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Strawberry sweetness and consumer preference are enhanced by specific volatile compounds

Horticulture Research 2021年第1期8卷 870-884页

作者： Zhen Fan Tomas Hasing Timothy S.Johnson Drake M.Garner Michael L.Schwieterman Christopher R.Barbey Thomas a.colquhoun Charles A.Sims Marcio F.R.Resende Vance M.Whitaker Horticultural Sciences Department University of FloridaIFAS Gulf Coast Research and Education CenterWimaumaFLUSA Elo Life Systems DurhamNCUSA Department of Environmental Horticulture and Plant Innovation Center Institute of Food and Agricultural SciencesUniversity of FloridaGainesvilleFLUSA Plenty Unlimited Inc.South San FranciscoCA 94080USA Food Science and Human Nutrition Department University of FloridaGainesvilleFLUSA Horticultural Sciences Department University of FloridaGainesvilleFLUSA

Breeding crops for improved flavor is challenging due to the high cost of sensory evaluation and the difficulty of connecting sensory experience to chemical *** main goal of this study was to identify the chemical drivers of sweetness and consumer liking for fresh strawberries(Fragaria×ananassa).Fruit of 148 strawberry samples from cultivars and breeding selections were grown and harvested over seven years and were subjected to both sensory and chemical *** panel consisted of at least 100 consumers,resulting in more than 15,000 sensory data points per *** sugars,two acids and 113 volatile compounds were *** liking was highly associated with sweetness intensity,texture liking,and flavor intensity,but not sourness *** least square analyses revealed 20 volatile compounds that increased sweetness perception independently of sugars;18 volatiles that increased liking independently of sugars;and 15 volatile compounds that had positive effects on *** learning-based predictive models including sugars,acids,and volatiles explained at least 25%more variation in sweetness and liking than models accounting for sugars and acids *** compounds such asγ-dodecalactone;5-hepten-2-one,6-methyl;and multiple medium-chain fatty acid esters may serve as targets for breeding or quality control attributes for strawberry products.A genetic association study identified two loci controlling ester production,both on linkage group 6 ***-segregating makers in these regions can be used for increasing multiple esters *** study demonstrates a paradigm for improvement of fruit sweetness and flavor in which consumers drive the identification of the most important chemical targets,which in turn drives the discovery of genetic targets for marker-assisted breeding.

关键词： volatile sugar esters

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Correction: Strawberry sweetness and consumer preference are enhanced by specific volatile compounds

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Horticulture Research 2021年第1期8卷 3067-3067页

作者： Zhen Fan Tomas Hasing Timothy S.Johnson Drake M.Garner Michael L.Schwieterman Christopher R.Barbey Thomas a.colquhoun Charles A.Sims Marcio F.R.Resende Vance M.Whitaker Horticultural Sciences Department University of Florida IFAS Gulf Coast Research and Education Center Wimauma FL USA Elo Life Systems Durham NC USA Department of Environmental Horticulture and Plant Innovation Center Institute of Food and Agricultural Sciences University of Florida Gainesville FL USA Plenty Unlimited Inc. South San Francisco CA 94080 USA Food Science and Human Nutrition Department University of Florida Gainesville FL USA Horticultural Sciences Department University of Florida Gainesville FL USA

Since the publication of this article 1,the corresponding author discovered that an additional researcher contributed data and should be included as an *** ***(Plenty Unlimited,Inc.,South San Francisco,CA 94080,US)has... 详细信息

关键词： volatile specific compounds

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MRI引导下经尿道超声前列腺适形治疗:应用于人体的初步可行性分析

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国际医学放射学杂志 2012年第6期 595-595页

作者： R.Chopra a.colquhoun M.Burtnyk W.A.N'djin I.Kobelevskiy A.Boyes 高晓 Imaging Research Sunnybrook Research Institute2075 Bayview AveRoom C713TorontoONCanada M4N3M5

摘要目的评价MRI引导下经尿道超声治疗人前列腺癌的可行性和安全性。材料与方法本试验性研究已获得伦理审查委员会的批准。8例局限性前列腺癌(Gleason评分≤7,前列腺特异抗原水平≤15μg/L)病人(年龄,49～60岁,平均60岁)入组,

关键词：尿道超声经尿道前列腺男生殖器 MRI 超声治疗

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Neuroendocrine tumors with hepatic metastases: A review of evolving treatment options

