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3D-assembled microneedle ion sensor-based wearable system for the transdermal monitoring of physiological ion fluctuations

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Microsystems & Nanoengineering 2023年第2期9卷 127-142页

作者： xinshuo Huang Shantao Zheng Baoming Liang Mengyi He Feifei Wu Jingbo Yang Hui-jiuan Chen xi xie State key laboratory of Optoelectronic Materials and Technologies School of Electronics and Information TechnologyGuangdong Province Key Laboratory of Display Material and TechnologySun Yat-Sen UniversityGuangzhouChina Pazhou Lab 510330 GuangzhouChina School of Biomedical Engineering Sun Yat-Sen UniversityGuangzhouChina

Monitoring human health is of considerable significance in *** particular,the ion concentrations in blood are important reference indicators related to many *** array-based sensors have enabled promising breakthroughs in continuous health monitoring due to their minimally invasive *** this study,we developed a microneedle sensing-array integrated system to continuously detect subcutaneous ions to monitor human health status in real time based on a fabrication strategy for assembling planar microneedle sheets to form 3D microneedle *** limitations of preparing 3D microneedle structures with multiple electrode channels were addressed by assembling planar microneedle sheets fabricated via laser micromachining;the challenges of modifying closely spaced microneedle tips into different functionalized types of electrodes were *** microneedle sensing system was sufficiently sensitive for detecting real-time changes in Ca^(2.),K^(+),and Na^(+) concentrations,and it exhibited good detection *** in vivo results showed that the ion-sensing microneedle array successfully monitored the fluctuations in Ca^(2.),k^(+),and Na^(+) in the interstitial fluids of rats in real *** using an integrated circuit design,we constructed the proposed microneedle sensor into a wearable integrated monitoring *** integrated system could potentially provide information feedback for diseases related to physiological ion changes.

关键词： needle system breakthrough

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Lack of Association Between DNMT3B Polymorphisms and Sporadic Parkinson's Disease in a Han Chinese Population

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Neuroscience Bulletin 2018年第5期34卷 867-869页

作者： Hong Pan Jun-Yi Shen Juan-Juan Du Shi-Shuang Cui Jin Liu Yi-Qi Lin Yi-xi He Yang Fu Chao Gao Gen Li Sheng-Di Chen Jian-Fang Ma laboratory of Neurodegenerative Diseases Institute of Health Sciences Shanghai Institutes for Biological SciencesChinese Academy of Sciences University of Chinese Academy of Sciences Department of Neurology and Collaborative Innovation Center for Brain Science Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine

Recently, several single nucleotide polymorphisms （SNPs; rs34094401 on RAD51B, rs41309351 on CPXM1, rs143555311 on MPHOSPHIO, rs14162.2.0 on SER- PINA1, and rs2.2.913 on DNMT3B） have been associated with Parkinson＇s disease （PD） in Caucasians [1-3]. Con- sidering the genetic variance among different ethnic populations, it is essential to know whether these candidate SNPs are also associated with PD in other ethnic cohorts. Therefore, we investigated these newly-reported risk SNPs in 2.9 PD patients and 2.9 controls to test their association with PD.

关键词： ALPHA-SYNUCLEIN METHYLATION DNA

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Longitudinal transcriptome analyses show robust T cellimmunity during recovery from COVID-19

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Signal Transduction and Targeted Therapy 2021年第1期6卷 105-116页

作者： Hong-Yi Zheng Min Xu Cui-xian Yang Ren-Rong Tian Mi Zhang Jian-Jian Li xi-Cheng Wang Zhao-Li Ding Gui-Mei Li xiao-Lu Li Yu-Qi He xing-Qi Dong Yong-Gang Yao Yong-Tang Zheng key laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences and Yunnan Province KIZ-CUHK Joint Laboratory of Bioresources and Molecular Research in Common DiseasesCenter for Biosafety Mega-ScienceKunming Institute of ZoologyChinese Academy of SciencesKunmingYunnan 650223China Yunnan Infectious Disease Hospital Kunming 650301China Kunming Biological Diversity Regional Center of Large Apparatus and Equipments Public Technical Service CenterChinese Academy of SciencesKunmingYunnan 650223China Kunming College of Life Science University of Chinese Academy of SciencesKunmingYunnan 650204China CAS Center for Excellence in Brain Science and Intelligence technology Chinese Academy of SciencesShanghai 200031China

Understanding the processes of immune regulation in patients infected with the severe acute respiratory syndrome coronavirus 2.SARS-CoV-2.is crucial for improving ***,we performed longitudinal whole-transcriptome RNA sequencing on peripheral blood mononuclear cell(PBMC)samples from 18 patients with coronavirus disease 2.19(COVID-19)during their treatment,convalescence,and *** analyzing the regulatory networks of differentially expressed messenger RNAs(mRNAs),microRNAs(miRNAs)and long non-coding RNAs(lncRNAs)between the different clinical stages,we found that humoral immunity and type I interferon response were significantly downregulated,while robust T-cell activation and differentiation at the whole transcriptome level constituted the main events that occurred during recovery from *** formation of this T cell immune response might be driven by the activation of activating protein-1(AP-1)related signaling pathway and was weakly affected by other clinical *** findings uncovered the dynamic pattern of immune responses and indicated the key role of T cell immunity in the creation of immune protection against this disease.

