Differential levels of cytokines and soluble FasL between tuberculous and malignant effusions
会议名称：《中华医学会结核病学分会2010年学术年会》
会议日期：2010年
学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 100214[医学-肿瘤学] 10[医学]
关 键 词：tuberculosis pleurisy cytokine sFasL apoptosis
摘 要：Tuberculosis(TB) remains the major infectious cause of death *** pleurisy(TBP) is a common manifestation of extra-pulmonary TB,still difficult to *** is regarded as a positive response to Mtb infection,characterized by an extensive inflammatory exudate in the pleural *** effort has been devoted to clarify the immunity mechanism of TB and identification of immunologically important factors in TBP. This study compared the differences of 3 cytokines(IFN-γ,IL-2,IL-4) and soluble Fas ligand(sFasL) both in serum and pleural effusion between TBP and MP,using an enzyme-linked immunosorbent assay(ELISA).In addition,we also evaluated the relationship between sFasL and *** and pleural effusion samples were collected from 36 patients with tuberculous pleurisy,30 patients with malignant pleurisy caused by lung cancer and 30 healthy *** data showed in both groups,the levels of cytokines and sFasL were significantly higher in pleural effusion than in serum;the levels of IFN-γboth in serum and pleural effusion was significantly higher in TBP than MP;the levels of sFasL were significantly higher in TBP than MP;pleural sFasL concentrations correlated with IFN-γin TBP patients,R=0.588,P*** summary,we show that serum and pleural effusion levels of cytokines and sFasL differ in TBP and MP *** this study is limited by the small number of patients investigated,our findings might advance our understanding of the immune mechanism of tuberculosis.