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Dispersion of ventricular mRNA of RyR2 and SERCA2 associated with arrhythmogenesis in rats

Acta Pharmacologica Sinica 2004年第6期25卷 36-41页

作者： Hong-lan WANG, De-zai DAI2, Feng GAO3, Yan-pin ZHANG3, Feng LU Research Division of Pharmacology, china Pharmaceutical university, nanjing 2.0009, china 3laboratorial center ofmedicine, southeast university, nanjing 2.0009, china Research Division of Pharmacology China Pharmaceutical University Nanjing 210009 China

AIM: To investigate the effect of CPU86017 on the changes of mRNA abundance of different calcium handling system in infarcted heart. METHODS: Rats were subjected to left coronary ligation to induce myocardial infarc- tion (MI). The treatment with either propranolol (Pro) 5 mg/kg ip or CPU86017 1, 2, and 4 mg/kg ip was initiated on the next day of operation and continued for 20 d. Medication with isoproterenol (Isop) 3 mg/kg sc started on the d 17-21. Ventricular mRNA abundance of ryanodine receptor 2 (RyR2), sarcoplasmic reticulum Ca2+-ATPase (SERCA2), L-type Ca2+ channel, and Na+/Ca2+exchanger (NCX1) were measured. RESULTS: Arrhythmic scores (AS) in the Isop group was raised up to 5.27±1.75 (P3. The AS was depressed by Pro (1.63±1.53, P3.00±1.24, and 1.70±1.85, P<0.01 vs Isop). The significant dispersion of depressed mRNA abundance of RyR2 and SERCA2 was associated with an increase in AS in Isop group, and it was much depressed in the left than the right ventricle. The dispersion and depression of mRNA were restored significantly by Pro and CPU86017, asso- ciated with suppression on AS. In Isop group, the mRNA abundance of L-type Ca2+ channel was not changed; and a moderate increase in the mRNA of NCX1 was seen, the changes were regressed by Pro and CPU86017. CONCLUSION: Isop-induced arrhythmogenesis in MI heart was correlated mainly with a dispersion of depressed mRNA abundance in ventricle likely due to the consequence of PKA over-phosphorylation. A suppression of arrhythmia by Pro and CPU86017 resulted from a regression of the dispersion and depression of RyR2 and SERCA2.

关键词： myocardial infarction isoproterenol arrhythmia calcium 4-chlorobenzyltetrahydroberberine

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Propranolol and verapamil inhibit mRNA expression of RyR2 and SERCA in L-thyroxin-induced rat ventricular hypertrophy

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Acta Pharmacologica Sinica 2004年第03期25卷 93-97页

作者： rat ventricular hypertrophy1 Xiao-dong WU2,De-zai DAI2,Qiu-pin ZHANG3,Feng GAO3 Research Division of Pharmacology,china Pharmaceutical university 3laboratorial center ofmedicine,southeast university,nanjing 2.0009,china Research Division of Pharmacology China Pharmaceutical University laboratorial center of Medicine Southeast University

AIM: To study the alteration in the mRNA level of cardiac ryanodine receptor 2 (RyR2) and sarco-endoplasmic reticulum Ca2+-ATPase (SERCA) in L-thyroxin-induced hypertrophy. METHODS: L-thyroxin (500 g/kg) daily was injected for 10 d. RT-PCR was used to determine mRNA expression. RESULTS: An increase in the relative amount of RyR2 (111 %) and SERCA mRNA (65 %) expression was observed in the hypertrophied rats (RyR2: 77±11; SERCA: 87±10, n=9) compared with the normal rats (RyR2: 36±10; SERCA: 53±10, n=9). Propranolol was effective to inhibit the increase in RyR2 (51±7) and SERCA (63±13) mRNA expression in hypertrophied rats, respectively. Verapamil also reduced RyR2 (62±5) and SERCA (75±8) mRNA expression. CONCLUSION: Both RyR2 and SERCA mRNA level in L-thyroxin-induced cardiac hypertrophy was over-expressed and propranolol or verapamil inhibited the alteration.

