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Acta Pharmacologica Sinica 2005年第2期26卷 186-191页

作者： Zhi-jun GE~(1,2),Yin-ming ZENG~1,Yong-fei TAN~2~1jiangsu province key laboratory of anesthesiology,xuzhou medical college,xuzhou 221002,china ~2jiangsu province People's Hospital of Yixing,Yixing 214200,china jiangsu province key laboratory of anesthesiology Xuzhou Medical College Xuzhou China jiangsu province People's Hospital of Yixing Yixing China

Aim:To investigate the relationship between spinal cord norepinephrine,α1andα2adrenergic receptors and antinociception of propofol in ***:Kunming mice were *** tests were investigated with the tail-immersion test and the acetic acid-induced writhing *** effects of subcuta-neous（sc）,intrathecal（ith）and intracerebroventricular（icv）injection propofolon pain threshold were *** influences of pretreatment with ith 6-hydroxydopamine,α1R antagonist prazosin,or α2R antagonist yohimbine on theantinociception of propofol were ***:Significant antinociceptionwas produced by propofol（25,50 mg/kg,sc）and propofol（20,40μg,ith）in tail-immersion test and acetic the acid-induced writhing test（P20,and 40 μg）did not produce any effect on pain threshold in mice（P>0.05）.The 6-hydroxydopamine（5 and 10μg）,prazosin（5 and 10μg）,oryohimbine（5 and 10μg）ith alone did not affect basal tai-flick latency（TFL）inconscious mice,but significantly reduced the TFL as measured by tail-immersiontest in propofol（50mg/kg,sc）-treated mice,compared with basal TFL and ve-hicle groups（P2R.

关键词： propofol spinal cord antinociception prazosin yohimbine norepinephrine

Effects of H2S on cerebral arterioles myogenic responses in aging

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Effects of H2S on cerebral arterioles myogenic responses in ...

Regulation of Bcl-2,Bax and caspase-3 expression by shear stress via the PI3K/Akt pathway in mesenteric arterioles of aged rats

中国生理学会第23届全国会员代表大会暨生理学学术大会

作者： Lei LIU~1,You-Jian QI~1,Dong SUN~2,Chang-Dong YAN~(1,△) 1 Departments of Physiology,xuzhou medical Vollege,xuzhou,jiangsu,221002,Chin 2 jiangsu province key laboratory of anesthesiology,xuzhou medical college,xuzhou,jiangsu,221002,china

Objective:The potential biological significance of hydrogen sulfide(HS) has attracted growing interest in recent *** aim of this study was to illustrate the effect of HS on myogenic response and the role of HS in ***:Responses to changes in intravascular pressure of isolated rat cerebral arterioles were investigated under no-flow *** arterioles of young and old rats were isolated and *** diameters were measured with an image-shearing device and then *** response to step increases in perfusion pressure(from 20 to 120 mmHg,by 20 mmHg steps),arterioles constricted and developed active tone. Results:Isolated cerebral arterioles from young and old rats exhibited myogenic responses through the pressure ranges of 20 to 120 mmHg,and the old rats arterioles decreased their myogenic tones than the arterioles from young *** myogenic tones were reduced by NaHS in both young and old *** young group,glibenclamide the K channel blockers,significantly reduced the HS-induced attenuation of myogenic tones,the blockade of nitric oxide synthase further increased HS-induced attenuation of myogenic tones,and the cAMP synthesis inhibitor SQ22536 did not change the effect of HS,***,in old group,all these inhibitors did not change the effect of HS on myogenic *** of the endothelium significantly reduced NaHS-induced reduction of myogenic response in both young and old ***:Our results demonstrate that the effect of HS on myogenic response is partially mediated through K channel in young rats but not in old rats,and HS can attenuated myogenic tones through the way of endothelial cells.

关键词： cerebral arterioles myogenic reactivity hydrogen sulfide aging

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Regulation of Bcl-2,Bax and caspase-3 expression by shear st...

