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Food Quality and Safety 2021年第2期5卷 161-169页

作者： Hyung soo Kim Dae Yong jang Ye Ji Koo Eun Chul Pack Seung Ha Lee Dal Woong Choi Health Science Research Center Korea UniversitySeoulRepublic of Korea department of Public Health Sciences Graduate SchoolKorea UniversitySeoulRepublic of Korea School of Health and Environmental Sciences Korea UniversitySeoulRepublic of Korea and department of Health and Safety Convergence Science Graduate SchoolKorea UniversitySeoulRepublic of Korea.

Condensed phosphates are used as food additives,especially in marine products and meat,to improve food *** import and consumption of fishery and processed marine food products in Republic of Korea have reportedly increased by~5 per cent ***,processed marine food products are often intentionally adulterated with excessive amounts of condensed phosphates to increase their *** intake of condensed phosphates via consuming processed marine food products can lead to various adverse effects on human health due to anionic ***,we conducted a safety assessment of condensed phosphates in 14 types of fishery and processed marine food products in Korea for the first *** analysis of various factors including gender,age,and region was also performed,and the risk level of exposure for each group was *** assessments by age and gender indicated that infants were at the highest *** the regional safety assessment,Chungnam,the most inland region,showed the lowest *** both the general and the high-intake groups(95th percentile)in all classifications,the risk was lower(<20 per cent)than the international standard,and the phosphorus content of the 14 types of processed marine products in Korea was confirmed to be safe for human consumption.

关键词： Condensed phosphates safety assessment ion chromatography fishery and processed marine food products

An intrinsically stretchable multi-biochemical sensor for sweat analysis using photo-patternable ecoflex

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npj Flexible Electronics 2023年第1期7卷 220-228页

作者： Seungwan Kim Joohyuk Kang Injun Lee Jinhyeong jang Chan Beum Park Wonryung Lee Byeong-soo Bae Wearable Platform Materials Technology Center(WMC) 291 Daehak-roYuseong-guDaejeon 34141Republic of Korea Department of Materials Science and Engineering Korea Advanced Institute of Science and Technology(KAIST)291 Daehak-roYuseong-guDaejeon 34141Republic of Korea Center for Theragnosis Biomedical Research InstituteKISTSeoul 02792Republic of Korea

Ecoflex is widely used in bioelectronics due to its outstanding properties of low modulus and large *** its use as an encapsulation layer in multi-channel wearable devices,a patterning procedure is ***,conventional patterning strategies for Ecoflex,such as soft lithography,punching,and laser ablation,lack sufficient quality and process *** address this,we propose a process-compatible method of patterning Ecoflex by developing Photo-patternable Ecoflex(PPE).The PPE layer,used as an encapsulation layer,effectively dissipates strain energy at homogeneous interfaces,resulting in a 50%increase in electrical conductance under 250%*** PPE,we fabricated intrinsically stretchable multi-sensors that monitor bio-signals like glucose,lactate,pH,and humidity in *** sensors maintain durable sensitivity under strain up to 50%and for 1000 cycles at 20%***,we mounted these stretchable multi-chemical sensors on an arm to monitor glucose and lactate levels in sweat.

关键词： lithography pattern intrinsic

Chemoresistive materials for electronic nose:Progress,perspectives,and challenges

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InfoMat 2019年第3期1卷 289-316页

作者： Seo Yun Park Yeonhoo Kim Taehoon Kim Tae Hoon Eom soo Young Kim Ho Won jang Department of Materials Science and Engineering Research Institute of Advanced MaterialsSeoul National UniversitySeoulRepublic of Korea Center for Integrated Nanotechnologies Los Alamos National LaboratoryLos AlamosNew Mexico School of Chemical Engineering and Materials Science Chung-Ang UniversitySeoulRepublic of Korea

An electronic nose(e-nose)is a device that can detect and recognize odors and flavors using a sensor *** has received considerable interest in the past decade because it is required in several areas such as health care,environmental monitoring,industrial applications,automobile,food storage,and ***,there are still obstacles in developing a portable e-nose that can be used for a wide variety of *** practical applications of an e-nose,it is necessary to collect a massive amount of data from various sensing materials that can transduce interactions with molecules reliably and analyze them via pattern *** addition,the possibility of miniaturizing the e-nose and operating it with low power consumption should be ***,it should work efficiently over a long period of *** satisfy these requirements,several different chemoresistive material platforms including metal oxides,organics such as polymers and carbonbased materials,and two-dimensional materials were investigated as sensor elements for an *** an individual material has limited selectivity,there is a continuing effort to improve the selectivity and gas sensing properties through surface decoration and compositional and structural *** produce a reliable e-nose,which can be used for practical applications,researches in various fields have to be *** paper reviews the progress of research on e-noses based on a chemoresistive gas sensor array and discusses the inherent challenges and potential solutions.

