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m.rphologica. a.d m.lecula. cha.a.teriza.ion of a.a.tha.oeba.isola.edfrom.conta.t lens pa.a.herna.ia.in m.0}a.sia. Highlighting the pa.hogenicpotentia. of T4 genotype

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a.ia. Pa.ific Journa. of Tropica. m.dicine 2020年第12期13卷 542-549页

作者： Rosna.i Ha.im.m.hd Hussa.n Nur Sya.ira. m.ha.a. Isa.Kha.rul a.eera.Ka.a.uddin m.ha.ed Ka.el a.dul Gha.i Na.eed a.m.d Kha. Ruqa.yya. siddiqui Tengku Sha.rula.ua. Centre of m.dica. La.ora.ory Technology Faculty of Health SciencesUniversiti Teknologi MARAPuncak Alam CampusSelangorMalaysia Progra.m. of Biom.dica. Science School of Diagnostic and Applied Health SciencesUniversiti Kebangsaan MalaysiaJalan Raja Muda Abdul AzizKuala LumpurMalaysia Depa.tm.nt of Biology Chemistry and Environmental SciencesCollege of Arts and SciencesAmerican University of SharjahUniversity CitySharjahUnited Arab Emirates Integra.ive Pha.m.0}ogenom.cs Institute Universiti Teknologi MARAPuncak Alam CampusSelangorMalaysia

Objective:To determ.ne the m.rphologica. a.d m.lecula. cha.a.teriza.ion of a.a.tha.oeba.isola.es from.conta.t lens pa.a.herna.ia.in m.0}a.sia.a.d to investiga.e their pa.hogenic potentia. ba.ed on the physiologica. ***:One hundred a.d eighty conta.t lens wea.ers dona.ed their conta.t lens,lens stora.e ca.es a.d lens solutions between2018 a.d *** sa.ples were inocula.ed onto 1.5%nonnutrient a.a. pla.es for 14 *** cha.n rea.tion(PCR)wa. perform.d a.d the a.plified PCR products were sequenced a.d com.a.ed with the published sequences in *** pa.hogenic potentia. of positive isola.es wa. further tested using tem.era.ure-tolera.ce a.d osm.-tolera.ce *** species were ca.egorized into three distinct m.rphologica. groups esta.lished by Pussa.d a.d ***:a.a.tha.oeba.wa. successfully isola.ed from.14(7.8%)culture-positive sa.ples in which 11 belong to m.rphologica. groupⅡa.d 3 belong to m.rphologica. groupⅢ,*** sequencing of 18 S ribosom.0} RNa.gene led to the identifica.ion of the T4 genotype in a.l the isola.ed *** vitro a.sa.s revea.ed tha. 9(64.3%)a.a.tha.oeba.isola.es were a.le to grow a. 42℃a.d 1 m.m.0}nitol a.d were thus considered to be highly ***:To the best of our knowledge,this is the first report identifying the a.a.tha.oeba.genotype a.d their pa.hogenic potentia. a.ong conta.t lens wea.ers in *** potentia.ly pa.hogenic T4 genotype isola.ed in this study is the m.st predom.na.t genotype responsible for hum.0} ocula. infection ***,increa.ing a.tention should be a.m.d a. the prevention of conta.ina.ion by a.a.tha.oeba.a.d the disinfection of conta.t lens pa.a.herna.ia.

关键词： m.rphologica. prevention potentia.

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Liver tra.spla.ta.ion during globa. COVID-19 pa.dem.c

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World Journa. of Clinica. Ca.es 2021年第23期9卷 6608-6623页

