检索结果-南通市图书馆

Chinese Journal of Cancer Research 1989年第2期1卷 39-43页

作者： A.Cardinale R.Lagalla a.guarino Institute of Radiology University of Palermo Palermo ItalyInstitute of Radiology University of Palermo Palermo ItalyInstitute of Radiology University of Palermo Palermo Italy

Between January 1985 and July 1987, 1,622 cancer patients were evaluated to outline the possible applications and limits of various investigative techniques for evaluating metastases. Seventy-three cases with superficial metastases of the dermal-hypodermal (59) layers, of the muscles (11) and of other target organs (3) were included in the *** non-glandular superficial metastases are a relatively rare occurrence, diagnostic imaging techniques are indicated for evaluating their extent and anatomical connections. Secondary neoplasms were studied using the imaging techniques of sono-graphy, computed tomography and *** diagnostic reliability of these three techniques was evaluated, taking into account their ability to determine the extent of metastases and of assessing *** is considered as a satisfactory screening technique, but CT is an even better tool for evaluating the extent and anatomical connections of such lesions. Xeroradiography has been made obsolete by the introduction of the other two techniques.

关键词： A COMPARISON OF XERORADIOGRAPHY IMAGING OF NON-GLANDULAR SUPERFICIAL METASTASES ULTRASONO-GRAPHY AND COMPUTED TOMOGRAPHY US

Processing of Baculovirus Late and Very Late mRNAs

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

中国病毒学 2007年第2期22卷 108-116页

作者： Linda a.guarino Department of Entomology Texas A&M University College Station Texas 77843-2475 USA

Baculoviruses encode a DNA-directed RNA polymerase that is evolutionarily divergent from cellular polymerases. This RNA polymerase is a multifunctional complex that has the ability to recognize late promoters, transcribe linked genes, and process transcripts at both the 5’ and 3’ ends. The LEF-4 subunit of the viral RNA polymerase is the mRNA capping enzyme, with both RNA triphosphatase and guanylyltransferase activities. Conversion to cap 1 structures is mediated by the viral enzyme MTase1 and another as yet unidentified methyltransferase. Termination is an intrinsic property of the viral RNA polymerase and occurs at oligoU rich sequences. Polyadenylation of the released transcripts is also a function of the viral RNA polymerase. Thus, although viral mRNAs resemble host messages with respect to their 5’ and 3’ end structures, the processing is mediated by viral enzymes and, in the case of the 3’ ends, by mechanisms that differ from the host cell.

关键词：杆状病毒聚合酶 RNA 基因编码

Gastrointestinal and liver infections in children undergoing antineoplastic chemotherapy in the years 2000

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2016年第25期22卷 5853-5866页

作者： Elio Castagnola Eliana Ruberto Alfredo guarino Infectious Diseases Unit Istituto Giannina Gaslini Department of Translational Medical Science Section of Pediatrics University of Naples Federico II

AIM: To review gastrointestinal and liver infections in children undergoing antineoplastic chemotherapy. To look at gut microflora features in oncology ***: We selected studies published after year 2000, excluding trials on transplanted pediatric patients. We searched English language publications in MEDLINE using the keywords: "gastrointestinal infection AND antineoplastic chemotherapy AND children", "gastrointestinal infection AND oncology AND children", "liver infection AND antineoplastic chemotherapy AND children", "liver abscess AND chemotherapy AND child", "neutropenic enterocolitis AND chemotherapy AND children", "thyphlitis AND chemotherapy AND children", "infectious diarrhea AND children AND oncology", "abdominal pain AND infection AND children AND oncology", "perianal sepsis AND children AND oncology", "colonic pseudo-obstruction A N D o n c o l o g y A N D c h i l d A N D c h e m o t h e r a p y ", "microflora AND children AND malignancy", "microbiota AND children AND malignancy", "fungal flora AND children AND malignancy". We also analysed evidence from several articles and book ***: Gastrointestinal and liver infections represent a major cause of morbidity and mortality in children undergoing antineoplastic chemotherapy. Antineoplastic drugs cause immunosuppression in addition to direct toxicity, predisposing to infections, although the specific risk is variable according to disease and host features. Common pathogens potentially induce severe diseases whereas opportunistic microorganisms may attack vulnerable hosts. Clinical manifestations can be subtle and not specific. In addition, several conditions are rare and diagnostic process and treatments are not standardized. Diagnosis may be challenging, however early diagnosis is needed for quick and appropriate interventions. Interestingly, the source of infectionin those children can be exogenous or endogenous. Indeed, mucosal damage may allow the penetrance of endogenous micr

