鱼类粘膜免疫研究进展

作     者：罗晓春 谢明权 黄玮 李安兴 LUO Xiao-chun1, XIE Ming-quan1, HUANG Wei2, LI An-xing1(1.Institute of Hydrobiology, Life Science College, Sun Yat-sen University, Guangzhou 510275, China;2. Aquaculture School of Guangdong Province, Guangzhou 510320, China)

作者机构：中山大学生命科学学院水生生物研究所 广东省水产学校 中山大学生命科学学院水生生物研究所 广东广州510275 广东广州510320 

出 版 物：《水产学报》 (Journal of Fisheries of China)

年 卷 期：2005年第29卷第3期

页      面：411-416页

核心收录：

学科分类：0906[农学-兽医学] 09[农学] 

基　　金：广东省自然基金团队项目(20023002) 

主　　题：鱼类 粘膜组织 特异性免疫 非特异性免疫 免疫调节 

摘      要：Fish immunology has achieved great progress in recent years. While before 1990s, most researches focused on the fish systematic immunity, and the mucosal immunity of fish had not been given enough attention. Indeed, it has been shown that fish mucosal immunity plays an important role in disease defense. Fish mucosal immunity research has made some exciting progress in this decade. This review will focus on such progress: Constitution of mucosal-associated tissues and distribution of different immune cells, including T/B lymphocytes, granules, monocytes, macrophages, goblet cells, etc, in these sites have been well described with the development of some monoclonal antibody to these cells and associated techniques. Non-specific immune response mechanism of mucosal tissues reported these years, such as secretion of non-specific anti-bacteria and anti-fungi substances in mucus, the respiratory burst, enzyme activity of immune cells and so on, is believed important for fish disease defense. The specific immunity of mucosal tissues also attracts much interest and makes great achievement in antigen presenting, MHC genes, antibody producing and antibody secreting cells, comparison of serum and mucus immunoglobulin, relationships of immune response between different mucosal immune tissues. Whether mucosal immune system is independent of systematic immune system is another interesting question and causes great concern. In recent years, some evidences from phyletic evolution and ontogenesis show that mucosal immunity is prior to systematic immunity in evolution. Dynamics of antibody producing of mucosal tissues and serum in immersion or oral vaccines immunized fish also shows immune response can be elicited in mucosal tissues independent of systematic immune system. Some researchers also begin to pay attention to factors involved in mucosal immune regulations, for instance, neuromodulators and cytokines. The level of these factors changes in fish immune response process but th