A novel mechanism of painful signal processing:Propagation failure of unmyelinated fibers in diabetic neuropathy rats

中国生理学会第23届全国会员代表大会暨生理学学术大会

作者： Yan LIU~(1,2),Yan-Hua CHANG~3,Chang-Dong YAN~1,Hong LIU~(3,*) 1 Department of Physiology xuzhou medical college,xuzhou 221002,china 2 jiangsu province key laboratory of anesthesiology, xuzhou medical college,xuzhou 221002,china 3 Department of Pathology xuzhou medical college,xuzhou 221002,china

＜正＞Objective:To investigate whether shear stress would regulate the expression of Bcl-2,Bax and Caspase-3 via the PI3K/Akt pathway in arterioles of aged ***:Second-order mesenteric arterioles of young（6 months） and aged（24 months） male SD rats were selectively ligated to elevate blood flow in first-order arterioles as high blood flow（HF）.A 3rd to 5th first-order arteriole proximal to the HF arteriole was selected as the normal blood flow （NF）.Three weeks after surgery,the arterioles were isolated and measured by vascular perfusion *** changes of arteriolar wall elasticity and the wall thickness of the first-order arterioles with HF and NF were *** expression of Akt,p-Akt,Bcl-2,Bax and Caspase-3 in NF and HF of young and aged rats were determined by western ***:（1） Compared with young rats,the content of arteriolar collagen fiber was increased,whereas the elasticity of arterioles was reduced in aged *** increased intravascular fluid shear stress,the elasticity of arterioles was increased and the function of arterioles was improved,however,there was no significant change in arteriolar morphology.（2） Western blot analysis showed that shear stress increased expression of p-Akt and Bcl-2,while decreased expression of Bax and Caspase-3 in NF arterioles of both *** aged rats,shear stress regulated p-Akt,Bcl-2 and Caspase-3 production in HF arterioles to a level similar to NF arterioles of young ***:Shear stress increased phosphorylated Akt production and played a key role in the regulation of Bcl-2,Bax and *** it can increase the flexibility and state of rat *** results suggest that shear stress acts as an efficient stimulus to improve function of mesenteric arterioles in aged rats via the PI3K/Akt pathway.

关键词： shear stress mesenteric arterioles aged Akt Bcl-2 Bax caspase-3

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A novel mechanism of painful signal processing:Propagation f...

Water-Driven Malleable,Weldable and Eco-Friendly Recyclable Carbon Fiber Reinforced Dynamic Composites

中国神经科学学会第四次会员代表大会暨第八届全国学术会议

作者： Xiu-Chao WANG~1,Wei SUN~1,Bei MIAO~(1,2),Wen-Ting WANG~1,Ceng LUO~1,Yi-Hui LIU~1,Fang KUANG~1,Jun-Ling XING~1, Hui XU~1,Gong JU~1,Xue-Jun SONG~2,San-Jue HU~(1,*) 1 Institute of Neuroscience,the Fourth Military medical University,Xi’an 710033,china 2 jiangsu province key laboratory of anesthesiology,xuzhou medical college,xuzhou 221002,china

Objective The precise mechanism of painful diabetic neuropathy(PDN) in unmyelinated fibers(C-fibers) remains unclear despite of the finding of hyper-responsivity in some subset of *** previous work found that conduction failures(CF) of main axon in C-fibers are one of adaptation phenomenon and information processing in peripheral *** present study is to investigate the roles of CF and it’s mechanisms in *** Streptozotocin (STZ,70mg/kg) diabetic model was induced with SD male *** injecting STZ 3-4 weeks,the behavioral responses to mechanical and heat stimulations were tested to the appearance of diabetic neuropathy *** single C fibers discharge was induced by mechanical and electrical stimulations for testing the changes of CF degree in C fibers within the coccygeal *** cell patch clamp recording in whole dorsal root ganglion(DRG) neurons was used to explore the excitability change and the intensity of sodium current in *** channel expression alterations were tested in DRG and C fibers of coccygeal nerve in control and NPD ***(1) A rat model of PDN induced by STZ has been set up. (2) The discharge numbers of single C-fiber in PDN were significantly higher than the control group in mechanical stimulations(100 g).High frequency firing(>3Hz) was found in about 1/3 of C-fibers in *** degree of PDN was distinctly lower than that of control ***,low dose TTX(100nM) could increase CF degree in partial PDN.(3) The threshold of action potential in PDN was lower than control *** its half width of action potential also was faster than control.(4) Sodium current of PDN was larger than control group.(5) Immunochemistry data showed that the numbers of Nav 1.7 cell,Nav 1.8 and Nav 1.9 in PDN were higher than *** the fluorescence intensities of Nav 1.7, Nav 1.8 and Nav1.9 in PDN also increased in coccygeal *** The results demonstrat that CF of the axon of C fibers is weakened during P

