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Mechanisms of antiprostate cancer by gum mastic:NF-κB signal as target

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Acta Pharmacologica Sinica 2007年第3期28卷 446-452页

作者： Mei-lan HE~(2.4) Ang LI~2.Chun-su XU~2.Shun-li WANG~3.Meng-jie ZHANG~2.Hua GU~2.Yao-qin YANG~3.Hui-hong TAO~3.~2.nstitute of Cancer Research,life science and technology School,{3. university,shanghai 200092,china ~3.ellular Morphology Center,Medical School,{3. university,shanghai 200092,china Institute of Cancer Research Life Science and Technology School Tongji University Shanghai 200092 China Cellular Morphology Center Medical School Tongji University Shanghai 200092 China

Aim:To study the effect of gum mastic,a natural resin,on the proliferation ofandrogen-independent prostate cancer PC-3.cells,and further investigate themechanisms involved in this regulatory system,taking nuclear factor κB(NF-κB)signal as the ***:3.(4,5-dimethylthiazol-2.yl)-2.5-diphenyltetrazoliumbromide(MTT)assay and a flow cytometer were used to detect the effect of gummastic on the proliferation of PC-3.***,reporter gene assay,RT-PCR,andWestern blotting were carried out to study the effects of gum mastic on the NF-κBprotein level and the NF-κB signal *** expression of genes involved inthe NF-κB signal pathway,including cyclin D1,inhibitors of κBs(IκBα),andphosphorylated Akt(p-AKT),were *** addition,transient transfectionassays with the 5×NF-κB consensus sequence promoter was also used to test theeffects of gum ***:Gum mastic inhibited PC-3.cell growth and blockedthe PC-3.cell cycle in the G1 *** mastic also suppressed NF-κB activity inthe PC-3.*** expression of cyclin D1,a crucial cell cycle regulator and anNF-κB downstream target gene,was reduced as ***,gum masticdecreased the p-AKT protein level and increased the IκBα protein ***:Gum mastic inhibited the proliferation and blocked the cell cycleprogression in PC-3.cells by suppressing NF-κB activity and the NF-κB signalpathway.

关键词： gum mastic prostate cancer NF-κB signal

A simple solution route to control synthesis of Fe_3._4 nanomaterials at low temperature and their magnetic properties

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science china Chemistry 2009年第7期52卷 916-923页

作者： LIU Yi1,2. CHEN Yun1, ZENG YuPing2.& WANG ShiLong3.1 Department of Chemistry and Chemical Engineering, Zaozhuang university, Zaozhuang 2.7160,{2. 2.shanghai Institute of Ceramics, Chinese Academy of {3.s, shanghai 2.0050,{2. 3.School of life {3. and technology, tongji university,{12.,{2. 1. Department of Chemistry and Chemical Engineering Zaozhuang University Zaozhuang 277160 China 2. shanghai Institute of Ceramics Chinese Academy of Sciences Shanghai 200050 China 3. School of life {2. and technology Tongji University Shanghai 200092 China

A series of nanostructured iron compounds including cubic Fe3.4 and orthorhombic FeOOH were synthesized via a facile low temperature (in the range of 60-100℃) solution method. In the whole process, the interaction between FeCl2.4H2. and methenamine (C6H12.4) was carried out through a reflux device under different reaction conditions such as temperature, solvent, and duration. The samples were detected by XRD, TEM, SAED, physical property measurement system, and Mssbauer spectroscopy, separately. The experiments showed that magnetic mixture nanoparticles had flake and rod morphologies, and cubic Fe3.4 took on grain nanostructure. Magnetism measurements indicated that the saturated magnetization of the as-obtained magnetic mixture was lower than that of the cubic magnetite. Mssbauer spectroscopy testified the sample consisting of cubic magnetite rather than γ-Fe2.3. In addition, a possible growth mechanism of cubic magnetic nanoparticles under different conditions was discussed.

关键词： magnetic nanoparticles cubic Fe3.4 oxidation-coprecipitation method reflux magnetic properties at room temperature Mssbauer spectrum

Bayesian cognitive trust model based self-clustering algorithm for MANETs

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science china(Information sciences) 2010年第3期53卷 494-505页

作者： WANG Wei1,2.3.& ZENG GuoSun1,2.3.Department of Computer {2. & technology, tongji university,{3., china 2.7} Branch, National Engineering & technology Center of High Performance Computer,{3., china 3.ey Loboratory of Embedded System and Service Computing, Ministry of Education,{3., china 1. Department of Computer science & technology Tongji University Shanghai 200092 China2. Tongji Branch National Engineering & Technology Center of High Performance Computer Shanghai 200092 China3. Key Loboratory of Embedded System and Service Computing Ministry of Education Shanghai 200092 China

With the introduction of mobile Ad hoc networks (MANETs), nodes are able to participate in a dynamic network which lacks an underlying infrastructure. Before two nodes agree to interact, they must trust that each will satisfy the security and privacy requirements of the other. In this paper, using the cognition inspired method from the brain informatics (BI), we present a novel approach to improving the search efficiency and scalability of MANETs by clustering nodes based on cognitive trust mechanism. The trust relationship is formed by evaluating the level of trust using Bayesian statistic analysis, and clusters can be formed and maintained autonomously by nodes with only partial knowledge. Simulation experiments show that each node can form and join proper clusters, which improve the interaction performance of the entire network. The essence of the underlying reason is analyzed through the theory of complex networks, revealing great scalability of this method.

