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The role of MC1R gene in buffalo coat color

Science china(Life sciences) 2010年第2期53卷 267-272页

作者： MIAO YongWang1,2,WU GuiSheng3,WANG Lei2,LI DaLin4,TANG ShouKun5,LIANG JianPing2,MAO HuaMing2,LUO HuaiRong3 & ZHANG YaPing1,6 1 laboratory for Conservation and Utilization of Bio-resource,Yunnan University,kunming 650091,china 2 Faculty of Animal Science and Technology,Yunnan Agricultural University,kunming 650201,china 3 kunming institute of Botany,chinese academy of sciences,kunming 650204,china 4 Yunnan institute of Buffalo Science and Technology,kunming 650021,china 5 Animal Husbandry and Veterinary Station of Luxi city,Luxi 678400,china 6 state key laboratory of genetic resources and evolution,kunming institute of zoology,chinese academy of sciences,kunming 650223,china laboratory for Conservation and Utilization of Bio-resource Yunnan University Faculty of Animal Science and Technology Yunnan Agricultural University kunming institute of Botany Chinese Academy of Sciences

Melanocortin-1 receptor (MC1R) plays a major role in pigmentation in many *** investigate if the MC1R gene is associated with coat color in water buffalo,the coding region of MC1R gene of 216 buffalo samples was sequenced,which included 49 black river buffalo (Murrah and Nili-Ravi),136 swamp buffalo (Dehong,Diandongnan,Dechang,Guizhou,and Xilin) with white and gray body,and 31 hybrid offspring of river buffalo Nili-Ravi (or Murrah) and swamp *** the three variation sites found,SNP684 was synonymous,while SNP310 and SNP384 were nonsynonymous,leading to p.S104G and p.I128M changes,*** Individuals carrying homozygote EBR/EBR were *** genotype and phenotype analysis of the hybrid offspring of black river buffalo and gray swamp buffalo further revealed that the river buffalo type allele EBR or the allele carrying the amino acid p.104S was important for the full function of *** in silico functional analysis showed that the amino acid substitutions p.G104S and p.M128I had significant impact on the function of *** results indicate that the allele EBR or the allele carrying the amino acid p.104S was associated with the black coat color in buffalo.

关键词： Buffalo coat color MC1R

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Diversity and evolution of MicroRNA gene clusters

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Science china(Life sciences) 2009年第3期52卷 261-266页

作者： ZHANG YanFeng,ZHANG Rui & SU Bing state key laboratory of genetic resources and evolution,kunming institute of zoology,chinese academy of sciences,kunming 650223,china state key laboratory of genetic resources and evolution Kunming Institute of Zoology Chinese Academy of Sciences Kunming China

microRNA(miRNA) gene clusters are a group of miRNA genes clustered within a proximal distance on a *** a large number of miRNA clusters have been uncovered in animal and plant genomes,the functional consequences of this arrangement are still poorly *** in a polycistron,the coexpressed miRNA clusters are pivotal in coordinately regulating multiple processes,including embryonic development,cell cycles and cell *** this review,based on recent progress,we discuss the genomic diversity of miRNA gene clusters,the coordination of expression and function of the clustered miRNAs,and the evolutionarily adaptive processes with gain and loss of the clustering miRNA genes mediated by duplication and transposition events.

关键词： microRNA gene clusters gene duplication adaptive evolution transposition

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Advances in herpetological research emanating from china

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Zoological Research 2016年第1期37卷 4-6页

作者： Robert W.MURPHY the state key laboratory of genetic resources and evolution,kunming institute of zoology,chinese academy of sciences and the Centre for Biodiversity and Conservation Biology,Royal Ontario Museum state key laboratory of genetic resources and evolution Kunming Institute of Zoology Chinese Academy of Sciences Centre for Biodiversity and Conservation Biology Royal Ontario Museum. bob.murphy@utoronto.ca.

