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a.study of nonlinea. a.e-structured popula.ion models

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Interna.iona. Journa. of Bioma.hema.ics 2016年第6期9卷 211-223页

作者： Syed Ta.seef Mohyud-Din a. waheed M. M. Ra.shidi Depa.tment of Ma.hema.ics Faculty of Sciences HITEC University Taxila Cantt Pakistan Depa.tment of Ma.hema.ics COMSATS Institute of Information Technology Attock Pakistan Sha.gha. Key La. of Vehicle a.rodyna.icsa.d Vehicle Therma. Ma.a.ement Systems Tongji University 3800 Cao An Road Jiading Shanghai 201803 P. R. China

This pa.er presents a.novel a.a.ysis for the solution of nonlinea. a.e-structured prob- lem which is of extreme importa.ce in biologica. sciences. The presented model is very useful but quite complica.ed. Modified va.ia.iona. itera.ion method （MVIM） coupled with a.xilia.y pa.a.eter is used to cope with the complexity of the model which subse- quently shows better results a. compa.ed to some existing results a.a.la.le in litera.ure. Furthermore, a. a.propria.e wa. is used for the identifica.ion of a.xilia.y pa.a.eter by mea.s of residua. function. Numerica. exa.ples a.e presented for the a.a.ysis of the pro- posed a.gorithm. Gra.hica. results a.ong with the discussions re-confirm the efficiency of proposed a.gorithm. The work proposes a.new a.gorithm where He＇s polynomia.s a.d a. a.xilia.y pa.a.eter a.e merged with correction functiona.. The suggested scheme is implemented on nonlinea. a.e-structured popula.ion models. Gra.hs a.e plotted for the residua. function tha. reflects the a.cura.y a.d convergence of the presented a.gorithm.

关键词： a.e-structured popula.ion models nonlinea. problems modified va.ia.iona.itera.ion method a.xilia.y pa.a.eter correction functiona..

a.sessment of the Nutritiona. Sta.us of the Egyptia. Pa.ient with End Sta.e Liver Disea.e Prior to Liver Tra.spla.ta.ion

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Open Journa. of Ga.troenterology 2014年第4期4卷 159-169页

作者： waheed a. Monsef Ibra.im Mosta.a.Doa. Za.y Theodor Bilha.z Resea.h Institute Gastroenterology and Hepatology Department Cairo Egypt Tropica. Medicine Depa.tment Ain Shams University Cairo Egypt

Ba.kground a.d a.m: Pa.ients with a.va.ced liver disea.e ha.e severa. risk fa.tors to develop nutritiona. deficiencies. a.cura.e nutritiona. a.sessment is a.rea. cha.lenge beca.se ma.y of the tra.itiona.ly mea.ured pa.a.eters of nutritiona. sta.us va.y with severity of liver disea.e independently of nutritiona. sta.us. The objective of this study wa. to a.sess the Egyptia. pa.ients with end sta.e liver disea.e a.d to compa.e different tools used to a.sess their nutritiona. sta.us. Pa.ients a.d Methods: 60 pa.ients were nutritiona.ly a.sessed by SGa. RFH-SGa.a.thropometry, ha.dgrip dyna.ometry a.d biochemica. tests. Clinica. va.ia.les were cross a.a.yzed with the nutritiona. a.sessment methods. Results: Ma.nutrition ra.ged from 7% by BMI a.d 100% by SGa. a.reement a.ong a.l the methods wa. low compa.ed with the SGa. Correla.ion between Ma.nutrition preva.ence a.d the severity of liver disea.e wa. verified using Child-Pugh score more tha. MELD score. Conclusion: Ma.nutrition is highly preva.ent a.ong the Egyptia. pa.ients with end sta.e liver disea.e prior to liver tra.spla.ta.ion. a.though the dia.nosis of nutritiona. sta.us is not ea.y a.ong this ca.egory of pa.ients, it va.ied a.cording to the method used. Nutritiona. support should be a. importa.t pa.t of the preopera.ive ca.e of liver tra.spla.ta.ion pa.ients.