关键词： Gastrointestinal tract Liver Microflora Infection Oncology Chemotherapy Children

Impact of chronic kidney disease on mortality in older adults treated with pacemaker implantation

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Geriatric Cardiology 2017年第10期14卷 597-603页

作者： Fabio Fabbian Alfredo De Giorgi Matteo guarino Michele Malagu Matteo Bertini Department of Medical Sciences Clinical Medical Unit University Hospital St. Anna University of Ferrara Ferrara Italy Department of Medical Sciences Cardiology Unit University Hospital St. Anna University of Ferrara Ferrara Italy

Objective To investigate whether chronic kidney disease could negatively impact survival in older adults needing pacemaker implantation after admission for bradyarrhythmias. Methods This retrospective observational study considered 538 older adults consecutively admitted, who had been followed-up for 31 ± 20 months. Subjects with poor short-term prognosis were excluded. Charlson comorbidity index （CCI） and estimated glomerular filtration rate （eGFR） was calculated, along with the independent relationship between all-cause mortality and clinical data. Hazard Ratio （HR） was calculated by Cox regression analysis. Results Mean age of the population was 85 ± 3.7 years, and causes for implantation were atrioventricular block in 51.9% and other bradyarrhythmias in 48.1% of cases. Mean eGFR was 58.3 ± 24 mL/min per 1.73 m2, and mean CCI was 3.65 ± 2.28. Death for all-causes was recorded in 213 subjects. Deceased patients were older, had lower eGFR, higher comorbidity, higher prevalence of myocardial infarction, congestive heart failure, cerebrovascular disease, dementia and chronic pulmonary disease. Age （HR： 1.081, 95% CI： 1.044-1.119; P 〈 001）, CCI （HR： 1.651, 95% CI： 1.286-2.121, P 〈 001） and eGFR 〈 45 mL/min per 1.73 m2 （HR： 1.360, 95% CI： 1.024-1.806; P = 0.033） were predictors of death. Conclusions Renal dysftmction, as well as comorbidity, impacts negatively survival of older adults treated with pacemaker implantation because of bradyarrhythmias.

关键词： Bradyarrhythmias Charlson comorbidity index Chronic kidney disease Comorbidity Glomerular filtration rate Mortality Pacemaker

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

When lifestyles sign

Hepatobiliary Surgery and Nutrition 2019年第1期8卷 69-71页

作者： Maria.guarino Cedric Bovet Jean-Francois Dufour Hepatology Department for BioMedical ResearchUniversity of BernBernSwitzerland Gastroenterology Department of Clinical Medicine and SurgeryUniversity of Naples“Federico II”NaplesItaly University Institute of Clinical Chemistry InselspitalUniversity of BernBernSwitzerland University Clinic of Visceral Surgery and Medicine Inselspital BernBernSwitzerland

Nonalcoholic fatty liver disease(NAFLD)has a global prevalence of 25%,reflecting the global epidemic of obesity and diabetes(1).The onset and development of NAFLD are closely associated with dietary habits and lifestyle;consequently,lifestyle modifications including weight loss,increased physical activity,and dietary changes remain the treatment of choice for *** when drugs to treat non-alcoholic steatohepatitis will be available,lifestyle changes will remain an essential component of the therapeutic plan of these *** the last years,a strong association between lifestyle and hepatocellular carcinoma(HCC)has become evident(2-4).In patients with NAFLD,the annual incidence of HCC is 0.44 per 1,000 person/year and almost 50%of cases develops in a non-cirrhotic liver resulting in a diagnosis at an advanced stage with a worse prognosis(1,5).Nonetheless,the high prevalence of NAFLD with the relatively low risk for HCC makes a surveillance program cost-ineffective in non-cirrhotic patients(6).