关键词： heart hypertrophy arrhythmia ryanodine receptors Ca2+-transporting ATPase L-thyroxin propranolol verapamil reversed transcriptase polymerase chain reaction

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中国政治经济学年度发展报告（2023）（下）

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政治经济学评论 2024年第3期 90+207-208页

作者： center for Studies of Contemporary Political Economy,Research Institute for 21st-Century Marxism,Nankai university·university of Chinese Academy of Social Science center for Teaching and Research on Capital,Renmin university of china National Institute of Socialist Political Economy with Chinese Characteristics,Renmin university of china 南开大学·中国社会科学院大学21世纪马克思主义研究院当代政治经济学研究中心中国人民大学《资本论》教学与研究中心中国人民大学全国中国特色社会主义政治经济学研究中心

编者按2023年，高质量发展扎实推进，新质生产力加快形成，我国经济总体回升向好，圆满实现发展主要预期目标。为针对性地破解经济恢复发展中的难题，聚焦推进中国式现代化进程中的重点、难点问题，中国政治经济学界开展系统深入研究，...

编者按2023年，高质量发展扎实推进，新质生产力加快形成，我国经济总体回升向好，圆满实现发展主要预期目标。为针对性地破解经济恢复发展中的难题，聚焦推进中国式现代化进程中的重点、难点问题，中国政治经济学界开展系统深入研究，取得系列代表性成果。为准确刻画学界研究进展和轨迹，推动中国经济学理论体系的构建和完善，本刊精选议题如期奉上《中国政治经济学年度发展报告（2023）》。自2010年起，本刊连续十四年发布《中国政治经济学年度发展报告》，“年度发展报告”专栏已成为本刊标志性特色栏目。2023年报告聚焦12个专题，分为（上）（下）两篇，其中专题1—6于报告（上）篇刊登，专题7—12由报告（下）篇刊登。2023年报告（下）选题如下：

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Observation of fractal patterns on superconducting Bi_2Sr_2Ca_1Cu_2O_(7-x) films on silicon by AFM

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Chinese Science Bulletin 1997年第6期42卷 526-528页

作者： QIAN Wensheng, LIU Rong and WEI TongIiMicroelectronics center, southeast university, nanjing 210096, china Microelectronics center Southeast University Nanjing China

SUPERCONDUCTING Bi2Sr2Ca1CU2O7-x（BSCCO） films have been prepared in-situ on Si substrates with yttria stabilized zirconia （YSZ） buffer layers by rf magnetron sputtering. The superconducting BSCCO films have a critical temperature （Tc） of 82 K. Atomic force microscope （AFM） and transmission electron microscope （TEM） were used to image the surface morphology and microstructure of superconducting BSCCO films. Fractal patterns were

关键词： fractal BSCCO films.

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Mechanical behavior of a shelter system based on cable-strut structures

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Journal of Zhejiang university-Science A(Applied Physics & Engineering) 2012年第12期13卷 895-903页

作者： Jian-guo CAI1,2,Ya ZHOU1,Jian FENG1,2,Yi-xiang XU3 (1Key Laboratory of C&PC Structures of Ministry of Education,southeast university,nanjing 210096,china) (2National Prestress Engineering Research center,southeast university,nanjing 210096,china) (3Department of Civil Engineering,Strathclyde university,Glasgow,UK) 1. Key Laboratory of C&PC Structures of Ministry of Education Southeast University Nanjing 210096 China 2. National Prestress Engineering Research center Southeast University Nanjing 210096 China 3. Department of Civil Engineering Strathclyde University Glasgow UK

A shelter system based on cable-strut structures,consisting of compressive struts and high-tensile elements,is described in this *** deployment of the shelter is achieved by tightening inclined *** cables are used to terminate the *** state of self-stress of the cable-strut structures in the fully deployed configuration is given,and the minimum strut length and the maximum load design of the shelter are *** mechanical behavior of the system was studied under symmetrical and asymmetrical load *** results show that the shelter in the deployed configuration satisfies the ultimate limit and the serviceability limit state ***,the stability of the cable-strut system is investigated,considering the effect of imperfections on the buckling of the *** conclude that the influence of imperfections based on the consistent imperfection mode method is not significant.