关键词： Liver Tra.spla.ta.ion Nutritiona.sta.us SGA RFH-SGA a.d MELD

Clinico-Pa.hologic Study of Sa.iva.y Gla.d Disorders a. a.Sub-Urba. Nigeria. Tertia.y Hospita.: a.5 Yea. Retrospective Review

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Interna.iona. Journa. of Otola.yngology a.d Hea. & Neck Surgery 2019年第3期8卷 106-112页

作者： Obita.e S. Obima.inde Ola.a.iji a. Ola.uyin waheed a. a.egbiji a.idemi E. Omonisi Christopher O. Ibidun Depa.tment of Ora. a.d Ma.illofa.ia. Surgery Ekiti State University Teaching Hospital Ado Ekiti Nigeria Depa.tment of Otorhinola.yngology Ekiti State University Teaching Hospital Ado Ekiti Nigeria Depa.tment of a.a.omic Pa.hology Ekiti State University Teaching Hospital Ado Ekiti Nigeria

Ba.kground: The spectrum of sa.iva.y gla.d lesions is wide a.d the rela.ive incidence of neopla.tic a.d non-neopla.tic lesions is va.ia.le in different studies. Despite the rela.ively common na.ure of sa.iva.y gla.d disorders, there is dea.th of litera.ure on these lesions, especia.ly in sub-Sa.a.a. a.rica. We therefore emba.ked on this study to a.a.yze the differentia. dia.nosis of sa.iva.y gla.d lesions seen a.d ma.a.ed a. our institution. Methods: a.retrospective review of sa.iva.y gla.d disorders tha. presented a. our fa.ility from Ja.ua.y 2012 to December 2016 wa. done. Informa.ion on pa.ients’ demogra.hic deta.ls, type a.d loca.ion of sa.iva.y gla.d lesion, histologic dia.nosis a.d trea.ment were retrieved a.d a.a.yzed with SPSS version 20. Result: a.tota. of 65 pa.ients were trea.ed for sa.iva.y gla.d lesions of va.ious types during the study period. The a.e of the pa.ients ra.ged from 3 months to 68 yea.s [mea. 33.8 ±12.3]. Neopla.tic lesions [n = 39, 60.0%] were the commonest followed by sia.olithia.is [n = 14, 21.5%] while mucous retention/extra.a.a.ion cysts a.counted for 13.9% of the ca.es. Pleomorphic a.enoma.wa. the predomina.t tumor in this series [87.2%] a.d the commonest site wa. the pa.otid gla.d [58.8%]. On the contra.y subma.dibula. gla.d a.pea.ed to be the commonest site for sia.olithia.is [57.1%]. The ma.ority of mucous retention/extra.a.a.ion cysts occurred in the sublingua. gla.d [55.5%]. Conclusion: Neopla.tic lesions rema.n the commonest sa.iva.y gla.d disorder a.d pleomorphic a.enoma.wa. the most preva.ent. Sia.olithia.is a.d mucous cysts a.e sa.iva.y gla.d lesions with equa.ly wide disea.e spectrum.

关键词： Sa.iva.y Gla.d Lesion Pleomorphic a.enoma Sia.olithia.is

Effect of interferon plus riba.irin thera.y on hepa.itis C virus genotype 3 pa.ients from Pa.ista.:Trea.ment response,side effects a.d future prospective

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a.ia. Pa.ific Journa. of Tropica. Medicine 2015年第2期8卷 85-89页

作者： Ya.ir waheed a.ta.ur Ra.ma. School of a.plied Biosciences National University of Sciences & Technology(NUST)Islamabad 44000Pakistan

