检索结果-南通市图书馆

Future directions for screening and treatment in congenital hearing loss

在线全文

学校读者我要写书评

暂无评论

Precision Clinical Medicine 2020年第3期3卷 175-186页

作者： Ryan K.thorpe Richard j.H.Smith Molecular Otolaryngology and Renal Research Laboratories Carver College of MedicineUniversity of Iowa375 Newton RdIowa CityIA 52242USA Department of Otolaryngology–Head and Neck Surgery University of Iowa200 Hawkins DrIowa CityIA 52242USA The Interdisciplinary Graduate Program in Genetics University of Iowa375 Newton RdIowa CityIA 52242USA Iowa Institute of Human Genetics University of Iowa375 Newton RdIowa CityIA 52242USA

Hearing loss is the most common neurosensory *** results froma variety of heritable and acquired causes and is linked to multiple deleterious effects on a child’s development that can be ameliorated by prompt identification and individualized *** hearing loss in newborns is challenging,especially in mild or progressive cases,and its management requires a multidisciplinary team of healthcare providers comprising audiologists,pediatricians,otolaryngologists,and genetic *** physiologic newborn hearing screening has resulted in earlier diagnosis of hearing loss than ever before,a growing body of knowledge supports the concurrent implementation of genetic and cytomegalovirus testing to offset the limitations inherent to a singular screening *** this review,we discuss the contemporary role of screening for hearing loss in newborns as well as future directions in its diagnosis and treatment.

关键词： genetic hearing loss deafness cytomegalovirus newborn screening precision medicine

Exploring the anti-cancer effects of Panax notoginseng through network pharmacology and molecular modeling

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Genes & Diseases 2023年第6期10卷 2229-2232页

作者： Erin M.thorpe Michael Kalafatis Yan Xu Department of Chemistry Science and Research CenterCleveland State University2121 Euclid AvenueClevelandOH 44115USA

The second leading cause of death worldwide is *** is a general term that refers to a highly diverse and complex set of over 200 diseases where abnormal cells grow uncontrollably and avoid death.1 These diseases can start almost anywhere within the body and may develop the ability to invade nearby tissues and *** cancer is the byproduct of a unique combination of various genetic and environmental factors.1 Even within the same individual,different cells may possess distinct cancerous mutations which can mutate further over time.

关键词： diseases cancer Cancer

Growing Economic Interdependence of China and the Gulf Cooperation Council

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

China & World Economy 2008年第2期16卷 109-124页

作者： Michael thorpe Sumit Mitra College of Graduate Studies University of WollongongDubaiUnited Arab Emirates College of Graduate Studies University of WollongongDubaiUAE

The six nations of the Gulf Cooperation Council （GCC） have approximately 40percent of total proven oil reserves as well as 23 percent of the world＇s gas reserves. Although rising oil revenues have led to greater outward investment flows, there is also a growing need for significant expansion of the domestic energy sector＇s capacity. Meanwhile, China＇s sustained economic boom has resulted in China emerging as the world＇s second largest consumer and importer o foil, with close to 40percent of its import demand presently sourced from the GCC. This share will grow significantly in the future. Commercial relations between the GCC and China have to date been dominated by energy-related bilateral investment flows and China＇s oil imports. Although this will continue to be a central feature, trade and investment links in non-energy areas will further broaden and deepen the relationship. China ＇s relationship with the USA in terms of energy is also emerging as a major issue. Rather than being competitors, a mutual dependence on stable and secure supplies from the GCC highlights the need for a cooperative relationship.

关键词： China Gulf Cooperation Council economic interdependence oil

On predicting mantle mushroom plumes

在线全文

学校读者我要写书评

暂无评论

Geoscience Frontiers 2011年第2期2卷 223-235,235+233-234页

作者： Ka-Kheng Tan Rex B. thorpe Zhidan Zhao Global Environment Centre HELP University College BZ-2 Pusat Bandar Damansara 50490 Kuala Lumpur Malaysia Department of Chemical and Process Engineering University of Surrey Guildford GU2 7XH U School of Earth Sciences and Resources China University of Geosciences Beijing 100083 China