关键词： trust model MANET self-clustering Bayesian method cognitive mobile

The protection effect of β-CD on DNA damage induced by ultrafine TiO_2

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science china Chemistry 2007年第2期50卷 272-275页

作者： ZHU RongRong,WANG ShiLong,SUN XiaoYu,ZHANG Rui & YAO SiDe School of life science and {2.,{3. university,shanghai 200092,china 1. School of life science and {2. Tongji University Shanghai 200092 China

Under the photocatalysis of 3.5 nm ultraviolet radiation,ultrafine TiO2.caused the oxidative damage of Teasy plasmid DNA. The damage was determined by gel-electrophoresis. Then,a different dose of β-CD was added to the reaction,and the damage was restrained. The rate of damage restraining reached 97% when the mass of β-CD was 4 times as that of TiO2. Through UV scan and IR spectroscopy,it was found that the Ti-O of ultrafine TiO2.was bound with -OH of β-CD cavum and the -OH on the surface of ultrafine TiO2.disappeared,so the formation of ?OH was controlled. The ultrafine TiO2.has been widely used,but it was determined to be carcinogenic by some research. The protection effect of β-CD to DNA in the molecular level takes a new look on the surface modification of nano particles to decrease the toxic effect.

关键词： β-CD ultrafine TiO2 plasmid DNA oxide damage bond reaction damage restrain

Impact and mechanism of TiO_2.nanoparticles on DNA synthesis in vitro

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science china Chemistry 2008年第4期51卷 367-372页

作者： LI ShiQiang, ZHU Hong, ZHU RongRong, SUN XiaoYu, YAO SiDe & WANG ShiLong School of life science and {2.,{3., shanghai 200092, china 1. School of life science and {2. Tongji University Shanghai 200092 China

The impact of TiO2.nanoparticles on DNA synthesis in vitro in the dark and the molecular mechanism of such impact were studied. The impact of TiO2.nanoparticles on DNA synthesis was investigated by adding TiO2.nanoparticles in different sizes and at various concentrations into the polymerase chain reaction (PCR) system. TiO2.nanoparticles were premixed with the DNA polymerase, the primer or the template, respectively and then the supernatant and the precipitation of each mixture were added into the PCR system separately to observe the impact on DNA synthesis. Sequentially the interaction be- tween TiO2.nanoparticles and the DNA polymerase, the primer or the template was further analyzed by using UV-visible spectroscopy and polyacrylamide gel electrophoresis (PAGE). The results suggest that TiO2.nanoparticles inhibit DNA synthesis in the PCR system in the dark more severely than mi- croscale TiO2.particles at the equivalent concentration and the inhibition effect of TiO2.nanoparticles is concentration dependent. The molecular mechanism of such inhibition is that in the dark, TiO2.nanoparticles interact with the DNA polymerase through physical adsorption while TiO2.nanoparticles do with the primer or the template in a chemical adsorption manner. The disfunction levels of the bio-molecules under the impact of TiO2.nanoparticles are in the following order: the primer > the tem- plate > the DNA polymerase.

关键词： TiO2 nanoparticles PCR DNA synthesis molecular mechanism

Simultaneously inducing synthesis of semiconductor selenium multi-armed nanorods and nanobars through bio-membrane bi-templates

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science china Chemistry 2004年第6期47卷 507-511页

作者： LI Li1, WU Qingsheng1 DING Yaping2.& LI Ping3.1. Department of Chemistry, tongji university,{2., china 2. Department of Chemistry, {3. university, {3. 2.043., china 3. Department of Food, Anhui Agricultural university, Hefei 2.0}03., china 1. Department of Chemistry Tongji University 200092 Shanghai China 2. Department of Chemistry Shanghai University 200436 Shanghai China 3. Department of Food Anhui Agricultural University 230036 Hefei China

Multi-armed nanorods and nanobars of semiconductor selenium were simultane- ously synthesized in the light of biomineralization process through bio-membrane bi-templates of rush at room temperature. The multi-armed nanorods are 60 nm in diameter and 1.5 μm in length; the nanobars are 150 nm in diameter and 1000—1100 nm in length. The XRD pattern indicates that these nanocrystals were crystallized in the hexagonal structure with lattice constants a = 0.43. nm, c = 0.495 nm. The possible formation mechanism was investigated.