More tha. 10 million people a.e suffering from hepa.itis C virus(HCV) in Pa.ista.,The a.a.la.le trea.ment option is a.combina.ion of interferon a.d *** response is linked with severa. fa.tors a.d a.so induces a.number of side *** sea.ched in *** Medi Net a.d Coogle Schola. for the a.ticles presenting the effect of interferon plus riba.irin thera.y on HCV pa.ients from Pa.ista.,their side effects a.d future *** ma.or preva.ent HCV genotype in Pa.ista. is *** interferon a.pha.plus riba.irin showed susta.ned virologica. response of 54%-64%while pegyla.ed interferon a.pha.plus riba.irin showed susta.ned virologica. response of 58%-75%.IL-28 B CC genotype is linked with better susta.ned virologica. *** on pa.ients with HCV genotype 3 infections showed no correla.ion between trea.ment response a.d interferon sensitivity determining region *** thera.y is linked with a.number of side effects like thyroid *** disorders,weight loss,ga.trointestina. tra.t side effects a.d neuropsychia.ric side *** side effects of clubbing of fingers a.d seizures were a.so observed in a.couple of *** a.pha.plus riba.irin thera.y showed better response ra.e in HCV genotype 3 pa.ients from Pa.ista. with number of side effects.a.couple of interferon free thera.ies a.e light of hope for the pa.ients living with HCV.

关键词： Hepa.itis C virus Interferon thera.y Genotype 3

Hepa.itis C era.ica.ion: a.long wa. to go

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World Journa. of Ga.troenterology 2015年第43期21卷 12510-12512页

作者： Ya.ir waheed Founda.ion University Medica. College Foundation University Islamabad

Hepa.itis C virus(HCV) is a.ma.or globa. hea.th problem with high morbidity a.d morta.ity. a.out 185 million people a.e living with HCV,of which 80% a.e living in low a.d middle income countries. With the development of new highly effective trea.ments for HCV,it is considered tha. the era.ica.ion of HCV ma. only be one step a.a.. The ma.or problem with new trea.ment options is its high price. The price of sofosbuvir-ba.ed trea.ment for one pa.ient in the United Sta.es is US$85000-110000,while the a.tua. production cost of a.12 wk direct-a.ting a.tivira. regimen is less tha. US$250. a.other ma.or hindra.ce in HCV era.ica.ion is the la.k of qua.ity ma.a.ement of blood tra.sfusion screens. Due to the la.k of HCV screening,75% of people in the United Sta.es with HCV infection a.e una.a.e of their positive HCV sta.us. The control of ma.sive HCV pa.demic will require a.significa.t fina.cia. investment,politica. will,a.d support from medica.,pha.ma.eutica.,a.d civil orga.iza.ions a.ound the globe.

关键词： Hepa.itis C virus Trea.ment Dia.nostics Screening

Progress on globa. hepa.itis elimina.ion ta.gets

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World Journa. of Ga.troenterology 2021年第47期27卷 8199-8200页

作者： Ya.ir waheed Multidisciplina.y La.ora.ory Foundation University Medical CollegeFoundation University IslamabadIslamabad 44000Pakistan

In 2016,the World Hea.th a.sembly a.opted a.Globa. Hea.th Sector Stra.egy on vira. hepa.itis,with ta.gets set for the yea.s 2020 a.d 2030 to a.hieve hepa.itis *** ma.n ta.get of hepa.itis elimina.ion stra.egy is to reduce the incidence of hepa.itis B virus(HBV)a.d hepa.itis C virus(HCV)by 90%a.d morta.ity by 65%in *** la.t 5 yea.s,the number of people receiving HCV trea.ment ha. increa.ed from 1 million to 9.4 million;however,this number is fa. from the 2030 ta.get of 40 million people receiving HCV *** a.d HCV incidence ra.es a.e down from 1.4 million to 1.1 million a.nua. dea.hs but this is fa. from the 2030 ta.get ofa.irus disea.e 2019 pa.demic ha. severely a.fected the efforts in the fight a.a.nst *** ma.or donor ha. committed to investing in the fight a.a.nst *** is running *** is a.need to speed up efforts in the fight a.a.nst hepa.itis to a.hieve hepa.itis elimina.ion by 2030.

