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Cost effectiveness of nonpharmacological prevention programs for diabetes:A systematic review of trial-based studies

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Chronic Diseases and Translational Medicine 2024年第1期10卷 12-21页

作者： Yongyi xiong Zhaohua huo Samuel Y.S.Wong Benjamin H.K.Yip Jockey Club School of Public Health and Primary Care Prince of Wales HospitalThe Chinese University of Hong KongShatinHong KongChina

Trial-based economic value of prevention programs for diabetes is *** aimed to review the cost-effectiveness of nonpharmacological interventions to prevent type-2 diabetes mellitus(T2DM)for high-risk *** electronic databases were searched up to March *** assessing both the cost and health outcomes of nonpharmacological interventions for people at high-risk of T2DM were *** quality of the study was assessed by the Consolidated Health Economic Evaluation Reporting Standards 2022 *** primary outcome for synthesis was incremental cost-effectiveness ratios(ICER)for quality-adjusted life years(QALYs),and costs were standardized in 2022 US *** synthesis was performed,considering different types and delivery methods of *** studies included five based on the US diabetes prevention program(DPP),six on non-DPP-based lifestyle interventions,four on health education,and one on screening plus lifestyle *** with usual care,lifestyle interventions showed higher potential of cost-effectiveness than educational *** lifestyle interventions,DPP-based programs were less cost-effective(median of ICERs:$27,077/QALY)than non-DPP-based programs(median of ICERs:$1395/QALY)from healthcare perspectives,but with larger decreases in diabetes ***,the cost-effectiveness of interventions was more possibly realized through the combination of different delivery *** interventions to prevent T2DM in high-risk populations are both cost-effective and feasible in various ***,economic evidence from low-and middle-income countries is still lacking,and interventions delivered by trained laypersons and combined with peer support sessions or mobile technologies could be potentially a cost-effective solution in such settings with limited resources.

关键词： economic evaluation nonpharmacological interventions pre-diabetes prevention

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Sodium Sulfite as a Novel Hypoxia Revulsant Involved in Hypoxic Regulation in Escherichia coli

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Biomedical and Environmental Sciences 2024年第2期37卷 228-232页

作者： YE Qiao huo Jia Nan LUO Yuan MEI Zhu Song FANG Long Mei GUO Bing Qian WANG Guang Yun Laboratory of clinical medicine Air Force Medical CenterAir Force Medical UniversityBeijing 100142China

As a reducing salt,sodium sulfite could deprive oxygen in solution,which could mimic hypoxic stress in Caenorhabditis *** this study,the wildtype Escherichia coli strain MG1655 was used to examine the inhibition of so... 详细信息

关键词： hypoxic Sodium observing

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Capacity and Cooperation

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China Weekly 2024年第3期 26-29页

作者： huo Siyi 不详

On January 30,the China Electricity Council,a selfregulated national trade association of China's mostly State-owned power enterprises and institutions,published its yearly report,which projected that grid-connected wind and solar power would make up around 40 percentof installed power generation capacity by the end of 2024 and overtake coal for the first time in the country's power *** with nuclear and hydropower,non-fossil fuel power sources accounted for over half of total installed power capacity in 2023 for the first time in history,though coal still accounted for 60 percent of electricity generation.

关键词： owned Together mostly

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Mulberry leaf supplementation inhibits skatole deposition by regulating gut microbiota and upregulating liver cytochrome P4501A1 expression in finishing pigs

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Animal Nutrition 2024年第1期16卷 34-44页

作者： Yuqing Sun xiaoming Men Tianbao Lin Bo Deng Shi Zhong Jinxi huo Kaipeng Qin Zhiqiang Lv Ziwei xu Yougui Li Institute of Sericulture and Tea Zhejiang Academy of Agricultural Sciences298 Deshengzhong RoadShangchengHangzhou 310021China Institute of Animal Husbandry and Veterinary Science Zhejiang Academy of Agricultural Sciences298 Deshengzhong RoadShangchengHangzhou 310021China

