PTTG和PCNA蛋白在神经胶瘤中的表达及其意义(英文)

作     者：Rufei Dai,Shiming Zhang Department of Neurosurgery,The First Affiliated Hospital of Suzhou University,Suzhou 215128,China 

作者机构：Department of Neurosurgery The First Affiliated Hospital of Suzhou University Suzhou China 

出 版 物：《Oncology and Translational Medicine》 (肿瘤学与转化医学(英文))

年 卷 期：2009年第8卷第2期

页      面：110-113页

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：Supported by a grant from the Natural Science Foundation of College and University of Jiangsu Province(No.05KJD320238) 

主　　题：pituitary tumor transforming gene(PTTG) proliferating cell nuclear antigen(PCNA) glioma immunohistochemistry 

摘      要：Objective:To investigate the expressions and their relationship of pituitary tumor transforming gene(PTTG)and proliferating cell nuclear antigen(PCNA)in ***:The protein expressions of PTTG and PCNA were detected by immunostaining assay using streptavidin-peroxidase(SP)method in 80 cases of ***:The positive rates of PTTG in grades I-IV gliomas were 56.3%,68.2%,80.8%,and 100.0% respectively,and the protein expression of PTTG increased with the increasing of the pathological grade(χ2 = 9.602,P 0.05);The positive rates of PCNA protein were 37.5%,54.5%,69.2%,and 93.8% respectively,and the protein expression of PCNA increased with the increasing of the pathological grade(χ2 = 12.147,P 0.01).The expression of PTTG had positive correlation with the expression of PCNA protein(γs = 0.557,P 0.01).Conclusion:The expressions of PTTG and PCNA proteins were related to malignant degree of glioma,and may cooperate with each other in the tumorigenesis and progression and can be considered as the indicators of the biological behaviors in glioma.