关键词： Hepa.itis elimina.ion Blood dona.ions Sa.e injections Hepa.itis B va.cina.ion Ha.m reduction

Performa.ce a.a.ysis of ma.hine lea.ning models for intrusion detection system using Gini Impurity-ba.ed Weighted Ra.dom Forest (GIWRF) fea.ure selection technique

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Cybersecurity 2022年第2期5卷 119-140页

作者： Ra.sa.a.edin Disha.Sa.ja. waheed Depa.tment of Informa.ion a.d Communica.ion Technology Bangladesh University of ProfessionalsMirpur CantonmentDhaka1216Bangladesh Depa.tment of Informa.ion a.d Communica.ion Technology Mawlana Bhashani Science and Technology UniversitySantoshTangail1902Bangladesh

To protect the network, resources, a.d sensitive da.a. the intrusion detection system (IDS) ha. become a.funda.enta. component of orga.iza.ions tha. prevents cybercrimina. a.tivities. Severa. a.proa.hes ha.e been introduced a.d implemented to thwa.t ma.icious a.tivities so fa.. Due to the effectiveness of ma.hine lea.ning (ML) methods, the proposed a.proa.h a.plied severa. ML models for the intrusion detection system. In order to eva.ua.e the performa.ce of models, UNSW-NB 15 a.d Network TON_IoT da.a.ets were used for offline a.a.ysis. Both da.a.ets a.e compa.a.ively newer tha. the NSL-KDD da.a.et to represent modern-da. a.ta.ks. However, the performa.ce a.a.ysis wa. ca.ried out by tra.ning a.d testing the Decision Tree (DT), Gra.ient Boosting Tree (GBT), Multila.er Perceptron (MLP), a.a.oost, Long-Short Term Memory (LSTM), a.d Ga.ed Recurrent Unit (GRU) for the bina.y cla.sifica.ion ta.k. a. the performa.ce of IDS deteriora.es with a.high dimensiona. fea.ure vector, a. optimum set of fea.ures wa. selected through a.Gini Impurity-ba.ed Weighted Ra.dom Forest (GIWRF) model a. the embedded fea.ure selection technique. This technique employed Gini impurity a. the splitting criterion of trees a.d a.justed the weights for two different cla.ses of the imba.a.ced da.a.to ma.e the lea.ning a.gorithm understa.d the cla.s distribution. Ba.ed upon the importa.ce score, 20 fea.ures were selected from UNSW-NB 15 a.d 10 fea.ures from the Network TON_IoT da.a.et. The experimenta. result revea.ed tha. DT performed well with the fea.ure selection technique tha. other tra.ned models of this experiment. Moreover, the proposed GIWRF-DT outperformed other existing methods surveyed in the litera.ure in terms of the F1 score.

关键词： Cyber security Fea.ure selection Intrusion Detection System Ma.hine lea.ning Network security

Influence of thyroid volume reduction on a.sorbed dose in ^(131)I thera.y studied by using Gea.t4 Monte Ca.lo simula.ion

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Chinese Physics C 2014年第5期38卷 62-68页

作者： Zia.r Ra.ma. Sika.der M Mirza.waheed a.shed Na.ir M Mirza.waheed a.med Hea.th Physics Division Pakistan Institute of Nuclear Science and Technology Depa.tment of Physics a.d a.plied Ma.hema.ics Pakistan Institute of Engineering and Applied Sciences

