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The presence and outcome of biliary sphincter disorders in liver-transplant recipients according to the Rome IV classification

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Gastroenterology Report 2021年第4期9卷 299-305,I0001页

作者： Alejandro Fernandez-Simon Oriol Sendino Karina Chavez-Rivera Henry Córdova Jordi Colmenero Gonzalo Crespo Yilliam Fundora Franco Samaniego Pablo Ruiz Constantino Fondevila.miquel Navasa Andrés Cárdenas GI Unit Institut Clı´nic de Malalties Digestives i MetaboliquesHospital Clı´nicUniversity of BarcelonaBarcelonaSpain Institut d’Investigacions Biomèdiques August Pi-Sunyer(IDIBAPS)and Ciber de Enfermedades Hepáticas y Digestivas(CIBEREHD) BarcelonaSpain Liver Transplant Unit Institut Clínic de Malalties Digestives i MetabóliquesHospital ClínicUniversity of BarcelonaBarcelonaSpain

Background Biliary sphincter disorders after liver transplantation(LT)are poorly *** aim to describe the presence and outcome of patients with papillary stenosis(PS)and functional biliary sphincter disorders(FBSDs)after LT according to the updated Rome IV *** We reviewed all endoscopic retrograde cholangiopancreatographies(ERCPs)performed in LT recipients between January 2003 and December *** on clinical and endoscopic findings was obtained from electronic health records and endoscopy *** and clinical findings were collected at the time of ERCP and 1 month after *** Among the 1,307 LT recipients,336 underwent 849 ***(1.0%)patients met the updated Rome IV criteria for PS[former sphincter of Oddi dysfunction(SOD)type I]and 14 patients(1.0%)met the Rome IV criteria for FBSD(former SOD type II).Biliary sphincterotomy was performed in 13 PS and 10 FBSD *** month after sphincterotomy,bilirubin,gamma-glutamyl transferase and alkaline phosphatase levels decreased in 85%,61%,and 92%of those in the PS group(P¼0.019,0.087,and 0.003,respectively)and in 50%,70%,and 80%of those in the FBSD group(P¼0.721,0.013,and 0.093,respectively).All the 14 patients initially suspected of having a FBSD turned out to have a different diagnosis during the *** PS after LT is uncommon and occurs in only 1%of LT *** data do not support the presence of an FBSD after *** is a safe and effective procedure in LT recipients with PS.

关键词： sphincter of Oddi dysfunction liver transplantation biliary sphincterotomy papillary stenosis functional biliary sphincter disorder

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SUMOylation Inhibition Mediated by Disruption of SUMO El-E2 Interactions Confers Plant Susceptibility to Necrotrophic Fungal Pathogens

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Molecular Plant 2017年第5期10卷 709-720页

作者： Laura Castano-miquel Abraham Mas Ines Teixeira Josep Segui Anna Perearnau Bhagyasree N. Thampi Arnaldo L. Schapire Natalia Rodrigo Gaelle La Verde Silvia Manrique Maria Coca L. Maria Lois Center for Research in Agricultural Genomics - CRAG Edifici CRAG-Campus UAB Bellaterra (Cerdanyola del Vall~s) 08193 Barcelona Spain

Protein modification by SUMO modulates essential biological processes in eukaryotes. SUMOylation is facilitated by sequential action of the El-activating, E2-conjugating, and E3-1igase enzymes. In plants, SUMO regulates plant development and stress responses, which are key determinants in agricultural productivity. To generate additional tools for advancing our knowledge about the SUMO biology, we have developed a strategy for inhibiting in vivo SUMO conjugation based on disruption of SUMO El-E2 interactions through expression of E1 SAE2uFDct domain. Targeted mutagenesis and phylogenetic analyses revealed that this inhibition involves a short motif in SAE2uFDct highly divergent across kingdoms. Transgenic plants expressing the SAE2UFDCt domain displayed dose-dependent inhibition of SUMO conjugation, and have revealed the existence of a post-transcriptional mechanism that regulates SUMO E2 conjugating enzyme levels. Interestingly, these transgenic plants displayed increased suscep- tibility to necrotrophic fungal infections by Botrytis cinerea and Plectosphaerella cucumerina. Early after fungal inoculation, host SUMO conjugation was post-transcriptionally downregulated, suggesting that targeting SUMOylation machinery could constitute a novel mechanism for fungal pathogenicity. These findings support the role of SUMOylation as a mechanism involved in plant protection from environmental stresses. In addition, the strategy for inhibiting SUMO conjugation in vivo described in this study might be applicable in important crop plants and other non-plant organisms regardless of their genetic complexity.