关键词： Foldable structures Cable-strut structures Mechanical behavior Self-stress Stability

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A new heuristic algorithm for the circular packing problem with equilibrium constraints

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Science china(Information Sciences) 2011年第8期54卷 1572-1584页

作者： LIU JingFa 1,2,LI Gang 3 & GENG HuanTong 1 1 School of Computer and Software,nanjing university of Information Science & Technology,nanjing 210044,china 2 Network Information center,nanjing university of Information Science & Technology, nanjing 210044,china 3 School of Mathematics and Physics,nanjing university of Information Science & Technology,nanjing 210044,china 1. School of Computer and Software Nanjing University of Information Science & Technology Nanjing 210044 China2. Network Information Center Nanjing University of Information Science & Technology Nanjing 210044 China3. School of Mathematics and Physics Nanjing University of Information Science & Technology Nanjing 210044 China

The circular packing problem with equilibrium constraints is an optimization problem about simplified satellite module layout design.A heuristic algorithm based on tabu search is put forward for solving this *** algorithm begins from a random initial configuration and applies the gradient method with an adaptive step length to search for the minimum energy *** jump out of the local minima and avoid the search doing repeated work,the algorithm adopts the strategy of tabu *** the process of tabu search,we improve the traditional neighboring solutions,tabu objects and the acceptance criteria of the current solution *** test two sets of benchmarks consisting of 11 representative instances from the current *** numerical results show that the proposed algorithm breaks the records in seven out of 11 instances,and obtains the optimal solutions for the other four instances.

关键词： equilibrium constraints packing problem heuristic algorithm tabu search layout optimization

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Preparation and Characterization of Nanocomposite MgFe_2O_4/SiO_2

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Journal of Wuhan university of Technology(Materials Science) 2009年第3期24卷 354-358页

作者：徐莉 College of Science Nanjing Forestry University

Nanocomposites MgFe2O4/SiO2 were successfully synthesized by the sol-gel method in the presence of N, N-dimethylformamide （DMF）. The formation of pure MgFe2O4 was confirmed by powder X-ray diffraction （XRD） and electron diffraction. The structural evolution of MgFe2O4 nanocrystals was followed by powder X-ray diffraction and IR absorption spectroscopy. The formation of spinel structure of MgFe2O4 started at 800 ℃, and completed at 900 ℃, The transmission electron microscopy （TEM） measurements suggest that the particle sizes increase with the increasing annealing temperature, and the mean particle sizes of the spherical samples annealed at 800 ℃, 900 ℃ and 1 050 ℃ are ca. 3 nm, 8 nm and 11 nm, respectively. Magnetization measurements at room temperature and 78 K indicate supemaramagnetic nature of these MgFe2O4 nanocrvstals.

关键词： nanocomposite sol-gel magnesium ferrite magnetic property

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Study on lithogeochemistry of Middle Jurassic basalts from southern china represented by the Fankeng basalts from Yongding of Fujian Province

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Science china Earth Sciences 2006年第10期49卷 1020-1031页

作者： ZHOU Jincheng1,2, JIANG Shaoyong1,2, WANG Xiaolei1,2, YANG Jinghong 1,2 & ZHANG Mengqun 3 1. State Key Laboratory of Mineral Deposit Research, nanjing university, nanjing 210093, china 2. Department of Earth Sciences, nanjing university, nanjing 210093, china 3. Modern Analysis center, nanjing university, nanjing 210093, china 1. State Key Laboratory of Mineral Deposit Research Nanjing University Nanjing 210093 China 2. Department of Earth Sciences Nanjing University Nanjing 210093 China 3. Modern Analysis center Nanjing University Nanjing 210093 China