关键词： NAFLD diagnosis drugs

Risk stratification of HCC occurrence after HCV eradication:a complicate plot of risk factors related and unrelated to the previous viral disease

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Hepatobiliary Surgery and Nutrition 2020年第4期9卷 511-513页

作者： Valentina Cossiga Maria.guarino Filomena Morisco Nicola Caporaso Gastroenterology Unit Department of Clinical Medicine and SurgeryUniversity of Naples“Federico II”NaplesItaly

Hepatocellular carcinoma(HCC)is the fifth most common cancer and the second most frequent cause of cancer-related death *** C virus(HCV)infection is one of leading cause of cirrhosis,that is the strongest risk factor ... 详细信息

关键词： cancer death cirrhosis

Gastrointestinal neuromuscular apparatus: An underestimated target of gut microbiota

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2016年第45期22卷 9871-9879页

作者： Michele Pier Luca.guarino Michele Cicala Lorenza Putignani Carola Severi Digestive Disease Unit of Campus Bio Medico University of Rome 00128 Rome Italy Unit of Parasitology Bambino Gesù Children’s Hospital IRCCS 00100 Rome Italy Department of Internal Medicine and Medical Specialties University Sapienza 00100 Rome Italy

Over the last few years, the importance of the resident intestinal microbiota in the pathogenesis of several gastrointestinal diseases has been largely investigated. Growing evidence suggest that microbiota can influence gastrointestinal motility. The current working hypothesis is that dysbiosis-driven mucosal alterations induce the production of several inflammatory/immune mediators which affect gut neuro-muscular functions. Besides these indirect mucosal-mediated effects, the present review highlights that recent evidence suggests that microbiota can directly affect enteric nerves and smooth muscle cells functions through its metabolic products or bacterial molecular components translocated from the intestinal lumen. Tolllike receptors, the bacterial recognition receptors, are expressed both on enteric nerves and smooth muscle and are emerging as potential mediators between microbiota and the enteric neuromuscular apparatus. Furthermore, the ongoing studies on probiotics support the hypothesis that the neuromuscular apparatus may represent a target of intervention, thus opening new physiopathological and therapeutic scenarios.

关键词： Microbiota Gastrointestinal motility Smooth muscle Enteric nervous system Probiotics Irritable bowel syndrome

Proton pump inhibitor resistance, the real challenge in gastro-esophageal reflux disease

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2013年第39期19卷 6529-6535页

作者： Michele Cicala Sara Emerenziani Michele Pier Luca.guarino Mentore Ribolsi Unit of Digestive Disease Campus Bio Medico University of Rome00128 RomeItaly

Gastro-esophageal reflux disease(GERD)is one of the most prevalent chronic *** proton pump inhibitors(PPIs)represent the mainstay of treatment both for healing erosive esophagitis and for symptom relief,several studies have shown that up to 40%of GERD patients reported either partial or complete lack of response of their symptoms to a standard PPI dose once *** mechanisms have been proposed as involved in PPIs resistance,including ineffective control of gastric acid secretion,esophageal hypersensitivity,ultrastructural and functional changes in the esophageal *** diagnostic evaluation of a refractory GERD patients should include an accurate clinical evaluation,upper endoscopy,esophageal manometry and ambulatory pH-impedance monitoring,which allows to discriminate non-erosive reflux disease patients from those presenting esophageal hypersensitivity or functional *** has been primarily based on doubling the PPI dose or switching to another *** with proven disease,not responding to PPI twice daily,are eligible for anti-reflux surgery.