关键词： SUMQ inhibition development flowering necrotrophic fungi El-activating enzyme El-E2interaction disruption

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Multilevel Modular DCIDC Converter for Regenerative Braking Using Supercapacitors

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Journal of Energy and Power Engineering 2012年第7期6卷 1131-1137页

作者： miquel Massot-Campos Daniel Montesinos-Miracle Joan Bergas-Jane Alfred Rufer Centre d'lnnovacio Tecnologica en Convertidors Estatics i Accionaments (CITCEA-UPC) Departament d'Enginyeria Electrica Universitat Politecnica de Catalunya ETS d'Enginyeria Industrial de Barcelona Barcelona 08028 Spain Laboratoire d'Electronique Industrielle Ecole Polytechnique Federal de Lausanne (LEI-EPFL) Lausanne CH-1015 Switzerland

Regenerative braking is presented in many electric traction applications such as electric and hybrid vehicles, lifts and railway. The regenerated energy can be stored for future use, increasing the efficiency of the system. This paper outlines the benefits of the MMC （modular multilevel converter） in front of the cascaded or series connection of converters to achieve high voltage from low voltage storage elements such as supercapacitors. The paper compares three different solutions and shows that the MMC can benefit from weight and volume reduction of the output inductance when shifted switching modulation strategy is used. Using this modulation strategy, not only the output frequency is increased, but also the magnitude of the inductor applied voltage is reduced, reducing inductor size and volume.

关键词： Multilevel converters power converters for EV power converters for HEV supercapacitors.

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Personalization on the TV on Demand

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Journalism and Mass Communication 2011年第1期1卷 43-47页

作者： Antoni Bibiloni Coil miquel Mascaro Portells Pere Antoni Palmer Rodriguez University of Balearic Islandsm Spain

The Interactive Intemet TV Project is intended to be a web tool for publishing, indexing and viewing videos; that offers ontology based recommendations. The application has been developed and tested as a platform for e-learning in a univerasity context and in Optiva Media Company. It combines expertise in education and television to develop a prototype,., where the contents are generated using an automatic recommendation model based on personal profiles of each user; and that can be accessed from different devices： computers, mobile phones and so on.

关键词： content-based retrieval MPEG-7 ontologies recommendation IPTV Java mobile devices

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lpxA/lpxC/lpxD基因突变致鲍曼不动杆菌耐多黏菌素作用机制

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中国感染与化疗杂志 2015年第6期15卷 569-574页

作者：张文利 Joan-miquel Balada-Llasat Vijay Pancholi Bhowmik Aurosree Bhavani Gopalakrishnan Preeti Pancholi 中国新疆乌鲁木齐市第一人民医院(乌鲁木齐儿童医院)检验科乌鲁木齐830002 美国俄亥俄州立大学Wexner医学中心病理部微生物科美国俄亥俄州立大学Wexner医学中心病理部

目的探讨细胞膜脂质A生物合成基因lpxA/lpxC/lpxD突变导致鲍曼不动杆菌临床株对多黏菌素耐药的机制。方法用透射电子显微镜(TEM)观察细菌细胞壁、细胞内外膜的变化;用气相色谱(GC)法定量测定脂肪酸含量观察脂多糖(LPS)的变化。此外,用... 详细信息

目的探讨细胞膜脂质A生物合成基因lpxA/lpxC/lpxD突变导致鲍曼不动杆菌临床株对多黏菌素耐药的机制。方法用透射电子显微镜(TEM)观察细菌细胞壁、细胞内外膜的变化;用气相色谱(GC)法定量测定脂肪酸含量观察脂多糖(LPS)的变化。此外,用分子生物学方法确定菌株编码细胞膜脂质生物合成的lpxA/lpxC/lpxD基因突变。结果 TEM显示多黏菌素耐药鲍曼不动杆菌细胞外膜和内膜完整性降低,失去细胞壁膜间隙的均一性。GC结果表明短碳链饱和脂肪酸和脂肪酸醇有下降趋势,且几乎失去了所有的未知脂肪酸,但长碳链饱和、不饱和脂肪酸和脂肪酸醇的量都增加了。参与细胞膜脂质生物合成的lpx、lpxC和lpxD基因发现有缺失、点突变和插入等改变。结论多黏菌素耐药鲍曼不动杆菌存在lpxA/lpxC/lpxD基因突变及细胞内外膜改变。