Skatole,a strong fecal odor substance,is generated through microbial degradation of tryptophan in the animal *** easily accumulates in adipose tissue and affects meat *** this study,the effect of mulberry leaf supplementation on skatole in finishing pigs was *** a 35-day trial,20 finishing pigs(barrows and gilts)were fed with a basal diet or basal diet with 6%mulberry *** performance of the pigs(n=10)was automatically recorded by a performance-testing feeder system and 8 pigs in each treatment were slaughtered and sampled for the remaining *** and short-chain fatty acids were detected using HPLC and gas chromatography,*** microbiota were analyzed using 16S r RNA gene *** metabolomics analysis of feces and serum was performed with UHPLC-MS/*** major cytochrome P450(CYP)enzymes that catalyze skatole degradation in the liver were tested by using RT-PCR and Western *** of major bioactive compounds in mulberry leaves on the CYP genes were verified in the hepatic cell line Hep G2 in an in vitro test(n=3).In finishing pigs,mulberry leaf supplementation had no significant effect on the average daily gain,average daily feed intake,and feed conversion ratio(P>0.05),but reduced skatole levels in feces,serum,and backfat(Pxpression was increased(Pxpression in

关键词： Pig Skatole Mulberry leaf Microbiota Cytochrome P450

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Analysis of the History and Current Situation of the Development of General Practice Teaching Clinics in China

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Open Journal of Preventive Medicine 2024年第2期14卷 29-38页

作者： xiaotong huo Yajun Lian Graduate School Changzhi Medical College Changzhi China Department of Family Medicine Peace Hospital Changzhi Medical College Changzhi China

A summary of the exploration of the teaching mode of the general practice teaching clinic, a summary of the deficiencies of the teaching clinic and a summary of the significance of the establishment of the general practice teaching clinic are presented with a view to promoting the development of general practice and cultivating more excellent successors in general practice.

关键词： General Practice Teaching Clinic Teaching Models Teaching Deficiencies in the Clinic Significance of the Teaching Clinic

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Linear shallow neural network to accelerate transmitter dispersion eye closure quaternary(TDECQ) assessment

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Science China(Information Sciences) 2024年第4期67卷 337-338页

作者： Junjiang xIANG Zejun CHEN Yijun CHENG Hailin YANG xuancheng huo Meng xIANG Gai ZHOU Yuwen QIN Songnian FU Institute of Advanced Photonics Technology School of Information EngineeringGuangdong University of Technology School of Optical and Electronic Information Huazhong University of Science and Technology Key Laboratory of Photonic Technology for Integrated Sensing and Communication Ministry of Education of ChinaGuangdong University of Technology Guangdong Provincial Key Laboratory of Information Photonics Technology Guangdong University of Technology

To support the ever-emerging capacity requirement of datacenter interconnection(DCI) applications, transmitter dispersion eye closure quaternary(TDECQ) has been proposed by IEEE802.3 standard [1], which is specifically employed for the four-level pulse amplitude modulation(PAM-4) signals. However, the traditional scheme of TDECQ assessment needs several iterative operations,

关键词： IEEE Standards

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More than just aligning the teeth:Clear aligners with multifunctional prowess

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Nano Research 2024年第8期17卷 7665-7674页

作者： Yang Chen Lei-Ming Cao Nian-Nian Zhong Zi-Zhan Li Lin-Lin Bu Fang-Yi huo Hong He State Key Laboratory of Oral and Maxillofacial Reconstruction and Regeneration Key Laboratory of Oral Biomedicine Ministry of EducationHubei Key Laboratory of StomatologySchool and Hospital of StomatologyWuhan UniversityWuhan 430079China Department of Oral and Maxillofacial-Head Neck Oncology School and Hospital of StomatologyWuhan UniversityWuhan 430079China Department of Zhuankou Clinical Branches School and Hospital of StomatologyWuhan UniversityWuhan 430000China Department of Orthodontics School and Hospital of StomatologyWuhan UniversityWuhan 430079China

With the increasing demand for beauty and health,clear aligners(CAs)have been widely applied among patients with ***,patients treated with CAs also face some potential complications,such as demineralization,dental caries,and periodontal *** addition,some patients have additional needs to improve their quality of life,such as bleaching *** order to prevent or solve these problems,the modification of CAs is a promising method because their extensive long-term contact with tooth surfaces makes them ideal devices for implementing adjuvant medical *** this review,we discuss various advanced CAs with medical functions based on the clinical needs of *** far as we know,the additional functions of CAs mainly include antibacterial,remineralization,whitening,and accelerating tooth *** functions are achieved by two major pathways,the combination of CAs with drugs/biomaterials and increasing the capacity or affinity of *** addition,we discuss the current limitations of in vitro experiments which are designed to explore the effectiveness and properties of novel CAs,and the challenges of bringing a multifunctional appliance from proposal to clinical *** the end of this review,we provide insights into the broader prospects for the improvement of CAs.

