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Impact of leg bending in the patient-specific computational fluid dynamics of popliteal stenting

Acta Mechanica Sinica 2021年第2期37卷 279-291页

作者： a.ferrarini A.Finotello G.Salsano F.Auricchio D.Palombo G.Spinella B.Pane M.Conti Department of Civil Engineering and Architecture University of PaviaPaviaItaly Department of Surgical and Integrated Diagnostic Sciences University of GenoaGenoaItaly Department of Radiology IRCCS Ospedale Policlinico San MartinoGenoaItaly Vascular and Endovascular Surgery Unit IRCCS Ospedale Policlinico San MartinoGenoaItaly

Endovascular treatment of the femoro-popliteal artery has recently become a valuable therapeutic option for popliteal arterial ***,its efficacy remains controversial due to the relatively high rate of complications,such as stent occlusion as result of intra-stent *** elucidation of the interplay among vessel geometrical features,local hemodynamics,and leg bending seems crucial to understand onset and progression of popliteal intra-stent *** this aim,patient-specific computational fluid dynamic simulations were performed in order to assess the intra-stent hemodynamics of two patients endovascularly treated for popliteal arterial aneurysm by stent-grafts and experiencing intra-stent *** Newtonian and non-Newtonian blood rheological models were *** were presented in terms of tortuosity,luminal area exposed to low(1.5 Pa)time-averaged wall shear stress(TAWSS),area exposed to high(>0.3)oscillatory shear index(OSI),and flow *** outcomes demonstrated that leg bending induced significant hemodynamic differences(>50%increase)in both patients for all the considered variables,except for OSI in one of the two considered *** both leg configurations,stent-graft overlapping induced a severe discontinuity of the lumen diameter where the proximal stented zone is characterized by low tortuosity,low velocity,low helicity,low TAWSS,and high OSI;while the distal part has higher tortuosity,velocity,helicity,TAWSS,and lower *** study on applied boundary conditions showed that the different inlet velocity profiles for a given inlet waveform affect slightly the numerical solution;conversely,the shape and magnitude of the prescribed inlet waveform is *** on the comparison between the Newtonian and non-Newtonian blood models,the area with low TAWSS is greater in the Newtonian model for both patients,while no significant difference occurs between the surfaces with hig

关键词： Popliteal artery aneurysm Peripheral stenting Endovascular treatment Femoropopliteal segment Medical image analysis

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Correction to: Impact of leg bending in the patient-specific computational fluid dynamics of popliteal stenting

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Acta Mechanica Sinica 2021年第7期37卷 1192-1192页

作者： a.ferrarini A.Finotello G.Salsano F.Auricchio D.Palombo G.Spinella B.Pane M.Conti Department of Civil Engineering and Architecture.University of Pavia PaviaItaly Department of Surgical and Integrated Diagnostic Sciences University of GenoaGenoaItaly Department of Radiology IRCCS Ospedale Policlinico San MartinoGenoaItaly Vascular and Endovascular Surgery Unit IRCCS Ospedale Policlinico San MartinoGenoaItaly

In the original publication of the article a fund note has not been displayed appropriately in the acknowledgment *** missing fund note is updated in this correction.

关键词： bending section. dynamics

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Spatio-temporal patterns of the Red-footed Falcon's hunting behavior during the nestling period suggest ad hoc conservation policies

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Avian Research 2021年第1期12卷 118-123页

作者： Marco Gustin Alessandro ferrarini Conservation Department BirdLifeLIPU(Lega Italiana Protezione Uccelli)Via Udine 343100 ParmaItaly

The Red-footed Falcon(Falco vespertinus)is a species of high international conservation *** analyzed its hunting behavior at the two largest colonies in Italy during the nestling *** accurate data-loggers,we tracked three adult Red-footed Falcons in June and July,2019 and collected 4703 GPS *** detected clear patterns of hovering and perching activity(HPA)in both time and *** occupied one-third of the Red-footed Falcons’day,and showed two peaks just after sunrise(between 35 and 40%of the monitoring time)and just before sunset(50‒60%)in both June and July,and minimum(20‒30%)at night and during the hottest time interval(10:00 a.m.‒4:00 p.m.).Almost 40%of HPA occurred within 50 m from *** findings,although preliminary,have important implications for the conservation of these two colonies that are located within two Natura 2000 *** detected spatio-temporal patterns of Red-footed Falcons’hunting behavior suggests the creation of two nested protection belts:the inner one is a narrow belt(up to 50 m from the two rows of trees that host the two colonies)with integral conservation,and hopefully increase the alfalfa crops and fallow land,and the outer belt(50 m‒2 km)with optimized agricultural activities.

