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C-phycocyanin shows neuroprotective effect against rotenone-induced Parkinson’s disease in mice

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Asian Pacific Journal of Tropical Biomedicine 2024年第7期14卷 279-287页

作者： Hritik rathod Ritu M.Soni Jigna S.Shah Department of Pharmacology Institute of Pharmacy Nirma UniversityAhmedabadGujaratIndia

Objective:To investigate the neuroprotective effect of C-phycocyanin in a mouse model of rotenone-induced Parkinson’s ***:C-phycocyanin(50 mg/kg,i.p.,daily)was administered to rotenone(30 mg/kg,p.o.,daily)treated mice for 28 *** studies(Y-maze,rotarod,round beam walk,and wire-hang tests)were carried out to assess neurobehavioral *** and malondialdehyde were determined in both serum and striatal *** proteins(AKT,AMPK,NF-κB,BDNF,and alpha-synuclein)in the striatum were estimated using *** analyses(hematoxylin and eosin stainning as well as Nissl staining)were carried out to assess structural abnormalities in the ***:C-phycocyanin significantly increased BDNF levels and decreased alpha-synuclein *** also slightly upregulated AMPK and AKT levels without significant difference compared with the rotenone ***,rotenone-induced elevated oxidative stress and structural abnormalities in the striatum were markedly mitigated by ***:C-phycocyanin might have potential neuroprotective effects against Parkinson’s *** studies are warranted to verify its efficacy and to understand the molecular mechanisms behind the neuroprotective effects of C-phycocyanin in Parkinson’s disease.

关键词： Parkinson’s disease C-phycocyanin Alphasynuclein BDNF Oxidative stress Rotenone

Active and passive modulation of solar light transmittance in a uniquely multifunctional dual-band single molecule for smart window applications

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Journal of Energy Chemistry 2024年第1期88卷 293-305,I0007页

作者： Pooja V.Chavan Pramod V.rathod Joohyung Lee Sergei V.Kostjuk Hern Kim Department of Energy Science and Technology Environmental Waste Recycle InstituteMyongji UniversityYonginGyeonggi-do 17058Republic of Korea Department of Chemical Engineering Myongji UniversityYonginGyeonggi-do 17058Republic of Korea Research Institute for Physical Chemical Problems of the Belarusian State University MinskBelarus

Functional materials may change color by heat and electricity separately or simultaneously in smart *** materials have not only demonstrated remarkable potential in the modulation of solar radiation but are also leading to the development of indoor environments that are more comfortable and conducive to improving individuals'quality of ***,dual-responsive materials have not received ample research attention due to economic and technological *** a consequence,the broader utilization of smart windows faces *** address this new generational multistimulus responsive chromic materials,our group has adopted a developmental strategy to create a poly(NIPAM)n-HV as a switchable material by anchoring active viologen(HV)onto a phase-changing poly(NIPAM)n-based smart material for better utility and *** constructed smart windows facilitate individualistic reversible switching,from a highly transparent state to an opaque state(thermochromic)and a red state(electrochromic),as well as facilitate a simultaneous dual-stimuli response reversible switching from a clear transparent state to a fully opaque(thermochromic)and orange(electrochromic)*** privacy can be attained in smart windows designed for exclusive settings by achieving zero *** unique chromic mode operates independently and modulates visible and near-infrared(NIR)light in a distinct ***,these smart windows with thermal and electric dual-stimuli responsiveness demonstrate remarkable heat regulation capabilities,rendering them highly attractive for applications in building facades,energy harvesting,privacy protection,and color display.