关键词： conduction failure unmyelinated fibers persistent sodium channel diabetic painful neuropathy dorsal root ganglion

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Chinese Journal of Chemistry 2024年第5期42卷 516-522页

作者： Ping Yu Qirui Huang Yi Wang Wan Peng Zichen Jia Haiyue Wang Juanjuan Ma Chunyu Wang xuzhou Yan School of Environmental and Chemical Engineering Jiangsu Key Laboratory of Function Control Technology for Advanced MaterialsJiangsu Ocean UniversityLianyungangJiangsu222005 China School of Chemistry and Chemical Engineering Frontiers Science Center for Transformative MoleculesShanghai Jiao Tong UniversityShanghai200240 China

Traditional carbon fiber-reinforced polymers based on thermoset matrix have been extensively used in the fields of wind turbine blades,automotive sector,and aerospace,among many ***,there is still a major challenge of recycling those polymers due to the high cost and adverse impacts on the *** this work,we apply a polyimine network as matrix,which possess considerable tensile and thermal properties,to prepare the carbon fiber reinforced polyimine materials with trifluoromethyl diphenoxybenzene units(CFRFP)using a prepreg-based compression molding *** CFRFP can be reshaped or reprocessed by heat or with water rapidly,and exhibited multifunction,including welding,chemical recycling,*** unique findings gained from our study will facilitate the manufacturing capability and enrich the types of fiber-reinforced composites.

关键词： Dynamic chemistry Green chemistry Fiber-reinforced composites Fluoropolyimine Welding Reshaping Recycling Renewable resources

Isoflurane preconditioning protects against ischemia-reperfusion injury partly by attenuating cytochrome c release from subsarcolemmal mitochondria in isolated rat hearts

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Acta Pharmacologica Sinica 2005年第7期26卷 813-820页

作者： Li-ping QIAN Shan-shan ZHU~2 Jun-li CAO Yin-ming ZENG jiangsu Provincial key Lab of anesthesiology,jiangsu Institute of anesthesiology,xuzhou medical college,xuzhou 221002,china jiangsu Provincial key Lab of anesthesiology Jiangsu Institute of Anesthesiology Xuzhou Medical College Xuzhou China

Aim:To examine if isoflurane preconditioning can attenuate ischemia/reperfusioninjury by reducing cytochrome c release from inner mitochondrial ***:Isolated hearts of Sprague-Dawley rats were perfused on *** were randomly assigned to a non-treated group(CON group,n=12)or three isoflurane preconditioning groups(0.5% ISC group,1.0% ISC group,and 2.0% ISC group;n=12).In the latter three groups,isoflurane was given atconcentrations of 0.5%,1.0%,and 2.0% for 15 min with 15-rain washout before30-min *** mitochondria of the myocardium were isolatedafter 60-min *** of the each heart was recorded,infarctsize of the hearts and contents of cytosolic cytochrome or mitochondrial cyto-chrome c were measured at the end of *** of isolated mito-chondria in the four groups was evaluated,***:Compared withthe CON group,cytosolic cytochrome c in 0.5% ISC group,1.0% ISC group,and2.0% ISC group were significantly decreased along with a significant increase ofmitochondrial cytochrome *** size of the hearts in the four groups were56%±12%,41%±12%,32%±7% and 33 %±11%,*** values of thethree isoflurane preconditioning groups were significantly lower than that of theCON group(P2.0% isofluraneon reducing cytochrome c release were more remarkable than 0.5% and 1.0%concentrations of ***:Myocardioprotective effects ofisofluranc preconditioning were associated with attenuation of cytochrome c lossfrom the inner membrane of subsarcolemmal mitochondria.

