The role of EphA7 in tubulogenesis of pronephric tubule in Xenopus
会议名称：《2012全国发育生物学大会》
会议日期：2012年
学科分类：0905[农学-畜牧学] 09[农学] 090501[农学-动物遗传育种与繁殖]
摘 要：The kidney is an essential organ that functions in filtering wastes,absorbing nutrients and *** pronephros of Xenopus,which contains a single nephron,offers a simplified in vivo system to study the events of tubulogenesis, including the establishment of cell polarity and lumen *** Eph receptors are the largest sub-family of receptor tyrosine kinases(RTKs) and are widely involved in animal growth and development,including segmentation,axon guidance,cell migration,***,their roles in kidney development remain largely *** found that EphA7 is specifically distributed at the subapical region in Xenopus embryonic pronephric tubule epithelial cells and knockdown of XEphA7 disturbed the epithelial cell polarity and blocked pronephric tubulogenesis,suggesting that polarized Eph signaling might be essential in the control of cell polarity and lumen formation in Xenopus pronephric tubulogenesis. Conclusions:Our data indicate that Xenopus EphA7 is necessary for the development of pronephros by maintaining the polarity of the tubule epithelial cells.