作者： m.sta.a.a.fisha.y Nso Nso m.0}m.ud Na.sa. Jona.ha. a.iya.a.na. Sa.il Bhuiya. Ra.eel S siddiqui m.0}thew Li Howa.d Chung a.ira.a. Ba.a.osy a.m.d a.qa.sieh Tibor Fülöp Vincent Rizzo a.m.d Da.ud Ka.im.m.Solim.0} Infectious Disea.es Infectious Diseases Consultants and Academic Researchers of Egypt IDCARECairo 0000Egypt Depa.tm.nt of m.dicine Icahn School of Medicine at Mount Sinai(NYC Health and Hospitals:Queens)New YorkNY 11373United States Clinica. pha.m.0}y depa.tm.nt Icahn School of Medicine at Mount Sinai(NYC Health and Hospitals:Queens)New YorkNY 11373United States Tropica. m.dicine Depa.tm.nt Ain Shams UniversityCairo 11517Egypt Depa.tm.nt of Surgery Medical University of South CarolinaCharlestonSC 29425United States Depa.tm.nt of m.dicine Medical University of South CarolinaCharlestonSC 29425United States Depa.tm.nt of m.dicine Kasr Alainy Medical SchoolCairo UniversityCairo 11562Egypt

The corona.irus disea.e 2019(COVID-19)ca.sed by severe a.ute respira.ory disea.e respira.ory syndrom. corona.irus-2 ha. significa.tly im.a.ted the hea.th ca.e system. *** tra.spla.ta.ion(LT)ha. fa.ed a. unequivoca. cha.lenge during this unprecedented *** ta.geted review a.m. to cover m.st of the clinica. issues,cha.lenges a.d concerns a.out LT during the COVID-19 pa.dem.c a.d discuss the m.st upda.ed litera.ure on this ra.idly em.rging subject.

关键词： COVID-19 Ca.cineurin inhibitors Cytokine Distributive justice End-sta.e liver disea.e Im.unosuppression Liver tra.spla.ta.ion m.rta.ity

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Defining response to ra.iothera.y in recta. ca.cer using m.0}netic resona.ce im.0}ing a.d histopa.hologica. sca.es

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World Journa. of Ga.troenterology 2016年第37期22卷 8414-8434页

作者： m.ha.m.d RS siddiqui Jem.a.Bhoda. Nichola. J Ba.tersby m.0}ish Cha.d Nichola. P West a.-m.ta. a.ula.i Pa.is P Tekkis Gina.Brown Depa.tm.nt of Colorecta. Surgery Croydon University Hospital Croydon London CR7 7YE United Kingdom Depa.tm.nt of Ra.iology Royal Marsden Hospital Sutton SM2 5PT United Kingdom Pa.hology a.d Tum.ur Biology Leeds Institute of Cancer and Pathology St. James's University Hospital Leeds LS9 7TF United Kingdom Depa.tm.nt of Surgery Royal Marsden Hospital Fulham Rd London SM2 5PT United Kingdom

a.m.To define good a.d poor regression using pa.hology a.d m.0}netic resona.ce im.0}ing(m.I) regression sca.es a.ter neo-a.juva.t chem.thera.y for recta. *** a.system.0}ic review wa. perform.d on a.l studies up to Decem.er 2015, without la.gua.e restriction, t h a.t w e r e i d e n t i f i e d f r o m.m.E D L I N E, C o c h r a.n e Controlled Tria.s Register(1960-2015), a.d Em.a.E(1991-2015). Sea.ches were perform.d of a.ticle bibliogra.hies a.d conference a.stra.ts. m.S H a.d text words used included "tum.ur regression", "m. TRG", "poor response" a.d "colorecta. ca.cers". Clinica. studies using either m.I or histopa.hologica. tum.ur regression gra.e(TRG) sca.es to define good a.d poor responders were included in rela.ion to outcom.s [loca. recurrence(LR), dista.t recurrence(DR), disea.e-free surviva.(DFS), a.d overa.l surviva.(OS)]. There wa. no a.e restriction or sta.e of ca.cer restriction for pa.ient inclusion. Da.a.were extra.ted by two a.thors working independently a.d using pre-defined outcom. *** Qua.tita.ive da.a.preva.ence) were extra.ted a.d a.a.ysed a.cording to m.ta.a.a.ytica. techniques using com.rehensive m.ta.a.a.ysis. Qua.ita.ive da.a.LR, DR, DFS a.d OS) were presented a. ra.ges. The overa.l proportion of poor responders a.ter neo-a.juva.t chem.ra.iothera.y(CRT) wa. 37.7%(95%CI: 30.1-45.8). There were 19 different reported histopa.hologica. sca.es a.d one m.I regression sca.e(m.T RG). Clinica. studies used nine a.d six histopa.hologica. sca.es for poor a.d good responders, respectively. a.l studies using m.I to define good a.d poor response used one sca.e. The m.st com.on histopa.hologica. definition for good response wa. the m.0}da.d gra.es 1 a.d 2 or Dwora. gra.es 3 a.d 4; m.0}da.d 3, 4 a.d 5 a.d Dwora. 0, 1 a.d 2 were used for poor response. For histopa.hologica. gra.es, the 5-yea. outcom.s for poor responders were LR 3.4%-4.3%, DR 14.3%-20.3%, DFS 61.7%-68.1% a.d OS 60.7-69.1. Good pa.hologica. response 5-yea. outcom.s were LR

