU University Medical CenterCancer Center AmsterdamAmsterdam 1007 MBThe Netherlands Amsterdam Rheumatology and Immunology Center VU University Medical CenterAmsterdam 1007 MBThe Netherlands

P-glycoprotein(ABCB1),multidrug resistance protein-1(ABCC1)and breast cancer resistance protein(ABCG2)belong to the ATP-binding cassette(ABC)superfamily of proteins that play an important physiological role in protection of the body from toxic xenobiotics and endogenous *** this,these transporters determine the toxicity profile of many drugs,and confer multidrug resistance(MDR)in cancer cells associated with a poor treatment outcome of cancer *** has long been hypothesized that inhibition of ABC drug efflux transporters will increase drug accumulation and thereby overcome MDR,but until now no approved inhibitor of these transporters is available in the *** this review we present molecular strategies to overcome this type of drug resistance and discuss for each of these strategies their promising value or indicate underlying reasons for their limited success.

关键词： Breast cancer resistance protein ATP-binding cassette transporters multidrug resistance multidrug resistance protein

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基于深度学习的SCRNA-SEQ分析和下游任务方法

基于深度学习的SCRNA-SEQ分析和下游任务方法

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作者： farah Naz 山东大学

学位级别：硕士

活细胞构成大量生物实体之间相互作用的复杂系统。基因、转录产物、蛋白质、代谢物和物种以时间和空间控制的方式进行细胞过程。通常,这些相互作用及其参数不能通过实验直接测量。2013年标志着单细胞测序被公认为最有希望解决复杂生物... 详细信息

活细胞构成大量生物实体之间相互作用的复杂系统。基因、转录产物、蛋白质、代谢物和物种以时间和空间控制的方式进行细胞过程。通常,这些相互作用及其参数不能通过实验直接测量。2013年标志着单细胞测序被公认为最有希望解决复杂生物学研究问题的测序方法。从那时起,单细胞测序技术得到了进步,导致单细胞数据显著增加。然而,处理这些庞大而复杂的数据集的计算挑战增加了三倍。通常,单细胞测序技术需要设计一个建模方法,然后这些算法的适用性取决于用例,特别是问题的大小。一般来说,所有方法都受到生物测量中的噪声、与模型复杂性相关的稀缺数据以及非线性和组合行为的挑战。然而,所需的计算成本高的数值算法必须以计算有效的方式实现。通过将深度学习（DL）等人工智能（AI）方法与单细胞RNA测序（scRNA-seq）技术提供的生物数据相结合,可以揭示细胞的潜在结构并更准确地预测细胞的有效亚群。然而,在涉及生物因素和技术噪音时,这种有说服力的技术是微妙的。由于各种原因,单细胞数据分析可能是计算密集型的,例如在数据中输入缺失值、对其进行去噪、考虑数据的零膨胀（ZI）特性,以及最具挑战性的是降维。除了传统的机器学习（ML）方法之外,深度学习（DL）被认为是单细胞分析的一个有竞争力的选择。深度生成方法可以从组学数据中学习底层结构,例如路径或基因系统。我们对此类分析技术进行了介绍和概述,特别说明了它们在单细胞表达数据中的用法。具体来说,在论文中,提出了深度学习（DL）模型的统一数学公式;变分自编码器（VAE）、自编码器（AE）和生成对抗网络（GAN）,比较它们的训练步骤和策略及其损失函数,还将这些模型类型的损失函数与单细胞RNA-seq数据处理步骤中的特定对象相联系。深度生成模型通过有效封装基因对之间的非线性依赖关系,帮助学习高维多组学和单组学数据的结构;由于它们基于神经网络（NN）的结构块,它们通常难以解释。论文的描述风格将有助于为分析管道的每个级别选择合适的算法。对最近建立的模型和技术的全面调查将作为一个有用的信息门户,用于了解深度学习（DL）在scRNA-seq分析中的应用,并激发其在多领域新兴挑战任务中的应用-组学和单细胞测序领域。关键点:1.单细胞RNA测序技术生成数百万个转录组图谱,允许对隐藏的表达功能结构或细胞类型进行生物学研究,更准确地预测它们的效果或对治疗的反应,或利用亚群来弥补研究空白。2.本研究检查了当前基于深度学习（DL）的单细胞数据分析算法所面临的挑战及其在分析管道中的作用。3.每项技术都对所调查的深度学习（DL）模型进行了数学解释,并对模型的特殊属性进行了讨论。4.还对每种技术都提供了对评估措施、比较算法和数据集的全面概述。5.最后,我们使用单细胞表达数据证明了在实际应用中概述的策略的适用性。6.我们提出了一个基于深度学习的管道,用于使用自编码器进行降维的单细胞RNA-seq下游分析。

