Effects of intrathecal NMDA and AMPA receptors agonists or antagonists on antinociception of propofol

作     者：Ai-jun XU, Shi-ming DUAN, Yin-ming ZENGJiangsu Province Key Laboratory of Anesthesiology, Xuzhou Medical College, Xuzhou 221002, China 

出 版 物：《Acta Pharmacologica Sinica》 (中国药理学报(英文版))

年 卷 期：2004年第1期

页      面：11-16页

核心收录：

学科分类：1001[医学-基础医学(可授医学、理学学位)] 10[医学] 

主　　题：N-methyl-D-aspartate receptors AMPA receptors spinal injections antinociception propofol 

摘      要：AIM: To study the effects of intrathecal (it) agonists and antagonists of N-methyl-D-aspartate (NMDA) and alpha amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid (AMPA) receptors and NMDAR1 antisense oligodeoxynucleotides (AS ODN) on the antinociception of propofol. METHODS: Hot-plate test (HPPT) and acetic acid-induced writhing test were used to measure the nociceptive thresholds in mice. The effects of intrathecal NMDA,