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2011中国妇产科学术会议暨浙江省计划生育与生殖医学学术年会暨生殖健康讲习班

作者： Song Qi-ying,Shen Zong-ji department of Obstetrics and Gynecology,the first hospital affiliatedto suzhou university,Jiangsu suzhou 215006, china

Objective To assess the roles and the effects of inhibin A and activin A in the fetal growth. Methods Maternal antepartum blood,umbilical vein blood and placenta and were collected from the forty-three pregnant woman in obstetrical department of our hospital,which including FGR and normal pregnancy respectively 23 *** placental samples were detected by HE stain,and the expression of inhibin/activin subunit -α,-βA were analysed by *** concentration of maternal antepartum blood and umbilical vein blood were measured using ELISA. Results(1) In HE stain slides of the placental samples,villi developing well,blood vessels expanding distinctly,there were less interstitial cells and more syncytiotrophoblast(STB) nodes and cell bridges in normal pregnancy group than FGR ***/activin subunit -α,-βA expressed in STBs mainly.A significant higher expression of the inhibin/activin-α,-βA subunit in FGR syncytiotrophoblast compared to normal pregnancies was observed.(2) The ELISA results of maternal blood and umbilical blood in the FGR group showed higher than the normal pregnancy group *** level of serum inhibin A and activin A were negatively correlated with their birth weight and subcutaneous fat thickness.(3) All fetus had detectable inhibin A and actvin A levels that were lower compared to the mothers;and there were no relationship between fetal and maternal levels.(4) Inhibin/activin-α,-βA subunit were positively correlated with maternal levels.(5) Area under ROC curve of inhibin A was 0.862,and area under ROC curve of activin A was 0.782. Conclusion Inhibin A and activin A play an important roles in adjust fetus growth and placenta *** matermal serum Inhibin A and activin A can be regarded as one of the clinical indexes to evaluate fetus growth and placental function.

关键词： inhibin A activin A fetal growth restriction placenta ROC curve

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A clinical study on double-unit umbilical cord blood transplantation in adults with hematologic disease

A clinical study on double-unit umbilical cord blood transpl...

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第13届全国实验血液学会议

作者： Xiao Ma De-Pei Wu,Ai - Ning Sun,et al. first affiliated hospital soochow university Jiangsu Institute of Hematology suzhou 215006

＜正＞Objective:In this study,we explored the efficiency and toxicity of 46 cases of double-unit CBT in adults with hematologic disease. Methods:The tolerance;transplant related complications;survival rate and disease free survival rate were observed and analyzed.A nonmyeloablative conditioning regimen included cyclophosphamide,fludarabine and 2Gy TBI. Cyclosporine combined mycophenolate mofetil and ATG were used to prevent graft versus host disease（GVHD）. Results:All these 46 patients tolerated the therapy well while four patients had graft *** acute GVHD was presented in 6 *** GVHD was occurred in 18 *** infection complications were occurred

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The contribution of autophagy-lysosomal pathway to neuronal death and its underlying mechanisms in the rat models of permanent focal cerebral ischemia

The contribution of autophagy-lysosomal pathway to neuronal ...

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中国神经科学学会第四次会员代表大会暨第七届全国学术会议

作者： Ya-Dan WEN department of Pharmacology,soochow university School of Medicine,suzhou 215123,china

＜正＞Objective To investigate activation of autophagy by permanent focal cerebral ischemia,the effects of blocking autophagy-lysosomal pathway,and evaluate relationships between its neuroprotection and the expression of LC3 and cathepsin B and Bcl-2 in rat models of permanent focal cerebral *** Permanent middle cerebral artery occlusion（pMCAO） model was induced by using intraluminal filament technique in *** of autophagy in neurons in ischemic cortex was observed using electron microscopy.3-MA（150-600 nmol） or CBI（5-10μg） was injected intracerebroventricularly（i.c.v.） immediately after the onset of ***-four hours after the occlusion,the neuroprotections of 3-MA or CBI were analyzed by scoring neurological deficits,assessing brain infarction volume with 2,3,5-triphenyl tetrazolium chloride（TTC）,determining the brain water *** blot was employed to determine alternations in LC3/Beclin l/cathepsin B levels in ischemic cortex 0 h,1 h,3 h,6 h,12 h,and 24 h after the occlusion,and alternations in LC3/Beclin l/cathepsin B/Bcl-2 levels in ischemic 3 h cortex after given 3-MA or *** Permanent focal cerebral ischemia induced the robust formation of autophagosome and enhanced presence of secondary lysosomes, fragmented endoplasmic reticulum,swollen *** deficits,infract areas and brain water content were significantly reduced in rats treated with 3-MA（300-600 nmol） or CBI（7.5-10μg）;3-MA（600 nmol） or CBI（10μg） could significantly reduce infract volume and brain water *** expression of LC3/Beclin 1/cathepsin B was significantly increased and peak at 3hr after pMACO,but the expression of Bcl-2 was significantly decreased 3 hr after the occlusion. 3-MA（600 nmol） or CBI（10μg） supressed the ischemia-induced increase in LC3/Beclin 1/cathepsin B,and recovered Bcl-2 levels in the ischemic ***（1） Permanent focal cerebral ischemia increased the formation of autophagosomes and actived lysosome