The warming of Earth owing to human activities is resulting in an episode of mass extinction. If global warming is not abated quickly, up to one-fourth of the species on our planet will face extinction in only 35 years. The loss of biodiversity is more than just many species disappearing. It could signal the beginning of the collapse of our ecosystems because the loss of one species can trigger a domino effect. Among vertebrates, the so-called cold bloodied species--fishes, amphibians and reptiles--are the most threatened groups.

关键词： Advances in herpetological research emanating from china

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Positive Darwinian selection in human population:A review

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chinese Science Bulletin 2008年第10期53卷 1457-1467页

作者： WU DongDong1,3 & ZHANG YaPing1,2 1 state key laboratory of genetic resources and evolution, kunming institute of zoology, chinese academy of sciences, kunming 650223, china 2 laboratory for Conservation and Utilization of Bio-resource, Yunnan University, kunming 650091, china 3 Graduate University of chinese academy of sciences, Beijing 100049, china state key laboratory of genetic resources and evolution Kunming Institute of Zoology Chinese Academy of Sciences Kunming China Graduate University of chinese academy of sciences Beijing China laboratory for Conservation and Utilization of Bio-resource Yunnan University Kunming China

This paper reviews a large number of genes under positive Darwinian selection in modern human populations, such as brain development genes, immunity genes, reproductive related genes, perception receptors. The research on the evolutionary property of these genes will provide important insight into human evolution and disease mechanisms. With the increase of population genetics and comparative genomics data, more and more evidences indicate that positive Darwinian selection plays an indispensable role in the origin and evolution of human beings. This paper will also summarize the methods to detect positive selection, analyze the interference factors faced and make suggestions for further research on positive selection.

关键词：自然选择积极选择达尔文进化论人类学种群遗传

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The evolution of cooperation in asymmetric systems

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Science china(Life sciences) 2010年第1期53卷 139-149页

作者： WANG RuiWu1 & SHI Lei2 1 state key laboratory of genetic resources and evolution,kunming institute of zoology,chinese academy of Science,kunming 650223,china 2 Statistics and Mathematics College,Yunnan University of Finance and Economics,kunming 650221,china state key laboratory of genetic resources and evolution Kunming Institute of Zoology Chinese Academy of Science Kunming 650223 Chin Statistics and Mathematics College Yunnan University of Finance and Economics Kunming 650221 China

Explaining the "Tragedy of the Commons" of the evolution of cooperation remains one of the greatest problems for both biology and social *** interaction,which is one of the most important characteristics of cooperative systems,has not been sufficiently considered in the existing models of the evolution of *** the inequality in the number and payoff between the cooperative actors and recipients in cooperation systems,discriminative density-dependent interference competition will occur in limited dispersal *** model and simulation show that the local but not the global stability of a cooperative interaction can be maintained if the utilization of common resource remains unsaturated,which can be achieved by density-dependent restraint or competition among the cooperative *** intense density dependent interference competition among the cooperative actors and the ready availability of the common resource,with a higher intrinsic contribution ratio of a cooperative actor to the recipient,will increase the probability of *** cooperation between the recipient and the cooperative actors can be transformed into conflict and,it oscillates chaotically with variations of the affecting factors under different environmental or ecological *** higher initial relatedness(*** to kin or reciprocity relatedness),which is equivalent to intrinsic contribution ratio of a cooperative actor to the recipient,can be selected for by penalizing less cooperative or cheating actors but rewarding cooperative individuals in asymmetric *** initial relatedness is a pivot but not the aim of evolution of *** explains well the direct conflict observed in almost all cooperative systems.