关键词： chemoresistive materials electronic nose metal oxides polymers two-dimensional materials

Superhydrophobic and antireflective nanograss-coated glass for high performance solar cells

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Nano Research 2014年第5期7卷 670-678页

作者： Hyo Jin Gwon Yensil Park Cheon Woo Moon Sahn Nahm Seok-Jin Yoon soo Young Kim Ho Won jang Electronic Materials Research Center Korea Institute of Science and Technology Seou1136-791 Korea Department of Materials Science and Engineering Korea University Seoul 136-701 Korea School of Chemical Engineering and Materials Science Chung-Ang University Seou1156-756 Korea Department of Materials Science and Engineering Research Institute of Advanced Materials Seoul National University Seou1151-744Korea

We present a facile method for producing superhydrophobic nanograss-coated （SNGC） glass surfaces that possess both reduced reflectivity and self-cleaning properties at the air/glass interface. The refractive index of a CaF2 nanograss （NG） layer on a glass substrate, deposited by glancing angle vapor deposition, is 1.04 at 500 nm, which is the second-lowest value ever reported so far. The fluorinated NG layer gives rise to a high water contact angle （〉150°） and very efficient cleaning out of dust with water drops. Using the dual functionalities of the SNGC glass, we demonstrate superhydrophobic and antireflective organic photovoltaic cells with excellent power conversion efficiency.

关键词： superhydrophobic antireflective self-cleaning nanograss solar cells glancing angle deposition

3D image reconstruction with controllable spatial filtering based on correlation of multiple periodic functions in computational integral imaging

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Chinese Optics Letters 2015年第3期13卷 22-26页

作者： Jae-Young jang Myungjin Cho Eun-soo Kim Department of Optometry Eulji University 553 Sanseong-daero Sujeong-guSeongnam-si Gyonggi-do South Korea Department of Electrical Electronic and Control Engineering Hankyong National University

We propose a novel method of slice image reconstruction with controllable spatial filtering by using the correlation of periodic delta-function arrays （PDFAs） with elemental images in computational integral imaging. The multiple PDFAs, whose spatial periods correspond to object＇s depths with the elemental image array （EIA）, can generate a set of spatially filtered EIAs for multiple object depths compared with the conventional method for the depth of a single object. We analyze a controllable spatial filtering effect by the proposed method. To show the feasibility of the proposed method, we carry out preliminary experiments for multiple objects and present the results.

关键词： image reconstruction with controllable spatial filtering based on correlation of multiple periodic functions in computational integral imaging EIA

Effect of natural extract eye drops in dry eye disease rats

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International Journal of Ophthalmology(English edition) 2020年第7期13卷 1023-1030页

作者： soo Youn Choi Youngsub Eom Jee Yong Kim Dong Hoon jang Jong Suk Song Hyo Myung Kim Department of Ophthalmology Korea University College of MedicineSeoul 02841Republic of Korea BGN World Tower Eye Clinic Seoul 05551Republic of Korea Department of Ophthalmology Korea University Ansan HospitalKorea University College of MedicineGyeonggi-do 15355Republic of Korea Medical O Co. Ltd.Seoul 06025Republic of Korea

AIM:To investigate the therapeutic effect of natural extract eye drops containing bee venom,musk,and deer antlers in dry eye disease(DED)animal ***:Scopolamine-injected DED rats and lacrimal gland-excised rats were allocated into control,saline,and natural extract groups respectively and a normal group(lacrimal gland excision was not performed)in lacrimal gland-excised *** eye drop instillation 4 times a day for 5 d,corneal fluorescein staining(CFS)scores,tear MUC5AC levels,and tear lactic dehydrogenase(LDH)levels were ***:In scopolamine-injected rats,the natural extract-treated group had significantly lower CFS scores(1.7±0.5,4.7±1.4,3.8±1.9,P=0.006)and tear LDH levels(0.10±0.01,0.19±0.01,0.16±0.08 OD,P=0.014)but higher tear MUC5AC levels(12.9±3.7,7.9±2.0,9.7±3.6 ng/m L,P=0.041)compared with the control and saline-treated *** were no significant differences between the control and saline-treated *** lacrimal gland-excised rats,the natural extract-treated group also had lower CFS scores(4.3±1.2,11.5±2.3,9.0±1.9,P<0.001,P=0.001)and tear LDH levels(0.30±0.08,0.48±0.12,0.39±0.05 OD,P<0.05)but higher tear volume(4.3±0.9,1.9±0.7,2.8±1.1 mm,P=0.005,P=0.124)and tear MUC5 AC levels(8.2±2.0,2.9±1.2,5.4±2.2 ng/m L,P<0.001,P=0.047)compared with the control and saline-treated *** were no significant differences in the CFS scores,tear MUC5AC level,and tear LDH level between the normal and natural extracttreated ***:The natural extract consisting of bee venom,musk,and deer antlers may have effectiveness in DED treatment by restoring the damaged ocular surface,increasing tear volume,and recovering the tear mucin layer in DED rats.