关键词： immunity transcriptome interferon

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中国肾脏移植组织配型技术临床应用指南

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中华医学杂志 2024年第27期104卷 2483-2501页

作者：中华医学会器官移植学分会中国医疗保健国际交流促进会肾脏移植分会中国医药生物技术协会移植技术分会薛武军郑瑾张雷何军蔡俊超刘龙山不详西安交通大学第一附属医院肾病医院肾移植科西安交通大学器官移植研究所西安710061 西安交通大学第一附属医院肾病医院肾移植科海军军医大学附属长海医院器官移植科苏州大学附属第一医院江苏省血液研究所苏州才博医学研究所中山大学附属第一医院器官移植科

组织配型是影响肾脏移植成功和移植物长期存活的关键因素之一。目前我国各移植中心实验室组织配型技术及应用情况发展不一。为了推动肾脏移植组织配型临床诊疗的标准化,由中华医学会器官移植学分会、中国医疗保健国际交流促进会肾脏移... 详细信息

组织配型是影响肾脏移植成功和移植物长期存活的关键因素之一。目前我国各移植中心实验室组织配型技术及应用情况发展不一。为了推动肾脏移植组织配型临床诊疗的标准化,由中华医学会器官移植学分会、中国医疗保健国际交流促进会肾脏移植分会、中国医药生物技术协会移植技术分会联合发起制订了《中国肾脏移植组织配型技术临床应用指南》。本指南使用2.09版牛津大学循证医学中心的证据分级与推荐强度标准对每个临床问题的证据质量和推荐强度进行分级。针对肾脏移植组织配型相关的实验室检测技术和临床应用的15个临床问题,提出了符合我国临床诊疗实践的2.条推荐意见,旨在肾脏移植术前推广组织配型,提高受者和移植肾脏长期存活时间,发挥精准医学在肾脏移植领域应用价值。

关键词：肾移植组织配型指南

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Increased prognostic value of clinical–reproductive model in Chinese female patients with esophageal squamous cell carcinoma

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World Journal of Gastroenterology 2022年第13期28卷 1347-1361页

作者： Dong-Yun Zhang Jian-Wei Ku Xue-Ke Zhao Hai-Yan Zhang xin Song Hong-Fang Wu Zong-Min Fan Rui-Hua Xu Duo You Ran Wang Ruo-xi Zhou Li-Dong Wang State key laboratory of Esophageal Cancer Prevention&Treatment and Henan key laboratory for Esophageal Cancer Research of the First Affiliated Hospital Zhengzhou UniversityZhengzhou 450052Henan ProvinceChina Department of Pathology Nanyang Medical CollegeNanyang 473061Henan ProvinceChina Department of Endoscopy The Third Affiliated HospitalNanyang Medical CollegeNanyang 473061Henan ProvinceChina Department of Pathology The First Affiliated HospitalNanyang Medical CollegeNanyang 473061Henan ProvinceChina Department of Medical Oncology Affiliated Cancer Hospital of Zhengzhou UniversityHenan Cancer HospitalZhengzhou 450052Henan ProvinceChina Department of Biology University of RichmondRichmondVA 23173United States

BACKGROUND In china,it has been well recognized that some female patients with esophageal squamous cell carcinoma(ESCC)have different overall survival(OS)time,even with the same tumor-node-metastasis(TNM)stage,challenging the prognostic value of the TNM system *** effective predictive model is needed to accurately evaluate the prognosis of female ESCC *** To construct a novel prognostic model with clinical and reproductive data for Chinese female patients with ESCC,and to assess the incremental prognostic value of the full model compared with the clinical model and TNM *** A new prognostic nomogram incorporating clinical and reproductive features was constructed based on univariatie and Cox proportional hazards survival analysis from a training cohort(n=175).The results were recognized using the internal(n=111)and independent external(n=85)validation *** capability of the clinical–reproductive model was evaluated by Harrell’s concordance index(C-index),Kaplan–Meier curve,time-dependent receiver operating characteristic(ROC),calibration curve and decision curve *** correlations between estrogen response and immune-related pathways and some gene markers of immune cells were analyzed using the TIMER 2.0 *** A clinical–reproductive model including incidence area,age,tumor differentiation,lymph node metastasis(N)stage,estrogen receptor alpha(ESR1)and beta(ESR2.expression,menopausal age,and pregnancy number was constructed to predict OS in female ESCC *** to the clinical model and TNM stage,the time-dependent ROC and C-index of the clinical–reproductive model showed a good discriminative ability for predicting 1-,3-,and 5-years OS in the primary training,internal and external validation *** on the optimal cut-off value of total prognostic scores,patients were classified into high-and low-risk groups with significantly different *** estrogen response was significantly associated with p53 and apop

