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Weight of CURB-65 for community-acquired pneumonia

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Weight of CURB-65 for community-acquired pneumonia

中华医学会第七届全国呼吸道感染学术大会暨第一届多学科抗感染治疗学术研讨会

作者： Qi Guoguangzhou institute of respiratory diseases(State Key Laboratory of respiratory diseases) 518033

Background The CURB-65 score is a simple well validated tool for the assessment of severity in community-acquired pneumonia(CAP).Whether each of the criteria is of equal weight is not clear. The purpose of this study was to determine the weight of CURB-65. Methods 1230 adult patients admitted to our hospital from 2005 to 2009 for CAP were reviewed retrospectively. Results The overall hospital mortality rate was 1.3%.The hospital mortality rate increased directly with increasing CURB-65 score:0,1.0,8.2,16.7,and 100.0%for CURB-65 scores of 0,1,2,3, and 4,respectively(x2 = 219.494,p7.547(p7 mmol·L-1 was most strongly associated with SOFA scores and hospital length of stay(LOS).Age>65 yrs was most strongly associated with *** presence of low blood pressure was not associated with mortality,SOFA scores,hospital LOS,and *** greater than 65 yrs of age had higher incidence of confusion and urea>7 mmol·L-1,and a lower incidence of low blood pressure. Conclusions Each of CURB-65 was of unequal weight in predicting hospital mortality,SOFA scores,hospital LOS,and costs.

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Diagnostic performance of integrated positron emission tomography/computer tomography for mediastinal lymph nodes staging in non-small cell lung cancer:a bivariate systematic review and meta-analysis

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Diagnostic performance of integrated positron emission tomog...

中华医学会第五届全国胸部肿瘤及内窥镜学术会议

作者： Yan-ling Lv~(institute of respiratory diseases,First Affiliated Hospital,Guangxi medical University,Nanning

Introduction Accurate clinical staging of mediastinal lymph nodes(MLN)for patients with non-small cell lung cancer (NSCLC)is important in determining therapeutic options and *** positron emission tomography and computed tomography(PET/CT)scanning is becoming widely used for MLN staging in patients with non-small cell lung *** performed a bivariate meta-analysis to determine the pooled sensitivity and specificity of this imaging

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热带海洋珍珠贝类立克次体病研究──Ⅴ.超微病理学及致病机理研究

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海洋学报 1999年第3期21卷 113-118,T003页

作者：吴信忠潘金培中国科学院南海海洋研究所广州510301

对海水养殖大珠母贝和合浦珠母贝类立克次体（Rickettsia-likeorganism,RLO）病（简称RLO病）的超微病理学进行了研究．结果显示细胞及亚细胞结构经历由变性发展到坏死的病变过程，如胞核由核浓缩、核碎裂发展为核溶解；线粒体出现肿胀... 详细信息

对海水养殖大珠母贝和合浦珠母贝类立克次体（Rickettsia-likeorganism,RLO）病（简称RLO病）的超微病理学进行了研究．结果显示细胞及亚细胞结构经历由变性发展到坏死的病变过程，如胞核由核浓缩、核碎裂发展为核溶解；线粒体出现肿胀，嵴和基质改变及内质网脱颗粒、扩张和囊泡变等一系列混浊肿胀和水泡变性的基本特征；最终，细胞器完全溶解消失使胞质疏松，呈崩解或溶解状．结合先前组织细胞病理学和本文超微病理学研究的结果认为，RLO导致宿主细胞变性坏死的机制有：（1）直接损伤细胞的质膜；（2）直接干扰或破坏细胞的正常代谢；（3）对肝胰腺的广泛破坏可能通过破坏血管内皮系统间接造成肝胰腺上皮细胞的血供障碍，进而引起营养和呼吸代谢障碍或（和）与菌体释放的内毒素有关．

关键词：大珠母贝合浦珠母贝类立克次体病热带海洋

respiratory support for severe acute respiratory syndrome: integration of efficacy and safety

