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Differential levels of cytokines and soluble FasL between tuberculous and malignant effusions

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Differential levels of cytokines and soluble FasL between tu...

中华医学会结核病学分会2.10年学术年会

作者： HaiYan Cui,Qing Zang,Bo Su,Wei Li,ShenJie Tang~* department of TB,shanghai Pulmonary {2.,{3. university School of Medicine,shanghai,2.043., china

Tuberculosis(TB) remains the major infectious cause of death *** pleurisy(TBP) is a common manifestation of extra-pulmonary TB,still difficult to *** is regarded as a positive response to Mtb infection,characterized by an extensive inflammatory exudate in the pleural *** effort has been devoted to clarify the immunity mechanism of TB and identification of immunologically important factors in TBP. This study compared the differences of 3.cytokines(IFN-γ,IL-2.IL-4) and soluble Fas ligand(sFasL) both in serum and pleural effusion between TBP and MP,using an enzyme-linked immunosorbent assay(ELISA).In addition,we also evaluated the relationship between sFasL and *** and pleural effusion samples were collected from 3. patients with tuberculous pleurisy,3. patients with malignant pleurisy caused by lung cancer and 3. healthy *** data showed in both groups,the levels of cytokines and sFasL were significantly higher in pleural effusion than in serum;the levels of IFN-γboth in serum and pleural effusion was significantly higher in TBP than MP;the levels of sFasL were significantly higher in TBP than MP;pleural sFasL concentrations correlated with IFN-γin TBP patients,R=0.588,P<*** summary,we show that serum and pleural effusion levels of cytokines and sFasL differ in TBP and MP *** this study is limited by the small number of patients investigated,our findings might advance our understanding of the immune mechanism of tuberculosis.

关键词： tuberculosis pleurisy cytokine sFasL apoptosis

Ultrasonographic characteristics of thyroid carcinoma and analysis of the misdiagnosis and omission cases

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Ultrasonographic characteristics of thyroid carcinoma and an...

第二届长三角超声医学论坛暨2.09年浙江省超声医学学术年会

作者： department of Ultrasound,Tumor hospital of Fudan {2.,{3. 2.003.2}china Fen WANG

Objective Ultrasonography is an irreplaceable imaging modality for thyroid *** the resolution higher and higher,ultrasound can provide more information benefiting for diagnosis,meanwhile the diversity of ultrasonograp...

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消化性溃疡与血浆神经降压素的关系

现代医学 2003年第4期31卷 227-228页

作者：张东伟邹颂海同济大学附属同济医院消化内科上海200065 同济大学附属同济医院放射免疫室上海200065

目的　探讨消化性溃疡 (pepticulcer ,PU)、幽门螺旋杆菌 (helicobacterpylori ,Hp)与血浆神经降压素 (neu rotensin ,NT)的关系。方法　采用放射免疫分析法测定 3.5例正常对照、3.0例胃溃疡患者和 3.2.十二指肠球部溃疡患者的血浆NT... 详细信息

目的　探讨消化性溃疡 (pepticulcer ,PU)、幽门螺旋杆菌 (helicobacterpylori ,Hp)与血浆神经降压素 (neu rotensin ,NT)的关系。方法　采用放射免疫分析法测定 3.5例正常对照、3.0例胃溃疡患者和 3.2.十二指肠球部溃疡患者的血浆NT值 ,并对结果进行比较分析。结果　胃溃疡和十二指肠球部溃疡组的NT值低于正常对照组 ,差异均有显著性 (均P 0 0 5 ) ;消化性溃疡Hp(+ )组血浆NT值虽比消化性溃疡Hp(-)组血浆NT值高 ,但两组差异无显著性 (P >0 0 5 )。结论　消化性溃疡与血浆NT有关系。

关键词：消化性溃疡神经降压素幽门螺旋杆菌放射免疫分析法

^(99m)Tc-YIGSR as a Receptor Tracer in imaging the Ehrlich Ascites Tumor-bearing Mice as Compared with ^(99m)Tc-MIBI

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Journal of Huazhong university of Science and Technology(Medical Sciences) 2007年第4期27卷 471-474页

作者：胡佳秦光明张永学安锐兰小莉 department of Nuclear Medicine Union Hospital Tongji Medical College Huazhong University of Science and Technology department of Nuclear Medicine Shenzhen Second People's Hospital