关键词： bee venom musk deer antler natural extract dry eye disease rat

Direct vapor phase growth process and robust photoluminescence properties of large area MoS2 layers

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Nano Research 2014年第12期7卷 1759-1768页

作者： V. Senthilkumar Le C. Tam Yong soo Kim Yumin Sim Maeng-Je Seong Joon. I. jang Department of Physics and Energy Harvest Storage Research Center (EHSRC) University ofUIsan Ulsan 680-749 South Korea Department of Physics Applied Physics and Astronomy Binghamton University New York 13902 USA Department of Physics Chung-Ang University Seoul 156-756 South Korea

There has been growing research interest in the use of molybdenum disulfide in the fields of optoelectronics and energy harvesting devices, by virtue of its indirect-to-direct band gap tunability. However, obtaining large area thin films of MoS2 for future device applications still remains a challenge. In the present study, the amounts of the precursors （S and MOO3） were varied systematically in order to optimize the growth of highly crystalline and large area MoS2 layers by the chemical vapor deposition method. Careful control of the amounts of precursors was found to the key factor in the synthesis of large area highly crystalline flakes. The thickness of the layers was confirmed by Raman spectroscopy and atomic force microscopy. The optical properties and chemical composition were studied by photoluminescence （PL） and X-ray photoelectron spectroscopy. The emergence of strong direct excitonic emissions at 1.82 eV （A-exciton, with a normalized PL intensity of -55 × 10^3） and 1.98 eV （B-exciton, with a normalized PL intensity of -5 × 10^3） of the sample at room temperature clearly indicates the high luminescence quantum efficiency. The mobility of the films was found to be 0.09 cm^2/（V.s） at room temperature. This study provides a method for the controlled synthesis of high-quality two-dimensional （2D） transition metal dichalcogenide materials, useful for applications in nanodevices, optoelectronics and solar energv conversion.

关键词： molybdenum disulfide CVD growth large area Raman photo-luminescence field-effect ransistor (FET)

Pharmacological advantages of melatonin in immunosenescence by improving activity of T lymphocytes

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The Journal of Biomedical Research 2016年第4期30卷 314-321页

作者： Yeong-Min Yoo Su Kil jang Gwang-Hoon Kim Jung-Youl Park Seong-soo Joo Department of Biomedical Engineering College of Health ScienceYonsei UniversityWonjuGangwon-do 220-710Republic of Korea College of Life Science Gangneung-Wonju National UniversityGangneungGangwon-do 210-702Republic of Korea Industry-Academic Cooperation Foundation Hanbat National UniversityDaejeon 305-719Republic of Korea

Melatonin plays a critical role in regulating photoperiodic signals and has recently been shown to decrease immunosenescence with age. In this study, we examined whether melatonin activates T lymphocytes as major adaptive immune cells in in vitro and in vivo models. Splenocytes, CD4＋, and naive CD4 T lymphocytes were isolated from the spleen of BALB/c mice and the cell population patterns and mRNA profiles associated with T cell activation （CD28 and p21） and the melatonin receptor （MT1A and MT1B） were assessed. The T cell activation- related proteins Ki67 and Bcl2 were also evaluated to confirm the relationship between gene and protein levels. Our data clearly revealed that CD28, p21, MT 1 A, and MT 1B mRNA were highly expressed in the presence of melatonin. Co-culture of CD4＋ T lymphocyte and peritoneal macrophage 7 days after melatonin administration to young and aged mice significantly increased APRIL mRNA, suggesting induction or maintenance of T lymphocyte responses. We also found that the intracellular amount of Ki67 and Bcl2 proteins were significantly upregulated in aged CD4＋ T lymphocytes, suggesting enhancing T cell proliferation and ling-term maintenance of memory T cells. Taken together, we conclude that melatonin supplementation may enhance immunity in aged individuals by upregulating immunosenescence indices in association with T lymphocytes and may be an attractive pharmacological candidate for aged and immunocompromised individuals.

