Ultrasound-assisted intensified aqueous extraction of phenolics from waste Syzygium cumini leaves:Kinetic studies and evaluation of antioxidant,antidiabetic and anticancer potential

作     者：Komal V.Mahindrakar Virendra K.Rathod 

作者机构：Department of Chemical EngineeringInstitute of Chemical TechnologyMatunga(E)Mumbai400019India 

出 版 物：《Food Bioscience》 (食品生物科学（英文）)

年 卷 期：2022年第46卷第2期

页      面：594-604页

核心收录：

学科分类：0832[工学-食品科学与工程（可授工学、农学学位）] 081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 070303[理学-有机化学] 0703[理学-化学] 

基　　金：The authors gratefully acknowledge the University Grants Commission(UGC)India for providing financial assistance in the research work.‘In vitro testing for anticancer activity evaluation of drugs was done at Anti-Cancer Drug screening facility(ACDSF)at ACTREC Tata Memorial Centre Navi Mumbai’ 

主　　题：Syzygium cumini leaves Ultrasound-assisted extraction Antioxidant phenolic compounds Anticancer activity Antidiabetic activity 

摘      要：This is the first report illustrating the extraction of total phenolic compounds(TPC)using the ultrasound-assisted aqueous extraction(USAE)technique from waste Syzygium cumini leaves(WSCL).A kinetic study indicated that Peleg’s model was appropriately fitted to the experimental data when the effect of different parameters was checked on extraction with respect to *** yields of total phenolic contents(TPC)and total flavonoid contents(TFC)were 78.38 mg GAE/g,and 10.15 mg CE/g,respectively,at optimized parameters of 1:25 WSCL:water,35℃ temperature,134 W power,50%duty cycle and in 9 min of sonication *** yields of TPC and TFC obtained by 5 sequential stirred batch extraction were 79.36 mg GAE/g and 10 mg CE/g,*** cost and energy requirement of the USAE process was around 3000 times less than that of the Soxhlet *** images showed the changes in the morphology of the WSCL surface area before and after ultrasonic *** analysis showed the presence of O-H,N-H,C-H,C=C,and halogenated functional *** obtained WSCL extract showed antioxidant potential with an IC_(50) value of 15.64μg/***_(50) values of extract forα-amylase andα-glucosidase inhibitions were 8.3 and 6.64μg/*** activity against breast,cervical,and lung cancer showed the potential with GI50 values 252.8,112.5,and 97.8μg/mL,*** extract of Syzygium cumini leaves can be used to treat oxidative stress,diabetes,and cancer.