关键词： Smart windows Thermochromism Electrochromism Energy saving Dual-responsive material

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万寿菊纤维:新一代天然纤维

国际纺织导报 2022年第4期50卷 3-5页

作者： O.Sadalkar R.Shinde a.rathod R.Sawant 权家友(译) 于俊荣(校) 贾瓦哈拉尔达尔达工程与技术研究所印度不详

天然纤维因具有可再生和环保等特性,日益受到人们的重视。研究了一种具有独特物理性能的环保型新型天然纤维,它以万寿菊茎为原料,适用于纺织及其相关领域的各种应用。研究的主要目的是在纺织工业中引入新型纤维,以制备具有独特物理力学... 详细信息

天然纤维因具有可再生和环保等特性,日益受到人们的重视。研究了一种具有独特物理性能的环保型新型天然纤维,它以万寿菊茎为原料,适用于纺织及其相关领域的各种应用。研究的主要目的是在纺织工业中引入新型纤维,以制备具有独特物理力学性能的非织造布与复合材料产品。这种新型天然纤维是采用水沤法工艺从万寿菊植物的茎中提取的。介绍了万寿菊纤维的提取方法,测试分析了纤维线密度、回潮率、扭转刚度和弯曲刚度等物理特性。

关键词：天然纤维万寿菊纤维水沤法纤维提取

Catatonia:A deep dive into its unfathomable depths

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World Journal of Psychiatry 2024年第2期14卷 210-214页

作者： Peter Phiri Gayathri Delanerolle Oliver Hope Tharangini Murugaiyan Geoffrey Dimba Shanaya.rathod Zukiswa Zingela Research&Innovation Department Southern Health NHS Foundation TrustSouthampton SO303JBUnited Kingdom School of Psychology Faculty of Environmental and Life SciencesUniversity of SouthamptonSouthampton SO171BJHampshireUnited Kingdom Acute Inpatients Services Southern Health NHS Foundation TrustBasingstoke RG249RHUnited Kingdom Home Treatment Team South WestSurrey and Borders Partnerships NHS Foundation TrustGuildford GU27XLSurreyUnited Kingdom Faculty of Health Sciences Nelson Mandela UniversitySummerstrand 6001GqeberhaSouth Africa

This editorial addresses catatonia,a complex neuropsychiatric syndrome characterised by a spectrum of psychomotor *** editorial seeks to clarify the ambiguous aspects of catatonia,integrating recent research findings,including global studies and diagnostic *** discusses catatonia’s clinical manifestations,prevalence,and associated psychiatric and medical conditions,with particular emphasis on its frequent co-occurrence with schizophrenia and mood *** prevalence of catatonia,which varies across psychiatric populations,is illustrated by a significant study conducted in Nelson Mandela Bay,South *** study provides valuable insights into the effectiveness of the Bush-Francis Screening Instrument compared to the Diagnostic and Statistical Manual 5 criteria in diagnosing *** editorial evaluates treatment approaches,primarily focusing on benzodiazepines and electroconvulsive therapy,and discusses emerging therapeutic *** underscores the importance of robust diagnostic frameworks and early intervention in managing catatonia,as recommended by the latest evidence-based consensus ***,it suggests future research directions,particularly in exploring the neurobiological and genetic factors of catatonia,to enhance our understanding and improve treatment *** editorial succinctly aims to demystify catatonia and provide valuable insights for clinicians and researchers in mental health care.

关键词： Catatonia Schizophrenia Neuropsychiatry Benzodiazepines Electroconvulsive therapy Bush-Francis screening instrument Diagnosis

Liver transplantation for hepatocellular carcinoma in India: Are we ready for 2040?

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World Journal of Transplantation 2024年第1期14卷 141-153页

作者： Hirak Pahari Amruth Raj Ambreen Sawant Dipak S Ahire Raosaheb rathod Chetan Rathi Tushar Sankalecha Sachin Palnitkar Vikram Raut Department of Liver Transplant and HPB Surgery Medicover HospitalsNavi Mumbai 410210MaharashtraIndia Department of Liver Transplant Anaesthesia Medicover HospitalsNavi Mumbai 410210MaharashtraIndia Department of Gastroenterology and Hepatology Medicover HospitalsNavi Mumbai 410210India Department of Gastroenterology and Hepatology Medicover HospitalsNavi Mumbai 410210MaharashtraIndia Department of Gastroenterology and Hepatology Medicover HospitalsAurangabad 431003India Department of Gastroenterology and Hepatology Medicover HospitalsNashik 422009India Department of Gastroenterology and Hepatology Medicover HospitalsPune 411026India