关键词： cooperation altruism density dependent tragedy of the commons oscillation chaos asymmetric interaction interference competition

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Application of the phylogenetic analysis in mitochondrial disease study

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chinese Science Bulletin 2008年第18期53卷 2733-2738页

作者： WANG ChengYe1,2,3, KONG QingPeng1,2 & ZHANG YaPing1,2? 1 state key laboratory of genetic resources and evolution, kunming institute of zoology, chinese academy of sciences, kunming 650223, china 2 laboratory for Conservation and Utilization of Bio-resource, Yunnan University, kunming 650091, china 3 Graduate University of chinese academy of sciences, Beijing 100049, china state key laboratory of genetic resources and evolution Kunming Institute of Zoology Chinese Academy of Sciences Kunming China laboratory for Conservation and Utilization of Bio-resource Yunnan University Kunming China Graduate University of chinese academy of sciences Beijing China

Mitochondrial disease currently received an increasing concern. However, the case-control design commonly adopted in this field is vulnerable to genetic background, population stratification and poor data quality. Although the phylogenetic analysis could help solve part of these problems, it has not received adequate attention. This paper is a review of this method as well as its application in mito- chondrial disease study.

关键词：线粒体疾病分析单元型种群分布

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Molecular evolution of stress-response gene Leptin in high-altitude chinese snub-nosed monkeys (Rhinopithecus genus)

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chinese Science Bulletin 2010年第36期55卷 4132-4135页

作者： WANG XiaoPing1,2, JIN Wei1,2, YU Li1,2 & ZHANG YaPing1,2 1 laboratory for Conservation and Utilization of Bio-resource, Yunnan University, kunming 650091, china 2 state key laboratory of genetic resources and evolution, kunming institute of zoology, chinese academy of sciences, kunming 650223, china laboratory for Conservation and Utilization of Bio-resource Yunnan University Kunming China state key laboratory of genetic resources and evolution Kunming Institute of Zoology Chinese Academy of Sciences Kunming China

chinese snub-nosed monkeys (genus Rhinopithecus, subfamily Colobinae), including R. bieti, R. brelichi and R. roxellana, are well-known as the non-human primates with the highest known altitudinal distribution. They represent an interesting model organism of adaptation to the extreme environmental stresses. However, no study at the molecular level has yet been reported for the high-altitude adaptation in chinese snub-nosed monkeys. Leptin, as an adipocyte-derived hormone, is believed to play an important role in energy homeostasis in adaptation to high altitude environments. In the present study, we sequenced and compared leptin sequences of the chinese snub-nosed monkeys (R. bieti and R. roxellana) with their lowland close relative R. avunculus and other Colobines. Unexpectedly, no amino acid changes were observed in the 7 Colobinae species examined, including the 2 chinese snub-nosed monkeys, indicating no difference in the evolutionary pattern of the Leptin gene between high-altitude monkeys and their lowland counterparts. In contrast to a previous finding of adaptive evolution of Leptin gene in plateau pikas, our study suggests that this gene may not have an important role in high-altitude adaptation of chinese snub-nosed monkeys. Other nuclear genes associated with energy metabolism, or mitochondrial genes, are most likely to be involved the molecular mechanism underlying adaptation of these monkeys to cold and hypoxia associated with the highland environment.

关键词： Leptin基因金丝猴属瘦素基因压力反应分子进化高空鼻极端环境

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A new genus and species of treefrog from Medog,southeastern Tibet,china(Anura,Rhacophoridae)

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Zoological Research 2016年第1期37卷 15-20页

作者： Ke JIANG Fang YAN Kai WANG Da-Hu ZOU Cheng LI Jing CHE state key laboratory of genetic resources and evolution,kunming institute of zoology,chinese academy of sciences Sam Noble Oklahoma Museum of Natural History and Department of Biology,University of Oklahoma Tibet University Imaging Biodiversity Expedition state key laboratory of genetic resources and evolution Kunming Institute of Zoology Chinese Academy of Sciences Kunming Yunnan 650223 China. state key laboratory of genetic resources and evolution Kunming Institute of Zoology Chinese Academy of Sciences Kunming Yunnan 650223 China Sam Noble Oklahoma Museum of Natural History and Department of Biology University of Oklahoma Norman OK 73072-7029 U.S.A. state key laboratory of genetic resources and evolution Kunming Institute of Zoology Chinese Academy of Sciences Kunming Yunnan 650223 China Tibet University Lhasa Tibet 850000 China. Imaging Biodiversity Expedition Beijing 100107 China. state key laboratory of genetic resources and evolution Kunming Institute of Zoology Chinese Academy of Sciences Kunming Yunnan 650223 China. chej@***.

