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DRY-WET-PAINTING ANTIRUST PAINT: PERFORMANCE AND MECHANISM

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材料保护 1992年第8期 15-20页

作者： Chemistry Division, wuhan university of Water {2. Engineering, wuhan, china(430063) Xu Xiaoming, Zhang Zhen and Zhou Yufan

A dry-wet-painting antirust paint based on epoxy resin is studied for the protection of various steel structural materials in industry. From the measurements the paint is shown to be excelent adhesion, good mechanical performance, and outstanding corrosion resistance with both dry and wet painting. As a part of a systematic study of the mechanism of dry-wet-painting action we have investigated the crosslinking and morphology of dry and wet coating by FT-IR and SEM. The results indicate that water acts only as a catalyst in the crosslink process without altering the mode of erosslinking reaction, and the micrograph of structur of dry-painting coat is similar to that of wet-paintin coat. The mechanism of dry-wet-painting for the paint is proposed

关键词： PERFORMANCE AND MECHANISM DRY-WET-PAINTING ANTIRUST PAINT mode 材料保护

Role of melatonin in Alzheimer-like neurodegeneration

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Acta Pharmacologica Sinica 2006年第1期27卷 41-49页

作者： Jian-zhi WANG~(2.4) Ze-fen WANG~(2.3)2.Pathophysiology Department,Key Laboratory of Neurological Diseases of Hubei Province,Tongji Medical School,Huazhong university of Science and technology,{2. 430030,china 3 Department of Physiology,Medical college,{2. university {2. 430071,china Pathophysiology Department Key Laboratory of Neurological Diseases of Hubei Province Tongji Medical School Huazhong University of Science and Technology Wuhan China Department of Physiology Medical College Wuhan University Wuhan China

Alzheimer disease (AD),an age-related neurodegenerative disorder with progres-sive loss of memory and deterioration of comprehensive cognition,is character-ized by extracellular senile plaques of aggregated β-amyloid (Aβ),and intracellularneurofibrillary tangles that contain hyperphosphorylated tau *** showed that melatonin,an indoleamine secreted by the pineal gland,mayplay an important role in aging and AD as an antioxidant and *** decreases during aging and patients with AD have a more profoundreduction in this *** from clinical trials indicate that melatonin supple-mentation improves sleep,ameliorates sundowning,and slows down the progres-sion of cognitive impairment in Alzheimer's *** efficiently pro-tects neuronal cells from Aβ-mediated toxicity via antioxidant and anti-amyloidproperties:it not only inhibits Aβ generation,but also arrests the formation ofamyloid fibrils by a structure-dependent interaction with Aβ.Our recent studieshave demonstrated that melatonin efficiently attenuates Alzheimer-like *** the exact mechanism is still not fully understood,a direct regulatory influence of melatonin on the activities of protein kinases andprotein phosphatases is ***,melatonin also plays a role inprotecting cholinergic neurons and in ***,the neuroprotectiveeffects of melatonin and the underlying mechanisms by which it exerts its effectsare *** capacity of melatonin to prevent or ameliorate tau and Aβpathology further enhances its potential in the prevention or treatment of AD.

关键词： Alzheimer disease melatonin tau,beta amyloid

HYDRODYNAMIC MODEL OF THE WEIS-FOGH HYDROFOIL

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Journal of Hydrodynamics 1996年第4期8卷 35-39页

作者： Zhang She-sheng Wu Xiu-heng Wang Xian-fu(Department of mathematics, wuhan transportation {2., wuhan 430063, P. R. china) wuhan transportation Univ Wuhan China

The paper discusses a mathematic model of the Weis-Fogh hydrofoil under the flow upstream with a separation vortex. The analysis makes use of a single-vortex model. We establish the motion equation of the vortex and the initial condition. Applying the complex function theory, we also obtain the analytic formula of the hydrodynamic integrations'which have the complex parameter and the singularity POint. The numeric results compare well with experiment.