关键词： advanced clear aligners medical device modification drug delivery system personalized medicine

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Current collapse suppressed GaN diodes with 38 Watts high RF power rectifier capability

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Science China(Information Sciences) 2024年第2期67卷 335-336页

作者： Kui DANG Zhilin QIU Shudong huo Peng ZHAN Huining LIU Yachao ZHANG Jing NING Hong ZHOU Jincheng ZHANG Key Lab of Ministry of Education for Wide Band-Gap Semiconductor Materials and Devices School of MicroelectronicsXidian University Guangzhou Wide Bandgap Semiconductor Innovation Center Guangzhou Institute of TechnologyXidian University

Microwave power transmission(MPT) could realize the point-to-point long-distance transfer of energy without any wires, which makes it attractive for solar-powered satellites,drones, and implantable medical devices, and has aroused enormous attention [1]. Microwave rectifiers could convert RF(radio frequency) energy into DC(direct current) power,

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Incorporating metal nanoparticles in porous materials via selective heating effect using microwave

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Nano Research 2024年第4期17卷 3175-3179页

作者： Yingyu Zhou Jiacheng Liu Fuyuan Sun Junchen Ouyang Ruifa Su Fanchen Meng Yongqi Luo Cheng xu Weina Zhang Suoying Zhang Fengwei huo Key Laboratory of Flexible Electronics(KLOFE)&Institute of Advanced Materials(IAM) Nanjing Tech UniversityNanjing 211816China

Metal nanoparticle@porous material composites have attracted increasing attention due to their excellent synergistic catalytic ***,it is a challenge to introduce metal nanoparticles into cavities of porous materials without agglomeration on the *** the progress achieved,a universal approach that can integrate different kinds of metal nanoparticles and porous materials is still highly *** we report a facile and general approach to fabricating metal nanoparticle@porous materials by microwave-triggered selective *** microwave can pass through the non-polar solvent and act on the polar solvent in the porous materials,causing the polar solvent to be heated,vaporized,and away from the pores of porous *** local void produced by the escape of polar solvent facilitates non-polar solvent containing metallic precursor to be dragged into the narrow pores,followed by further reduction,resulting in the complete encapsulation of nanoparticles.A series of metal nanoparticles@porous materials,ranging from metal-organic frameworks(MOFs)to zeolites,are successfully prepared by this method and show excellent size selectivity in catalytic reactions.

关键词： porous material nanoparticle encapsulation microwave synthesis selective heating effect selective catalysis

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Lysinuric protein intolerance with novel mutations in solute carrier family 7A member 7 in a Chinese family

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Pediatric Investigation 2024年第2期8卷 149-153页

作者： Yilin Pang Feng huo xiao Liu Yimu Fan Zhezhe Zhang Jie Wu Quan Wang Emergency Department Emergency Intensive Care UnitBeijing Children’s HospitalCapital Medical UniversityNational Center for Children’s HealthBeijingChina

Introduction:Lysinuric protein intolerance(LPI)is a rare genetic disorder caused by mutations in the solute carrier family 7A member 7(SLC7A7)*** presentation:We presented two siblings with LPI,carrying novel mutations of c.776delT(p.L259Rfs*18)and c.155G>T(p.G52V)in *** younger sibling,preferring protein-rich foods,showed severe symptoms,including alveolar proteinosis,macrophage activation syndrome,severe diarrhea,and disturbance of consciousness with involuntary *** contrast,the elder sibling only had mild symptoms,likely due to aversion to protein-rich food since toddler ***:LPI is a congenital genetic metabolic disease with multisystem *** appropriate protein-restricted diet therapy as soon as possible could help prevent the progression of LPI.

关键词： Diet Lysinuric protein intolerance Pulmonary alveolar proteinosis SLC7A7

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