A new genus and species of threefrog is described from Medog, southeastern Tibet, china based on morphological and phylogenetic data. The new genus can be distinguished from other treefrog genera by the following combination of characters：（1） body size moderate, 45.0 mm in male; （2） snout rounded; （3） canthus rostralis obtuse and raised prominently, forming a ridge from nostril to anterior corner of eyes; （4） web rudimentary on fingers; （5） web moderately developed on toes; （6） phalange ＂Y＂ shaped, visible from dorsal side of fingers and toes; （7） skin of dorsal surfaces relatively smooth, scatted with small tubercles; （8） iris with a pale yellow, ＂X＂ shaped pattern of pigmentation.

关键词： Taxonomy New genus New species Theloderma moloch Nasutixalus medogensis sp. nov.

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evolution of cd59 gene in mammals

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Science china(Life sciences) 2007年第6期50卷 773-779页

作者： GONG YuanYing1,2, PENG MinSheng1,2, ZHOU WeiPing1,3,4 & ZHANG YaPing1,4 1 state key laboratory of genetic resources and evolution, kunming institute of zoology, chinese academy of sciences, kunming 650223, china 2 Graduate University of the chinese academy of sciences, Beijing 100049, china 3 Molecular and Cell Biology, University of Science and Technology of china, Hefei 230026, china 4 laboratory for Conservation and Utilization of Bio-resources, Yunnan University, kunming 650091, china state key laboratory of genetic resources and evolution Kunming Institute of Zoology Chinese Academy of Sciences Kunming China Graduate University of the chinese academy of sciences Beijing China Molecular and Cell Biology University of Science and Technology of China Hefei China laboratory for Conservation and Utilization of Bio-resources Yunnan University Kunming China

The CD59-coding sequences were obtained from 5 mammals by PCR and BLAST, and combined with the available sequences in GenBank, the nucleotide substitution rates of mammalian cd59 were calcu- lated. Results of synonymous and nonsynonymous substitution rates revealed that cd59 experienced negative selection in mammals overall. Four sites experiencing positive selection were found by using "site-specific" model in PAML software. These sites were distributed on the molecular surface, of which 2 sites located in the key functional domain. Furthermore, "branch-site-specific" model detected 1 positive site in cd59a and cd59b lineages which underwent accelerated evolution caused by positive selection after gene duplication in mouse.

关键词： cd59, evolution, positive selection

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The role of EphA7 in tubulogenesis of pronephric tubule in Xenopus

The role of EphA7 in tubulogenesis of pronephric tubule in X...

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2012全国发育生物学大会

作者： Jian Sun,Yu Shi,Jie-Jing Li,Bing-Yu Mao state key laboratory of genetic resources and evolution,kunming institute of zoology,chinese academy of sciences, kunming,china,650223

The kidney is an essential organ that functions in filtering wastes,absorbing nutrients and *** pronephros of Xenopus,which contains a single nephron,offers a simplified in vivo system to study the events of tubulogenesis, including the establishment of cell polarity and lumen *** Eph receptors are the largest sub-family of receptor tyrosine kinases(RTKs) and are widely involved in animal growth and development,including segmentation,axon guidance,cell migration,***,their roles in kidney development remain largely *** found that EphA7 is specifically distributed at the subapical region in Xenopus embryonic pronephric tubule epithelial cells and knockdown of XEphA7 disturbed the epithelial cell polarity and blocked pronephric tubulogenesis,suggesting that polarized Eph signaling might be essential in the control of cell polarity and lumen formation in Xenopus pronephric tubulogenesis. Conclusions:Our data indicate that Xenopus EphA7 is necessary for the development of pronephros by maintaining the polarity of the tubule epithelial cells.

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