关键词： hydrofoil mathematic model hydrodynamic force

Refrigerant Control Strategies for Residential Air-Conditioning and Heat-Pump System

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湖南大学学报（自然科学版） 2009年第S1期36卷 91-95页

作者： SU Shun-yu,ZHANG Chun-zhi,CHEN Jian(college of Urban Construction,wuhan {2. of Science and technology,wuhan,Hubei 430070,china) college of Urban Construction Wuhan University of Science and Technology Wuhan 430070 China

This paper simulated the optimal refrigerant charge inventory of a refrigeration system in air-conditioning operation and heat-pump operation respectively,and studied the refrigerant control strategies in this *** void fraction in two-phase fluid region was calculated by Harms *** based on distributed parameter model and Harms model,the refrigerant charge inventory in condenser and evaporator were calculated and analyzed in air-conditioning conditions and heat-pump conditions,*** calculating results of different refrigerant mass between refrigeration and heating conditions indicate that the optimal refrigerant charge inventory in heat-pump conditions is lower than that in air-conditioning *** avoid the decrease of COP due to the surplus refrigerant in heating conditions,we introduced the liquid reservoir control method and associate capillary control *** of them could increase the heating capacity of the air-source heat *** difference of optimal refrigerant charge inventory in air-conditioning and heat-pump system can be controlled by the liquid reservoir or the associate capillary.

关键词： air-source heat pump control strategy distributed parameter model charge inventory

Effect of hydrogen peroxide on persistent sodium current in guinea pig ventricular myocytes

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Acta Pharmacologica Sinica 2005年第7期26卷 828-834页

作者： Ji-hua MA~2.An-tao LUO Pei-hua ZHANG Cardio-Electrophysiological Research Laboratory,Medical college,wuhan {2. of Science and technology,wuhan 430080,china Cardio-Electrophysiological Research Laboratory Medical College Wuhan University of Science and Technology Wuhan China

Aim:To study the effect of hydrogen peroxide(H2.2.on persistent sodium cur-rent(1Na.p)in guinea pig ventricular ***:The whole-cell,cell-attached,and inside-out patch-clamp techniques were applied on isolated ven-tricular myocytes from guinea ***:H2.2.0.1 mmol/L,0.5 mmol/L and 1.0mmol/L)increased the amplitude of whole-cell *** a concentration-dependentmanner,and glutathione(GSH 1 mmol/L)reversed the increased INa.p.H2.2.1mmol/L)increased persistent sodium channel activity in cell-attached and inside-out *** mean open probability was increased from control values of0.015±0.004 and 0.012.0.003 to 0.106±0.011 and 0.136e0.010,respectively(P2. and 0.02.±0.006,respectively,after the addition of 1 mmol/L GSH(P2.2..The time whenopen probability began to increase and reached a maximum was shorter in inside-out patches than that in cell-attached patches(4.8e 1.0 min vs 11.5+3.9 min,P2.2.ncreased the *** pig ventricular myocytes in a concentration-dependent manner,possiblyby directly oxidating the cell membrane.

关键词： hydrogen peroxide myocardium patch clamp techniques sodium channels

A quasi-physical algorithm for solving the linear separation problem in n-dimensional space

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Journal of Central South university of technology 2001年第4期8卷 272-277页

作者： HUANG Jia yuan (college of Computer Science, Huazhong university of Science and {2., wuhan 430074, china) college of Computer Science Huazhong University of Science and Technology Wuhan China

A quasi physical algorithm was proposed for solving the linear separation problem of point set in n dimensional *** original idea of the quasi physical algorithm is to find an equivalent physical world for the primitive mathematical problem and to observe the vivid images of the motion of matter in it so as to be inspired to obtain an algorithm for solving the mathematical problem. In this work, the electrostatics with two kinds of matter is found to be the equivalent physical world. As a result,the proposed algorithm is evidently more efficient and robust than the famous LMS algorithm and ETL algorithm. The efficiency of the quasi physical algorithm is about 10-50 times of the LMS algorithm’s for representative instances. A typical Boolean valued instance shows that it is hard for ETL algorithm but very easy for the quasi physical *** this instance, point set A and B is {000, 010, 011, 111} and {001,100}, respectively.

关键词： linear separation problem neural network algorithm quasi-physical method electrostatics

Surface Films Formed on SnO_2.Anode in Lithium Secondary Batteries by FTIR Spectroscopy

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Journal of wuhan university of technology(Materials Science) 2008年第5期23卷 662-665页

作者：黄峰 Hubei Refractories and High-temperature Ceramics Key Laboratory Wuhan University of Science and Technology

The chemical composition of the passivating layer formed on nano SnO2.anodes in 1 M LiClO4＋（ethylene carbonate）EC ＋（dimethyl carbonate）DMC at different charge/discharge states in lithium secondary batteries was studied using extra reflectance FTIR spectra. Results show that solvent decomposition reaction that generally occurs on the surface of carbon and alkali metal electrodes also takes place on nano-SnO2.anode, and the major constituent of the passivating layer is Li2.O3 and ROCO2.i. Formation of the passivating layer would certainly lead to the irreversible capacity loss.

