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TLR4 signaling induced TLR2 expression in the process of mimic cerebral ischemia/reperfusion in vitro

中国科学：生命科学英文版 2010年第2期53卷 223-228页

作者： SUN Peng1,ZHANG Qing2,HAN JiYuan1,TIAN Yuan3.& ZHANG JingHui3.1Department of Emergency,Union Hospital,Tongji Medical College,huazhong university of science and technology,wuhan 43.022,china 2Department of Anesthesia,Union Hospital,Tongji Medical College,huazhong university of science and technology,wuhan 43.022,china 3.epartment of General Surgery,Union Hospital,Tongji Medical College,huazhong university of science and technology,wuhan 43.022,china Department of Emergency Union Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan China Department of Anesthesia Union Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan China Department of General Surgery Union Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan China

Both TLR4 and TLR2 participated in the mediation of the inflammatory injury in the process of partial cerebral ischemia/***,it still remains unclear whether a crosstalk exists between TLR2 and TLR4 in ischemic cerebral *** the present study,we investigated the effect of TLR4 signaling on TLR2 expression during mimic cerebral I/R in ***-2 cells were cultured and treated with ischemia/reperfusion,then transfected with the plasmid pEGFP-H1/TLR4-siRNA,the plasmid pEGFP-H1/control sequence-siRNA and the blank plasmid,***,the expression of TLR2 and TLR4 mRNA and protein,NF-κB p65 mRNA and supernatant TNF-α level were significantly higher in ischemia/reperfusion treated cells than those lack of ischemia/reperfusion treatment,and as compared with those in ischemia/reperfusion treated cells without transfection,no significant differences about the above mentioned gene and protein expression were found in the blank plasmid tranfected cells and the plasmid pEGFP-H1/control sequence-siRNA transfected cells respectively,while the expression levels in the plasmid pEGFP-H1/TLR4-siRNA transfected cells were significantly ***,in order to determine the effects of pyrrolidinediethyldithiocarbamate (PDTC),an NF-κB inhibitor,on the TLR4-induced TLR2 expression in BV-2 cells treated with ischemia/reperfusion,it was found that TLR4 and TLR2 mRNA expressions in PDTC pretreated cells were significantly lower in comparison with normal saline pretreated cells and non-pretreated *** data suggested that TLR2 activation,signaled by TLR4 and regulated by NF-κB,might be directly involved play an important role in ischemia/reperfusion induced brain damage.

关键词： Toll-like receptor 4 Toll-like receptor 2 cerebral ischemia/reperfusion microglia

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Energy Efficient Beacon Discovering Scheme for Node Localization in Wireless Sensor Networks

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wuhan university Journal of Natural sciences 2010年第4期15卷 303-307页

作者： LIU Xinxin1,2, ZHAO Erdun3. CHEN Kun2 1. School of Computer, wuhan university, wuhan 43.072, Hubei, {3. 2. wuhan Digital Engineering Research Institute, wuhan 43.074, Hubei, {3. 3. Department of Computer science, huazhong Normal university, wuhan 43.079, Hubei, {3. School of Computer Wuhan University Wuhan Hubei China wuhan Digital Engineering Research Institute Wuhan Hubei China Department of Computer science Huazhong Normal University Wuhan Hubei China

Efficient sensor node localization is a crucial part of many location-dependent applications that utilize wireless sensor networks (WSNs). To cope with the problem of insufficient bea-con node for localization,we design a beacon discovery protocol in this paper that helps the blind node to find beacons nearby and present an energy efficient scheme for the beacon that receives the request from a blind node to adjust its radio range. We obtain the relationship between the mean energy consumption with adjust-ment number by the mathematical analysis. Numerical results show that great energy saving is achieved when the optimal ad-justment number is adopted.