关键词： Biotelemetry Falco vespertinus Hovering Italy Natura 2000 site Perching

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A new general index of home range overlap and segregation:the Lesser Kestrel in Southern Italy as a case study

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Avian Research 2021年第1期12卷 108-117页

作者： Alessandro ferrarini Giuseppe Giglio Stefania Caterina Pellegrino Marco Gustin Conservation Department LIPU-BirdLife Italy(Lega Italiana Protezione Uccelli)Via Udine 3/a43122 ParmaItaly

Background:There is increasing interest in evaluating home-range overlap(or,otherwise,segregation)between bird species,and between or within bird populations,to inform spatial *** far,studies of home-range overlap typically make use of comparisons between pairs of individuals,populations or species,and return a matrix of pairwise overlaps(e.g.,percent overlaps).However,when the number of individuals,populations or species to be compared is elevated,an overlarge overlap matrix is difficult to interpret from an ecological ***:We propose here a new,conceptually simple and computationally efficient index(general overlap index;GOI)for the ready computation within GIS of home range overlap of an arbitrarily large number(i.e.,n≥2)of individuals,populations or *** the number of home ranges to be compared,GOI always returns a single score between 0 and *** a case study,we applied our index to 24,074 GPS points of 10 Lesser Kestrels(Falco naumanni)in order to estimate within-colony and between-colony overlaps in two neighboring colonies in Southern ***:Within-colony overlap was elevated for both colonies(96.41%at Cassano delle Murge,n=5 individuals;81.38%at Santeramo in Colle,n=5 individuals),while between-colony overlap was low(19.12%;n=2 colonies)and,after a randomization procedure,more spatially-segregated than expected by ***:Modern biotelemetry offers huge amounts of data describing the space use of animal *** use of intuitive and straightforward indices,like GOI,can be useful to promptly extract ecological information from such an amount of data(*** change in space use over successive years,evaluating the reliability of various home-range estimators).

关键词： Between-colony overlap Falco naumanni Home range randomization Overlap estimator Spatial segregation Within-colony overlap

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A new methodology for computing birds＇ 3D home ranges

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Avian Research 2018年第2期9卷 168-173页

作者： Alessandro ferrarini Giuseppe Giglio Stefania Caterina Pellegrino Anna Grazia Frassanito Marco Gustin Conservation Department LIPU - BirdLife (Lega Italiana Protezione Uccelli) Via Udine 3/a 43122 Parma Italy Alta Murgia National Park Via Firenze 10 70024 Gravina in Puglia Bari Italy.

Background： So far, studies of avian space use are mostly realized in 2D, with the vertical dimension ignored. We propose here a new, relatively simple and computationally reasonable method for the estimation of volumetric （i.e. 3D） avian home ***： Through accurate GPS data-loggers, we collected 25,405 GPS points on Lesser Kestrels＇（Fdlco noumonni） space use during the nestling period in one main colony in *** applied our 3D home range estimator to the whole GPS dataset, and also separately to diurnal and nocturnal GPS ***： The 3D colony home range resulted equal to 28.12 km3. By considering daytime and night-time separately, the volumetric home ranges resulted considerably ***： Our 3D home range estimator, because of its intuitive and straightforward properties, can easily capi-talize on the datasets offered by modern biotelemetry （data-loggers, light detection and LIDAR sensors） and enhance conservation strategies for mitigating anthropogenic impacts on bird species. Its applications embrace, but are not limited to, more accurate estimates of collision risk with power lines, aircrafts and wind farms, and increased knowledge of birds＇space requirements in order to persist in their distribution areas.

关键词： Avian space use Biotelemetry GPS data-loggers Vertical dimension Volumetric home range

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Pramipexole, a dopamine D3/D2 receptor-preferring agonist, attenuates reserpine-induced fibromyalgia-like model in mice

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Neural Regeneration Research 2022年第2期17卷 450-458页

作者： Carlos Pereira Martins Rodrigo Sebben Paes Gabriela Mantovani Baldasso Eduarda Gomes ferrarini Rahisa Scussel Rubya Pereira Zaccaron Ricardo Andrez Machado-de-Avila Paulo Cesar Lock Silveira Rafael Cypriano Dutra Laboratory of Autoimmunity and Immunopharmacology Department of Health SciencesCampus AraranguaUniversidade Federal de Santa CatarinaAraranguáSCBrazil Post-Graduate Program of Neuroscience Center of Biological SciencesUniversidade Federal de Santa CatarinaFlorianópolisSCBrazil Laboratory of Experimental Physiopathology Program of Postgraduate in Science of HealthUniversidade do Extremo Sul CatarinenseCriciumaSCBrazil

