GSK-LSD1,an LSD1 inhibitor,quashes SARS-CoV-2-triggered cytokine release syndrome in-vitro

作     者：Kyung Soo Hong June Hong Ahn Jong Geol Jang Jong Ho Lee Hong Nam Kim Dongha Kim Wonhwa Lee Kyung Soo Hong;June Hong Ahn;Jong Geol Jang;Jong Ho Lee;Hong Nam Kim;Dongha Kim;Wonhwa Leep

作者机构：Division of Pulmonology and AllergyDepartment of Internal MedicineCollege of MedicineYeungnam University and Regional Center for Respiratory DiseasesYeungnam University Medical CenterDaegu 42415Republic of Korea Department of Laboratory MedicineCollege of MedicineYeungnam UniversityYeungnam University Medical CenterDaegu 42415Republic of Korea Brain Science InstituteKorea Institute of Science and Technology(KIST)Seoul 02792Republic of Korea Division of Bio-Medical Science and TechnologyKIST SchoolKorea University of Science and Technology(UST)Seoul 02792Republic of Korea Department of AnatomyCollege of MedicineThe Catholic University of KoreaSeoul 06591Republic of Korea Aging Research CenterKorea Research Institute of Bioscience and BiotechnologyDaejeon 34141Republic of Korea 

出 版 物：《Signal Transduction and Targeted Therapy》 (信号转导与靶向治疗（英文）)

年 卷 期：2020年第5卷第1期

页      面：255-257页

核心收录：

学科分类：0710[理学-生物学] 1007[医学-药学(可授医学、理学学位)] 1006[医学-中西医结合] 100706[医学-药理学] 100602[医学-中西医结合临床] 10[医学] 

基　　金：supported by a grant from the National Research Foundation of Korea(NRF)funded by the Ministry of Education(NRF-2020R1A4A4079817(to W.L.)and 2019R1C1C1004022(to D.K.) 

主　　题：drugs mortality cytokine 

摘      要：Dear Editor,Since the COVID-19 demonstrated a remarkable transmission speed and a high mortality risk,COVID-19 is currently declared as a pandemic by the World Health *** is the first time that the WHO has declared a pandemic since H1N1 in *** of 6 September 2020,the total number of COVID-19 patients is 26,763,217(876,616 deaths),and it continues to rise(https://***/).In spite of the urgent demand for the vaccines and therapeutics,global efforts are primarily focused on the utilization of the existing anti-viral drugs,such as remdesivir,hydroxychloroquine,and dexamethasone,to relieve the symptoms due to the limited development of renovative therapeutics.