关键词： localization wireless sensor networks energy- efficient radio range adjustment

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Online uniform machine covering with the known largest size

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Progress in Natural science:Materials International 2007年第11期17卷 1271-1278页

作者： Cao Shunjuan1,2 and Tan Zhiyi1,3.1. Department of Mathematics, Zhejiang university, Hangzhou 3.0027, china 2. Department of Mathematics, Zhejiang Forestry university, Hangzhou 3.13.0, china 3. State Key Laboratory of CAD & CG, Zhejiang university, Hangzhou 3.0027, china) Department of Mathematics Zhejiang University Hangzhou 310027 China Department of Mathematics Zhejiang Forestry University Hangzhou 311300 China State Key Laboratory of CAD and CG Zhejiang University Hangzhou 310027 China

This paper investigates the semi-online scheduling problem with the known largest size on two uniform machines. The objective is to maximize the minimum machine completion time. Both lower bounds and algorithms are given. Algorithms are optimal for the majority values of s≥1, where s is the speed ratio of the two machines. The largest gap between the competitive ratio and the lower bound is about 0.064. Moreover, the overall competitive ratio 2 matches the overall lower bound.

关键词： scheduling and covering uniform machine design and analysis of algorithm online competitive ratio

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Spectral anomalies and spectral switches of partially coherent and polychromatic light diffracted at an aperture

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science china(Physics,Mechanics & Astronomy) 2004年第1期47卷 24-35页

作者： Lü Baida1, 3.& PAN Liuzhan1, 2 1. Institute of Laser Physics and Chemistry, Sichuan university, Chengdu 610064, china 2. Department of Physics, Luoyang Normal College, Luoyang 471022, china 3. State Key Laboratory of Laser {3., huazhong university of science and technology, wuhan 43.074, china Correspondence should be addressed to L Baida (email: badalu@***) Received July 10, 2003 Institute of Laser Physics and Chemistry Sichuan University Chengdu China State Key Laboratory of Laser technology Huazhong University of Science and Technology Wuhan China Department of Physics Luoyang Normal College Luoyang China

Based on the propagation theory of partially coherent light in the space-frequency domain, the anomalous spectral behavior and spectral switches in the far field of partially coherent and polychromatic light diffracted at an aperture are studied. It is shown that, as compared with spatially fully coherent and polychromatic light whose spectral anomalies are induced only by aperture diffraction, the spectral anomalies and spectral switches of partially coherent and polychromatic light depend on the aperture diffraction, spatial correlationβ and bandwidth of the original spectrum. Detailed numerical calculations are made to illustrate the behavior of spectral switches of partially coherent and polychromatic light, and the results for spatially fully coherent and polychromatic light are treated as a special case ofβ=1 and included in our theory.

关键词： spectral anomaly spectral switch partially coherent and polychromatic light far field aperture diffraction

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A novel method to analyze damping effect of VSC based FACTS

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science china(Technological sciences) 2008年第12期51卷 2112-2119页

作者： DU WenJuan1,WANG HaiFeng2 & CHENG ShiJie3.1 Southeast university,Nanjing 210096,china 2 Queen’s university of Belfast,Belfast,BT9 5AH,UK 3.{3.,wuhan 43.074,china Southeast university Nanjing China Queen’s university of Belfast Belfast UK huazhong university of science and technology Wuhan China

A novel method to analyze the damping effect of the VSC based FACTS(VBF) device is proposed,which is developed on the basis of the well-known equalarea criterion and small-disturbance analysis of power system *** use of the proposed method,two conclusions are obtained for study of the damping effect of the *** research results clearly show the contribution of the VBF control to the damping of power system *** results of an example power system are used to verify the effectiveness of the proposed method.

关键词： power system low frequency oscillations FACTS equal-area criterion

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On the siltation of the middle Yangtze River

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science china Earth sciences 2004年第5期47卷 463-480页

作者： YIN Hongfu1, CHEN Guojin2, LI Chang抋n1 & WEI Yuan3.1. School of Earth sciences, china university of Geosciences, wuhan 43.074, china 2. Hydrogeological Team, Hubei Bureau of Geology and Mineral Resources, Jingzhou 43.100, china 3. Geological Survey of Jiangxi Province, Nanchang 3.0201, china School of Earth sciences China University of Geosciences Wuhan 430074 China Hydrogeological Team Hubei Bureau of Geol./Mineral Rsrc. Jingzhou 434100 China Geological Survey of Jiangxi Prov. Nanchang 330201 China