关键词： isoflurane reperfusion injury cytochromec mitochondria

Effects of intrathecal NMDA and AMPA receptors agonists or antagonists on antinociception of propofol

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Acta Pharmacologica Sinica 2004年第1期 11-16页

作者： Ai-jun XU, Shi-ming DUAN, Yin-ming ZENGjiangsu province key laboratory of anesthesiology, xuzhou medical college, xuzhou 221002, china

AIM: To study the effects of intrathecal (it) agonists and antagonists of N-methyl-D-aspartate (NMDA) and alpha amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid (AMPA) receptors and NMDAR1 antisense oligodeoxynucleotides (AS ODN) on the antinociception of propofol. METHODS: Hot-plate test (HPPT) and acetic acid-induced writhing test were used to measure the nociceptive thresholds in mice. The effects of intrathecal NMDA,

关键词： N-methyl-D-aspartate receptors AMPA receptors spinal injections antinociception propofol

Activation of ERK/CREB pathway in spinal cord contributes to chronic constrictive injury-induced neuropathic pain in rats

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Acta Pharmacologica Sinica 2005年第7期26卷 789-798页

作者： Xue-song SONG~2 Jun-li CAO~(3,4,5) Yan-bing XU~3 Jian-hua HE~3 Li-cai ZHANG~3 Yin-ming ZENG~(3,4)2 Department of anesthesiology,First Clinical college of N.Bethune Centre of Health Sciences,Jilin University,Changchun 130021,china 3 Department of anesthesiology,Affiliated Hospital of xuzhou medical college,xuzhou 221002,china 4 jiangsu Institute of anesthesiology,xuzhou 221002,china Department of anesthesiology First Clinical College of N. Bethune Centre of Health Sciences Jilin University Changchun China Department of anesthesiology Affiliated Hospital of Xuzhou Medical College Xuzhou China jiangsu Institute of anesthesiology Xuzhou China

Aim:To investigate whether activation and translocation of extracellular signal-regulated kinase(ERK)is involved in the induction and maintenance of neuro-pathic pain,and effects of activation and translocation of ERK on expression ofpCREB and Fos in the chronic neuropathic ***:Lumbar intrathecalcatheters were chronically implanted in male Sprague-Dawley *** left sciaticnerve was loosely ligated proximal to the sciatica's trifurcation at approximately 1.0mm intervals with 4-0 silk *** mitogen-activated protein kinase kinase(MEK)inhibitor U0126 or phosphorothioate-modified antisense oligonucleotides(ODN)were intrathecally administered every 12 h,1 d pre-chronic constrictioninjury(CCI)and 3 d *** and mechanical nociceptive thresholdswere assessed with the paw withdrawal latency(PWL)to radiant heat and vonFrey *** expression of pERK,pCREB,and Fos were assessed by bothWestern blotting and immunohistochemical ***:Intrathecal injec-tion of U0126 or ERK antisense ODN significantly attenuated CCI-induced me-chanical allodynia and thermal *** significantly increased the ex-pression of p-ERK-IR neurons in the ipsilateral spinal dorsal horn to injury,not inthe contralateral spinal dorsal *** time courses of pERK expression showedthat the levels of both cytosol and nuclear pERK,but not total ERK,were in-creased at all points after CCI and reached a peak level on postoperative d *** significantly increased the expression of pCREB and ***-CREB-positive neurons were distributed in all laminae of the bilateral spinal cord and Foswas expressed in laminae I and II of the ipsilateral spinal dorsal *** of U0126 or ERK antisense ODN markedly suppressed the increase ofCCI-induced pERK,pCREB and c-Fos expression in the spinal ***:The activation of ERK pathways contributes to neuropathic pain in CCI rats,andthe function of pERK may partly be accomplished via the cAMP

关键词： extracellular signal-regulated kinases cyclic AMP-response DNA-binding protein pain hyperalgesia spinal cord

Ginkgo biloba extract suppresses hypertrophy and extracellular matrix accumulation in rat mesangial cells

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Acta Pharmacologica Sinica 2006年第9期27卷 1222-1230页