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Chinese medical Journal 2005年第17期118卷 1411-1412页

作者： WANG Chen and CAO Zhi-xinChaoyang Hospital, Capital University of medical Sciences Beijing institute of respiratory Medicine, Beijing 100020, china ChaoyangHospital CapitalUniversityofMedicalSciences

Severe acute respiratory syndrome （SARS） is an acute respiratory illness caused by infection with the SARS virus. The most obvious clinical characteristic of SARS is rapidly progressive pneumonia, and about 20% patients need intensive care due to acute lung injury （ALI） and acute respiratory distress syndrome （ARDS）.1-3 In the absence of effective drugs for SARS, supportive care, especially respiratory support techniques （RSTs）, is of primary importance. On the other hand, offering RSTs to SARS patients may carry a high-risk of infection to healthcare workers because of the high infectivity of SARS. Therefore, the strategy of RSTs for SARS should be the integration of efficacy and safety. In this issue of the Chinese medical Journal, an article from Hong Kong has retrospectively compared both the safety and efficacy of noninvasive positive pressure ventilation （NIPPV） with that of invasive mechanical ventilation （IMV） in the treatment of respiratory failure in SARS.

关键词： NIPPV integration of efficacy and safety respiratory support for severe acute respiratory syndrome

Application　of　Electrical　Impedance　Principle　in　the　Diagnosis　of　Diaphragm　Fatigue

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Journal of Huazhong University of Science and Technology(medical Sciences) 1995年第4期15卷 227-230,237页

作者：牛汝楫 institute of respiratory diseases Tongji Hospital Tongji Medical University Wuhan

The chest and abdomen impedance respirographs (IRG) , including the one dimensional IRG and the two dimensional IRG were designed and produced by applying the principle of bioelectrical impedance. Using IRG the non-synchronized chest and abdomen respiratory motions occurring in diaphragmatic fatigue were measured. The results showed that all 203 normal controls showed synchronized style of chest and abdomen respiratory motions. In 189 COPD patients 117 (61.9%) showed non-synchronized respiratory motions which could be further divided into three types: type Ⅰ showed complete contra-directional respiratory movements of chest and abdomen respiration, with M>24 % and a angle>120°; type Ⅱ showed staggered peak of the chest and abdomen motion curves (13 %

关键词： electrical impedance diaphragm fatigue COPD

IL-4受体基因Ile50Val位点多态性与哮喘易感性的研究

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中国实用内科杂志 2006年第S1期26卷 112-113,116页

作者：吴斌宋泽庆邓日强陈敏广东医学院附属医院呼吸科广东524023

目的探讨 IL-4受体基因 Ile50Val位点多态性和哮喘易感性及时血浆总 IgE、可溶性 IL-4受体水平的影响。方法用等位基因特异性 PCR 法分析位点多态性,ELISA 法测定血浆总 IgE 和可溶性 IL-4R 的浓度。结果对照组和哮喘组中,Ile/Val 基因... 详细信息

目的探讨 IL-4受体基因 Ile50Val位点多态性和哮喘易感性及时血浆总 IgE、可溶性 IL-4受体水平的影响。方法用等位基因特异性 PCR 法分析位点多态性,ELISA 法测定血浆总 IgE 和可溶性 IL-4R 的浓度。结果对照组和哮喘组中,Ile/Val 基因型频率分布差异有显著性 x^2=18.94,P<0.01,两组中两等位基因的分布差异有显著性 x^2=20.88,P<0.01,变异等位基因携带者惠哮喘的风险高于未携带者,OR=2.64,P<0.01。在对照组和哮喘组中 Ile/Ile 基因型血浆总 IgE 和可溶性 IL-4R 的浓度明显高于 Val/Val 基因型,同基因型哮喘组血浆总 IgE 和可溶性 IL-4R 的浓度明显高于对照组。结论 IL-4受体基因 Ile50Val 位点多态性和哮喘相关,并影响血浆总 IgE、可溶性 IL-4受体水平。