About 5.2×108 t/a of silts from the upper reach of the Yangtze River are transported through Yichang into the middle Yangtze River. The middle Yangtze itself and its tributaries yield ca. 0.8×108 t silts annually. Of this total 6×108 t/a input of silts, ca. 1.2×108 t/a are deposited within the river artery and lakes, while ca 4.83.108 t/a are at first transported into the lower reach through Datong, and then either deposited along the river and the Yangtze Delta, or output into the sea. Along the middle Yangtze River silting generally exceeds scouring, but the spatial and temporal distributions of scour-and-fill, as well as its distribution in the river valley transections, are uneven. Along the Yichang-Chenglingji and Jiujiang-Datong Segments of the middle Yangtze, scouring exceeds or equals silting. Silting mainly occurs along the Luoshan-wuhan-Huangshi Segments with wuhan as the pivotal point, as well as in the Dongting and Poyang Lakes. Even in these silting-dominated areas, there are times and parts of segments that scouring prevails. As to the transections, generally the river channel of main stream is scouring-dominated, forming V-shaped sections to a depth of 203. m or more, whereas the floodplains and bar islands are silting-dominated, forming wide and relatively high flats, which are often artificially transformed into protected embankments. Because the Jingjiang Levee separates the Jianghan Plain from Yangtze to the south, little has been deposited in that plain except a few sediments from the Han River—a tributary of the middle Yangtze. This factor plus the tectonic sag of that plain has made the altitude of plain surface several meters lower than that of the levee in most of the areas. Sil-tation along the Luoshan-wuhan-Huangshi Segments has resulted in the elevation of flood level in this and upstream segments. River channel scouring plus floodplain silting have caused the transections of the middle Yangtze valley typically with deep channel and height

关键词： the middle Yangtze, scour-and-fill, siltation, silt utilization.

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Inhibition of Inositol-1-phosphate Synthetase in Mycobacterium Tuberculosis by Chitosan-antisense Nanoparticles

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Journal of wuhan university of technology(Materials {3.) 2009年第1期24卷 87-90页

作者：李媛媛徐顺清 MOE Key Laboratory School of Public Health Tongji Medical College Huazhong University of Science and Technology

Oligodeoxynucleotides （ODNs） were combined with the biodegradable polymer chitosan to form chitosan-ODN nanoparticles by complex coacervation, in order to improve the sta-bility and intracellular penetration. The diameter of the nanoparticles was light strength size and ranged between 60 and 219 nm with a mean value of 13. nm, while zeta potential was between ＋12 and ＋20 mV at pH 5.5. The chitosan-ODN nanoparticles could partially protect the encapsulated ODN from nuclease degradation. Moreover, chitosan-ODN nanoparticles were much more effective in inhibiting the proliferation of *** than free ODN.

关键词： chitosan antisense oligodeoxynucleotides nanoparticle tuberculosis

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On-line parallel reversed phase two-dimensional liquid chromatography for high-throughput analysis of complex proteomic samples

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science china Chemistry 2006年第6期49卷 527-533页

作者： WANG Zhicong1,3. ZHANG Qinghe2, LI Tong2, ZHAO Zhongyi3.& ZHANG Weibing1 1. Dalian Institute of Chemical Physics, Chinese Academy of sciences, Dalian 116011, china 2. Dalian Elite Analytical Instrument Co., Ltd., Dalian 116011, china 3. Faculty of Material science and Chemical Engineering, china university of Geosciences, wuhan 43.074, china Dalian Institute of Chemical Physics Chinese Academy of Sciences Dalian China Faculty of Material science and Chemical Engineering China University of Geosciences Wuhan China Dalian Elite Analytical Instrument Co. Ltd. Dalian China

A comprehensive two-dimensional liquid chromatographic system (2D SCX/RP) is con- structed with a 10-port-2-way valve using strong cation exchange chromatography (Hypersil SCX, 100 mm×4.6 mm I.D.) followed by reversed phase chromatography (Hypersil BDS C18, 15 mm×4.6 mm I.D.) to separate the complex peptides from globin peptic hydrolysate. After the sample was loaded on the SCX column, the phosphate buffer (pH 4.0) was used to elute the peptides. Then, elutes flowed through the interface and the peptides focused on the head of the trapping columns (Hypersil BDS C18, 15 mm×4.6 mm I.D.) but salt passed into the waste. After the valve was switched, the samples were flushed with a backward flow into the RP analytical column. The peptides on the SCX were eluted with 12 discontinuous steps linearly increasing salt concentrations. The peptides enriched on the trapping column were desalted and separated by the RP columns. The resolution and the resolved peaks of the 2D SCX/RP system were greatly increased and the total peak capacity reached as high as 2280.