BACKGROUND Liver transplantation(LT)for hepatocellular carcinoma(HCC)has been widely researched and is well established *** cornerstone of this treatment lies in the various criteria formulated by expert consensus and *** variations among the criteria are staggering,and the short-and long-term outcomes are *** To study the differences in the current practices of LT for HCC at different centers in India and discuss their clinical implications in the *** We conducted a survey of major centers in India that performed LT in December 2022.A total of 23 responses were *** centers were classified as high-and low-volume,and the current trend of care for patients undergoing LT for HCC was *** Of the 23 centers,35%were high volume center(>500 Liver transplants)while 52%were high-volume centers that performed more than 50 transplants/*** 39%of centers had performed>50 LT for HCC while the percent distribution for HCC in LT patients was 5%–15%in approximately 73%of the *** a few,most centers were divided equally between University of California,San Francisco(UCSF)and center-specific criteria when choosing patients with HCC for LT,and most(65%)did not have separate transplant criteria for deceased donor LT and living donor LT(LDLT).Most centers(56%)preferred surgical resection over LT for a Child A cirrhosis patient with a resectable 4 cm HCC ***-emission tomography-computed tomography(CT)was the modality of choice for metastatic workup in the majority of centers(74%).Downstaging was the preferred option for over 90%of the centers and included transarterial chemoembolization,transarterial radioembolization,stereotactic body radiotherapy and atezolizumab/bevacizumab with varied *** alphafetoprotein(AFP)cut-off was used by 74%of centers to decide on transplantation as well as to downstage tumors,even if they met the *** criteria for successful downstaging v

关键词： Hepatocellular carcinoma Liver transplant India Downstaging Survey Milan University of California,San Francisco Portal vein tumor thrombus Expanded criteria

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赤色意象印度Hampi艺术实验室

室内设计与装修 2024年第10期 70-75页

作者：无 Aagam Mehta(摄影) Kartik rathod(摄影) Kunal Sharma(摄影) Sameep Padora(摄影) 小麦(译) sP+a 不详

Hampi艺术实验室归属于JSW基金会,它坐落在印度卡纳塔克邦维贾亚纳加尔市,占地面积超过20000m^(2)。项目的设计灵感源自通加巴德拉河沿岸的景观,是对周围山丘的意象雕琢。据建筑师介绍,该项目的核心是一个“流动空间”的概念。

关键词：占地面积流动空间卡纳塔克邦意象设计灵感印度

Association of retreating monsoon and extreme air pollution in a megacity

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Journal of Environmental Sciences 2021年第8期33卷 97-104页

作者： Gufran Beig Aditi rathod Suvarna Tikle Sujit Maji S.B.Sobhana Indian Institute of Tropical Meteorology Ministry of Earth SciencesPune 411008India

The world’s top ranked mega city Delhi is known for deteriorated air ***,the analysis of air pollution data of 5 years(2014–2018)reveals that years 2016 and 2017,which were marked by an unusual delayed withdrawal of monsoon,witnessed an unprecedented extreme levels of toxic PM2.5 particles(≤2.5μm in diameter)touching a peak level of~760μg/m3(24 hr average),immediately after the monsoon retreat,surpassing WHO standards by~30 time and Indian national standards by~12 times,jeopardising lives of its ***,the normal monsoon withdrawal years do not show such extreme levels of *** high resolution WRF-Chem model along with meteorological data are used in this work to understand that how the delayed monsoon withdrawal and associated vagarious anticyclonic circulation resulted in trapping externally generated pollutants ceaselessly under colder conditions,leading to historic air quality crisis in landlocked mega city in these selected *** sensitivity analysis confirmed that when WRF-chem model forced the climatology of normal monsoon year(2015)to simulate the pollution scenario of 2016 and 2017 for the above time period,the crisis *** findings suggest that such unusual monsoon patterns are on the hook to spur extreme pollution events in recent time.