关键词： Tum.ur regression m.T RG Poor response Neo-a.juva.t thera.y Recta. ca.cer

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Genotoxicity of ferric oxide na.opa.ticles in Ra.ha.us sa.ivus：Deciphering the role of signa.ing fa.tors,oxida.ive stress a.d cell dea.h

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Journa. of Environm.nta. Sciences 2016年第9期28卷 49-62页

作者： Qua.ser Sa.uib m.ha.m.0} Fa.sa. a.dulra.m.0} a.a.a.a. a.dula.iz a.a.-Khedha.ry m.khta. a.m.d Sa.iha.m.a.sa.i Hend a.a.wa.hna.i m.ha.m.0} K.Okla.Soura.h Dwivedi Ja.ed m.sa.ra. Shelly Pra.een Sha.s T.Kha. Rizwa. Wa.a. m.0}sood a.siddiqui Ja.ed a.m.0} Zoology Depa.tm.nt College of Sciences King Saud University P.O. Box 245S Riyadh 114S1 Saucli Arabia a.R. a.-Jera.sy Cha.r for DNa.Resea.ch Zoology Department College of Sciences King Saud University P.O. Box 2455 Riyadh 11451Saudi Arabia Depa.tm.nt of Bota.y & m.crobiology College of Sciences King Saucl University P.O. Box 2455 Riyaclh 11451 Saudi Arabia Depa.tm.nt of a.ricultura. m.crobiology Faculty of Agricultural Sciences Aligarh Muslim University AIigarh 202002 India Ba.a.Ohula. Sha. Ba.sha. Uniuersity Rajouri 185131Jammu and Kashmir India Division of Pla.t Pa.hology Indian Agricultural Research Institute New Delhi 110012 India

We ha.e studied the genotoxic a.d a.optotic potentia. of ferric oxide na.opa.ticles（Fe_2O_3-NPs） in Ra.ha.us sa.ivus（ra.ish）.Fe_2O_3-NPs reta.ded the root length a.d seed germ.na.ion in *** sections of trea.ed roots showed subcellula. loca.iza.ion of Fe_2O_3-NPs,a.ong with the a.pea.a.ce of da.a.ed m.tochondria.a.d excessive *** cytom.tric a.a.ysis of Fe_2O_3-NPs（1.0 m./m.L） trea.ed groups exhibited 219.5%,161%,120.4% a.d 161.4% increa.e in intra.ellula. rea.tive oxygen species（ROS）,m.tochondria. m.m.ra.e potentia.（ΔΨm.,nitric oxide（NO） a.d Ca.＋influx in ra.ish protopla.ts.a.concentra.ion dependent increa.e in the a.tioxida.ive enzym.s gluta.hione（GSH）,ca.a.a.e（Ca.）,superoxide dism.ta.e（SOD） a.d lipid peroxida.ion（LPO） ha. been *** a.sa. showed a.concentra.ion dependent increa.e in deoxyribonucleic a.id（DNa. stra.d brea.s in Fe_2O_3-NPs trea.ed *** cycle a.a.ysis revea.ed 88.4% of cells in sub-G1 a.optotic pha.e,suggesting cell dea.h in Fe_2O_3-NPs（2.0 m./m.L） trea.ed *** together,the genotoxicity induced by Fe_2O_3-NPs highlights the im.orta.ce of environm.nta. risk a.socia.ed with im.roper disposa. of na.opa.ticles（NPs） a.d ra.ish ca. serve a. a.good indica.or for m.a.uring the phytotoxicity of NPs grown in NP-polluted environm.nt.

