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Alternation of AFP-mRNA level detected in blood circulation during liver resection for HCC and its significance

World Journal of Gastroenterology 2002年第5期8卷 818-821页

作者： Xiao-Ping Chen Hong Zhao Hepatic surgery Center,tongji hospital,tongji medical college,huazhong university of science and technology,wuhan 430030,Hubei Province,china Xi-Ping Zhao department of Clinic Immunology,tongji hospital,tongji medical college,huazhong university of science and technology,wuhan 430030,Hubei Province,china HepaticsurgeryCenter TongjiHospitalTongjiMedicalCollegeHuazhongUniversityofScienceand

AIM: To investigate whether the current manipulation ofliver resection for hepatocellular carcinoma(HCC)causesdissemination of liver tumor cells into blood ***: Fifty patients with HCC, but without evidencesof metastases, were enrolled for the study. Samples ofperipheral blood before skin incision and after abdominalwall suture, and those of hepatic venous blood and portalvenous blood after liver parenchyma dissection,wereobtainedAFP-mRNA was extracted from the blood samplesand detected with reverse transcription polymerase chainreaction assay. The changes of its expression during theoperation were accessed by the ratio of fluorescence of AFPand β-actin primers-amplified ***: The rate of its expression before and afteroperation in peripheral blood, and during operation in portalvenous and hepatic venous blood was 42.0 %, 34.0 %, 42.0 %and 56.0 % respectively, There was no difference betweenthem. However, the ratio of fluorescence of AFP and β-actinprimers-amplified products from hepatic venous blood duringoperation is significantly higher than the other three typesof samples (P＜0.05).CONCLUSION: the current manipulation of liver resectionfor HCC can cause the releases of AFP mRNA-expressedcells from the liver, probably including tumor cells, intohepatic vein. These cells may spread into blood circulationand become the source of recurrence after operation.

关键词：肝癌肝切除术血液循环甲胎蛋白 mRNA 临床意义

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Effect of Gingko Injection on the Expression of NF-κB in Pulmonary Vessels of Rats with Portal Hypertension

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生物医学工程学杂志 2005年第S1期22卷 107-108页

作者： Chao WANG Juan HAN Zhong Yan LIU Zhen YANG (department of Integrative surgery, tongji hospital, Tong ji medical college, Hua Zhong university of science and technology, wuhan 430030, china) department of Integrative surgery Tongji Hospital Tong ji Medical College Hua Zhong University of Science and Technology Wuhan 430030 China

1 IntroductionDomestic scholars have originated the conception of'portal hypertensive vasculopathy ( PHV)', which concerns multiple organ vasculopathies in portal hypertensive patients. Portal hypertensive pulmonary vasculopathy is also a kind of internal organ vasculopathy. The transcription factor nuclear factor κB (NF-κB) regulates the expressions of genes that contribute to acute inflammatory reactions in endothelium. Few have reported about the expression of NF-κB in pulmonary vessels of rats related with portal hypertension (PH). Firstly we detected the expression of NF-κB in pulmonary vessels of rats with PH induced by biliary cirrhosis. Then through injecting of gingko (GI) into abdominal cavity, we found that NF-κB's expression was inhibited. We propose that NF-κB may play an important role in the pathogenesis of PHV and GI can hinder the improvement of PHV through inhibiting the expression of NF-κB. This outcome may provide certain theoretic basis for a novel therapy of portal hypertension.

关键词： Effect of Gingko Injection on the Expression of NF GI B in Pulmonary Vessels of Rats with Portal Hypertension

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Adenoma of the middle ear

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Journal of Otology 2007年第2期2卷 109-113页

作者： XIAO Hong-jun1, WEI Yong-hao1, NIE Xiu2 1 department of Otolaryngology, 2 department of Pathology, union hospital, tongji medical college, huazhong university of science and technology. wuhan 430022, Hubei. department of Otolaryngology Union Hospital Tongji Medical College Huazhong University of Science and Technology. Wuhan 430022 Hubei. department of Pathology Union Hospital Tongji Medical College Huazhong University of Science and Technology. Wuhan 430022 Hubei.

