Construction And Expression Of Targeting Diphtheria Immunetoxin For Cervical Cancer Therapy

作     者：Xin Zhao 1 Song Guoxing 2 Xu Xuemei 2 1.Department of Respiratory Communicable Diseases The Institute of Communicable Disease Control and Prevention China CDC 2.Department of Biophysics and Structure Biology Peking Union Medical College Beijing 100005 China 

会议名称：《24th International Papillomavirus Conference and Clinical Workshop》

会议日期：2007年

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

摘      要：正Background Diphtheria toxin-based immunotoxin is a novel class of targeted agents,which is composed of diphtheria toxin fragment or mutant without native receptor-binding activity and antibody or cytokine It is capable of specifically recognizing and killing the target cells through inhibiting the cytosol protein synthesis and triggering apoptosis Diphtheria toxin-based immunotoxin has exhibited encouraging power for tumor therapy.