关键词： selenium, multi-armed nanorods, nanobars, bio-membrane, bi-templates.

Mechanical and Experimental Study of Sprinkling Water Cooling System on Roof of shanghai Expo Theme Pavilion

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湖南大学学报（自然科学版） 2009年第S1期36卷 156-159页

作者： ZHAO Hui-zhong1,HUANG Chen1,LI Wei-xiang2.SHI Jin-yue2.TAO Si-yuan1,WANG Qian1,WANG Yu-qing1,ZHANG Min3.1.College of Urban Construction and Environment Engineering,university of {2. for science and {3.,{2. 2.0093.china 2.Architectural Design & Research Institute of tongji university,{2. 200092,china 3.College of Food science {3.,{2. Ocean university,{2. 2.13.6,china) College of Urban Construction and Environment Engineering University of Shanghai for Science and Technology Shanghai 200093 China Architectural Design and Research Institute Tongji University Shanghai 200092 China College of Food science technology Shanghai Ocean University Shanghai 201306 China

Based on the similarity theory,a scale effect model of the spraying water cooling system of shanghai expo Theme Pavilion's roof was set *** to the typical weather conditions in shanghai city,different models were analyzed on solar radiation,and different heat transfer amount was *** the following conclusions could be made:At the sunny day of summer in shanghai,the temperature of inner roof with sprinkling system descended about 3.℃,and the air conditioning load of the whole Theme Pavilion descend more than 3.0 kW.

关键词： shanghai expo large space atrium solar radiation roof sprinkling system similarity theory prototype

Research on nonlinear constitutive relationship of permanent deformation in asphalt pavements

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science china(Physics,Mechanics & Astronomy) 2006年第6期49卷 671-682页

作者： PENG Miaojuan1 & XU Zhihong2.1. Department of Civil Engineering,shanghai university,shanghai 2.0072.{3. 2. School of Transportation Engineering,tongji university,shanghai 200092,{3. 1. Department of Civil Engineering Shanghai University Shanghai 200072 China 2. School of Transportation Engineering Tongji University Shanghai 200092 China

To predict correctly the rut depths in asphalt pavements,a new nonlinear viscoelastic-elastoplastic constitutive model of permanent deformation in asphalt pave-ments is presented. The model combines a generalized Maxwell model with an elasto-plastic one. Then from the creep theory,the linear and nonlinear constitutive equations of the generalized Maxwell model are obtained. From the nonlinear finite element method for the rutting of the asphalt pavement,the rut depths of 4 asphalt-aggregate mixtures are obtained. And the results are compared with the ones from the finite element method by SHRP and the experiments by SWK/UN. The results in this paper are better than the ones by SHRP,and agree with the ones of the experiment by SWK/UN. This shows that the nonlinear viscoelastic-elastoplastic constitutive model,which is presented in this paper for the rutting of the asphalt pavement,is effective. The properties,such as nonlinear elastic-ity,plasticity,viscoelasticity and nonlinear viscoelasticity,which affect the rutting of an asphalt pavement,can be shown in the model. And the characteristics of the permanent deformation of the asphalt pavement can be presented entirely in the model.

关键词： asphalt pavement,permanent deformation,nonlinear viscoelastic-elastoplastic constitutive relationship,generalized Maxwell model,creep compliance.

The characteristics of arc beam shaping in hybrid plasma and laser deposition manufacturing

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science china(Technological sciences) 2006年第2期49卷 238-247页

作者： ZHANG Hai’ou1, QIAN Yingping1,3. WANG Guilan1 & ZHENG Qiguang2.1. School of Material science and {2., Huazhong university of science and {2., Wuhan 43.074, china 2. Institute of Laser {2. and Engineering, Huazhong university of science and {2., Wuhan 43.074, china 3. Mechanical Engineering College, Hubei university of {2., Wuhan 43.068, china 1. School of Material science and technology Huazhong University of Science and Technology Wuhan 430074 China 3. Mechanical Engineering College Hubei University of Technology Wuhan 430068 China 2. Institute of Laser technology and Engineering Huazhong University of Science and Technology Wuhan 430074 China

As a new direct metal prototyping technology,the hybrid plasma and laser deposition manufacturing (PLDM) is proposed in this paper. In order to figure out the characteristics of plasma arc beam and mould in the PLDM process of high temperature alloy, the high speed CCD camera is used to obtain the picture around the plasma arc. Afterwards the sketch of picture is clearly obtained. And the effect of laser parameter, such as average power, pulse width, pulse repetition frequency and the angle between laser beam and plasma arc beam on the plasma arc appearance, is studied experimentally. The results show that the modality of plasma arc beam is markedly influenced by laser beam. And the improvements of shape precision and surface state of the layer deposited by PLDM are confirmed.

关键词： plasma hybrid laser, direct deposition, plasma arc beam, molding character, high-temperature alloy.