Fibromyalgia(FM) is a complex pathology described as persistent hyperalgesia including somatic and mood dysfunctions, depression and anxiety. Although the etiology of FM is still unknown, a significant decrease in biogenic amines is a common characteristic in its pathogenesis. Here, our main objective was to investigate the role of dopamine D3/D2 receptor during the reserpine-induced pain in mice. Our results showed that pramipexole(PPX) – a dopaminergic D3/D2 receptor agonist – inhibited mechanical allodynia and thermal sensitivity induced by reserpine. Relevantly, PPX treatment decreased immobility time and increased the number of grooming in the forced swimming test and splash test, respectively. Animals that received PPX remained longer in the open arms than the reserpine group using elevated plusmaze apparatus. The repeated PPX administration, given daily for 4 days, significantly blocked the mechanical and thermal allodynia during FM model, similarly to pregabalin, although it failed to affect the reserpine-induced thermal nociception. Reserpine administration induced significant downregulation of dopamine concentration in the central nervous system, and repeated treatment with PPX restored dopamine levels in the frontal cortex and spinal cord tissues. Moreover, PPX treatment inhibited oxidants production such as DCFH(2′,7′-dichlorodihydrofluorescein) and nitrite, also decreased oxidative damage(carbonyl), and upregulated the activity of superoxide dismutase in the spinal cord. Together, our findings demonstrated the ability of dopamine D3/D2 receptor-preferring agonist in reducing pain and mood dysfunction allied to FM in mice. All experimental protocols were approved by the Universidade Federal de Santa Catarina(UFSC) Ethics Committee(approval No. 2572210218) on May 10, 2018.

关键词： dopamine dopaminergic system fibromyalgia hyperalgesia pain pramipexole reserpine

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COVID-19 (SARS-CoV-2 infection) in lymphoma patients: A review

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World Journal of Virology 2021年第6期10卷 312-325页

作者： Valentina Bonuomo Isacco ferrarini Michele Dell'Eva Eugenio Sbisà Mauro Krampera Carlo Visco Section of Haematology Department of MedicineUniversity of VeronaVerona 37134Italy

Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infection now has a global resonance and represents a major threat for several patient *** from initial case series suggested that cancer patients in general might have an unfavorable outcome following coronavirus disease 2019(COVID-19),due to their underlying conditions and cytotoxic *** recently,data regarding the incidence and clinical evolution of COVID-19 in lymphomas have been reported with the aim to identify those more frequently associated with severe complications and *** with lymphoma appear particularly vulnerable to SARS-CoV-2 infection,only partly because of the detrimental effects of the anti-neoplastic regimens(chemotherapy,pathway inhibitors,monoclonal antibodies)on the immune ***,we systematically reviewed the current literature on COVID-19 in adult patients with lymphoma,with particular emphasis on disease course and prognostic *** also highlighted the potential differences in COVID-19 clinical picture according to lymphoma subtype,delivered treatment for the hematological disease and its relationship on how these patients have been managed thus far.

关键词： Lymphoma SARS-CoV-2 infection Hematological malignancies COVID-19 Rituximab Bendamustine

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解决问题的设计

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现代装饰 2019年第11期 98-105页

作者： Mario ferrarini Natevo TON Antonino Sciortino OKHA Showroom Yonoh DesignByThem Trabà 苏烨 Angeletti Ruzza Design Artefatto Design Studio

"‘住,字可拆分为‘人’与‘主’,好的家居设计要以人为本位。"居住专家、畅销书《小家,越住越大》作者逯薇在助阵SIID家委会成立仪式上带来《家的设计》主题分享时强调,设计能解决问题,但单凭设计师的创意,却只能提供一间好看的房子,... 详细信息

"‘住,字可拆分为‘人’与‘主’,好的家居设计要以人为本位。"居住专家、畅销书《小家,越住越大》作者逯薇在助阵SIID家委会成立仪式上带来《家的设计》主题分享时强调,设计能解决问题,但单凭设计师的创意,却只能提供一间好看的房子,只有加上"人",考虑用户需求,才能将房子变为"家"。

关键词：家居设计畅销书可拆分用户需求解决问题房子

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