Positive Darwinian selection in human population:A review

作     者：WU DongDong1,3 & ZHANG YaPing1,2 1 State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, China 2 Laboratory for Conservation and Utilization of Bio-resource, Yunnan University, Kunming 650091, China 3 Graduate University of Chinese Academy of Sciences, Beijing 100049, China 

作者机构：State Key Laboratory of Genetic Resources and Evolution Kunming Institute of Zoology Chinese Academy of Sciences Kunming China Graduate University of Chinese Academy of Sciences Beijing China Laboratory for Conservation and Utilization of Bio-resource Yunnan University Kunming China 

出 版 物：《Chinese Science Bulletin》 (CHINESE SCIENCE BULLETIN)

年 卷 期：2008年第53卷第10期

页      面：1457-1467页

核心收录：

学科分类：07[理学] 0713[理学-生态学] 

基　　金：the National Natural Science Foundation of China (Grant Nos. 30621092 and 30430110) Bureau of Science and Technology of Yunnan Prov-ince 

主　　题：自然选择 积极选择 达尔文进化论 人类学 种群遗传 

摘      要：This paper reviews a large number of genes under positive Darwinian selection in modern human populations, such as brain development genes, immunity genes, reproductive related genes, perception receptors. The research on the evolutionary property of these genes will provide important insight into human evolution and disease mechanisms. With the increase of population genetics and comparative genomics data, more and more evidences indicate that positive Darwinian selection plays an indispensable role in the origin and evolution of human beings. This paper will also summarize the methods to detect positive selection, analyze the interference factors faced and make suggestions for further research on positive selection.