The validity of ^99mTc-YIGSR, a novel receptor radio-tracer, in imaging the Ehrlich ascites tumor was evaluated. YIGSR, a pentapeptide of laminin, was labeled with ^99mTc by using a bifunctional chelator S-Acetly-NH3.MAG3. The MIBI was labeled with ^99mTc by following the kit instruction. The mice of tumor group were intravenously injected 1-2.mCi of ^99mTc-YIGSR or ^99mTc-MIBI via caudal vein, immobilized and imaged under a Gamma camera. The same procedure was performed in mice of blockade group, in which the unlabeled YIGSR was previously injected to block the receptor-recognition sites, and inflammation group serving as control. The reverse-phase Sep-Pak C18 chromatogram was found to have an essentially complete conjugation between YIGSR and S-Acetly-NH3.MAG3. The conjugated YIGSR could be radio-labeled successfully with ^99mTC at room temperature and neutral pH, with a radio-labeling yield of 62.. Without the chelator S-Acetly-NH3.MAG3. the YIGSR was labeled with ^99mTc at an efficiency of 4%. The imagological study revealed obvious tumor accumulation of ^99mTc-YIGSR 15 min after the injection, and the uptake peaked after 3.h with a tumor-to-muscle ratio （T/M） of 11.3.. The radio-tracer was slowly cleared up and resulted in a T/M of 3.01 at the 8th h after the injection. As for blocked group, the tumor uptake of radiotracer was significantly lower, with the highest T/M being 4.61 after 3.h and 0.89 after 8 h. The T/M was 3.72.at the 3.d h and 1.2. at the 8th h after the ^99mTc-YIGSR injection in the inflammatory group. The T/M was significantly higher in tumor group than in inflammatory group or control group （P〈0.001）. In the ^99mTc-MIBI group, the T/M was 1.40 at the 3.d h and 0.55 at the 8th h after the injection, which showed a significant difference as compared with ^99mTc-YIGSR （P〈0.001）. It is concluded that YIGSR can be successfully radiolabelled by using S-Acetly-NH3.MAG3. ^99mTc-YIGSR has many advantages in tumor imaging, such as quick and clear visual

关键词： laminin-YIGSR tumor receptor imaging radio-labeling ^99mTC S-Acetly-NH3.MAG3

Quality and Internal Characteristics of Huanghua Pears (Pyrus Pyrifolia Nakai,***) Treated with Different Kinds of Coatings during Long-Term Storage

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Quality and Internal Characteristics of Huanghua Pears (Pyru...

中国园艺学会第八届青年学术讨论会暨现代园艺论坛

作者： Ran Zhou~1 Yun Mo~2.Yunfei Li~(2.) Yanyun Zhao~3.Guixiang Zhang~4 Yunsheng Hu~4 (1 Institute of Refrigeration & Cryogenic Engineering,shanghai Jiao Tong {3.,shanghai,china 2.department of Food Science & Technology,School of Agriculture and Biology,shanghai Jiao Tong {3.,shanghai,china 3.department of Food Science & Technology,Oregon State {3.,Corvallis,USA 4 department of Radiology,shanghai Jiao Tong {3. Affiliated First People’s hospital,shanghai,china)

We studied the quality of and internal changes in Huanghua pears (Pyrus pyrifolia Nakai,***) coated with shellac,SemperfreshTM (sucrose polyester base coating),and carboxymethyl chitosan (CMC) during cold storage (4℃). The changes in respiration rate,weight loss,cell membrane permeability and texture profile analysis (TPA) such as hardness, brittleness and chewiness were recorded periodically for up to 60 days after harvest to compare the effects of the applied coatings. Magnetic resonance imaging was used to inspect the internal characteristics of pears after *** soluble solid contents (SSCs),titratahle acidity,ascorbic acid concentration,and taste scores were also *** data suggested that shellac coating was more effective in reducing the respiration rate and weight loss and in maintaining the quality of pears than Semperfresh and CMC coatings.