作者： Jian-yun WANG~2 Xiao-xing YIN~(2,6)Yun-ming WU~2 Dao-quan TANG~2 Yuan-yuan GAO~2 Mei-rong WAN~4 Xiao-yu HOU~3 Bei ZHANG~5 2 Department of Pharmacy,3 Provincial key Lab for Brain Diseases Bioinformation,xuzhou medical college,xuzhou 221002,china 4 Center-laboratory,Affiliated Hospital of xuzhou medical college,xuzhou 221002,china 5 Department of Obstetrics and Gynecology,The Third People's Hospital of xuzhou,xuzhou 221002,china Department of Pharmacy Xuzhou Medical College Xuzhou China Center-laboratory Affiliated Hospital of Xuzhou Medical College Xuzhou China Provincial key Lab for Brain Diseases Bioinformation Xuzhou Medical College Xuzhou China Department of Obstetrics and Gynecology The Third People's Hospital of Xuzhou Xuzhou China

Aim:To observe the effects of Ginkgo biloba extract（EGb）on the hypertrophy ofmesangial cells and the accumulation of extracellular matrix（ECM）in ***:Cultured mesangial cells were allotted into 7 groups:normal group,solvent control group,high glucose group,low dose of EGb group,moderatedose of EGb group,high dose of EGb group,and captopril *** of cellantioxidases,S phase percentage and G0/G1phase percentage,collagen Ⅳ andlaminin,Smad2/3 and Smad7,TGF-β1mRNA were measured by different ***:For EGb-treated groups,when compared with high glucose group,thecell percentage of S phase was raised and the percentage of G0/G1was *** intensity of oxidative stress was *** expression of Smad2/3 wasgreatly decreased and Smad7 was *** Ⅳ,laminin and TGF-β1mRNA were also ***:EGb can suppress cell hypertrophy andthe accumulation of ECM in rat mesangial cells,which means it could play a vitalrole in the delay of glomerulosclerosis in diabetic nephropathy.

关键词： ginkgo biloba extract glomerulosclerosis oxidative stress TGF-β1 Smads

Intrathecal administration of Cav3.2 and Cav3.3 antisense oligonucleotide reverses tactile allodynia and thermal hyperalgesia in rats following chronic compression of dorsal root of ganglion

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Acta Pharmacologica Sinica 2006年第12期27卷 1547-1552页

作者： Xian-jie WEN~(1,2)Zhang-jun LI~2 Zhi-xin CHEN~2 Zhi-yuan FANG~3 Chen-xiang YANG~1 Heng LI~1 Yin-ming ZENG~(2,4)1 Department of anesthesiology,the First People's Hospital of FoShan & Affiliated FoShan Hospital of Sun-Yat Sen University,Foshan 528000,china 2 jiangsu province Institute of anesthesiology,xuzhou medical college,xuzhou 221002,china 3 Department of anesthesiology,the Municipal Hospital of Suzhou,Suzhou 215002,china Department of anesthesiology the First People's Hospital of FoShan & Affiliated FoShan Hospital of Sun-Yat Sen University Foshan China jiangsu province Institute of anesthesiology Xuzhou Medical College Xuzhou China Department of anesthesiology the Municipal Hospital of Suzhou Suzhou China

Aim:The present study aimed to elucidate the role of T-subtype calcium channels（Cav3.1,Cav3.2,and Cav3.3）in the pathogenesis of neuropathic pain at spinal ***:The chronic compression of the dorsal root ganglion（CCD）rat modelwas *** antisense oligonucleotide of Cav3.1,Cav3.2,and Cav3.3 or nor-mal saline（NS）were intrathecally administered twice per day from the first day tothe fourth day after *** mechanical withdrawal threshold and pawthermal withdrawal latency were measured to evaluate the tactile allodynia andthermal hyperalgesia,***:CCD rats developed reliable tactileallodynia and thermal hyperalgesia after *** administration ofantisense oligonucleotide of Cav3.2 and Cav3.3 significantly relieved tactileallodynia and thermal hyperalgesia in CCD rats,but not ***:Cav3.2and Cav3.3 subtype calcium channels in the spinal cord may play an important rolein the pathogenesis of neuropathic pain,which may contribute to the manage-ment of the neuropathic pain.

关键词： T-type calcium channels neuropathic pain spinal cord antisense oligonucleotide