Adenoma of the middle ear is a primary tumor of the middle ear that can have exocrine (mucinous) and/or neuroendocrine differentiation. It is an uncommon tumor in the practice of otolaryngology. Based on the first des... 详细信息

关键词： Neck Adenoma of the middle ear

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CD151 gene delivery increases eNOS activity and induces ECV304 migration, proliferation and tube formation

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Acta Pharmacologica Sinica 2007年第1期28卷 66-72页

作者： Zhen-zhong ZHENG Zheng-xiang LIU~2 department of Cardiology,tongji hospital,tongji medical college,huazhong university of science and technology,wuhan 430030,china departmentofCardiology TongjiHospitalTongjiMedicalCollegeHuazhongUniversityofScienceandTechnologyWuhan430030China

Aim:To investigate the effects of CD 151 on the activity of endothelial NO syn-thase(eNOS),and ECV304 migration,proliferation and tube ***:pAAV-CD 151 and pAAV-anti-CD 151 were constructed and used to transientlytransfect ECV304 mediated with Lipofectamine *** transfection,the ex-pression of CD 151 was measured by Western *** migration assay wasperformed using Boyden transwell;proliferation assay was evaluated using the 3-[4,5-dimethylthiazol-2-yl]-2,5,diphenyltetrazolium bromide(MTT)method,andtube formation test was examined on matrigel,eNOS activity was assayed by L-[~3H]citrulline production from L-[~3H]*** involvement of eNOS was ex-plored using an eNOS inhibitor(L-NAME)and the effects in the process ***:CD 151 promotes cell migration,proliferation and tube *** addition,CD151 increases eNOS ***,cell migration,prolifera-tion and tube formation induced by CD 151 are inhibited when L-NAME is used,which indicates that there is an involvement of eNOS in CD151-induced cellmigration,cell proliferation and tube ***:CD 151 promotesECV304 migration,proliferation and tube *** mechanism is that CD151increases eNOS *** result also suggests that eNOS is involved in theangiogenic effects of CD151.

关键词： CDI51 endothelial NO synthase(eNOS) cell migration cell proliferation tube formation

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Evolution of Bright Screening-photovoltaic Spatial Optical Solitons

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Chinese Journal of Lasers 2001年第5期10卷 28-33页

作者： LIU Jinsong (State Key Laboratory of Laser technology, huazhong university of science and technology, wuhan 430074, china) 华中科技大学激光技术国家重点实验室湖北武汉

A numerical analysis of the dynamical evolution of bright screening photovoltaic (SP) spatial solitons in biased photovoltaic photorefractive materials in the case of neglecting the material loss and the diffusion is presented. When an incident optical beam is a bright SP soliton, the beam propagates along a linear path with its shape kept unchanged. When the incident optical beam is slightly different from a bright SP soliton, the beam reshapes itself and tries to evolve into a bright SP soliton after a short distance. However, when the incident optical beam is significantly different from a SP bright soliton, the beam cannot evolve into a stable bright SP soliton, and tends to experience periodic compression and expansion. For a low intensity input beam, the wave experiences a periodic process of compression first and then expansion during the initial part of the cycle. For a high intensity input beam, however, the wave will initially diffract and then experiences compression during the cycle.

关键词： nonlinear optics spatial optical solitons photorefractive effects

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A measure of centrality based on modularity matrix

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Progress in Natural science:Materials International 2008年第8期18卷 1043-1047页

作者： Gaoxia Wang, Yi Shen *, Enjie Luan The department of Control science and Engineering, huazhong university of science and technology, wuhan 430074, china The department of Control science and Engineering Huazhong University of Science and Technology Wuhan 430074 China

In this paper, a kind of measure of structural centrality for networks, called modularity centrality, is introduced. This centrality index is based on the eigenvector belonging to the largest magnitude eigenvalue of modularity matrix. The measure is illustrated and compared with the standard centrality measures using a classic dataset. The statistical distribution of modularity centrality is investigated by considering large computer generated graphs and two networks from the real world.

关键词： Centrality Modularity centrality Modularity matrix

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Response to Pain by Different Gestational Age Neonates

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Journal of huazhong university of science and technology(medical sciences) 2002年第1期22卷 84-86页

作者：夏传雄杨磊赵萍张小铭 department of Pediatrics Xiehe Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan 430022

One hundred infants were divided into the following 3 gestational age (GA) groups: (Ⅰ) premature infants ( n =30) with the gestational age between 29 and 32 weeks; (Ⅱ) premature infants ( n =30) with the gestational age between 33 and 36 weeks; (Ⅲ) full term infants ( n =40). The recorded responses of all infants to pain included the behavioral responses to painful stimuli (cry, facial activity and limbs movement) and the variety of heart rate. The results indicated that the infants of 3 groups had different degree response to various painful stimuli. Pain expression in full term infants was more significant than premature infants to same stimuli. 33 weeks GA infants were differential from 29 weeks GA infants. Full term infants showed more vertical mouth stretch and more taut tongue and more hand to mouth than premature infants, but more horizontal mouth stretch in premature infants.