This study investigates the mechanism of formation of convection plumes of mushroom shape in sub-solidus mantle and their prediction. The seismic-tomographic images of columnar structures of several hundreds kilometers in diameter have been reported by several researchers, while the much cherished mushroom-shaped plume heads could only be found in computational geodynamics （CGD） models and simple small-scale laboratory analogue simulations. Our theory of transient instability shows that the formation of convection plumes is preceded by the onset of convection caused by unsteady-state heat conduction at the boundaries, from which filamentous plumes first appear. The plumes generated at the Core Mantle Boundary （CMB） and lithosphere rising and falling through the mantle have been pre- dicted simply with our theory for various heat fluxes and viscosities, which still remain uncertain amongst geoscientists. The sizes of mushroom plumes in the sub-solidus mantle caused by heat fluxes of 20 and 120 mW/m2 at the CMB are found to be 1842 km and 1173 km with critical times over 825 Myr and 334 Myr respectively. They are comparable to some large continental flood basalt provinces, and they number between 17 and 41. The thickness of the thermal boundary layers at the CMB from which convection plumes evolved are found to be 652 km and 415 km for 20 and 120 mW/m^2 respectively. Top cooling may produce plunging plumes of diameter of 585 km and at least 195 Myr old. The number of cold plumes is estimated to be 569, which has not been observed by seismic tomograpby

关键词： Mantle mushroom plumesSizes Critical times Transient Reynoldsnumber

Cash transfer during the COVID-19 pandemic:a multicentre,randomised controlled trial

在线全文

学校读者我要写书评

暂无评论

Family Medicine and Community Health 2021年第4期9卷 50-56,I0016-I0021页

作者： Navindra Persaud Kevin E thorpe Michael Bedard Stephen W Hwang Andrew Pinto Peter jüni Bruno R da Costa 无 Department of Family and Community Medicine University of TorontoTorontoOntarioCanada MAP Centre for Urban Health Solutions Li Ka Shing Knowledge InstituteSt.Michael’s HospitalUniversity of TorontoTorontoOntarioCanada Department of Family and Community Medicine St Michael’s HospitalTorontoOntarioCanada Institute of Health Policy Managementand EvaluationUniversity of TorontoTorontoOntarioCanada Dalla Lana School of Public Health University of TorontoTorontoOntarioCanada Applied Health Research Centre Unity Health TorontoSt Michael's HospitalTorontoOntarioCanada Department of Family Medicine Northern Ontario School of MedicineThunder BayOntarioCanada Department of Medicine St Michael's HospitalUnity Health TorontoTorontoOntarioCanada Department of Medicine University of TorontoTorontoOntarioCanada Institute of Primary Health Care(BIHAM) University of BernTorontoSwitzerland DISTANSE COVID-19(Direct Income SupporT and Advice Negating Spread of Epidemic COVID-19:a randomized controlled trial)study team

Objective To evaluate the effect of a one-time cash transfer of$C1000 in people who are unable to physically distance due to insufficient *** Open-label,multi-centre,randomised superiority *** Seven primary care sites in Ontario,Canada;six urban sites associated with ***’s Hospital in Toronto and one in Manitoulin *** 392 individuals who reported trouble affording basic necessities due to disruptions related to *** After random allocation,participants either received the cash transfer of$C1000(n=196)or physical distancing guidelines alone(n=196).Main outcome measures The primary outcome was the maximum number of symptoms consistent with COVID-19 over 14 *** outcomes were meeting clinical criteria for COVID-19,SARS-CoV-2 presence,number of close contacts,general health and ability to afford basic *** The primary outcome of number of symptoms reported by participants did not differ between groups after 2 weeks(cash transfer,mean 1.6 vs 1.9,ratio of means 0.83;95%CI 0.56 to 1.24).There were no statistically significant effects on secondary outcomes of the meeting COVID-19 clinical criteria(7.9%vs 12.8%;risk difference−0.05;95%CI−0.11 to 0.01),SARS-CoV-2 presence(0.5%vs 0.6%;risk difference 0.0095%CI−0.02 to 0.02),mean number of close contacts(3.5 vs 3.7;rate ratio 1.10;95%CI 0.83 to 1.46),general health very good or excellent(60%vs 63%;risk difference−0.0395%CI−0.14 to 0.08)and ability to make ends meet(52%vs 51%;risk difference 0.0195%CI−0.10 to 0.12).Conclusions A single cash transfer did not reduce the COVID-19 symptoms or improve the ability to afford *** studies are needed to determine whether some groups may benefit from financial supports and to determine if a higher level of support is *** registration number NCT04359264.