关键词： cerebral ischemic stroke neuroprotection autophagy lysosome apoptosis LC3 cathepsinB 3-MA cathepsin B inhibitor Bcl-2

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PTTG和PCNA蛋白在神经胶瘤中的表达及其意义(英文)

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oncology and Translational Medicine 2009年第2期8卷 110-113页

作者： Rufei Dai,Shiming Zhang department of Neurosurgery,The first affiliated hospital of suzhou university,suzhou 215128,china department of Neurosurgery The First Affiliated Hospital of Suzhou University Suzhou China

Objective:To investigate the expressions and their relationship of pituitary tumor transforming gene(PTTG)and proliferating cell nuclear antigen(PCNA)in ***:The protein expressions of PTTG and PCNA were detected by immunostaining assay using streptavidin-peroxidase(SP)method in 80 cases of ***:The positive rates of PTTG in grades I-IV gliomas were 56.3%,68.2%,80.8%,and 100.0% respectively,and the protein expression of PTTG increased with the increasing of the pathological grade(χ2 = 9.602,P 37.5%,54.5%,69.2%,and 93.8% respectively,and the protein expression of PCNA increased with the increasing of the pathological grade(χ2 = 12.147,P < 0.01).The expression of PTTG had positive correlation with the expression of PCNA protein(γs = 0.557,P < 0.01).Conclusion:The expressions of PTTG and PCNA proteins were related to malignant degree of glioma,and may cooperate with each other in the tumorigenesis and progression and can be considered as the indicators of the biological behaviors in glioma.

关键词： pituitary tumor transforming gene(PTTG) proliferating cell nuclear antigen(PCNA) glioma immunohistochemistry

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Ketamine Addiction and Its Mechanisms

Ketamine Addiction and Its Mechanisms

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自主创新与持续增长第十一届中国科协年会

作者： BIAN Shizhong (department of Forensic Medicine, Medical College, soochow university, suzhou 215123, china)

Ketamine is a phencyclidine derivative acting primarily as a N-methyl-D-aspartate (NMDA) receptor antagonist. Its mechanism is complex and it can bind to a variety of receptors, involving NMDA receptor, opioid receptor, monoamine receptor, acetylcholine receptor and voltage-gated calcium channel receptor. In addition to the traditional anesthesia and pre-analgesic effect, ketamine also has anti-inflammatory, anti-seizure, the lifting of bronchospasm, and other pharmacological effects. Ketamine was widely abused in various places of entertainment because of hallucination and addiction. This article summarizes the pharmacology and toxicology of ketamine and ketamine abuse, discusses the possible mechanisms of ketamine addiction, from following aspects related to the mechanisms of drug addiction: enhanced effects and reward systems, anatomical structures and NMDA receptor.

关键词： toxicology ketamine addiction abuse

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Expression profiles of hippocampal regenerative sprouting -related genes and their regulation by E-64d in a developmental rat model of penicillin- induced recurrent epilepticus

Expression profiles of hippocampal regenerative sprouting -r...

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中华医学会第十七次全国儿科学术大会

作者： Hong Ni,Shou-yun Ren,Le-ling Zhang,Qi Sun,Tian Tian Neurology Laboratory,soochow university affiliated Children’s hospital Laboratory of Aging and Nervous Diseases,soochow university,suzhou 215003,china

Excessive Zn-induced neurotoxicity has been implicated in the pathogenesis of sprouting phenomenon in hippocampus after recurrent seizures,but little is presently known about molecular regulation of hippocampal zinc *** the purpose of investigating the role of E-64d, a calpain inhibitor,in the prevention of developmental seizure-induced hippocampal mossy fiber sprouting and related gene expression,a seizure was induced by penicillin every other day in

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IL-1β及幽门螺杆菌在氧介导GES-1细胞增殖中的作用

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苏州大学学报（医学版） 2008年第6期28卷 908-911页

作者：李岭陈卫昌江家贵苏州大学附属第一医院消化科江苏苏州215006 苏州大学放射医学与公共卫生学院放射生物学教研室江苏苏州215007

目的研究白细胞介素-1β(IL-1β)及幽门螺杆菌(Hp)对人胃黏膜上皮细胞(GES-1细胞)增殖及超氧自由基阴离子()的生成和低剂量对GES-1增殖的影响。方法用3H-TdR掺入法测定cpm值及MTT比色法分析检测总活细胞数来估计GES-1细胞DNA合成及... 详细信息