关键词： Esophageal squamous cell carcinoma Female Nomogram Prognosis Estrogen receptor

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Central nervous system relapse in a pediatric anaplastic large cell lymphoma patient with CLTC/ALK translocation treated with alectinib: A case report

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World Journal of Clinical Cases 2020年第9期8卷 1685-1692页

作者： Jing Yang Jun Li Wei-Yue Gu Ling Jin Yan-Long Duan Shuang Huang Meng Zhang xi-Si Wang Yi Liu Chun-Ju Zhou Chao Gao Hu-Yong Zheng Yong-Hong Zhang Beijing key laboratory of Pediatric Hematology Oncology National Discipline of PediatricsMinistry of EducationMOE Key Laboratory of Major Diseases in Children/Hematology Oncology CenterBeijing Children's HospitalCapital Medical UniversityNational Center for Children’s HealthBeijing 100045China Chigene(Beijing)Translational Medical Research Center Co. Ltd.Beijing 101111China

BACKGROUND The aberrant expression of the anaplastic lymphoma kinase(ALK)gene in ALKpositive(ALK+)anaplastic large cell lymphoma(ALCL)is usually due to t(2.5)/***,rarely,aberrant ALK expression can also result from a rearrangement of the ALK gene with various partner *** nervous system(CNS)metastasis is very rare in ALK+*** with CNS involvement show an inferior *** SUMMARY Here,we present the case of an 8-year-old girl diagnosed with ALK+*** presented with fever,skin nodules,leg swelling,and abdominal pain over the preceding 6 *** had extensive involvement and showed an extraordinary rare translocation,t(2.17)/CLTC-ALK,as demonstrated by *** underwent chemotherapy as per ALCL99,followed by vinblastine(VBL)maintenance treatment,and achieved complete ***,she developed CNS relapse during VBL *** patient achieved a durable second remission with high-dose chemotherapy(including methotrexate 8 g/m2.and continuous treatment with alectinib and *** Alectinib showed significant and durable CNS effects in this ***,more cases are needed to prove the efficacy and safety of alectinib for pediatric ALK+ALCL patients.

关键词： Anaplastic Lymphoma Pediatric CLTC/ALK Central nervous system Alectinib Case report

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微型超高速旋转盘腔流动与换热规律研究

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推进技术 2023年第9期44卷 138-148页

作者：赵熙刘剑宇全永凯中国航发贵阳发动机设计研究所贵州贵阳550081 北京航空航天大学航空发动机研究院航空发动机气动热力国防科技重点实验室北京102206 北京航空航天大学杭州创新研究院(余杭) 浙江杭州310023

通过数值模拟方法研究了带周向环罩的微型超高速旋转盘腔的流动与换热规律,盘腔的半径为4mm,转速为2.10^(5)~1×10^(6)r/min。结果表明:超强离心力及其衍生浮升力并没有给微型旋转盘腔带来与常规盘腔不同的流动结构,但是超强离心力及... 详细信息

通过数值模拟方法研究了带周向环罩的微型超高速旋转盘腔的流动与换热规律,盘腔的半径为4mm,转速为2.10^(5)~1×10^(6)r/min。结果表明:超强离心力及其衍生浮升力并没有给微型旋转盘腔带来与常规盘腔不同的流动结构,但是超强离心力及其衍生浮升力引起的粘性耗散效应导致旋转盘高半径处发生换热恶化现象,周向环罩的存在则进一步加剧了该现象。在高旋转雷诺数和低转盘过余温度工况下,强离心力及其衍生浮升力引起的粘性耗散效应更加显著,而周向环罩的影响相对弱化。

关键词：微型旋转盘腔流动与换热离心力离心浮升力粘性耗散换热恶化

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Lithium chloride ameliorates learning and memory ability and inhibits glycogen synthase kinase-3 beta activity in a mouse model of fragile X syndrome

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Neural Regeneration Research 2011年第31期6卷 2452-2459页