关键词： scRNA-seq 深度学习自编码器降维生物信息学

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Antioxidant antileishmanial cytotoxic and antimicrobial activities of a local plant Myrtus nivellei from Algeria Sahara

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Asian Pacific Journal of Tropical Biomedicine 2017年第8期7卷 702-707页

作者： farah Ramdane Rym Essid Nadia Fares Dahmane El Ouassis Sana Aziz Mahfoud Hadj Mahammed Mohamed Didi Ould Hadj Ferid Limam Biogeochemistry Laboratory in Desert Environments Kasdi Merbah University Faculty of Natural and Life Sciences El Oued University Laboratory of Bioactive Substances Biotechnology Center of Borj-Cedria Technopole National Institute of Forest Research Protection Laboratory of Ecosystem in Arid and Semi Arid Zone Kasdi Merbah University

To study the phytochemical constituents and in vitro biological activities of hydromethanolic extract and fractions from Algerian Sahara Myrtus nivellei (M. nivellei) collected in Hoggar region and to identify the active fraction that can act as an alternative of commonly used antibiotics and as antileishmanial or antioxidant *** screening of M. nivellei aerial parts was realised according to the literature. Extract was firstly prepared by using aqueous methanol then fractionated with ethyl acetate and butanol solvents. Total phenolics, tannis and flavonoids, of the hydromethanolic extract and their fractions were determined by Folin-Ciocalteu method as gallic acid equivalents and by aluminium chloride as rutin equivalent respectively. Extract and fractions were tested for their antimicrobial and antiparasital activities against standard bacteria using agar diffusion method and two kinds of leishmania visceral and cutaneous. The antioxidant activities were realized using phosphomolybdenum, FRAP and DPPH *** phytochemical screening exhibited the presence of flavonoids, tannins, saponins, and alkaloids. The experimental results showed that plant extract and fractions were high in phenolic compounds and exhibited an important role as antioxidant, antimicrobial and had a moderate antileishmanial *** observations lead us toward more studies in this field, so that we can get more benefits from our local Algerian medicinal plants.

关键词： Phenolic compounds Flavonoids Antioxidant activity Antimicrobial activity Antileishmanial activity Myrtus nivellei

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分析客户满意度：在线奢侈品客户对送货服务的看法

分析客户满意度：在线奢侈品客户对送货服务的看法

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作者： farah Firoozi 北京交通大学

学位级别：硕士

包括服装、时尚配饰、美容、珠宝和手表在内的个人奢侈品市场面临着许多不可预见的障碍。奢侈品购买者经常在他们喜爱的品牌中寻找卓越的品质和形象,并愿意为该商品的独家性支付溢价例如,奢侈品品牌在上网时面临重大障碍,因为购买决策... 详细信息

包括服装、时尚配饰、美容、珠宝和手表在内的个人奢侈品市场面临着许多不可预见的障碍。奢侈品购买者经常在他们喜爱的品牌中寻找卓越的品质和形象,并愿意为该商品的独家性支付溢价例如,奢侈品品牌在上网时面临重大障碍,因为购买决策主要基于情感而不是产品质量。高水平的服务质量是他们重视的另一件事。客户期望在线商店提供与线下商店不同的服务,例如安全交付、安全支付以及对客户电子邮件或电话的快速响应。最近的电子商务和零售研究建立了强大的客户体验议程,以正确满足在线购物者不断扩大和迅速变化的期望。但奢侈品供应商似乎还不明白如何传达“在线奢侈品精品店体验”。当奢侈品客户接触到一种产品时,他们会体验到情绪并进行冲动购买。这表明提供商将很难通过互联网将产品的“属性”“传达”给情感投入的客户。在线购买中的物品交付在确定客户满意度方面起着重要而微妙的作用。客户与卖家进行个人接触的唯一时间是在交货时。就满足高端客户而言,这是一个分水岭。近年来,中国大陆一直是奢侈品行业的驱动力。中国奢侈品行业正在经历从线下到线上的巨大变化,直接从中国大陆购买的消费者比例越来越高。中国在文化传统、物流基础设施、信用体系等方面与国外有很大不同。中国文化属于东方文化体系,中国的物流基础设施落后于其他发达国家。先前的研究表明,文化、物流和信用对客户行为和满意度有重要影响。因此,中国网购客户满意度的关键驱动因素可能与其他国家不同,这是可以理解的。技术趋同和各国收入差异的消失不会导致消费者行为的同质化。相反,由于文化差异,消费者行为将变得更加多样化。然而,很少有研究探讨中国背景下的网购客户满意度,因此对中国网购客户满意度的构建知之甚少。这对于了解当中国客户愿意在网上商店购买奢侈品时会获得什么满足感非常重要,他们只是找到了一个远程和自动化服务的界面。比起去实体精品店接受一些个人建议,他们会感到无限孤独。产品将是相同的,但客户在体验期间获得的价值意味着非常重要的额外奖励,即他们在某些材料或标志之前支付的奢侈品百分比。根据之前的研究,还没有关于受送货服务影响的在线奢侈品客户满意度的研究。在这项研究中,通过文献回顾和专家和权威人士的访谈,确定了影响在线奢侈品消费者满意度的与送货服务相关的关键因素,并生成了一个模型。包裹特征、配送时间、物流公司、配送员和配送车辆的个性化、可追溯性和响应性、价格和环境方面是影响客户满意度的关键配送服务因素。本研究收集数据的主要工具是一份由具有一定网购经验的中国奢侈品消费者填写的问卷。为了评估测量模型及其可靠性和有效性,计算了每个构造的Cronbach Alpha和提取的平均方差(AVE)。该模型使用Smart PLS中的结构方程建模(SEM)进行了经验测试。它显示了关于奢侈品交付服务因素的路径模型的SEM的输出。除假设7外,所有假设均得到支持。研究结果表明,所有因素都对客户满意度产生积极影响,而价格和环境对客户满意度没有显着影响。这表明价格对客户没有负面影响。环境方面不是奢侈品消费者的主要关注点。这项研究将帮助在线零售商提高购买后的满意度并最终增加在线客户。

