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5-Hydroxydecanoate inhibits proliferation of hypoxic human pulmonary artery smooth muscle cells by blocking mitochondrial KATP channels

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Acta Pharmacologica Sinica 2007年第10期28卷 1531-1540页

作者： Tao WANG~2.Zhen-xiang ZHANG~(2.4),Yong-jian XU~2.Qing-hua HU~3~2.Department of Respiratory Medicine,Tongji Hospital,Tongji Medical college,Huazhong university of Science and {2.,wuhan430030,china ~3 Key Laboratory of Pulmonary Diseases of the Ministry of Health of china and Department of Pathophysiology,TongjiMedical college,Huazhong university of Science and {2. wuhan 430030,china Department of Respiratory Medicine Tongji Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan China Key Laboratory of Pulmonary Diseases of the Ministry of Health of china and Department of Pathophysiology Tongji Medical College Huazhong University of Science and Technology Wuhan China

Aim:To study the effect of 5-hydroxydecanoate （5-HD） on the proliferation of 2.h hypoxic human pulmonary artery smooth muscle cells （HPASMC） and to explorethe pharmacological mechanisms of 5-HD as an inhibitor of mitochondrial mem-brane ATP-sensitive potassium channel ***:Normoxic or hy-poxic HPASMC in culture were stimulated by either diazoxide or 5-HD for 2. *** proliferation of HPASMC was examined by 3-（4,5-dimethyl-2.thiazol-yl）-2.5-diphenyl-2.-tetrazolium bromide （MTT） assay and proliferating cell nuclear anti-gen （PCNA） immunohistochemistry *** apoptosis of HPASMC wasassessed by terminal deoxynucleotidyl transferase-mediated dUTP nick end la-beling （TUNEL） assayand flow cytometric *** relative changes inmitochondrial membrane potential （ΔΨm） were measured using the rhodamine fluo-rescence （R-12.） ***:Both hypoxia and diazoxide stimulationincreased ΔΨmvalue measured by the absorbance of MTT,PCNA-positive stain-ing and decreased TUNEL-positive staining and apoptotic cells in *** and the concomitant stimulation of diazoxide obviously enhanced theeffects of hypoxia or diazoxide alone.5-HD significantly attenuated the effects ineach of the above ***,5-HD partially inhibited the effect ofhypoxia on R-12. fluorescence intensity in ***:5-HD caninhibit the proliferation of hypoxic HPASMC by blocking mitochondrial KATPchannels.

关键词： pulmonary artery smooth muscle cell hypoxia 5-hydroxydecanoate mitochondrial membrane ATP-sensitive potassium channel

THE UNITED METHOD FOR THE CALCULATION OF SEEPAGE CONTROL BY ADOPTING WEIGHTING SOIL LAYER ON THE BACK SIDE OF DIKE

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Journal of Hydrodynamics 2001年第4期13卷 92-97页

作者： Liu Chuan-shun, Yang Jin-zhong college of Water Conservancy and Hydropower Engineering, wuhan {2., wuhan 430072. china wuhan Univ. Wuhan 430072 China

Constructing a weighting soil layer at the downstream toe of dike on layered ground is an effective measure to prevent the foundation from blowout failures. In this paper, a series of differential equations describing the seepage flow in layered dike foundation were established, and a united method combining analytic method with one-dimensional finite difference method was proposed for solving the equations. The case study shows that the results calculated by the united method are considerably identical to the computational results of Finite Element Method (FEM), and the united method is very simple and easy compared to the FEM.

