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Attenuation of Carbon Tetrachloride-Induced Hepatotoxicity by Cow Urine Distillate in Rats

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biomedical and Environmental Sciences 2009年第4期22卷 345-347页

作者： M P GURURAJA a b joshi HIMANSHU joshi D SATHYANARAYANA E V S SUbRAHMANYAM K S CHANDRASHEKHAR Nitte Gulabi Shetty Memorial Institute of Pharmaceutical Sciences Paneer

Objective To study the carbon tetrachloride-induced hepatoprotective activity in cow urine. Methods Effect of cow urine distillate on liver function was studied in vivo in rats intoxicated with carbon tetrachloride （CC14）. Hepatotoxicity was induced by a 1 ： 1 （v/v） mixture of CCl4 in olive oil （5 mL/kg i.p）. Protective effect of cow urine distillate （in three dose levels） and standard drug Silymarin （100 mg/kg, p.o） on liver function were studied in intoxicated rats. Parameters in the study included liver function tests and histological observations. Results The cow urine distillate decreased the levels of SGOT, SGPT, ALP, GGT, and total bilirubin in a dose-dependent manner （P〈0.05） as sylimarin. Conclusion The observed protective effects of cow urine distillate on liver function might be due to the presence of antioxidants in cow urine.

关键词： Hepatotoxicity Cow urine distillate CCl4 Silymarin

Penile cancer:Updates in systemic therapy

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Asian Journal of Urology 2022年第4期9卷 374-388页

作者： Vidhu b.joshi Juskaran Chadha Jad Chahoud Department of biochemistry and Molecular biology Mayo ClinicRochesterMNUSA Department of Genitourinary Oncology H.Lee Moffitt Cancer Center and Research InstituteTampaFLUSA

Penile cancer is a rare genitourinary malignancy with a greater incidence in parts of Asia,South America,and *** are very poor in patients with advanced disease and in those who do not respond to frstine mutimodal *** systemic therapy options,platinum-based chemotherapy is used in the frst line;however,approximately half of patients do not *** rates to systeric therapy as subsequent line treatment are historically *** is also a paucity of prognostic and predictive tools within the context of penile *** such,there remains an urgent need to expand systemic treatment options for patients with advanced penile *** purpose of this review is to summarize the existing evidence for standard-of-care lines of systemic treatment,examine the potential of novel lines of systemic therapy,and provide an update as to the status of these new therapies within the context of penile cancer.

关键词： Penile cancer Chemotherapy Immunotherapy Human papilloma virus Human papilloma virus-vaccine Adoptive cell therapy

Effect of Sodium Metasilicate on Structural, Optical, Dielectric and Mechanical Properties of ADP Crystal

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Journal of Materials Science & Technology 2016年第1期32卷 62-67页

作者： Mohd Anis M.D. Shirsat S.S. Hussaini b.joshi G.G. Muley Department of Physics Sant Gadge Baba Amravati University Amravati 444602 Maharashtra India Crystal Growth Laboratory Department of Physics MiUiya Arts Science and Management Science College Beed 431122 Maharashtra India Intelligent Materials Research Laboratory Department of Physics Dr. Babasaheb Ambedkar Marathwada University Aurangabad 431005 Maharashtra India Science and Engineering Research board New Delhi 110016 India

For the first time, sodium metasilicate （SMS） doped ammonium dihydrogen phosphate （ADP） crystal was grown by slow evaporation solution technique. The unit cell parameters of grown crystal were deter- mined by means of single crystal X-ray diffraction technique. The qualitative analysis of SMS doped ADP crystal was carried out using energy dispersive X-ray and Fourier transform infrared analysis. The in- crease in optical transparency of doped ADP crystal was ascertained in the range of 200-900 nm using the UV-visible spectral analysis. The vital optical constants were evaluated using the transmittance data to explore various optical device applications of crystal. The assertive influence of SMS on mechanical and dielectric behavior of ADP crystal was investigated by means of Vickers microhardness analysis and dielectric studies, respectively. The enhancement in second harmonic generation （SHG） efficiency of SMS doped ADP crystal with reference to potassium dihydrogen phosphate （KDP） and ADP was confirmed from Kurtz-Perry SHG test. The Kerr lensing nonlinearity in SMS doped ADP crystal was identified by means of Z-scan analysis and the third order nonlinear optical susceptibility （χ3） was found to be 6.19 × 10-5 esu, which vitalizes its application for laser stabilization systems.

关键词： Crystal growth Nonlinear optical materials Dielectric properties Optical properties

Well behaved Class of Charge Analogue of Durgapal’s Relativistic Exact Solution

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Journal of Modern Physics 2011年第10期2卷 1156-1160页

作者： Pratibha Fuloria b. C. Tewari b. C. joshi 不详

We obtain a new class of charged super-dense star models after prescribing particular Forms of the metric potential and electric intensity. The metric describing the superdense stars joins smoothly with the Reissner-Nordstrom metric at the pressure free boundary. The interior of the stars possess their energy density, pressure, pressure density ratio and velocity of sound to be monotonically decreasing towards the pressure free interface. In view of the surface density ρb=2×1014g/cm3, the heaviest star occupies a mass 5.523 M⊙with its radius 13.98 km. In absence of the charge we are left behind with the regular and well behaved fifth model of Durgapal [1].