There exists an E-W trending Middle Jurassic volcanic zone in southern china. The Fankeng basalts in the Yongding basin of Fujian Province are considered to be a typical example. The Fankeng basalts have TiO2 contents in the range of 1.92%-3.21%. They are classified as high-Ti basalts. They also have higher total Fe (averaging FeO* = 11.09%). The Middle Jurassic Fankeng basalts from southwestern Fujian have obvious distinctive lithogeochemical features from early Cre- taceous basalts from southeastern coast of china. They have higher HFSE, such as Th, Nb, Ta, Zr and Ti. Their element ratios related with HFSE, such as Zr/Ba, La/Nb, La/Ta ,Zr/Y, Ti/Y, Ba/Nb, K/Ti and Rb/Zr are similar to those of OIB. The most samples have ε Nd(T) of-0.70-0.24, which are near chondrite. Some samples have higher ε Nd(T) of ***, these basaltic magmas might be derived from depleted asthenospheric mantle. The lithogeochemical characteristics of the Fankeng basalts may be caused by interaction between asthenosphere and lithosphere at the time. The (Early-) Middle Jurassic basalts and gabbros from southeastern Hunan, southern Jiangxi and northern Guangdong provinces show similar geochemical features to those of the Fankeng basalts from the Yongding of Fujian. Occurrence of these OIB-type basalts in the area may be regarded as the petrological mark of upwelling of asthenosphere at the time. Upwelling of asthenosphere has led to tectonic extension and the formation of rifted basin in the area.

关键词： interaction between asthenosphere and lithosphere, lithogeochemistry, basalts, Middle Jurassic, southern china.

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钟山风景名胜区旅游服务中心

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建筑实践 2024年第Z1期 128-137页

作者： Architects & Engineers Co., Ltd. of southeast university 东南大学建筑设计研究院有限公司

钟山风景名胜区旅游服务中心项目位于南京玄武湖东岸、紫金山西南侧，南临太阳宫，东为龙蟠路。该项目是江苏省重点文旅项目。2017年，东南大学韩冬青教授领衔的城市设计与建筑团队开展了《玄武湖东岸及旅游市集修建性详细规划》编制工...

钟山风景名胜区旅游服务中心项目位于南京玄武湖东岸、紫金山西南侧，南临太阳宫，东为龙蟠路。该项目是江苏省重点文旅项目。2017年，东南大学韩冬青教授领衔的城市设计与建筑团队开展了《玄武湖东岸及旅游市集修建性详细规划》编制工作，钟山风景名胜区旅游服务中心（旅游市集）核心地块概念性方案与整体城市设计充分融合，最终顺利通过主管部门评审并得以实施。在之后近5年的设计建造过程中，建设方、设计方与城市主管部门共同努力，为玄武湖东岸打造了一座人文、开放的城市客厅。2023年初，项目以“金陵STYLE浪漫中心”作为案名正式开放，迅速成为南京市民和游客的休闲旅游消费新地标。

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Crystal structure and single crystal EPR of (NH_4)_2(15-crown-5)_3[Cu(mnt)_2] and (NH_4)_2(benzo-15-crown-5)_4[Cu(mnt)_2]·0.5H_2O

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Science china Chemistry 2007年第5期50卷 607-613页

作者： SUI YunXia1, WEN LiLi2, ZHANG Huan3 & MENG QingJin2 1 center of Modern Analysis, nanjing university, nanjing 210093, china 2 State Key Laboratory of Coordination Chemistry, Coordination Chemistry Institute, nanjing university, nanjing 210093, china 3 Jiangnan Institute of Computing Technology, Wuxi 214083, china 1. center of Modern Analysis Nanjing University Nanjing 210093 China 2. State Key Laboratory of Coordination Chemistry Coordination Chemistry Institute Nanjing University Nanjing 210093 China 3. Jiangnan Institute of Computing Technology Wuxi 214083 China

The X-ray crystal structures of (NH4)2(15-crown-5)3[Cu(mnt)2] (1) and(NH4)2(benzo-15-crown-5)4-[Cu(mnt)2] ident to 0.5H2O (2) were *** single crystals arecomposed of distinct structures of ammonium-crown ether supramolecular cation and [Cu(mnt)2]^(2-)*** triple-decker dication in complex 1 and a sandwich dimmer in complex 2 wereobserved.X-Band EPR studies on the single crystals of both complex 1 and complex 2 have been carriedout at room temperature,which revealed that complex 2 showed a perfect hyperfine structure of Cuwhereas that of complex 1 could not be *** principal values and direction cosines of theprincipal axes of the g and A tensors were computed by a least-squares fitting *** spindensity of Cu(ll) was estimated according to the principal values of the A tensors and compared wellwith the results calculated based on DFT method.

关键词： supramolecular cation, H-bonding interaction, EPR, g and A tensors, DFT

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