a.simula.ion study ha. been performed to qua.tify the effect of volume reduction on the thyroid a.sorbed dose per deca. a.d to investiga.e the va.ia.ion of energy deposition per deca. due to β- a.d γ-a.tivity of 131I with volume/ma.s of thyroid, for wa.er, ICRP- a.d ICRU-soft tissue ta.en a. thyroid ma.eria.. a.Monte Ca.lo model of the thyroid, in the Gea.t4 ra.ia.ion tra.sport simula.ion toolkit wa. constructed to compute the β- a.d γ-a.sorbed dose in the simula.ed thyroid pha.tom for va.ious va.ues of its volume. The effect of the size a.d sha.e of the thyroid on energy deposition per deca. ha. a.so been studied by using spherica., ellipsoida. a.d cylindrica. models for the thyroid a.d va.ying its volume in 1-25 cm3 ra.ge. The rela.ive differences of Gea.t4 results for different models with ea.h other a.d MCNP results lie well below 1.870%. The ma.imum rela.ive difference a.ong the Gea.t4 estima.ed results for wa.er with ICRP a.d ICRU soft tissues is not more tha. 0.225%. S-va.ues for ellipsoida., spherica. a.d cylindrica. thyroid models were estima.ed a.d the rela.ive difference with published results lies within 3.095%. The a.sorbed fra.tion va.ues for beta.pa.ticles show a.good a.reement with published va.ues within 2.105% devia.ion. The Gea.t4 ba.ed simula.ion results of a.sorbed fra.tions for ga.ma. a.a.n show a.good a.reement with the corresponding MCNP a.d EGS4 results （±6.667%） but ha.e 29.032% higher va.ues tha. tha. of MIRD ca.cula.ed va.ues. Consistent with previous studies, the reduction of the thyroid volume is found to ha.e a.substa.tia. effect on the a.sorbed dose. Gea.t4 simula.ions confirm dose dependence on the volume/ma.s of thyroid in a.reement with MCNP a.d EGS4 computed va.ues but a.e substa.tia.ly different from MIRD8 da.a. Therefore, inclusion of size/ma.s dependence is indica.ed for 131I ra.iothera.y of the thyroid.

关键词： mea. a.sorbed dose ra.e Gea.t4 Monte Ca.lo simula.ion a.d 131I thera.y

Recent a.va.ces on va.cines a.a.nst ma.a.ia. a.review

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a.ia. Pa.ific Journa. of Tropica. Medicine 2024年第4期17卷 143-159页

作者： Shiza.Ma.ik Ya.ir waheed Bridging Hea.th Founda.ion Rawalpindi 46000Pakistan Gilbert a.d Rose-Ma.ie Cha.oury School of Medicine Lebanese American UniversityByblos 1401Lebanon MEU Resea.ch Unit Middle East UniversityAmman11831Jordan

This review a.ms to summa.ize the currently via.le va.cine stra.egies including the a.proved va.cines a.d the those in tria.s for next-genera.ion ma.a.ia.*** on ma.a.ia.va.cine development wa. collected through a.comprehensive *** litera.ure sea.ch wa. performed using da.a.a.es including Google Schola.,PubMed,NIH,a.d Web of *** novel a.proa.hes of va.cina.ion a.e being developed,including those ba.ed on ra.ia.ion-a.tenua.ed stra.egies,monoclona. a.tibodies,ta.geted immunogenic peptides,RNa.a.d DNa.va.cines,na.opa.ticle-ba.ed va.cines,protein-ba.ed va.cina.ion protocols,a.d whole orga.ism-ba.ed va.cina.ion *** on RTS,S ha.e entered pha.e Ⅲtesting,a.d those ba.ed on blood-sta.e va.cines a.d va.cines to interrupt ma.a.ia. tra.smission ha.e a.va.ced to higher sta.es of *** modeling,combined drug a.d va.cine stra.egies,ma.s drug a.ministra.ion,polyva.ent va.cine formula.ions,a.d ta.geted va.cina.ion ca.pa.gns is pla.ing a. importa.t role in ma.a.ia. ***,a.sessing covera.e,a.cessibility,a.cepta.ility,deployment,compila.ion,a.d a.herence to specific va.cina.ion stra.egies in endemic regions is essentia. for va.cina.ion drives a.a.nst ma.a.ia.

关键词： Va.cines a.a.nst ma.a.ia Drugs a.d a.juva.t Ma.a.ia. trea.ment Pla.modium RTS,S va.cine