关键词： melatonin aging CD4+ naive CD4 melatonin receptor

3D cell-printing of gradient multi-tissue interfaces for rotator cuff regeneration

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Bioactive Materials 2023年第1期19卷 611-625页

作者： Suhun Chae Uijung Yong Wonbin Park Yoo-mi Choi In-Ho Jeon Homan Kang Jinah jang Hak soo Choi Dong-Woo Cho Department of Mechanical Engineering Pohang University of Science and Technology77 Cheongam-roNam-guGyeongsangbuk-doPohang37673South Korea EDmicBio Inc. 111 Hoegi-roDongdaemun-guSeoul 02445South Korea Institute for Convergence Research and Education in Advanced Technology Yonsei University50 Yonsei-roSeodaemun-guSeoul03722South Korea Gordon Center for Medical Imaging Department of RadiologyMassachusetts General Hospital&Harvard Medical School14913th StreetBostonMA02114USA Department of Convergence IT Engineering Pohang University of Science and Technology77 Cheongam-roNam-guGyeongsangbuk-doPohang37673South Korea School of Interdisciplinary Bioscience and Bioengineering Pohang University of Science and Technology77 Cheongam-roNam-guGyeongsangbuk-doPohang37673South Korea Department of Orthopaedic Surgery Asan Medical CenterCollege of MedicineUniversity of Ulsan86 Asanbyeongwon-gilSongpa-guSeoul05505South Korea

Owing to the prevalence of rotator cuff(RC)injuries and suboptimal healing outcome,rapid and functional regeneration of the tendon-bone interface(TBI)after RC repair continues to be a major clinical *** the essential role of the RC in shoulder movement,the engineering of biomimetic multi-tissue constructs presents an opportunity for complex TBI reconstruction after RC ***,we propose a gradient cell-laden multi-tissue construct combined with compositional gradient TBI-specific bioinks via 3D cell-printing *** vitro studies demonstrated the capability of a gradient scaffold system in zone-specific inducibility and multi-tissue formation mimicking *** regenerative performance of the gradient scaffold on RC regeneration was determined using a rat RC repair *** particular,we adopted nondestructive,consecutive,and tissue-targeted near-infrared fluorescence imaging to visualize the direct anatomical change and the intricate RC regeneration progression in real time in ***,the 3D cell-printed implant promotes effective restoration of shoulder locomotion function and accelerates TBI healing in *** summary,this study identifies the therapeutic contribution of cell-printed constructs towards functional RC regeneration,demonstrating the translational potential of biomimetic gradient constructs for the clinical repair of multi-tissue interfaces.

关键词： 3D cell-printing Tissue-specific bioink Gradient tissue scaffolds Near-infrared fluorophores Rotator cuff repair

GSK-LSD1,an LSD1 inhibitor,quashes SARS-CoV-2-triggered cytokine release syndrome in-vitro

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Signal Transduction and Targeted Therapy 2020年第1期5卷 255-257页

作者： Kyung soo Hong June Hong Ahn Jong Geol jang Jong Ho Lee Hong Nam Kim Dongha Kim Wonhwa Lee Division of Pulmonology and Allergy Department of Internal MedicineCollege of MedicineYeungnam University and Regional Center for Respiratory DiseasesYeungnam University Medical CenterDaegu 42415Republic of Korea Department of Laboratory Medicine College of MedicineYeungnam UniversityYeungnam University Medical CenterDaegu 42415Republic of Korea Brain Science Institute Korea Institute of Science and Technology(KIST)Seoul 02792Republic of Korea Division of Bio-Medical Science and Technology KIST SchoolKorea University of Science and Technology(UST)Seoul 02792Republic of Korea Department of Anatomy College of MedicineThe Catholic University of KoreaSeoul 06591Republic of Korea Aging Research Center Korea Research Institute of Bioscience and BiotechnologyDaejeon 34141Republic of Korea

Dear Editor,Since the COVID-19 demonstrated a remarkable transmission speed and a high mortality risk,COVID-19 is currently declared as a pandemic by the World Health *** is the first time that the WHO has declared a pandemic since H1N1 in *** of 6 September 2020,the total number of COVID-19 patients is 26,763,217(876,616 deaths),and it continues to rise(https://***/).In spite of the urgent demand for the vaccines and therapeutics,global efforts are primarily focused on the utilization of the existing anti-viral drugs,such as remdesivir,hydroxychloroquine,and dexamethasone,to relieve the symptoms due to the limited development of renovative therapeutics.

关键词： drugs mortality cytokine