关键词： Huanghua pears Coatings Cold storage Quality TPA Magnetic resonance imaging

Effects of Intrinsic Nitric Oxide on the Expression of Interleukin-4 and IFN-γ mRNA in the Bronchial and Lung Tissues of Sensitized Rats

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Journal of Huazhong university of Science and Technology(Medical Sciences) 2000年第1期20卷 29-31页

作者：薛建敏徐永健张珍祥 department of Respiratory Medicine Tongji Hospital Tongji Medical University Wuhan

Summary: To investigate the effects of intrinsic nitric oxide (NO) on the expression of interleukin-4 (IL-4) mRNA and interferon-γ (IFN-γ) mRNA in the airway inflammation of asthma, the rat models of asthmatic inflammation were established by sensitizing and then challenging the animals with ovalbumin. The 2. animals were randomly divided into control group, sensitized group, sensitized and L-Arg-treated group as well as L-NAME-treated group equally. By using in situ hybridization combined with compute physiological quantitative imaging analysis techniques, the influence of intrinsic NO on the expression of IL-4 mRNA and IFN-Y mRNA in the airway inflammatory cells was observed. In situ hybridization study demonstrated that IL-4 mRNA expres- sion was obviously increased as compared with that in the control group, mainly distributed in the inflammatory cells in the submucous of airways in the sensitized group. The increase of intensity of IL-4 mRNA expression was positively correlated with the numbers of eosinophil (Eos) and lymphocyte (both with Pimaging analysis showed that L- NAME could inhibit the expression of IL-4 mRNA (P2.lymphocytes and the expression of IFN-γ mRNA of Th1 lymphocytes and in turn, promote the development of asthmatic airway inflammation.

关键词： asthma nitric oxide interleukin-4 interferon-γ in situ hybridization

中国人群腔内置管溶栓治疗深静脉血栓疗效与安全性的Meta分析

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华中科技大学学报（医学版） 2011年第5期40卷 614-617,622页

作者：李毅清张强周斌梅菲金毕华中科技大学同济医学院附属协和医院血管外科武汉430022 同济大学附属东方医院血管外科上海200120

目的比较腔内置管溶栓(ICDT)和选择性外周静脉溶栓(SPVT)治疗下肢深静脉血栓的优劣。方法通过检索中国学术期刊全文数据库、维普、万方以及EBASE和Pubmed等多个数据库近年的相关文献,运用Meta分析,评价ICDT和SPVT的疗效与安全性。结果... 详细信息

目的比较腔内置管溶栓(ICDT)和选择性外周静脉溶栓(SPVT)治疗下肢深静脉血栓的优劣。方法通过检索中国学术期刊全文数据库、维普、万方以及EBASE和Pubmed等多个数据库近年的相关文献,运用Meta分析,评价ICDT和SPVT的疗效与安全性。结果筛选后获得文献6篇(n=701,2.07～2.10年),其中未见死亡和严重肺栓塞病例报道。ICDT在疗效上相对于SPVT没有显著优势,但其起效时间和早期溶栓的成功率高于SPVT。结论在具备医疗条件的情况下,ICDT是相对有效和廉价的急性深静脉血栓治疗方案。

关键词：深静脉血栓腔内置管溶栓选择性外周静脉溶栓 Meta分析

Assessing coronary atherosclerotic plaque with intravascular ultrasoundvirtual histology in patients with acute coronary syndrome

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Assessing coronary atherosclerotic plaque with intravascular...

第二届长三角超声医学论坛暨2.09年浙江省超声医学学术年会

作者： department of Ultrasound,East hospital Affiliated to {2. {3.,shanghai 2.012.,china Can JIN Xing-ming LI Xu-hua JIANG Ming CHEN

Objective Coronary atherosclerotic plaque was assessed with intravascular ultrasound-virtual histology (IVUS-VH) in patients with acute coronary syndrome. Methods Thirty-eight patients with acute coronary artery syndrom(ACS) underwent coronary angigraphy(CAG) were ***-one atherosclerotic plaques in coronary with≥50%stenosis were

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Application of Color Doppler Ultrasonic Examination in Deep Vein Valvular Incompetence in Lower Limbs

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Journal of Huazhong university of Science and Technology(Medical Sciences) 1997年第1期17卷 49-53页

作者：吴亚群薛新波覃修福汪元芳张青萍 department of Surgery Tongji Hospital Tongji Medical University Wuhan

By use of color Doppler Flow imaging (CDFI), the morphologic and hemodynamic parameters such as the diameters of femoral and popliteal veins,blood flow velocity and the reflux 0f valve area were examined in lower extremity deep valvular incompetence (DVI) and normal control gr0ups. The purpose was to evaluate the value of CDFI in the diagnosis of DVI. The results demonstrated that the parameters between the two groups had a very significant difference (P<0. 001), indicating that the CDFI is non-invasive, cost-effective and safe and it might serve as a practical tool in the diagnosis of lower extremity deep va1vular incompetence.

关键词： color Doppler flow imagingl diagnosis lower extremity deep valvular incompetence