关键词：鲍曼不动杆菌基因突变多黏菌素耐药

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Hepatitis B surface antigen and hepatitis B core-related antigen kinetics after adding pegylated-interferon to nucleos(t)ids analogues in hepatitis B e antigen-negative patients

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World Journal of Hepatology 2020年第11期12卷 1076-1088页

作者： Teresa Broquetas Montserrat Garcia-Retortillo miquel Mico Lidia Canillas Marc Puigvehi Nuria Canete Susana Coll Ana Viu Juan Jose Hernandez Xavier Bessa JoseA Carrion Department of Gastroenterology Liver SectionHospital del Mar Medical Research InstituteBarcelona 08003Spain Departament of de Medicina Universitat Autònoma de BarcelonaBarcelona 08003Spain Laboratori de Referencia de Catalunya El Prat de LlobregatBarcelona 08820Spain

BACKGROUND Hepatitis B e antigen-negative chronic hepatitis B patients under nucleos(t)ids analogues(NAs)rarely achieve hepatitis B surface antigen(HBsAg)*** To evaluate if the addition of pegylated interferon(Peg-IFN)could decrease HBsAg and hepatitis B core-related antigen(HBcrAg)levels and increase HBsAg loss rate in patients under NAs *** Prospective,non-randomized,open-label trial evaluating the combination of Peg-IFN 180μg/week plus NAs during forty-eight weeks vs NAs in *** B e antigen-negative non-cirrhotic chronic hepatitis B patients of a tertiary hospital,under NAs therapy for at least 2 years and with undetectable viral load,were *** with hepatitis C virus,hepatitis D virus or human immunodeficiency virus co-infection and liver transplanted patients were *** and HBcrAg levels(log10 U/mL)were measured at baseline and during ninety-six *** loss rate was evaluated in both *** events were recorded in both *** kinetic of HBsAg for each treatment group was evaluated from baseline to weeks 24 and 48 by the slope of the HBsAg decline(log10 IU/mL/week)using a linear regression *** Sixty-five patients were enrolled,61%receiving tenofovir and 33%***-six(55%)were included in Peg-IFN-NA group and 29(44%)in NA *** matching by age and treatment duration,baseline HBsAg levels were comparable between groups(3.1 vs 3.2)(P=0.25).HBsAg levels at weeks 24,48 and 96 declined in Peg-IFN-NA group(-0.26,-0.40 and-0.44)and remained stable in NA group(-0.10,-0.10 and-0.10)(P<0.05).The slope of HBsAg decline in Peg-IFN-NA group(-0.02)was higher than in NA group(-0.00)(P=0.015).HBcrAg levels did not ***(22%)patients discontinued Peg-IFN due to adverse *** HBsAg loss was achieved in 3(8.3%)patients of the Peg-IFN-NA group and 0(0%)of the NA *** The addition of Peg-IFN to NAs caused a greater and faster decrease of HBsAg levels compared to N

关键词： Chronic hepatitis B Hepatitis B e antigen-negative Hepatitis B surface antigen Hepatitis B core-related antigen Pegylated-interferon Nucleos(t)ids analogues©The Author(s)2020.Published by Baishideng Publishing Group Inc.All rights reserved

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Study of native oil-bearing rocks of the Cuban basin by high resolution NMR spectroscopy

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Petroleum Research 2022年第4期7卷 495-499页

作者： Ilfat Z.Rakhmatullin Sergej V.Efimov Ekaterina I.Kondratyeva Lisset miquel Gonzalez Kajum R.Safiullin Mikhail A.Varfolomeev Alexander V.Klochkov Vladimir V.Klochkov Kazan Federal University 18 Kremlevskaya St.Kazan420008Russian Federation

Application of high resolution^(13)C nuclear magnetic resonance(NMR)spectroscopy to characterize Cuba oil and oil-containing rock samples from Cuban basin was *** chemical shifts of^(13)C NMR functional groups for later determination the composition of the oil and rock samples were *** different contribution of the studied samples in the aliphatic and aromatic areas was *** fractions of primary,secondary,quaternary,tertiary,aromatic groups,aromaticity factor and the mean length of hydrocarbon chain length of aliphatic hydrocarbons were *** analysis on the quantitative level for all major hydrocarbon components,the aromaticity factor and the mean length of the hydrocarbon chain were carried out.