关键词：哮喘白细胞介素4受体基因多态性 IgE

Adult congenital diaphragmatic hernia of the liver: a rare case report

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Science china(Life Sciences) 2010年第2期53卷 204-206页

作者： LIU LiGuo1,2,XU YiYao1,MAO YiLei1,SANG XinTing1,YANG ZhiYing1,LU Xin1,ZHONG ShouXian1 & HUANG JieFu1 1 Department of Liver Surgery,Peking Union medical college Hospital,Beijing 100730,china 2 Department of Abdominal Surgery,Cancer institute and Hospital,Chinese Academy of medical Science and Peking Union medical college,Beijing 100021,china. 1. Department of Liver Surgery Peking Union Medical College Hospital Beijing 100730 China2. Department of Abdominal Surgery Cancer Institute and Hospital Chinese Academy of Medical Science and Peking Union Medical College Beijing 100021 China

Congenital diaphragmatic hernia (CDH), which mainly occurs in the newborn or in childhood with severe respiratory distress and high mortality, is rarely found in adult, especially for those uncommon right CDH [1–4]. ... 详细信息

关键词： case In Adult congenital diaphragmatic hernia of the liver a rare case report

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鱼类粘膜免疫研究进展

水产学报 2005年第3期29卷 411-416页

作者：罗晓春谢明权黄玮李安兴中山大学生命科学学院水生生物研究所广东省水产学校中山大学生命科学学院水生生物研究所广东广州510275 广东广州510320

Fish immunology has achieved great progress in recent years. While before 1990s, most researches focused on the fish systematic immunity, and the mucosal immunity of fish had not been given enough attention. Indeed, it has been shown that fish mucosal immunity plays an important role in disease defense. Fish mucosal immunity research has made some exciting progress in this decade. This review will focus on such progress: Constitution of mucosal-associated tissues and distribution of different immune cells, including T/B lymphocytes, granules, monocytes, macrophages, goblet cells, etc, in these sites have been well described with the development of some monoclonal antibody to these cells and associated techniques. Non-specific immune response mechanism of mucosal tissues reported these years, such as secretion of non-specific anti-bacteria and anti-fungi substances in mucus, the respiratory burst, enzyme activity of immune cells and so on, is believed important for fish disease defense. The specific immunity of mucosal tissues also attracts much interest and makes great achievement in antigen presenting, MHC genes, antibody producing and antibody secreting cells, comparison of serum and mucus immunoglobulin, relationships of immune response between different mucosal immune tissues. Whether mucosal immune system is independent of systematic immune system is another interesting question and causes great concern. In recent years, some evidences from phyletic evolution and ontogenesis show that mucosal immunity is prior to systematic immunity in evolution. Dynamics of antibody producing of mucosal tissues and serum in immersion or oral vaccines immunized fish also shows immune response can be elicited in mucosal tissues independent of systematic immune system. Some researchers also begin to pay attention to factors involved in mucosal immune regulations, for instance, neuromodulators and cytokines. The level of these factors changes in fish immune response process but th

关键词：鱼类粘膜组织特异性免疫非特异性免疫免疫调节

Construction And Expression Of Targeting Diphtheria Immunetoxin For Cervical Cancer Therapy

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Construction And Expression Of Targeting Diphtheria Immuneto...

24th International Papillomavirus Conference and Clinical Workshop

作者： Xin Zhao 1 Song Guoxing 2 Xu Xuemei 2 1.Department of respiratory Communicable diseases The institute of Communicable Disease Control and Prevention china CDC 2.Department of Biophysics and Structure Biology Peking Union medical college Beijing 100005 china

＜正＞Background Diphtheria toxin-based immunotoxin is a novel class of targeted agents,which is composed of diphtheria toxin fragment or mutant without native receptor-binding activity and antibody or cytokine It is capable of specifically recognizing and killing the target cells through inhibiting the cytosol protein synthesis and triggering apoptosis Diphtheria toxin-based immunotoxin has exhibited encouraging power for tumor therapy.

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