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Liver Research 2018年第2期2卷 92-99页

作者： Steven D.colquhoun University of California Davis SacramentoCAUSA

Once considered exceptionally rare,neuroendocrine tumors(NET)are increasingly common and therefore of growing relevance to both clinicians and *** patients with such tumors present with symptoms,and,of those,90%have secondary liver *** the recent past,individuals with metastatic liver disease were offered little in the way of therapy,or *** the last few years,this fatalist approach has been rapidly replaced with a variety of new strategies for both systemic and loco-regional treatment *** sequential and parallel combined therapies,newly available drugs and a multi-disciplinary approach to patient management are all contributing to a revolution in the care and outcomes for this *** this review,the reader will be oriented to the relevant statistics,nomenclature and diagnostic modalities for this confusing set of *** important is an update on the rapidly expanding treatment options available for optimizing care among patients with liver involvement.

关键词： Neuroendocrine tumor(NET) Hepatic metastatic Treatment Carcinoid Multimodality Multidisciplinary

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Hepatocellular carcinoma clinical update: Current standards and therapeutic strategies

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Liver Research 2020年第4期4卷 180-190页

作者： Steven D.colquhoun Department of Surgery University of California DavisSacramentoCAUSA

Hepatocellular carcinoma(HCC)accounts for the vast majority of primary hepatic *** overall incidence of this disease has always been significant,but in recent years it has continued to rise,now making HCC one of the leading causes of cancer deaths ***,research into the mechanisms of carcinogenesis and treatment options for this disease has also been progressing *** the future for new insights and therapies appears more promising than ever,it also remains important to understand both the nature of HCC and the current state-of-the-art for treating affected *** surgery is often considered to be a first choice,many patients present with extensive disease and are therefore not operative ***,significant clinical advances over the last decade have contributed a number of new or improved treatment *** of these treatments require expertise from a variety of different clinical ***,managing patients with HCC has rapidly become a multi-modality,multi-disciplinary endeavor in which the details of each in-dividual’s circumstance can greatly impact outcomes,and strategies can be quite *** purpose of this review is to provide a perspective on the disease itself,the patients who become afflicted,the spectrum of currently available treatment options,and the strategies for their optimal *** knowledge can be critically important as new data become available on the research front.

关键词： Hepatocellular carcinoma(HCC) Ablation Transarterial chemoembolization(TACE) High intensity focused ultrasound(HIFU) Stereotactic body radiation therapy(SBRT) Irreversible electroporation(IRE) Liver surgery Liver transplantation

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Overexpression of Galectin-1 and Galectin-3 in hepatocellular carcinoma

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Liver Research 2020年第4期4卷 173-179页

作者： Tahereh Setayesh Steven D.colquhoun Yu-Jui Yvonne Wan Department of Pathology and Laboratory Medicine University of California DavisSacramentoCAUSA Department of Surgery University of California DavisSacramentoCAUSA

Galectins(Gals)are evolutionarily conserved proteins that bind to b-galactoside containing *** expression of Gals is associated with the development,progression,and metastasis of different types of *** the 11 Gals identified in humans,the roles of Gal-1 and Gal-3 have been extensively investigated in various ***,we summarize the roles of overly expressed Gal-1 and Gal-3 in the pathogenesis of hepatocellular carcinoma(HCC).The overexpression of Gal-1 and Gal-3 correlates with tumor growth,HCC cell migration and invasion,tumor aggressiveness,metastasis,and poor prognosis.A potentially promising future treatment strategy for HCC may include the combination of immunotherapy with Gal-1 *** research is warranted to investigate targeting Gal-1 and Gal-3 for HCC treatment.

