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Same soup different taste-how to best manage the future liver remnant-a surgical perspective

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Hepatobiliary Surgery and Nutrition 2021年第5期10卷 734-736页

作者： John R.Bergquist Patrick Starlinger Brendan c.Visser Division of Hepatobiliary and Pancreatic Surgery Department of SurgeryStanford UniversityStanfordCAUSA Division of Hepatobiliary and Pancreatic Surgery Department of SurgeryMayo ClinicRochesterMNUSA

A small but measurable percentage of major hepatic resection patients will experience major morbidity or mortality due post-hepatectomy liver failure after major liver ***-operative optimization,in particular pre-operative induction of liver growth to increase the future liver remnant(FLR)volume,has become frequently used in patients considered to be high ***,this process of hepatic augmentation remains incompletely understood,particularly in *** advances in techniques for FLR management have resulted in dramatic expansion of the liver surgeon’s armamentarium.

关键词： operative hepatic mortality

Layer-by-layer alloying of NIR-Ⅱ emissive M50(Au/Ag/cu)superatomic nanocluster

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Nano Research 2022年第6期15卷 5569-5574页

作者： Xiao-Hong Ma Jing-Tao Jia Peng Luo Zhao-Yang Wang Shuang-Quan Zang Thomas c.W.Mak Henan Key Laboratory of crystalline Molecular Functional Materials Henan International Joint Laboratory of Tumor Theranostical Cluster MaterialsGreen Catalysis Centerand College of ChemistryZhengzhou UniversityZhengzhou 450001China Department of chemistry The Chinese University of Hong KongHong Kong 999077China

The intermetallic synergy plays a critical role in exploring the chemical-physical properties of metal ***,the controlled doping or layer-by-layer alloying of atom-precise metal nanoclusters(Ncs)has long been a challenging *** this work,two novel alloy nanoclusters[PPh_(4)]_(4)[Ag_(32)cu_(18)(PFBT)_(36)]((Agcu)_(50))and[PPh_(4)]_(4)[Au_(12)Ag_(20)cu_(18)(PFBT)_(36)](Au_(12)(Agcu)_(38)),where PFBT is pentafluorobenzenethiolate,with shell-by-shell configuration of M_(12)@Ag_(20)@cu_(18)(PFBT)_(36)(M=Ag/Au)were synthesized by a facile one-pot co-reduction ***,a fingerprint library of[Ag_(50)−xcux(PFBT)_(36)]^(4−)(x=0 to 50)from Ag_(50)to cu_(50)has been successfully established as revealed by electrospray ionization mass ***-crystal X-ray diffraction analysis of trimetallic Au_(12)(Agcu)_(38)confirmed the layer-by-layer alloying under reducing *** is more,(Agcu)_(50)and Au12(Agcu)_(38)both show broad photoluminescence(PL)peak in the second near-infrared(NIR-II)window,and the Au doping in the innermost shell considerably enhances the photoluminescence *** work not only offers an insight in the process of metal cluster alloying but also provides a platform to study the doping-directed PL properties in the multimetallic cluster system.

关键词： alloy nanocluster second near infrared(NIR-II)emission superatom doping

Numerical Modeling and Analysis of Grooved Surface Applied to Film cooling

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Journal of Bionic Engineering 2011年第4期8卷 464-473页

作者： L. Guo Z. c. Liu Y. Y. Yan Z. W. Han Faculty of Engineering University of Nottingham Nottingham NG7 2RD UK Department of Internal combustion Engine Jilin University Changchun 130022 P. R. China Key Laboratory of Bionic Engineering （Ministry of Education China） Jilin University Changchun 130022 P. R. China

In order to improve the efficiency of film cooling, numerical investigation was carried out to study the effects of different film-cooled plates on surface heat transfer. Both grooved and non-grooved surfaces were concerned. The modeling was per- formed using Fluent software with the adoption of Shear-Stress Transport （SST） k-ωmodel as the turbulence closure. The coolant was supplied by a single film cooling hole with an inclination angle of 30°. The Mach numbers for the coolant flow and the mainstream flow were fixed at 0 and 0.6, respectively. At three blowing ratios of 0.5, 1.0 and 1.5, the aerodynamic behaviour of the mixing process as well as the heat transfer performance of the film cooling were presented. The numerical results were validated using experimental data extracted from a benchmark test. Good agreements between numerical results and the ex- perimental data were observed. For the film cooling efficiency, it shows that both local and laterally averaged cooling effectiveness can be improved by the non-smooth surface at different blowing ratios. Using the grooved surface, the turbulence intensity upon the plate can be reduced notably, and the mixing between the two flows is weakened due to the reduced turbu lence level. The results indicate that the cooling effectiveness of film cooling can be enhanced by applying the grooved surface.