关键词： nano-SnO2.anode lithium rechargeable batteries FTIR passivating layer

Efficient inhibition of human telomerase activity by antisense oligonucle-otides sensitizes cancer cells to radiotherapy

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Acta Pharmacologica Sinica 2006年第9期27卷 1185-1191页

作者： Xue-mei JI~2.Cong-hua XIE~2.Ming-hao FANG~3 Fu-xiang ZHOU~2.Wen-jie ZHANG~4 Ming-sheng ZHANG~2.Yun-feng ZHOU~(2.5)2.Department of Chemotherapy and Radiation Oncology,Zhongnan Hospital,wuhan university,wuhan 430071,china 3 Department of Emergency,Tongji Hospital,Tongji Medical college,Huazhong university of Science and technology,wuhan 430030,china 4 Cancer Research Institute,wuhan university,wuhan 430071,china Department of Chemotherapy and Radiation Oncology Zhongnan Hospital Wuhan University Wuhan China Department of Emergency Tongji Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan China Cancer Research Institute Wuhan University Wuhan China

Aim:To investigate the effect of the antisense otigonucleotides（ASODN）spe-cific for human telomerase RNA（hTR）on radio sensitization and proliferationinhibition in human neurogliocytoma cells（U2.1）.Methods:U2.1 cells weretransfected with hTR ASODN or nonspecific oligonucleotides（NSODN）.Beforeand after irradiation of60Co-γray,telomerase activity was assayed by telomericrepeat amplification protocol（TRAP-PCR-ELISA）,and DNA damage and repairwere examined by the comet *** classical colony assay was used to plotthe cell-survival curve,to detect the ***:hTR antisense oligo-nucleotides could downregulate the telomerase activity,increase radiation in-duced DNA damage and reduce the subsequent ***,it could in-hibit the proliferation and decrease the D0value which demonstrates ***,telomere length was unchanged over a short period ***:These findings suggest that an ASODN-based strategy may beused to develop telomerase inhibitors,which can efficiently sensitize radiotherapy.

关键词： oligonucleotides,antisense telomerase radiotherapy glioma,astrocytic gene therapy

Neuroprotective effects of scutellarin on rat neuronal damage induced by cerebral ischemia/reperfusion

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Acta Pharmacologica Sinica 2005年第12期26卷 1454-1459页

作者： Xia-min HU~(1,3) Mi-mei ZHOU~1 Xian-min HU~1 Fan-dian ZENG~2.1 Department of Pharmacology,Medical college of wuhan {2. of Science and technology,wuhan 430080,china 2.Institute of Clinical Pharmacology,Tongji Medical college of Huazhong {2. of Science and technology,wuhan 430080,china Department of Pharmacology Medical College of Wuhan University of Science and Technology Wuhan China Institute of Clinical Pharmacology Tongji Medical College of Huazhong University of Science and Technology Wuhan China

Aim:To investigate the neuroprotective effect and mechanisms of scutellarin,aflavonoid extracted from Erigeron breviscapus Hand Mazz,against neuronal dam-age following cerebral ischemia/***:Rats were pretreated igwith scutellarin for 7 d and then subjected to cerebral ischemia/reperfusion(I/R)injury induced by a middle cerebral artery occlusion(MCAO).The infarct volumeand neurological deficit were determined by TTC staining and Longa' s *** of the blood-brain barrier was evaluated by measurement of the Evansblue(EB)content in the brain with a *** total NOx contentwas *** oxide synthase(NOS)isoforms(iNOS,eNOS,nNOS)andthe key angiogenic molecules,vascular endothelial growth factor(VEGF)andbasic fibroblast growth factor(bFGF),were detected by Western ***:Scutellarin significantly reduced infarct volume(P<0.05 or P<0.01),amelioratedthe neurological deficit and reduced the permeability of the blood-brain barrier(BBB)(P<0.05).When rats were pretreated with scutellarin(50 or 75 mg/kg),upregulation of eNOS expression and downregulation of VEGF,bFGF,and iNOSexpression was observed,whereas scutellarin had no effect on nNOS ***:Scutellarin has protective effects for cerebral injury through regulat-ing the expression of NOS isoforms and angiogenic molecules.

关键词： scutellarin brain ischemia nitric-oxide synthase vascular endothelial growth factor basic fibroblast growth factor