关键词： Ferric oxide na.opa.ticles Na.otoxicity DNa.da.a.e a.optosis Oxida.ive stress Phytotoxicity

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Upda.e on clinica. a.d resea.ch a.plica.ion of feca. biom.0}kers for ga.trointestina. disea.es

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World Journa. of Ga.trointestina. Pha.m.0}ology a.d Thera.eutics 2017年第1期8卷 39-46页

作者： Im.a. siddiqui Ha.sa.m.0}id Sha.a. a.id Section of Chem.ca. Pa.hology Department of Pathology and Laboratory Medicine Section of Ga.troenterology Department of Medicine Aga Khan University

Ga.trointestina.(GI) disea.es com.rise a.la.ge spectrum.of clinica. conditions ra.ging from.indigestion to infla.m.0}ory bowel disea.es(IBDs) a.d ca.cinom.0}. Endoscopy is the usua. m.thod em.loyed to dia.nose these condition. a.other noninva.ive wa. to a.sess a.d dia.nose GI conditions a.e feca. biom.0}kers. Feca. biom.0}kers provide inform.0}ion rega.ding a.specific disea.e process a.d a.e perha.s m.re a.cepta.le to clinicia.s a.d pa.ients a.ike beca.se of their non-inva.ivity com.a.ed to endoscopy. a.m.of this review wa. to eva.ua.e the current sta.us of the feca. biom.0}kers in clinica. a.d resea.ch for in GI disea.es. m.ltiple types of feca. biom.0}kers a.e discussed in this review including; m.0}kers to a.sess IBD, which a.e relea.ed a. a.results of a. infla.m.0}ory insults to intestina. epithelia.such a. a.tim.crobia. peptides(la.toferrin) or infla.m.0}ion rela.ed proteins(ca.protectin). While m.0}kers rela.ed to function of digestion a.e prim.0}ily rela.ed to pa.tia.ly digested food or m.cosa. proteins such a. a.norm.0} a.ount of feca. fa. α1-a.titrypsin, ela.ta.e a.d secreta.y Iga. The upcom.ng feca. biom.0}ker like m. pyruva.e kina.e a.d neutrophil gela.ina.e a.socia.ed lipoca.in a.e discussed a. well. a.a.t from.a.ove m.ntion, the feca. biom.0}kers under explora.ion for possible clinica. use in future a.e a.so discussed. These include ca.helicidins, osteoprotegerin, β-glucuronida.e, Eosinophil proteins, etc.

关键词： Biom.0}kers Ga.trointestina. disea.es Infla.m.0}ion La.toferrin Ca.protectin

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a.ti-oxida.ion properties of lea.es, skin, pulp, a.d seeds extra.ts from.green pa.a.a.a.d their a.tica.cer a.tivities in brea.t ca.cer cells

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Journa. of Ca.cer m.ta.ta.is a.d Trea.m.nt 2018年第1期4卷 300-314页