关键词： dike weighting soil layer seepage calculation seepage control united method

Surface Nanocrystallization of Magnesium Alloy AZ91D by High-Energy Shot Peening

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Journal of wuhan university of technology(Materials Science) 2009年第4期24卷 515-519页

作者：张津 School of Materials Science & Engineering University of Science and Technology Beijing college of Materials Science & Engineering Chongqing University of Technology

High-energy shot peening （HESP）, a method to produce severe plastic deformation by high velocity flying balls, was applied on die cast magnesium alloy AZ91D. Effects of surface nanocrystallization by HESP and heat treatment at different temperatures were investigated. The mi- crostructure evolution was conducted using X-ray diffraction （XRD） and field emission scanning electronic microscopy （FESEM）. The hardness was measured by microhardness tester. The experimental results show that surface nanocrystrallization of AZ91D obtained by HESP would lead to the increase of microhardness. Low temperature heated at 100℃ for 1 h do not change the property obviously. However, both the microstructure and microhardness vary greatly after heat treatment at 400℃ for 1 h.

关键词： AZ91 D surface nanocrystallization HESP microhardnss corrosion resistance

A Nickel-Manganese-Modified Low Zinc Phosphate Solution for Cathode-Electrophoretic Painting of Steel Substrates

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材料热处理学报 2004年第5B期25卷 1159-1162页

作者： LIBao-song LINAn GANFu-xing ZHANGXu-jian collegeofResource＆EnvironmentScience WuhanUniversityWuhanChina wuhanBoxinPaintingMaterials＆InstrumentsCorporation WuhanChina

Phosphate coatings are partially dissolved in the cathodic area during the cathode-electrophoretic painting processes causing the result that the coatings adhesion, corrosion protection, alkaline resistance are decreased. Furthermore, the service life of the coated production will be shortened. The addition of Ni2., Mn2. to the phosphating bath to improve the corrosion stability, alkaline resistance, as well as the adhesion of coating layers is studied in the article. These heavy metals do not only catalyse the surface reactions but generate a more corrosion resistant surface. We perfected the trecation phosphate solution by reducing the sludge, accelerating the phosphating reactions, improving corrosion protection and alkaline resistance. More even and finer grain structures, excellent corrosion resistance were obtained compared to the traditional phosphating technique.

关键词：磷化处理电泳涂镀耐蚀性抗碱性钢

Robust H-infinity fuzzy control for uncertain Markovian jump nonlinear singular systems with wiener process

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控制理论与应用（英文版） 2010年第2期8卷 205-210页

作者： Aiqing ZHANG 1 , Huajing FANG 2.(1.college of Mathematics and Computer Science, Jianghan university, {2. Hubei 430056, china 2.Department of Control Science and Engineering, Huazhong university of Science and technology, {2. Hubei 430074, china) college of Mathematics and Computer Science Jianghan University Wuhan Hubei China Department of Control Science and Engineering Huazhong University of Science and Technology Wuhan Hubei China

This paper deals with the problems of robust stochastic stabilization and H-infinity control for Markovian jump nonlinear singular systems with Wiener process via a fuzzy-control approach. The Takagi-Sugeno (T-S) fuzzy model is employed to represent a nonlinear singular system. The purpose of the robust stochastic stabilization problem is to design a state feedback fuzzy controller such that the closed-loop fuzzy system is robustly stochastically stable for all admissible uncertainties. In the robust H-infinity control problem, in addition to the stochastic stability requirement, a prescribed performance is required to be achieved. Linear matrix inequality (LMI) sufficient conditions are developed to solve these problems, respectively. The expressions of desired state feedback fuzzy controllers are given. Finally, a numerical simulation is given to illustrate the effectiveness of the proposed method.

关键词： Fuzzy control H-infinity control Singular systems Stochastic stability Linear matrix inequality (LMI)

CD151 gene delivery increases eNOS activity and induces ECV304 migration, proliferation and tube formation

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Acta Pharmacologica Sinica 2007年第1期28卷 66-72页

作者： Zhen-zhong ZHENG Zheng-xiang LIU~2.Department of Cardiology,Tongji Hospital,Tongji Medical college,Huazhong university of Science and {2.,wuhan 430030,china Department of Cardiology Tongji Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan China