关键词： ^(13)C NMR spectroscopy Cuba oil Rock sample Functional group Qualitative analysis Quantitative composition Aromaticity

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Self-assembling protein nanocarrier for selective delivery of cytotoxic polypeptides to CXCR4^(+) head and neck squamous cell carcinoma tumors

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Acta Pharmaceutica Sinica B 2022年第5期12卷 2578-2591页

作者： Elisa Rioja-Blanco Irene Arroyo-Solera Patriciaálamo Isolda Casanova Alberto Gallardo Ugutz Unzueta Naroa Serna Laura Sánchez-García.miquel Quer Antonio Villaverde Esther Vázquez Ramon Mangues Lorena Alba-Castellón Xavier León Institut d'InvestigacióBiomèdica Sant Pau(IIB-Sant Pau) Barcelona 08041Spain Institut de Recerca contra la Leucèmia Josep Carreras Barcelona 08025Spain CIBER de Bioingeniería Biomateriales y Nanomedicina(CIBER-BBN)Madrid 28029Spain Department of Pathology Hospital de la Santa Creu i Sant PauBarcelona 08041Spain Institut de Biotecnologia i de Biomedicina Universitat Autònoma de BarcelonaBellaterra 08193Spain Departament de Genètica i de Microbiologia Universitat Autònoma de BarcelonaBellaterra 08193Spain Department of Otorhinolaryngology Hospital de la Santa Creu i Sant PauBarcelona 08041Spain

Loco-regional recurrences and distant metastases represent the main cause of head and neck squamous cell carcinoma(HNSCC) mortality. The overexpression of chemokine receptor 4(CXCR4) in HNSCC primary tumors associates with higher risk of developing loco-regional recurrences and distant metastases, thus making CXCR4 an ideal entry pathway for targeted drug delivery. In this context, our group has generated the self-assembling protein nanocarrier T22-GFP-H6, displaying multiple T22 peptidic ligands that specifically target CXCR4. This study aimed to validate T22-GFP-H6 as a suitable nanocarrier to selectively deliver cytotoxic agents to CXCR4^(+)tumors in a HNSCC model. Here we demonstrate that T22-GFP-H6 selectively internalizes in CXCR4^(+)HNSCC cells, achieving a high accumulation in CXCR4^(+)tumors in vivo, while showing negligible nanocarrier distribution in non-tumor bearing organs. Moreover, this T22-empowered nanocarrier can incorporate bacterial toxin domains to generate therapeutic nanotoxins that induce cell death in CXCR4-overexpressing tumors in the absence of histological alterations in normal organs. Altogether, these results show the potential use of this T22-empowered nanocarrier platform to incorporate polypeptidic domains of choice to selectively eliminate CXCR4^(+)cells in HNSCC. Remarkably, to our knowledge, this is the first study testing targeted proteinonly nanoparticles in this cancer type, which may represent a novel treatment approach for HNSCC patients.

关键词： Targeted drug delivery Protein nanoparticles CXCR4 receptor HNSCC Cell targeting Recombinant proteins Nanotoxins Cancer therapy

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Clinical and prognostic implications of delirium in elderly patients with non–ST-segment elevation acute coronary syndromes

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Journal of Geriatric Cardiology 2019年第2期16卷 121-128页

作者： miquel Vives-Borras Manuel Martinez-Selles Albert Ariza-Sole Maria T.Vidan Francesc Formiga Hector Bueno Juan Sanchis Oriol Alegre Albert Duran-Cambra Ramon Lopez-Palop Emad Abu-Assi Alessandro Sionis LONGEVO-SCA Investigators Department of Cardiology Hospital de la Santa Creu i Sant PauInstitute of Biomedical Research I1B Sant PauCIBERCVUniversitat Autonoma de BarcelonaBarcelonaSpain department of Cardiology Hospital General Universitario Gregorio MarahonC1BERCVUniversidad ComplutenseUniversidad EuropeaMadridSpain Hospital Universitari de Bellvitge L'Hospitalet de LlobregatBarcelonaSpain Hospital General Universitario Gregorio Maranon IiSGMCIBERFESUniversidad ComplutenseMadrid.Spain Hospital Doce de Octubre Centro Nacional de Investigaciones CardiovascularesMadridSpain Hospital Clinico de Valencia INCLIVAUniversidad de ValenciaCIBERCVSpain Hospital Universitario San Juan AlicanteSpain Hospital Alvaro Cunqueiro VigoSpain 不详