关键词： Galectin-1(Gal-1) Galectin-3(Gal-3) Liver cancer Hepatocellular carcinoma(HCC) Fibrosis Cirrhosis Non-alcoholic steatohepatitis(NASH) Metastasis Epithelial-mesenchymal transition(EMT)

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Hepatocellular carcinoma immunotherapy:The impact of epigenetic drugs and the gut microbiome

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Liver Research 2020年第4期4卷 191-198页

作者： Farzam Vaziri Steven D.colquhoun Yu-Jui Yvonne Wan Department of Pathology and Laboratory Medicine University of California DavisSacramentoCAUSA Department of Surgery University of California DavisSacramentoCAUSA

The incidence of hepatocellular carcinoma(HCC)has been increasing for *** disease has now risen to become the sixth most common malignancy overall,while ranking as the third most frequent cause of cancer *** several surgical interventions and loco-regional treatment options are available,up to 80%of patients present with advanced disease not amenable to standard ***,traditional cytotoxic chemotherapeutic agents are notoriously ineffective and essentially play no role in the management of affected *** has led to an enormous need for more effective sys-temic therapeutic *** recent years,immunotherapy has emerged as a potentially viable and exciting new alternative for the treatment of *** the current immunotherapeutic options remain imperfect,various strategies can be employed to further improve their *** findings have revealed epigenetic modulation can be effective as a new approach for improving HCC *** the gut microbiome(gut-liver axis)can also be an interesting subject in this ***,we explore the latest insights into the role of immunotherapy treating HCC,both mono and in combination with other *** also focus on the impact of epigenetic drugs and the microbiome in the overall effectiveness of HCC immunotherapy.

关键词： Hepatocellular carcinoma(HCC) Immunotherapy Gut microbiota Epigenetic drugs Combination therapy

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Whither Second-Sphere Coordination?

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CCS Chemistry 2022年第3期4卷 755-784页

作者： Wenqi Liu Partha J.Das Howard M.colquhoun J.Fraser Stoddart Department of Chemistry Northwestern UniversityEvanstonIL 60208 Department of Chemistry University of ReadingReading RG66DX School of Chemistry University of New South WalesSydneyNSW 2052 Department of Chemistry Stoddart Institute of Molecular ScienceZhejiang UniversityHangzhou 310027 ZJU-Hangzhou Global Scientific and Technological Innovation Center Hangzhou 311215

The properties of coordination complexes are dictated by both the metals and the *** use of molecular receptors as second-sphere ligands enables significant modulation of the chemical and physical properties of coordination *** this minireview,we highlight recent advances in functional systems based on molecular receptors as second-sphere coordination ligands,as applied in molecular recognition,synthesis of mechanically interlocked molecules,separation of metals,catalysis,and biomolecular *** functional systems demonstrate that second-sphere coordination is an emerging and very promising strategy for addressing societal challenges in health,energy,and the environment.

关键词： catalysis coordination complexes mechanically interlocked molecules metal recovery molecular recognition supramolecular chemistry

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Hepatocellular carcinoma diagnosis and treatment: An overview

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Liver Research 2020年第4期4卷 159-160页

作者： Steven D.colquhoun Yu-Jui Yvonne Wan Department of Surgery University of California DavisSacramentoCAUSA Department of Pathology and Laboratory Medicine University of California DavisSacramentoCAUSA

For decades,chronic liver disease has remained an increasing global health *** vaccines and antiviral therapies,both hepatitis B and C remain enormous clinical *** steatosis has become a rapidly increasing worldwide concern that can be appropriately characterized as an evolving epidemic.1 Aroundtheworld alcohol consumption is onthe rise,while autoim-mune conditions and environmental toxins all continue contrib-uting to this seemingly universal health *** common denominator of chronic liver disease is progressive hepatic inflam-mation leading to fibrosis and cirrhosis.

关键词： diagnosis clinical treatment

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预报雷暴、强雷暴和龙卷的判断树方法

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气象科技 1989年第2期17卷 44-50页

作者： J.R.colquhoun 周景林澳大利亚气象局

本文描述预报雷暴、强雷暴和龙卷的判断树方法。这个方法只应用一些气象参数,对这些现象的发展,这些参数被认为是最根本的。参数间的物理学关系用雷暴和强雷暴结构和动力学作了解释。预报输出也包括干微暴流、湿微暴流、下击暴流和局地... 详细信息

本文描述预报雷暴、强雷暴和龙卷的判断树方法。这个方法只应用一些气象参数,对这些现象的发展,这些参数被认为是最根本的。参数间的物理学关系用雷暴和强雷暴结构和动力学作了解释。预报输出也包括干微暴流、湿微暴流、下击暴流和局地洪水。对判断树方法只作了有限的主观评价。

关键词：判断树龙卷下击暴流垂直风切变上升气流下沉气流位温对流不稳定抬升指数风暴单体

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