Aim:To investigate the effects of CD 151 on the activity of endothelial NO syn-thase(eNOS),and ECV304 migration,proliferation and tube ***:pAAV-CD 151 and pAAV-anti-CD 151 were constructed and used to transientlytransfect ECV304 mediated with Lipofectamine *** transfection,the ex-pression of CD 151 was measured by Western *** migration assay wasperformed using Boyden transwell;proliferation assay was evaluated using the 3-[4,5-dimethylthiazol-2.yl]-2.5,diphenyltetrazolium bromide(MTT)method,andtube formation test was examined on matrigel,eNOS activity was assayed by L-[~3H]citrulline production from L-[~3H]*** involvement of eNOS was ex-plored using an eNOS inhibitor(L-NAME)and the effects in the process ***:CD 151 promotes cell migration,proliferation and tube *** addition,CD151 increases eNOS ***,cell migration,prolifera-tion and tube formation induced by CD 151 are inhibited when L-NAME is used,which indicates that there is an involvement of eNOS in CD151-induced cellmigration,cell proliferation and tube ***:CD 151 promotesECV304 migration,proliferation and tube *** mechanism is that CD151increases eNOS *** result also suggests that eNOS is involved in theangiogenic effects of CD151.

关键词： CDI51 endothelial NO synthase(eNOS) cell migration cell proliferation tube formation

Edge Crossing Minimization Algorithm for Hierarchical Graphs Based on Genetic Algorithms

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wuhan university Journal of Natural Sciences 2001年第Z1期6卷 555-559页

作者： Shen Wei xiang, Huang Jing wei college of Computer, wuhan {2., wuhan 430072. china college of Computer Wuhan University Wuhan China

We present an edge crossing minimization algorithm for hierarchical graphs based on genetic algorithms, and comparing it with some heuristic algorithms. The proposed algorithm is more efficient and has the following advantages: the frame of the algorithms is unified, the method is simple, and its implementation and revision are easy.

关键词： hierarchical graph edge crossing genetic algorithms

New procedure for the differential display of mitochondria RNA

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Chinese Science Bulletin 1999年第16期44卷 1502-1505页

作者： LING Xingyuan, ZHOU Peijiang and ZHU Yingguo1. Institute of Genetics , college of Life Science , wuhan {2. , wuhan 430072. china 2. The Center of Biotechnology , Anhui Agriculture {2. , Hefei 2.0036, china Corresponding author Institute of Genetics College of Life Science Wuhan University Wuhan China The Center of Biotechnology Anhui Agriculture University Hefei China

A novel approach for the differential display of mitochondria RNA has been described . The total mitochondria RNAs are ligated to a single-strand linker with T4 RNA ligase and then reversely transcripted into the first strands of cDNA. The first strands of cDNA that are ligated to another single-strand linker also with T4 RNA ligase can be directly used as the tem-

关键词： rice mitochondria RNA. mRNA differential display. amplification fragment length polymorphism (AFLP ) .

A NUMERICAL MODEL OF THE WEIS-FOGH MECHANISM WITH A SEPARATION VORTEX

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Journal of Hydrodynamics 1994年第4期6卷 97-102页

作者： Zhang She-sheng Wang Xian-fu (wuhan transportation {2., wuhan 430063, P. R. china)

The influence of leading-edge separation vortias on the WEis-FOOH mechanism for insect hovering is investigsted under the flow upstream. The analysis makes use of a single-vortex model. We establish the motion equation of the vortex and the initial condition,and confirm that the opening angle 90°is a removable singular Point of the motion equation, and give its asymptotic formula. The numerical results compere reasonably well with observations on a laboratory model at high Renolds number (SPedding 1986) and numerical results show that vortex separation significantly enhances the circulation on each of the wings, the circulation is found to depend on the history of the motion and to increase with a large opening angle, and that the circulation decreases with a large velocity of the flow far upsteam. The conclusions in this paper are helpful to designing new propulsion.

关键词： WEIS-FOGH mechanism numerical model separation flow vortex.