目的研究白细胞介素-1β(IL-1β)及幽门螺杆菌(Hp)对人胃黏膜上皮细胞(GES-1细胞)增殖及超氧自由基阴离子()的生成和低剂量对GES-1增殖的影响。方法用3H-TdR掺入法测定cpm值及MTT比色法分析检测总活细胞数来估计GES-1细胞DNA合成及细胞生成,衡量GES-1细胞增殖情况。用细胞色素C还原法测定GES-1细胞、Hp产生水平。检测不同浓度Hp生长曲线及生成情况。结果IL-1β以剂量依赖性增加GES-1细胞DNA合成及细胞数量。IL-1β增加GES-1细胞产生。GES-1细胞能够自身产生。Hp生长情况与接种的菌量有关,Hp能够自身产生大量,其耐受的浓度明显高于胃黏膜细胞。结论IL-1β在调节GES-1细胞增殖中有重要作用。IL-1β涉及Hp感染胃黏膜细胞的高增殖反应和胃癌的致癌过程。IL-1β促生成的作用可能在胃相关疾病的防治中具有一定的意义。

关键词：幽门螺杆菌白细胞介素-1β 人胃粘膜上皮细胞超氧自由基阴离子

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Neuroprotective effects of prostaglandin A1 and its inhibitory effect on NF-κB signaling pathway in rat models of permanent focal cerebral ischemia

Neuroprotective effects of prostaglandin A1 and its inhibito...

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中国神经科学学会第六届学术会议暨学会成立十周年庆祝大会

作者： Zhang Hui-ling, Gu Zhen-lun , Qin Zheng-hong department of Pharmacology, soochow university School of Medicine, suzhou 215007

Objective: Prostaglandin A1 (PGA1) is a cyclopentenone prostaglandin. Recently, we reported that PGA1 can inhibit excitotoxin-induced apoptosis of striatal neurons in vivo and rotenone-induced apoptosis of cultured SH-SY5Y cells, suggesting that PGA1 may have neuroprotective efficacy, possibly mediated by inhibition of NF-κB activation. The present study evaluated the neuroprotective potential of PGA1 and its effect on NF-κB signaling pathway in rat models of permanent focal cerebral ischemia. Methodes: Permanent middle cerebral artery occlusion (pMCAO) model was constructed by intraluminal

关键词： prostaglandin Al cerebral ischemia NF-κB

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LyGDI对肺癌A549细胞放射敏感性影响的观察

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中华肿瘤防治杂志 2012年第2期19卷 84-87页

作者：董玉金吴纪霞周新文淄博市中心医院肿瘤科山东淄博255000 苏州大学医学部放射医学与公共卫生学院放射毒理教研室江苏苏州215123 蚌埠市第一人民医院肿瘤科安徽蚌埠233000

目的:研究X射线对稳定转染鸟苷解离抑制因子(LyGDI)A549细胞株放射敏感性的影响及相关机制。方法:应用生长曲线观察细胞增殖能力,流式细胞术检测不同剂量照射后转染组和对照组细胞的周期分布及凋亡率,克隆形成试验观察转染组细胞放射敏... 详细信息

目的:研究X射线对稳定转染鸟苷解离抑制因子(LyGDI)A549细胞株放射敏感性的影响及相关机制。方法:应用生长曲线观察细胞增殖能力,流式细胞术检测不同剂量照射后转染组和对照组细胞的周期分布及凋亡率,克隆形成试验观察转染组细胞放射敏感性。结果:转染组细胞相对于对照组增殖能力减弱,F=212.55,P<0.01;克隆形成能力减弱,放射敏感性增加,F=7.56,P<0.05;流式细胞术检测到辐射诱导凋亡增加,F=18.45,P<0.01;细胞周期检测提示转染组G2期阻滞受抑制,F=6.29,P<0.05。结论:过度表达的LyGDI上调A549细胞放射敏感性,其可能机制为抑制G2期阻滞促进凋亡。

关键词：肺肿瘤/放射疗法细胞周期辐射耐受性

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The role of CXCR4/CXCL12 in primary central nervous system lymphomas and their clinical significance

The role of CXCR4/CXCL12 in primary central nervous system l...

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中国抗癌协会神经肿瘤专业委员会第八届学术会议

作者： Weiguo Tan,Ming Feng,Tingfeng Wu,Chunming Sun,Zhong Shao,Youxin Z hou*,Ziwei Du department of Neurosurgery & Brain and Nerve Reseach Laboratory,The first affiliated hospital of soochow university,suzhou 215006,china

Objective To elucidate the relationship of the expression of chemokine receptor CXCR4 and chemokine CXCL12 in 5 cases of primary central nervous system lymphomas and their clinical *** The expression of chemokine receptor and its ligand in 5 cases of PCNSL and 10 normal brain tissues were investigated using immunohistochemical and reverse transcription polymerase chain reaction（RT-PCR） ***:***:Of the 5 PCNSLs,all specimens（100%） were positive for CXCR4 and *** the 10 normal brain tissues,all specimens（100%） were positive for CXCL12,and none was positive for ***-PCR:Of the PCNSLs,all specimens expressed the RNA of CXCR4 and *** specimens of normal brain tissue was only expressed the RNA of ***:Chemokine receptor CXCR4 and chemokine CXCL12 play important roles in the pathogenesis of primary central nervous system lymphoma.

关键词： PCNSL Immunohistochemistry CXCR4 CXCL12 RT-PCR

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