关键词： Charged Fluids Reissener-Nordstom Metric General Relativity

Prediction of left ventricle ejection fraction from HRV in diabetics and cardiac diseased subjects:A mathematical model approach

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Medicine in Novel Technology and Devices 2024年第3期23卷 98-103页

作者： Ulka Shirole Manjusha joshi A.C.Patil College of Engineering Navi MumbaiIndia Amity University MumbaiIndia

Heart Rate variability(HRV)is the variation between beat-to-beat intervals in a consecutive *** provides enormous information about cardiac *** and echocardiography(2D echo)are the two major techniques used by medical practitioners to diagnose cardiac *** 2D echo provides more accurate results as compared to electrocardiography but costs ten times *** research provides low-cost solution for cardiac health diagnosis to the level of 2D echo derived from the *** and the 2D echo data of the same cohort are collected from 15 diabetics and 15 cardiac-diseased *** this research,we found a correlation between significant HRV parameters and 2D Echo *** correlation is obtained between LF/HF(low-frequency power to high-frequency power ratio),the HRV parameter,and LVEF(left ventricle ejection fraction),the 2D echo *** derived various mathematical models,to predict the LVEF,from LF/HF for both cardiac diseased and diabetics *** combined best-fit model is obtained using nonlinear regression with the goodness of fit,R^(2)=94.54%.

关键词： Left ventricle ejection fraction Heart rate variability Autonomous nervous system Cardiac health Diabetes

Impact of increasing one-carbon metabolites on traumatic brain injury outcome using pre-clinical models

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Neural Regeneration Research 2024年第8期19卷 1728-1733页

作者： Sanika M.joshi Theresa Currier Thomas Nafisa M.Jadavji College of Osteopathic Medicine Midwestern UniversityGlendaleCAUSA Department of biomedical Sciences Midwestern UniversityGlendaleCAUSA Department of Child Health College of Medicine–PhoenixUniversity of ArizonaPhoenixAZUSA College of Veterinary Medicine Midwestern UniversityGlendaleCAUSA Department of Neuroscience Carleton UniversityOttawaCanada

Traumatic brain injury is a major cause of death and disability worldwide,affecting over 69 million individuals ***-carbon metabolism has been shown to have beneficial effects after brain damage,such as ischemic ***,whether increasing one-carbon metabolite vitamins impacts traumatic brain injury outcomes in patients requires more *** aim of this review is to evaluate how one-carbon metabolites impact outcomes after the onset of traumatic brain ***,Web of Science,and Google Scholar databases were searched for studies that examined the impact of b-vitamin supplementation on traumatic brain injury *** search terms included combinations of the following words:traumatic brain injury,dietary supplementation,one-carbon metabolism,and *** focus of each literature search was basic science *** year of publication in the literature searches was not *** analysis of the literature has shown that dietary supplementation of b-vitamins has significantly improved the functional and behavioral recove ry of animals with traumatic brain injury compared to *** r,this improvement is dosage-dependent and is contingent upon the onset of supplementation and whether there is a sustained or continuous delive ry of vitamin supplementation post-traumatic brain *** details of supplementation post-traumatic brain injury need to be further ***,we conclude that b-vitamin supplementation improves behavioral outcomes and reduces cognitive impairment post-traumatic brain injury in animal model *** investigation in a clinical setting should be stro ngly considered in co njunction with current medical treatments for traumatic brain injury-affected individuals.

关键词： folic acid nicotinamide one-carbon metabolism riboflavin traumatic brain injury vitamin b12 vitamin b2 vitamin b3

在空气/水化学煤净化工艺中颗粒尺寸对黄铁矿氧化的效应

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煤炭转化 1986年第4期 84-93页

作者： J.b.joshi 林文元印度孟买大学化学工程系

本文报道了在燃烧前从煤中脱硫工艺的开发,采用的方法是在水煤浆中进行选择式氧化。研究了下Freeport煤中黄铁矿硫的氧化动力学特性和热值损耗。实验是以分批方式进行的。考察了煤颗粒尺寸(<72,72—99,150—208,208—430,700—1410μm)... 详细信息

本文报道了在燃烧前从煤中脱硫工艺的开发,采用的方法是在水煤浆中进行选择式氧化。研究了下Freeport煤中黄铁矿硫的氧化动力学特性和热值损耗。实验是以分批方式进行的。考察了煤颗粒尺寸(<72,72—99,150—208,208—430,700—1410μm),反应时间(0—5400秒),温度(150—200℃) 和氧气分压(0.28—1.36Mpa)的效应。煤中黄铁硫的氧化遵从“缩核”模型,发现氧与黄铁矿间的反应是速率控制机制。

关键词：颗粒尺寸存在模式模式分析黄铁矿硫化学反应控制速率控制机制