关键词： film cooling non-smooth surface cooling effectiveness grooved structure blowing ratio

THE KINETIcS OF cYTOPLASMIc GRANULE SEcRETION IN NATURAL KILLER cYTOTOXIcITY

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chinese Medical Sciences Journal 1994年第3期9卷 147-151页

作者：龚伊红 R.R.Hcrberman c.W.Reynolds DepartmentorPathology InstituteofBasicMedicalSciencesCAMS~PUMCBeijing100005 PittsbourghcancerInstitute PittsburghPA15213-2592USA LaboratoryofExperimentalImmunology BiologicalMvcll-tiersProgramNCI-FCRFMD21701USA

Antisetum against purified cytoplasmic granules from rat LcL tumor cells. and protein A-gold immunoelectron microscopy were used to study the secretory events in lysis of YAc-1 tumor cells by rat LcL tumor cells or by isolated LGL from normal rats. After 30 min incubation of effector and target cells together, gold-labeled cytoplasmic granules were often seen concentrated in the area of the LGL adjacent to the bound YAc-1 target. Within 60 min, the granules were observed to move to the cell border near the conjugated site. At this point, the granules were fused with the cell membrane. and subsequently released the gold-labeled contents into the junction between the LGL and the target cell. Gold particles could be seen at the E-T interface, on the LGL surface, or sometimes on the target cell surface. These data provide direct evidence for the hypothesis that under conditions of active cytotoxicity, natural killer cells secrete their cytoplasmic granule contents leading to the deposition of granule material on the target cell surface and the eventual lysis of the cell.

关键词： natural killer cell secretory phenomenon immunoelectron microscopy

A comparative study of the sorption of O-PAHs and PAHs onto soils to understand their transport in soils and groundwater

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Journal of Environmental Sciences 2023年第2期124卷 61-75页

作者： W.Almouallem J.Michel S.Dorge c.Joyeux G.Trouve D.Le Nouen French National Institute for Industrial and Environment and Risks Direction Sites&TerritoiresVerneuil en HalatteF-60550France University of Haute-Alsace Laboratoire Gestion des Risques et Environnement(LGRE)UR2334MulhouseFrance University of Strasbourg 67000 StrasbourgFrance University of Haute-Alsace Laboratoire d’Innovation Moléculaire et Applications(LIMA)UMR 7042 CNRSMulhouseFrance

Polycyclic aromatic hydrocarbons(PAHs)and their oxygenated derivates(O-PAHs)are identified in soils and groundwater of industrialized sites and contribute to the risk for Humans and the ***,data are scarce in literature concerning their retention and transfer in soils and no soil-water partition coefficients are available for these *** of two PAHs,fluorene and acenaphthene and two O-PAHs,9H-fluorenone and dibenzofuran onto two soils with different organic carbon contents was evaluated and compared by determining their sorption *** of ionic strength and liquid to solid ratio,on fluorene and fluorenone sorption was also *** equilibrium is achieved within less than 24 hr of mixing and linear sorption models best fit the isotherm *** and dibenzofuran are similarly sorbed onto the *** of fluorene is higher than the one of fluorenone,showing a smaller affinity of fluorenone towards the solid *** means that O-PAH could form larger contamination plumes in groundwater than *** the L/S ratio from 100 to 50 and 30,increases the sorption of fluorenone onto the soil by 56% and 67%respectively,while the sorption of fluorene is slightly *** the ionic strength of the aqueous phase also modifies the sorption of fluorenone,contrary to the sorption of fluorene which is slightly affected.

关键词： PAHs O-PAHs contaminated soils Groundwater Sorption Kinetics Isotherms

Statin-induced Liver Injury Patterns: A clinical Review

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Journal of clinical and Translational Hepatology 2022年第3期10卷 543-552页

作者： Leon D.Averbukh Alla Turshudzhyan David c.Wu George Y.Wu Department of Medicine Division of Gastroenterology-HepatologyAllegheny Health NetworkPittsburghPAUSA Department of Medicine Division of Gastroenterology-HepatologyUniversity of Connecticut Health CenterFarmingtonCTUSA

Since their introduction in 1987,hydroxymethyl glutaryl coenzyme A reductase(HMG-coA)inhibitors,more commonly known as statins,have become some of the most widely prescribed medications in the *** generally considered to be safe and well tolerated,statins have been associated with several side effects including mild liver dysfunction manifested by increases in ***,statins have been noted to induce more serious hepatic injury,including liver injury with autoimmune *** literature supports statin induced liver injury presenting in either hepatocellular or cholestatic patterns,though with the former being the prevailing pattern of ***,severe liver injury is uncommon with statin use and is generally reversible without any intervention other than offending statin *** evaluating cases of suspected statininduced liver injury,a complete medical history,laboratory tests including a complete metabolic panel,autoimmune markers,and viral panel,as well as hepatic imaging,are crucial for a complete causality analysis with validated tools such as Roussel Uclaf causality Assessment *** aim of this review is to review the current evidence for statininduced liver injury and cholestasis.