关键词： Monsoon Air pollution Climatology WRF-Chem Extreme events PM2.5

Metallurgical Behaviour and Carbon Diffusion in Buttering Deposits Prepared With and Without Buffer Layers

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Acta Metallurgica Sinica(English Letters) 2017年第2期30卷 120-132页

作者： Dinesh W.rathod Sunil Pandey Sivanandam Aravindan Pavan Kumar Singh Department of Mechanical Engineering Indian Institute of Technology Delhi Hauz-Khas New Delhi 110016 India School of MACE University of Manchester Manchester M13 9PL UK Bhabha Atomic Research Centre Mumbai 400085 India

Use of a buttering deposit on ferritic steel in dissimilar metal weld（DMW） joint is a common practice in nuclear plants to connect pressure vessel components（ferritic steel） to pipelines（austenitic stainless steel）.Carbon migration and metallurgical changes near fusion interface（ferritic steel–austenitic stainless steel） lead to a steeper gradient in material properties,and minimizing this gradient is the major challenge in the manufacturing of DMW *** 82 is often deposited on ferritic steel material as buttering to reducing the gradient of physical and attaining material *** 82/182 fillers are used to minimize the carbon migration,but the results are not truly *** this paper,Ni–Fe alloy（chromium-free） has been used as the intermediate buffer layer in the weld buttering deposit to address the issue of carbon migration and subsequent metallurgical *** weld pads with and without buffer layers of Ni–Fe alloy have been investigated and compared in detail for metallurgical properties and carbon ***–Fe buffer layer can significantly control the carbon migration which resists the metallurgical *** showed the better results in postweld heat treatment and thermally aged *** buttering deposit with Ni–Fe buffer layer could be the better choice for DMW joints requirements.

关键词： Dissimilar welds Buttering Carbon diffusion Buffer layer Metallurgical properties

Ultrasound-assisted intensified aqueous extraction of phenolics from waste Syzygium cumini leaves:Kinetic studies and evaluation of antioxidant,antidiabetic and anticancer potential

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Food Bioscience 2022年第2期46卷 594-604页

作者： Komal V.Mahindrakar Virendra K.rathod Department of Chemical Engineering Institute of Chemical TechnologyMatunga(E)Mumbai400019India

This is the first report illustrating the extraction of total phenolic compounds(TPC)using the ultrasound-assisted aqueous extraction(USAE)technique from waste Syzygium cumini leaves(WSCL).A kinetic study indicated that Peleg’s model was appropriately fitted to the experimental data when the effect of different parameters was checked on extraction with respect to *** yields of total phenolic contents(TPC)and total flavonoid contents(TFC)were 78.38 mg GAE/g,and 10.15 mg CE/g,respectively,at optimized parameters of 1:25 WSCL:water,35℃ temperature,134 W power,50%duty cycle and in 9 min of sonication *** yields of TPC and TFC obtained by 5 sequential stirred batch extraction were 79.36 mg GAE/g and 10 mg CE/g,*** cost and energy requirement of the USAE process was around 3000 times less than that of the Soxhlet *** images showed the changes in the morphology of the WSCL surface area before and after ultrasonic *** analysis showed the presence of O-H,N-H,C-H,C=C,and halogenated functional *** obtained WSCL extract showed antioxidant potential with an IC_(50) value of 15.64μg/***_(50) values of extract forα-amylase andα-glucosidase inhibitions were 8.3 and 6.64μg/*** activity against breast,cervical,and lung cancer showed the potential with GI50 values 252.8,112.5,and 97.8μg/mL,*** extract of Syzygium cumini leaves can be used to treat oxidative stress,diabetes,and cancer.

关键词： Syzygium cumini leaves Ultrasound-assisted extraction Antioxidant phenolic compounds Anticancer activity Antidiabetic activity