关键词： full term infants premature infants pain behavioral response

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Apoptosis and proliferation of intrahepatic bil educt after ischemia-reperfusion injury

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Hepatobiliary & Pancreatic Diseases International 2004年第3期3卷 428-432页

作者： Wen-Hui Xu, Qi-Fa Ye and Sui-Sheng Xia Institute of Organ Transplantation, tongji hospital,tongji medical college, huazhong university of science and technology,wuhan 430030, china Institute of Organ Transplantation Tongji Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan 430030 China. jzxwh@***

BACKGROUND: In orthotopic liver transplantation, ische-mic-reperfusion is one of the most important factors thatcause the incidence of biliary complicance. The aim of thisstudy was to investigate the effects of ischemia reperfusionon epithelial cells apoptosis and proliferation of intrahepaticbile duct (IBD) (>20 μm).METHODS: 30-minute warm ischemia was applied to ratlivers respectively, and experiment was performed on days2,7, 14, 28 after reperfusion. Apoptosis was determined insitu by morphology and TUNEL, and cholangiocyte proli-feration was evaluated in situ by morphometry of liver sec-tions stained for cytokeratin-19 ( CK-19) and by prolifera-ting cellular nuclear antigen staining in liver ***: Two days after ischemia reperfusion, apoptosisof cells was observed in large intrahepatic bile ducts (>20μm) (5.6%±1.2%) , but the number of large intrahepaticbile ducts reduced (0.32 ±0.06). Seven days after ischemiareperfusion, the apoptosis index of cholangiocytes de-creased to 1.2%±0.3%, and the number of intrahepatic bileducts began to proliferate and returned to nearly normal onday ***: Ischemia reperfusion causes a decrease inthe number of intrahepatic bile ducts (>20 μm) as a resultof a higher rate of apoptosis and absence of initial prolifera-tion.

关键词： apoptosis proliferation intrahepatic bile duct epithelial cells

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Effect of Intensive Therapy of Multiple Factors Intervention on Vascular Complications in Type 2 Diabetes

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Journal of huazhong university of science and technology(medical sciences) 2003年第1期23卷 16-18页

作者：吴汉妮张淑玲沈迪 departmentofEndocrinology XieheHospitalTongjiMedicalCollegeHuazhongUniversityofScienceandTechnology

The effects of intensive versus regular therapy on incidence and progress of microalbuminuria in type 2 diabetes were compared. During a follow-up of 3 years, 96 cases of diabetes mellitus were randomized to intensive and regular therapy groups. HbA 1c goal was same in the two groups, but the goal of blood pressure (Bp) and lipid was more strict in the intensive therapy group than in the regular therapy group. There was statistically significant difference in the incidence and progression of vascular complications between the two groups. Logistic stepwise-regression analysis (odds ration, OR) showed that there was significant difference in the progression of nephropathy (OR 0.24, 95 % CI 0.12-0.76), retinopathy (OR 0.38, 95 % CI 0.16-0.88), peripheral neuropathy (OR 0.42, 95 % CI 0.22-0.86) and autonomic neuropathy (OR 0.29, 95 % CI 0.12-0.86) between the two groups (P<0.01). It was concluded that intensive blood glucose controlling could retard diabetic vascular complications. Intensive therapy of multiple factors interventions (controlling Bp, regulating blood lipid, improving microcirculation) could decrease various risk factors for diabetic vascular complications.

关键词： type 2 diabetes vascular complications multiple factors intervention intensive therapy

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Study on the Changes in Microvessel Density in Hepatocellular Carcinoma Following Transcatheter Arterial Chemoembolization

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Journal of huazhong university of science and technology(medical sciences) 2001年第4期21卷 321-322,331页

作者：易继林廖晓峰杨志芳李兴睿 department of general surgery Tongji Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan 430030

To study the changes in intratumoral microvessel density (MVD) in hepatocellular carcinoma (HCC) following transcatheter arterial chemoembolization (TACE), MVD in 42 HCC specimens histologically verified was studied by using immunohistochemical method. Of all the specimens, 20 were obtained from the patients treated with surgical resection alone, 22 from those with second stage surgical resection after TACE. The results showed that the MVD in HCC tissues was 53.4±21 9 in the TACE group and 27.6±9.2 in the single operating group, respectively, with the difference being significant between them ( P <0.001). It was suggested that TACE might contribute to angiogenesis of HCC, possibly due to anoxic stress and ischemia reperfusion injury.

关键词： hepatocellular carcinoma chemoembolization, therapeutic microvessel density

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