关键词： Gastro-esophageal reflux disease Proton pump inhibitor Ambulatory pH-impedance monitoring Esophageal hypersensitivity Gastro-esophageal reflux disease treatment

Gastroesophageal reflux disease: Update on inflammation and symptom perception

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2013年第39期19卷 6523-6528页

作者： Annamaria Altomare Michele Pier Luca.guarino Silvia Cocca Sara Emerenziani Michele Cicala Unit of Digestive Disease Campus Bio Medico University of Rome00128 RomeItaly

Although gastroesophageal reflux disease(GERD)is a common disorder in Western countries,with a significant impact on quality of life and healthcare costs,the mechanisms involved in the pathogenesis of symptoms remain to be fully *** symptoms and complications may result from a multifactorial mechanism,in which acid and acid-pepsin are the important noxious factors *** contact of the esophageal mucosa with the refluxed content,probably caused by a defective anti-reflux barrier and luminal clearance mechanisms,would appear to be responsible for macroscopically detectable injury to the esophageal squamous *** on acid-sensitive nerve endings may play a role in nociception and esophageal sensitivity,as suggested in animal models of chronic acid ***,specific cytokine and chemokine profiles would appear to underlie the various esophageal phenotypes of GERD,explaining,in part,the genesis of esophagitis in a subset of *** these findings,which show a significant production of inflammatory mediators and neurotransmitters in the pathogenesis of GERD,the relationship between the hypersensitivity and esophageal inflammation is not ***,the large majority of GERD patients(up to 70%)do not develop esophageal erosions,a variant of the condition called non-erosive reflux *** summary aims to explore the inflammatory pathway involved in GERD pathogenesis,to better understand the possible distinction between erosive and non-erosive reflux disease patients and to provide new therapeutic approaches.

关键词： Gastroesophageal reflux disease Mucosal inflammation Heartburn Esophagitis Hypersensitivity

Direct-acting antivirals and hepatocellular carcinoma in chronic hepatitis C: A few lights and many shadows

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2018年第24期24卷 2582-2595页

作者： Maria.guarino Anna Sessa Valentina Cossiga Federica Morando Nicola Caporaso Filomena Morisco Gastroenterology Unit Department of Clinical Medicine and SurgeryUniversity of Naples Federico Ⅱ

With the introduction of direct-acting antiviral agents(DAA), the rate of sustained virological response(SVR) in the treatment of hepatitis C virus(HCV) has radically improved to over 95%. Robust scientific evidence supports a beneficial role of SVR after interferon therapy in the progression of cirrhosis, resulting in a decreased incidence of hepatocellular carcinoma(HCC). However, a debate on the impact of DAAs on the development of HCC is ongoing. This review aimed to analyse the scientific literature regarding the risk of HCC in terms of its recurrence and occurrence after the use of DAAs to eradicate HCV infection. Among 11 studies examining HCC occurrence, the de novo incidence rate ranged from 0 to 7.4%(maximum follow-up: 18 mo). Among 18 studies regarding HCC recurrence, the rate ranged from 0 to 54.4%(maximum "not well-defined" followup: 32 mo). This review highlights the major difficulties in interpreting data and reconciling the results of the included studies. These difficulties include heterogeneous cohorts, potential misclassifications of HCC prior to DAA therapy, the absence of an adequate control group, short follow-up times and different kinds of follow-up. Moreover, no clinical feature-based scoring system accounts for the molecular characteristics and pathobiology of the tumours. Nonetheless, this review does not suggest that there is a higher rate of de novo HCC occurrence or recurrence after DAA therapy in patients with previous HCV infection.

关键词： hepatocellular carcinoma hepatitis C virus direct-acting antiviral agents occurrence recurrence