Intrathecal administration of Cav3.2 and Cav3.3 antisense oligonucleotide reverses tactile allodynia and thermal hyperalgesia in rats following chronic compression of dorsal root of ganglion
Intrathecal administration of Cav3.2 and Cav3.3 antisense oligonucleotide reverses tactile allodynia and thermal hyperalgesia in rats following chronic compression of dorsal root of ganglion作者机构：Department of Anesthesiology the First People's Hospital of FoShan & Affiliated FoShan Hospital of Sun-Yat Sen University Foshan China Jiangsu Province Institute of Anesthesiology Xuzhou Medical College Xuzhou China Department of Anesthesiology the Municipal Hospital of Suzhou Suzhou China
出 版 物：《Acta Pharmacologica Sinica》 (中国药理学报(英文版))
年 卷 期：2006年第27卷第12期
页 面：1547-1552页
核心收录：
学科分类：1002[医学-临床医学] 100204[医学-神经病学] 10[医学]
主 题：T-type calcium channels neuropathic pain spinal cord antisense oligonucleotide
摘 要：Aim:The present study aimed to elucidate the role of T-subtype calcium channels（Cav3.1,Cav3.2,and Cav3.3）in the pathogenesis of neuropathic pain at spinal ***:The chronic compression of the dorsal root ganglion（CCD）rat modelwas *** antisense oligonucleotide of Cav3.1,Cav3.2,and Cav3.3 or nor-mal saline（NS）were intrathecally administered twice per day from the first day tothe fourth day after *** mechanical withdrawal threshold and pawthermal withdrawal latency were measured to evaluate the tactile allodynia andthermal hyperalgesia,***:CCD rats developed reliable tactileallodynia and thermal hyperalgesia after *** administration ofantisense oligonucleotide of Cav3.2 and Cav3.3 significantly relieved tactileallodynia and thermal hyperalgesia in CCD rats,but not ***:Cav3.2and Cav3.3 subtype calcium channels in the spinal cord may play an important rolein the pathogenesis of neuropathic pain,which may contribute to the manage-ment of the neuropathic pain.
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