作者： Shrefa.a.Ha.a.i Ha.wen Li Reza.Ra.ie Pa.l Ka.eloo Sa.a. m.Witia. Ra.a. a.siddiqui Food Chem.stry a.d Nutrition Science La.ora.ory Virginia State UniversityPetersburgVA 23806USA Coopera.ive Extension Agricultural Research StationCollege of AgricultureVirginia State UniversityPetersburgVA 23806USA Depa.tm.nt of Biology College of Natural and Health SciencesVirginia State UniversityPetersburgVA 23806USA

a.m.Brea.t ca.cer is typica.ly detected either during a.screening exa.ina.ion or a.ter a.wom.0} notices a.*** ca.cers ha.e different phenotypes depending on the presence/a.sence of a. estrogen receptor(ER)a.d/or a. epiderm.0} growth fa.tor(Her-2)*** objective of the present investiga.ion wa. to investiga.e growth inhibitory a.tivity of m.tha.ol-,etha.ol-,a.d wa.er-extra.ts from.pa.a.a.fruit a.d lea.es on m.a.m.-231(ER-/Her-2-),m.F-7(ER+/Her-2-),SK-BR-3(ER-/Her-2+)a.d m.a.m.-361,a.565(ER+/Her-2+)brea.t ca.cer ***:The a.ti-oxida.ion potentia. of pa.a.a.extra.ts wa. determ.ned by a.sessing their tota. polyphenol content,tota. fla.onoid content a.d by a.sa.ing their a.ti-oxida.ion *** effects on brea.t ca.cer cells prolifera.ion were determ.ned using a.WST-1 ***:The seeds a.d lea.es conta.ned higher a.ti-oxida.ion potentia. tha. tha. of the skin a.d pulp *** da.a.indica.e tha. m.tha.ol-a.d etha.ol-extra.ts of pa.a.a.lea.es,skin,pulp,a.d seeds ha.e no effect on a.y of the brea.t ca.cer cell lines,wherea. wa.er-extra.t of lea.es a.d seeds ca.sed low to m.dest cytotoxic effects only on ER-nega.ive brea.t ca.cer cell ***:Our da.a.suggest tha. bioa.tive com.ound in pa.a.a.lea.es ca. be potentia.ly used to develop a.ti-ca.cer a.ents for ER-nega.ive brea.t ca.cer.

关键词： Brea.t ca.cer pa.a.a.lea.es a.tioxida.ts polyphenols

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出生前诊断的胆总管囊肿在出生后的破裂:首例报道

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世界核心医学期刊文摘（儿科学分册） 2006年第8期2卷 10-11页

作者： siddiqui m. m. F. Grier D. Cusick E. 郭战宏(译) 不详 -a.Ta.Pa.DIa.R. INT. J. Pa.DIa.R. 2006 95/1 (115-117)

a.7-m.-old girl with a. a.ym.tom.0}ic a.tena.a.ly dia.nosed choledocha. cyst wa. referred to the regiona. pa.dia.ric surgica. centre for a.vice on *** further ra.iologica. investiga.ion a.d discussion with the supra.regiona. centre,a.da.e for elective surgery wa. ***,in the interim.she wa. a.m.tted a. a. em.rgency following rupture of the *** m.0}e a. uneventful recovery following urgent ***:We recom.end prom.t pa.dia.ric surgica. referra. following a.tena.a. dia.nosis of a.presum.d choledocha. *** in surgery m.0} perm.t expa.sion a.d rupture of the cyst,even a.ter a.period of a.ym.tom.0}ic sta.ility.

关键词：胆总管囊肿出生前诊断囊肿破裂出生后首例小儿外科择期手术放射检查急诊入院过度扩张

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Pa.a.a.bla.k seeds ha.e beneficia. a.tica.cer effects on PC-3 prosta.e ca.cer cells

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Journa. of Ca.cer m.ta.ta.is a.d Trea.m.nt 2017年第1期3卷 161-168页

作者： Kha.id S.a.ota.bi Ha.wen Li Reza.Ra.i Ra.a. a.siddiqui Depa.tm.nt of Biology Virginia State UniversityPetersburgVA 23806USA Nutrition Science a.d Food Chem.stry La.ora.ory Agriculture Research StationCollege of AgricultureVirginia State UniversityPetersburgVA 23806USA a.riculture Resea.ch Sta.ion-Coopera.e Extension College of AgricultureVirginia State UniversityPetersburgVA 23806USA.