关键词：消费者满意度网上购物奢侈品奢侈品客户送货服务电子零售商扫描电镜 SEM

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Water Dynamics of the Sefrou Watershed, Northern Tabular Middle Atlas, Morocco

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Journal of Geoscience and Environment Protection 2021年第9期9卷 102-130页

作者： farah El Hassani Youssef Hattafi Abderrahim Lahrach Department of Environment Engineering Faculty The Euromed University of Fez Fez Morocco Department of Environment Faculty of Science and Technology Sidi Mohammed Ben Abdellah University of Fez Fez Morocco

The Sefrou watershed, located in the northern part of the Tabular Middle Atlas, is the primary watershed in the Sebou region. Due to increasing socio-economic development, the need for a stable water supply is critical. Therefore, this watershed’s physiography and morphology are studied to aim and facilitate further research in the Sebou region. We rely on the hydrological regime, frequency analysis of extreme flows, rainfall volume, and flood periods forecast to enable that characterization. Our findings determined that the Sebou region is of pluvial type with abundant rainfall, especially in winters due to floods. Moreover, substratum parameters induce a large volume of water resources from upstream to downstream. However, the weak structure of the hydrographic network and the water balance has highlighted a considerable loss of these resources, which handicaps the irrigation system and the supply of drinking water to the region’s cities. Finally, the annual modulus and the different coefficients show hydroclimatic fluctuations of semi-arid climatic conditions, with a temperate winter. Our results suggest a need to monitor water runoff and protect surface soils from flooding and rapid erosion (by planting trees). We also propose installing barriers and a small dam to recharge groundwater and artificially store surface water in this watershed.

关键词： Middle Atlas Sebou Sefrou Watershed Basin Morphology Water Resources

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Impaired glymphatic function in the early stages of disease in a TDP-43 mouse model of amyotrophic lateral sclerosis

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Translational Neurodegeneration 2022年第1期11卷 707-717页

作者： Akram Zamani Adam K.Walker Ben Rollo Katie L.Ayers Raysha farah Terence J.O’Brien David K.Wright Department of Neuroscience Central Clinical SchoolMonash UniversityMelbourneVIC 3004Australia Queensland Brain Institute The University of QueenslandSt LuciaQLD 4072Australia The Murdoch Children’s Research Institute The Royal Children’s HospitalParkvilleVIC 3052Australia Department of Pediatrics The University of MelbourneParkvilleVIC 3052Australia Department of Medicine The Royal Melbourne HospitalThe University of MelbourneParkvilleVIC 3052Australia

Background: Multiple lines of evidence suggest possible impairment of the glymphatic system in amyotrophic lateral sclerosis (ALS). To investigate this, we used in vivo magnetic resonance imaging (MRI) to assess glymphatic func-tion early in the course of disease in a transgenic mouse with doxycycline (Dox)-controlled expression of cytoplasmic human TDP-43 (hTDP-43ΔNLS), mimicking the key pathology implicated in ALS. Methods: Adult TDP-43 transgenic and littermate monogenic control mice underwent longitudinal multimodal MRI one and three weeks after the cessation of Dox feed, together with weekly rotarod assessments of motor per-formance. Glymphatic function was assessed using dynamic contrast-enhanced MRI to track the clearance of an MR contrast agent injected into the cisterna magna. Results: Compared to their littermate controls, TDP-43 mice exhibited progressive neurodegeneration including that within the primary motor cortex, primary somatosensory cortex and corticospinal tract, significant weight loss includ-ing gastrocnemius atrophy, and shortened telomere length. Furthermore, in the presence of this ALS-like phenotype, these mice have significantly disrupted glymphatic function. Conclusions: Although the relationship between glymphatic clearance and ALS disease progression remains to be elucidated, these changes occurred very early in the disease course. This provides initial evidence to suggest that the glymphatic system might be a potential therapeutic target in the treatment of ALS.