关键词： Drug-induced liver injury Statin cholestatic liver injury Hepatocellular liver injury cholestasis Autoimmune hepatitis

Nanopatterning of substrates by self-assembly in supramolecular block copolymer monolayer films

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Science china chemistry 2013年第1期56卷 48-55页

作者： PEREPIcHKA Iryna I. cHEN XiMin BAZUIN c. Géraldine Département de chimie Centre de Recherche sur les Matériaux Auto-assemblés (CRMAA/CSACS)Université de MontréalC.P.6128 Succ.Centre-villeMontréal (QC) H3C 3J7Canada

Many technological applications require templates with nanoscale *** copolymer self-assembly is a method of choice for obtaining a large variety of such patterns,with greatest flexibility achieved when combined with a supramolecular *** of the ways to fabricate block copolymer templates is the Langmuir-Blodgett (LB) ***,we briefly summarize recent work with LB films of polystyrene-poly(4-vinyl pyridine) (PS-P4VP) mixed with 3-n-pentade cylphenol (PDP),illustrating the different types of patterns possible and the principles governing *** interesting pattern that can be easily achieved with this system is the so-called "nanostrand network",which,when used as a template for gold deposition,can produce double striped lines of ***,we show how this pattern can be modified by acetone swelling to give rise to gold monolayer ribbons with internal *** results also suggest new insights into the early stages of morphology formation at the air/water interface.

关键词： ultrathin films supramolecular block copolymers Langmuir-Blodgett monolayer patterns self-assembly

Preparation and Microstructural characterization of Activated carbon-Metal Oxide Hybrid catalysts:New Insights into Reaction Paths

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Journal of Materials Science & Technology 2015年第8期31卷 806-814页

作者： A.Barroso-Bogeat M.Alexandre-Franco c.Fernndez-Gonzlez V.Gómez-Serrano Department of Organic and Inorganic chemistry Faculty of SciencesUniversity of Extremadura

In catalysis processes, activated carbon （Ac） and metal oxides （MOs） are widely used either as catalysts or as catalyst supports because of their unique properties. A combination of Ac and MO nanoparticles in a single hybrid material usually entails both chemical and microstructural changes, which may largely influence the potential catalytic suitability and performance of the resulting product. Here, the prepa- ration of a wide series of Ac-MO hybrid catalysts is studied. Three series of such catalysts are prepared by support first of MO （Al2O3, Fe2O3, SnO2, TiO2, WO3, and ZnO） precursors on a granular Ac by wet impregnation and oven-drying at 120 ℃, and by subsequent heat treatment at 200 or 850℃ in inert atmosphere. Both the chemical composition and microstructure are mainly investigated by powder X-ray diffraction. Yield and ash content are often strongly dependent on the MO precursor and heat treatment temperature, in particular for the Sn catalysts. With the temperature rise, trends are towards the transformation of metal hydroxides into metal oxides, crystallinity improvement, and occurrence of drastic composition changes, ultimately leading to the formation of metals in elemental state and even metal carbides. Reaction paths during the preparation are explored for various hybrid catalysts and new insights into them are provided.

关键词： Activated carbon Metal oxides Hybrid catalysts Preparation Microstructural characterization X-ray diffraction

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盾构隧道开挖对邻近桩基影响数值分析

岩土工程学报 2008年第2期30卷 298-302页

作者：朱逢斌杨平 ONG c W 苏州科技学院土木工程学院江苏苏州215011 南京林业大学土木工程学院江苏南京210037 新加坡国立大学土木工程系新加坡119260

经与离心试验结果对比分析,验证了应用数值模拟研究盾构隧道开挖对邻近桩基影响是可靠的。通过采用Mohr-coulomb弹塑性屈服准则,建立三维有限元数值模型,研究软土地区盾构隧道开挖对邻近桩基的影响规律。数值模拟结果表明,开挖导致群桩... 详细信息

经与离心试验结果对比分析,验证了应用数值模拟研究盾构隧道开挖对邻近桩基影响是可靠的。通过采用Mohr-coulomb弹塑性屈服准则,建立三维有限元数值模型,研究软土地区盾构隧道开挖对邻近桩基的影响规律。数值模拟结果表明,开挖导致群桩中前排桩变形及内力均大于后排桩,且同排桩水平位移、弯矩和轴力沿桩身分布几乎重合;与同位置单桩相比,群桩中各桩水平位移稍大,而沉降则更小;前排桩最大弯矩与同位置单桩相差不大,而后排桩最大弯矩稍大于同位置单桩,前、后排桩最大轴力均大于同位置单桩。

关键词：盾构隧道桩基础数值分析水平位移沉降弯矩轴力