作者： Shengqiang Chen Xuegang Luo Quan Yang Weiwen Sun Kaiyi Cao xi Chen Yueling Huang Lijun Dai Yonghong Yi Department of Human Anatomy and Neurobiology College of Basic Medicine Central South University Changsha 410013 Hunan Province China key laboratory of Neurogenetics and Channelopathies of Guangdong Province the Ministry of Education Institute of Neuroscience Second Affiliated Hospital of Guangzhou Medical College Guangzhou 510260 Guangdong Province China laboratory Animal Research Center of Guangzhou Medical College Guangzhou 510182 Guangdong Province China

In the present study,Fmr1 knockout mice （KO mice） were used as the model for fragile X *** results of step-through and step-down tests demonstrated that Fmr1 KO mice had shorter latencies and more error counts,indicating a learning and memory *** treatment with 30,60,90,12.,or 2.0 mg/kg lithium chloride,the learning and memory abilities of the Fmr1 KO mice were significantly ameliorated,in particular,the 2.0 mg/kg lithium chloride treatment had the most significant *** blot analysis showed that lithium chloride significantly enhanced the expression of phosphorylated glycogen synthase kinase 3 beta,an inactive form of glycogen synthase kinase 3 beta,in the cerebral cortex and hippocampus of the Fmr1 KO *** results indicated that lithium chloride improved learning and memory in the Fmr1 KO mice,possibly by inhibiting glycogen synthase kinase 3 beta activity.

关键词： fragile X syndrome Fmr1 knockout mice step-down test step-through test learning and memory glycogen synthase kinase 3 beta lithium chloride

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基于混沌优化K均值算法的马铃薯芽眼的快速分割（英文）

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农业工程学报 2019年第5期35卷 190-196页

作者：席芮侯加林李立成山东农业大学机械与电子工程学院泰安271018 泰山职业技术学院机电技术工程系泰安271000

为提高芽眼分割的准确性,该文实现了基于混沌优化K均值算法的马铃薯芽眼的快速分割。K均值算法具有有效性及易于实现的优点,但是容易陷入局部最优值的缺点造成了其聚类结果的不准确。混沌系统由于其遍历性和不重复性,能够以较快的速度... 详细信息

为提高芽眼分割的准确性,该文实现了基于混沌优化K均值算法的马铃薯芽眼的快速分割。K均值算法具有有效性及易于实现的优点,但是容易陷入局部最优值的缺点造成了其聚类结果的不准确。混沌系统由于其遍历性和不重复性,能够以较快的速度执行全局搜索。该文提出的算法的主要思想就是将混沌变量映射到K均值算法的变量中,用混沌变量代替其寻找全局最优值。分割试验结果表明:该文提出的算法,不仅在分割准确性上优于当下流行的K均值算法和模糊C均值算法,而且在运行时间上也更胜一筹,K均值算法和模糊C均值算法分割一幅马铃薯芽眼的图像所需的平均时间分别为2.895 5 s和3.556 4 s,而该文提出的算法仅需1.109 s。当聚类数大于3时,该文提出的算法在运行时间上受聚类数目的影响非常小,这一特点可用于其他一些适合聚类数大于3的农作物上。试验结果还表明,对于该文中的样本,最佳聚类数不宜超过3。最后,精度试验验证了该文提出的算法能够对样本中的马铃薯芽眼实现完全,无遗漏的分割,总的分割精度为98.87%,其中,对正常的马铃薯芽眼分割精度可达100%,对特殊马铃薯的芽眼分割精度为91.67%,总体分割精度较好。因此,该文提出的算法能够为后续种薯的自动切块提供参考。

关键词：图像处理图像分割算法快速分割马铃薯芽眼 K均值混沌优化算法遍历性

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3,4-Secocycloartane Triterpenoids from the Cones of Pseudolarix amabilis

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Natural Products and Bioprospecting 2021年第1期11卷 119-126页

作者： Si-Jia xiao Bo Li Zheng-Rui Huang Wen-Lin Yuan Ji Ye Hui-Liang Li xi-Ke Xu Yun-Heng Shen Wei-Dong Zhang Department of Phytochemistry School of PharmacyNaval Medical University(Second Military Medical University)Shanghai 200433China State key laboratory of New Drug and Pharmaceutical Process Shanghai Institute of Pharmaceutical IndustryChina State Institute of Pharmaceutical IndustryShanghai 201203China Department of Applied Chemistry Xi’an University of TechnologyXi’an 710048China

Four new 3,4-secocycloartane triterpenoids,pseudolactones A-D(1-4),were isolated from the ethanol extract of the cones of Pseudol *** structures were established by extensive 1D-and 2.-NMR *** cones of *** are enriched in the ring-expanded or cleaved cycloartane *** work provides new insight into cycloartane triterpenoids from the cones of ***.

关键词： Pseudol arixamabilis Triterpenoids 3,4-Secocycloartane Pseudolactones A-D

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