关键词： Magnetic resonance imaging Diffusion-weighted imaging Neurodegeneration Cerebrospinal fluid Telomere

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Group psychological intervention for maternal depression: A nested qualitative study from Karachi, Pakistan

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World Journal of Psychiatry 2017年第2期7卷 98-105页

作者： Nusrat Husain Nasim Chaudhry Christine Furber Hina Fayyaz Tayyeba Kiran farah Lunat Raza Ur Rahman Saira Farhan Batool Fatima University of Manchester Honorary Consultant Psychiatrist Lancashire Care NHS Trust Manchester Academy of Health Sciences Centre Greater Manchester West Mental Health Trust University of Manchester Pakistan Institute of Living and Learning School of Nursing Midwifery and Social Work University of Manchester Lancashire Care NHS Foundation Trust Dow University of Health Sciences United Medical and Dental College

AIM To understand the experience of maternal depression, the factors implicated in accessing health, and the acceptability of the psychosocial intervention. METHODS The participants were recruited from the paediatrics outpatient department of Civil Hospital Karachi, Pakistan. The study started in December 2009 and completed in December 2010. Women with maternal depression, aged 18-44 years with children aged 0-30 mo who had received nutritional supplements, and participated in the intervention programme [called Learning through Play(LTP) plus] were included in the study. Qualitative interviews were conducted with 8 participants before the intervention and 7 participants after the intervention. A semi structured topic guide was used to conduct the *** Framework analysis procedures were used to analyse the qualitative data. Four themes emerged:(1) the women's contextual environment: Interpersonal conflicts, lack of social support and financial issues being the major barriers in assessing healthcare;(2) women's isolation and powerlessness within the environment: Sense of loneliness was identified as a restricting factor to access healthcare;(3) the impact of the intervention(LTP-Plus): Women felt "listened to" and seemed empowered; and(4) empowered transformed women within the same contextual environment: The facilitator provided a "gardening role" in nurturing the women resulting in a positive transformation within the same environment. The women's homes seemed to be more happy homes and there was a positive change in their behaviour towards their *** Findings informed the further development and testing of culturally-appropriate psychosocial intervention(LTP^+) for addressing maternal depression.

关键词： Low income Country Thinking Healthy Program Learning through play Maternal depression Framework analysis Exploratory analysis

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Ps-06013

Ps-06013

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第二届国际防痨和肺部疾病联合会亚太区学术大会暨2009...

作者： farah Zaman Khan Bangladesh Dental College ＆ Institute Of Medical Technology

＜正＞Bangladesh has enacted a tobacco control law in 2005 in accordance with some of the provisions of WHO ***,tobacco consumption in Bangladesh is increasing,especially among the youth and *** to a report,59%

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Turnkey algorithmic approach for the evaluation of gastroesophageal reflux disease after bariatric surgery

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Gastroenterology Report 2023年第1期11卷 123-130页

作者： Omar M.Ghanem Rabih Ghazi farah Abdul Razzak Fateh Bazerbachi Karthik Ravi Leena Khaitan Shanu N.Kothari Barham K.Abu Dayyeh Department of Surgery Mayo ClinicRochesterMNUSA Department of Medicine Mayo ClinicRochesterMNUSA CentraCare Interventional Endoscopy ProgramSt Cloud HospitalSt CloudMNUSA Department of Surgery CaseWestern Reserve UniversityClevelandOHUSA Department of Surgery Prisma HealthGreenvilleSCUSA

Bariatric surgeries are often complicated by de-novo gastroesophageal reflux disease(GERD)or worsening of pre-existing *** growing rates of obesity and bariatric surgeries worldwide are paralleled by an increase in the number of patients requiring post-surgical GERD ***,there is currently no standardized approach for the assessment of GERD in these *** this review,we delineate the relationship between GERD and the most common bariatric surgeries:sleeve gastrectomy(SG)and Roux-en-Y gastric bypass(RYGB),with a focus on pathophysiology,objective assessment,and underlying anatomical and motility *** suggest a stepwise algorithm to help diagnose GERD after SG and RYGB,determine the underlying cause,and guide the management and treatment.

关键词： RYGB sleeve gastrectomy bariatric surgery gastroesophageal reflux disease GERD

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