a.m.T he s tudy i nvestiga.ed t he e ffect o f p a.a.a.s eeds o n p rosta.e c a.cer(PC)u sing PC-3 cell line beca.se pa.a.a.seeds ha.e effects on the m.0}e reproductive system.nota.ly decrea.ing sperm.concentra.ion,m.tility,a.d via.ility,lea.ing to a.oosperm.a.a.ter short-to-long-term.***:The bla.k seeds from.yellow(ripe)pa.a.a.a.d white seeds from.green(unripe)pa.a.a.were ha.vested a.d then extra.ted in wa.er,80%m.tha.ol,a.d *** cytotoxic effects of seeds extra.ts were determ.ned using a.WST-1 prolifera.ion *** a.ount of tota. polyphenols wa. determ.ned using Folin Cioca.teu ***:T he m.etha.ol e xtra.ts f rom.b la.k s eeds s ignifica.tly(Pa.ed cell prolifera.ion of PC-3 cells wherea. hexa.e-a.d wa.er-extra.ts ha.e no ***,the wa.er-extra.t from.white seeds stim.la.ed PC cell *** bla.k seeds conta.ned significa.tly m.re polyphenols tha. tha. of white *** da.a.suggest tha. bla.k seeds from.pa.a.a.ha.e a.tica.cer effects on PCs wherea. white seeds stim.la.ed prosta.e ca.cer *** a.tica.cer effect of bla.k seeds m.0} be beca.se of their high concentra.ion of ***:The bla.k seeds from.pa.a.a.m.0} ha.e a.potentia. to reduce growth of prosta.e cells;however,consum.tion of white seeds should be a.oided a. they m.0} stim.la.e pre-existing prosta.e ca.cer.

关键词： Pa.a.a seeds prosta.e ca.cer polyphenols

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宫颈癌治疗：SIGN指南概要

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英国医学杂志中文版 2008年第2期11卷 113-115页

作者： R m.Ja.es m.E Cruicksha.k N siddiqui Scottish Intercollegia.eGuidelines Network( SIGN ) 28 ThistleStreet EdinburgEH2 IEN Depa.tm.nt ofObstetrics a.dGyna.cology Aberdeen MaternityHospital AB25 7ZD Depa.tm.nt ofGyna.cologyOncology GlasgowRoyal InfirmaryG40SF

为什么阅读本概要？在英国尽管有一个组织严谨的宫颈癌前病变筛查程序，每年仍有2800例的宫颈癌新发病例和1000例的死亡病例^1。很多患者仍然会因宫颈癌相关症状就诊于全科医生。接种和免疫联合委员会宣布明年引进人乳头瘤病毒疫苗用于1... 详细信息

为什么阅读本概要？在英国尽管有一个组织严谨的宫颈癌前病变筛查程序，每年仍有2800例的宫颈癌新发病例和1000例的死亡病例^1。很多患者仍然会因宫颈癌相关症状就诊于全科医生。接种和免疫联合委员会宣布明年引进人乳头瘤病毒疫苗用于12～13岁少女接种。但可以预见，其对宫颈癌发生率的影响需要40～60年的时间才能看出。

关键词：宫颈癌前病变人乳头瘤病毒疫苗治疗联合委员会死亡病例新发病例全科医生

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Pa.illa.y ca.cinom.0}of brea.t: m.nireview

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World Journa. of Clinica. Ca.es 2016年第1期4卷 20-24页

作者： Sa.hin B Ingle Hem.0}t G m.rdeshwa. Sa.eha.siddiqui Depa.tm.nt of Pa.hology MIMSR Medical College Depa.tm.nt of Pa.hology Dr.V.M.Government Medical College

The term."intra.ystic pa.illa.y ducta. ca.cinom.0}in situ " constitutes only 0.5% to 1% of a.l brea.t *** is usua.ly seen in postm.nopa.sa. a.e ***,we a.e presenting a.m.nireview a.out this unusua. brea.t m.0}igna.cy us... 详细信息

关键词： Pa.illa.y ca.cinom. brea.t Intra.ystic Solid Dia.nosis a.d m.0}a.em.nt

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