关键词： Canada centre random

Adult duodenal intussusception associated with congenital malrotation

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World journal of Gastroenterology 2007年第28期13卷 3892-3894页

作者： j Gardner-thorpe RH Hardwick NR Carroll P Gibbs NV jamieson RK Praseedom Cambridge Surgical HPB Unit Addenbrooke's HospitalHills RdCambridgeCB2 2QQUnited Kingdom Cambridge Oesophago-gastric Centre Addenbrooke's HospitalHills RdCambridgeCB2 2QQUnited Kingdom Department of Radiology Addenbrooke's HospitalHills RdCambridgeCB2 2QQUnited Kingdom

Enteroenteric intussusception is a condition in which full-thickness bowel wall becomes telescoped into the lumen of distal bowel. In adults, there is usually an abnormality acting as a lead point, usually a Meckels＇ diverticulum, a hamartoma or a tumour. Duodeno- duodenal intussusception is exceptionally rare because the retroperitoneal situation fixes the duodenal wall. The aim of this report is to describe the first published case of this condition. A patient with duodeno-duodenal intussusception secondary to an ampullary lesion is reported. A 66 year-old lady presented with intermittent abdominal pain, weight loss and anaemia. Ultrasound scanning showed dilated bile and pancreatic ducts. CT scanning revealed intussusception involving the full-thickness duodenal wall. The lead point was an ampullary villous adenoma. Congenital partial （type r[） malrotation was found at operation and this abnormality permitted excessive mobility of the duodenal wall such that intussusception was possible. This condition can be diagnosed using enhanced CT. Intussusception can be complicated by bowel obstruction, ischaemia or bleeding, and therefore the underlying cause should be treated as soon as possible.

关键词： Duodenum Duodeno-duodenal Intussusception Malrotation Ampullary

储粮熏蒸过程中磷化氢浓度的分布模型及验证研究

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

中国粮油学报 2015年第7期30卷 81-84页

作者：王远成 Graham R thorpe 赵会义曹阳魏雷山东建筑大学热能工程学院济南250101 教育部可再生能源建筑利用技术实验室济南250101 澳大利亚维多利亚大学工程与科学学院国家粮食局科学研究院北京100037

谷物在长期储存过程中会受到害虫的侵扰,通常需要使用诸如磷化氢等适量的熏蒸剂对仓储粮食进行熏蒸,从而杀死害虫,同时又要避免害虫产生耐药性和熏蒸剂的残留。本研究首先建立和验证了熏蒸剂(磷化氢)的对流扩散和吸附模型,并采用计算流... 详细信息

谷物在长期储存过程中会受到害虫的侵扰,通常需要使用诸如磷化氢等适量的熏蒸剂对仓储粮食进行熏蒸,从而杀死害虫,同时又要避免害虫产生耐药性和熏蒸剂的残留。本研究首先建立和验证了熏蒸剂(磷化氢)的对流扩散和吸附模型,并采用计算流体动力学方法对圆筒仓内谷物熏蒸过程中磷化氢质量浓度进行了数值预测,分析了熏蒸过程中磷化氢的质量浓度分布规律,得出熏蒸过程中磷化氢质量浓度分布是不均匀的,并且受到谷物吸附和不可逆化学反应的双重影响。

关键词：谷物存储熏蒸剂对流扩散数值模拟圆筒仓

在线全文

学校读者我要写书评

暂无评论

日本摩托车使用维修手册

温暖的力量布罗瑟德Go Orthodontistes牙科诊所

1989年

作者：索普（thorpe j.）编刘德华厉晔译

来源：汇雅图书（南通市图书馆... 评论

在线全文

汇雅图书（南通市图书馆）

学校读者我要写书评

暂无评论

室内设计与装修 2018年第8期 88-91页

作者： natasha thorpe 小西

Go Orthodontistes牙科诊所坐落于加拿大布罗瑟德的一栋商业大楼内。一条长长的入口廊道将这一精致的医疗空间与外部的商业空间连接起来，同时为180m^2的诊所提供了必要的储物空间：廊道的一侧是用于存放牙齿矫正器材的抽屉柜，另一侧... 详细信息

Go Orthodontistes牙科诊所坐落于加拿大布罗瑟德的一栋商业大楼内。一条长长的入口廊道将这一精致的医疗空间与外部的商业空间连接起来，同时为180m^2的诊所提供了必要的储物空间：廊道的一侧是用于存放牙齿矫正器材的抽屉柜，另一侧用作衣橱。为了让整个空间的设计协调统一，设计师以木质板条作为空间的主导元素，打造了一个温馨、开放的医疗空间。

关键词：牙科空间连接温暖商业大楼储物空间协调统一设计师加拿大