关键词： two-dimensional liquid chromatography, interface, trapping column, proteomics, globin.

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A Feedback-Based Web Search Engine

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wuhan university Journal of Natural sciences 2004年第5期9卷 561-568页

作者： ZHANG Wei-feng 1,2,3., XU Bao-wen 2,3.4 , ZHOU Xiao-yu 2,3.4 1. Department of Computer science and Engineering, Nanjing university of Posts and Telecommunications, Nanjing 210003. Jiangsu, china 2. Department of Computer science and Engineering, Southeast university, Nanjing 210096, Jiangsu, china 3. Jiangsu Institute of Software Quality, Nanjing 210096 Jiangsu, china 4. The State Key Laboratory of Software Engineering, wuhan university, wuhan 43.072, Hubei, china Department of Computer science and Engineering Nanjing University of Posts and Telecommunications Nanjing Jiangsu China Department of Computer science and Engineering Southeast University Najing Jiangsu China Jiangsu Institute of Software Quality Nanjing Jiangsu China The State Key Laboratory of Software Engineering Wuhan University Wuhan Hubei China

Web search engines are very useful information service tools in the Internet. The current web search engines produce search results relating to the search terms and the actual information collected by them. Since the selections of the search results cannot affect the future ones, they may not cover most people’s interests. In this paper, feedback information produced by the user’s accessing lists will be represented by the rough set and can reconstruct the query string and influence the search results. And thus the search engines can provide self-adaptability. Key words WWW - search engine - query reconstruction - feedback CLC number TP 3.1. 13..4 Foundation item: Supported by the National Natural science Fundation of china (603.3.66). National Grand Fundamental Research 973.Program of china (2002CB3.200). Opening Foundation of State Key Laboratory of Software Engineering in {3. university, Opening Foundation of Jiangsu Key Laboratory of Computer Information Processing technology in Soochow universityBiography: ZHANG Wei-feng (1975-), male, Ph.D. research direction: artificial intelligence, search engine, data mining, network language.

关键词： WWW search engine query reconstruction feedback

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Digital close-range photogrammetric application to small-scale physical simulation experiment

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中国有色金属学会会刊：英文版 2011年第S3期21卷 681-685页

作者： LI Chun-yi1, CUI Xi-min2, YU Yi-ju3.1. School of Surveying and Landing Information Engineering, Henan Polytechnic university, Jiaozuo 454003. china 2. College of Geoscience and Surveying Engineering, china university of Mining and technology, Beijing 100083. china 3. Surveying and Mapping Press, Beijing 100045, china School of Surveying and Landing Information Engineering Henan Polytechnic University Jiaozuo 454003 China College of Geoscience and Surveying Engineering China University of Mining and Technology Beijing 100083 China Surveying and Mapping Press Beijing 100045 China

In order to research the possibility of digital close-range photogrammetric surveying in small scale physical simulation experiment, physical model coinciding with engineering practice was constructed based on similar theory. The datum processing method and surveying precision of digital close-range photogrammetric were analyzed. And the function relationship between overburden subsidence factor qr and the ratio z/H of stratum horizon z and mining depth H was researched. The results show that surveying points position mean error along horizontal direction is ±0.13. mm and vertical direction is ±0.192 mm. Therefore, multi-taking station cross direction digital close-range photogrammetric can completely satisfy the precision need of physical simulation experiment. And the empirical formula can be utilized to represent evolution law of stratum subsidence factor.

关键词： close-range photogrammetric physical simulation light-rays adjustment surveying precision subsidence factor

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