Background Elderly patients with non-ST-segment elevation acute coronary syndromes(NSTE-ACS)may present delirium but its clinical relevance is *** study aimed at detennining the clinical associated factors,and prognostic implications of delirium in old-aged patients admitted for *** LONGEVO-SCA is a prospective multicenter registry including unselected patients with NSTE-ACS aged>80 *** variables and a complete geriatric evaluation were assessed during *** association between delirium and 6-month mortality was assessed by a Cox regression model weighted for a propensity score including the potential confounding *** also analysed its association with 6-month bleeding and cognitive or functional *** Among 527 patients included,thirty-seven(7%)patients presented delirium during the *** was more frequent in patients with dementia or depression and in those from nursing homes(27.0%vs.3.1%,24.3%vs.11.6%,and 11.1%V5.2.2%,respectively;all P<0.05).Delirium was significantly associated with in-hospital infections(27.0%vs.5.3%,P<0.001)and usage of diuretics(70.3%vs.49.8%,P=0.02).Patients with delirium had longer hospitalizations[median 8.5(5.5-14)vs.6.0(4.0-10)days,P=0.02]and higher incidence of 6-month bleeding and mortality(32.3%vs.10.0%and 24.3%vs.10.8%,respectively;both P<0.05)but similar cognitive or functional *** was independently associated with 6-month mortality(HR=1.47,95%CI:1.02-2.13,P=0.04)and 6-month bleeding events(OR=2.87;95%CI:1.98-4」6,P<0.01).Conclusions In-hospital delirium in elderly patients with NSTE-ACS is associated with some preventable risk factors and it is an independent predictor of 6-month mortality.

关键词： Acute coronary syndromes Delirium Prognosis The elderly

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Suppression of the External MitochondrialNADPH Dehydrogenase, NDB1, in Arabidopsisthaliana Affects Central Metabolism andVegetative Growth

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Molecular Plant 2014年第2期7卷 356-368页

作者： Sabá V. Wallstr?m[a] Igor Florez-Sarasa[b][c] Wagner L. Araújo[d][e] Mari Aidemark[a] María Fernández-Fernández[a] Alisdair R. Fernie[d] miquel Ribas-Carbó[b] Allan G. Rasmusson[a] [a] Department of Biology Lund University Biology building S?lvegatan 35 SE-223 62 Lund Sweden [b] Grup de Recerca en Biologia de les Plantes en Condicions Mediterrànies Universitat de les Illes Balears Ctra Valldemossa Km. 75 07122 Palma de Mallorca Spain [c] Present address: Max-Planck-Institut für Molekulare Pflanzenphysiologie Am Mühlenberg 1 14476 Potsdam-Golm Germany [d] Max-Planck-Institut für Molekulare Pflanzenphysiologie Am Mühlenberg 1 14476 Potsdam-Golm Germany [e] Present address: Departamento de Biologia Vegetal Universidade Federal de Vi?osa 36570-000 Vi?osa Minas Gerais Brasil

Ca2＋-dependent oxidation of cytosolic NADPH is mediated by NDB1, which is an external type II NADPHdehydrogenase in the plant mitochondrial electron transport chain. Using RNA interference, the NDB1 transcript wassuppressed by 80% in Arabidopsis thaliana plants, and external Ca2＋-dependent NADPH dehydrogenase activity becameundetectable in isolated mitochondria. This was linked to a decreased level of NADP＋ in rosettes of the transgenic ***-grown transgenic seedlings displayed decreased growth specifically on glucose, and respiratory metabolism of 14C-glucose was increased. On soil, NDBl-suppressing plants had a decreased vegetative biomass, but leaf maximumquantum efficiency of photosystem Ⅱ and CO2 assimilation rates, as well as total respiration, were similar to the wild-type. The in vivo alternative oxidase activity and capacity were also similar in all genotypes. Metabolic profiling revealeddecreased levels of sugars, citric acid cycle intermediates, and amino acids in the transgenic lines. The NDBl-suppressioninduced transcriptomic changes associated with protein synthesis and glucosinolate and jasmonate metabolism. Thetranscriptomic changes also overlapped with changes observed in a mutant lacking ABAINSENSITIVE4 and in A. thalianaoverexpressing stress tolerance genes from rice. The results thus indicate that A. thaliana NDB1 modulates NADP（H）reduction levels, which in turn affect central metabolism and growth, and interact with defense signaling.

关键词： citric acid cycle metabolic profiling mitochondrial respiration NADPH RNA interference type II NAD(P)Hdehydrogenase vegetative growth

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