Attenuation of Carbon Tetrachloride-Induced Hepatotoxicity by Cow Urine Distillate in Rats

作     者：M P GURURAJA A B JOSHI HIMANSHU JOSHI D SATHYANARAYANA E V S SUBRAHMANYAM K S CHANDRASHEKHAR 

作者机构：Nitte Gulabi Shetty Memorial Institute of Pharmaceutical SciencesPaneer 

出 版 物：《Biomedical and Environmental Sciences》 (生物医学与环境科学（英文版）)

年 卷 期：2009年第22卷第4期

页      面：345-347页

核心收录：

学科分类：0905[农学-畜牧学] 09[农学] 

主　　题：Hepatotoxicity Cow urine distillate CCl4 Silymarin 

摘      要：Objective To study the carbon tetrachloride-induced hepatoprotective activity in cow urine. Methods Effect of cow urine distillate on liver function was studied in vivo in rats intoxicated with carbon tetrachloride （CC14）. Hepatotoxicity was induced by a 1 ： 1 （v/v） mixture of CCl4 in olive oil （5 mL/kg i.p）. Protective effect of cow urine distillate （in three dose levels） and standard drug Silymarin （100 mg/kg, p.o） on liver function were studied in intoxicated rats. Parameters in the study included liver function tests and histological observations. Results The cow urine distillate decreased the levels of SGOT, SGPT, ALP, GGT, and total bilirubin in a dose-dependent manner （P〈0.05） as sylimarin. Conclusion The observed protective effects of cow urine distillate on liver function might be due to the presence of antioxidants in cow urine.